We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
Most Useful Reviews
9
Instant flu relief
9 people found this helpful
They work quickly! I felt immediate relief from flu symptoms as soon as I took the first cap. I had been feeling unwell, weak, and mentally confused due to a virus. With each cap I took, I regained strength and clarity. I highly recommend these and have ordered additional products from this brand, including Madre Labs C. However, I believe GOL raw C is superior. It's wise to stock up during colder weather as these are raw and could be compromised in hot conditions.
Read More
10
Effective post-flu
2 people found this helpful
These vitamins work 100% after I got sick with the flu.
Read More
9
Mild flu symptoms
1 people found this helpful
I see the effect! I ordered these vitamins in the autumn and took them for a month. After that, I fell ill with the flu but surprisingly suffered a very mild illness. In the early days of the illness, I took 1g each – four capsules. My husband, who doesn’t take vitamins, experienced a much harsher illness and was unwell for about a week and a half, but with vitamin C, it was considerably easier for me.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
User Reviews
USERS' SCORE
Good
Based on 60 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Instant flu relief
9 people found this helpful
They work quickly! I felt immediate relief from flu symptoms as soon as I took the first cap. I had been feeling unwell, weak, and mentally confused due to a virus. With each cap I took, I regained strength and clarity. I highly recommend these and have ordered additional products from this brand, including Madre Labs C. However, I believe GOL raw C is superior. It's wise to stock up during colder weather as these are raw and could be compromised in hot conditions.
Read More
10
Effective post-flu
2 people found this helpful
These vitamins work 100% after I got sick with the flu.
Read More
9
Mild flu symptoms
1 people found this helpful
I see the effect! I ordered these vitamins in the autumn and took them for a month. After that, I fell ill with the flu but surprisingly suffered a very mild illness. In the early days of the illness, I took 1g each – four capsules. My husband, who doesn’t take vitamins, experienced a much harsher illness and was unwell for about a week and a half, but with vitamin C, it was considerably easier for me.
Read More
10
Effective for children
Our son used to get frequent flu during seasonal changes. After following our doctor's recommendation to give him vitamin C, specifically the raw option, for the last 3–4 years, we’ve noticed a marked decrease in flu and cold symptoms.
Read More
10
Cold prevention
The Best! I take higher doses of this vitamin at the first sign of any cold or flu, and it stops it from developing further. I generally adore Garden Of Life products, but this has saved me for many years now.
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
Vitamin C is often touted as a remedy for the common cold and flu, but the scientific evidence supporting its effectiveness is mixed. Some studies suggest that taking Vitamin C may reduce the duration and severity of flu-like symptoms, particularly in people who are under physical stress, such as athletes. However, for the average person, the benefits of high-dose Vitamin C in preventing or treating the flu are not conclusively supported by research. It's generally recommended to maintain an adequate intake of Vitamin C as part of a balanced diet, but relying solely on supplements is not a guaranteed method for preventing the flu.
Incorporating Vitamin C-rich foods, such as citrus fruits, strawberries, and bell peppers, can support your immune system and overall health. It's important to note that while Vitamin C can contribute to your well-being, it should not replace conventional flu prevention measures, like vaccination and good hygiene practices. If you're already experiencing flu symptoms, it's advisable to consult with a healthcare professional for appropriate treatment options.
Based on user reviews, results from taking this vitamin C supplement for flu symptoms can often be felt quickly. Many users report experiencing immediate relief from their symptoms. For example, one user mentioned feeling stronger and more clear-headed almost as soon as they took their first capsule (Read Review). Another user observed that taking the supplement helped to significantly ease the severity of their flu when compared to a family member who didn't take it (Read Review).
In general, users noted a pattern of seeing benefits shortly after starting the supplement, particularly when taken at the first signs of illness. For instance, one reviewer emphasized the importance of taking vitamin C early to prevent the flu from developing further (Read Review). Overall, many users recommend taking the vitamin regularly, especially during peak flu season, to maintain optimal immune support and minimize the likelihood of getting sick.
The notion that vitamin C can provide some support against the flu is backed by various studies, albeit with certain limitations. According to a study examining its role in respiratory infections, vitamin C was shown to reduce the incidence of acute respiratory infections, including flu, by about 4% and shortened the duration of flu symptoms by approximately 9% [1]. This finding suggests that while vitamin C might not be a cure-all, it could contribute to milder flu experiences, particularly when combined with other immune-boosting substances.
Moreover, other research indicates that vitamin C may enhance immune responses during flu infections. For instance, a study found that when combined with red ginseng, vitamin C significantly improved immune cell activity and reduced lung inflammation in flu-infected subjects [3]. Additionally, vitamin C-conjugated compounds are being investigated for their potential to inhibit influenza virus activity directly, highlighting the interest in vitamin C as part of broader strategies against the flu [4]. Overall, while scientific research shows that vitamin C has potential benefits in the context of flu prevention and treatment, it is important to approach it as a complement to other methods rather than a standalone solution.
Users have reported a range of improvements in their flu symptoms after incorporating this vitamin C supplement into their routines. Many individuals highlighted rapid relief from symptoms, often feeling better almost immediately after taking the first capsule (Read Review). There are numerous anecdotes of mild illness experiences compared to family members who did not take the supplement, suggesting it may lessen the severity of flu symptoms (Read Review). Additionally, some users noted a marked reduction in the frequency of colds and flu when using the supplement regularly, citing experiences like remaining healthy while others around them fell ill (Read Review; Read Review).
Other users emphasized the vitamin's role in enhancing overall immunity and vitality, while some affirmed its effectiveness in the context of children's flu symptoms, leading to improvements in their health (Read Review; Read Review). Overall, while individual experiences can vary, a substantial number of reviews suggest that consistent use of this vitamin C supplement may lead to enhanced health and wellness during flu season.
Based on user reviews, many individuals have successfully combined this vitamin C supplement with other supplements or health practices to alleviate flu symptoms more effectively. For instance, one user reported taking a higher dose of vitamin C at the first sign of illness, which they found to prevent the flu from worsening (Read Review). Others have noted improvements in overall immune function when integrating this supplement into a broader wellness routine, such as maintaining a consistent intake during flu season (Read Review).
Additionally, some users highlighted the supplement's role in enhancing the effects of other measures taken to combat illness. One user mentioned that since their child started taking these vitamin C capsules, they hadn't experienced flu symptoms, suggesting a synergistic effect when combined with proper dietary practices (Read Review). Overall, while many users report positive experiences using this vitamin alongside other health strategies, the consensus leans towards increased immunity and reduced illness severity when combined with a holistic approach to health.
While there's no universally agreed-upon optimal dose of Vitamin C specifically for treating the flu, research provides some intriguing insights. A study found that oral Vitamin C dosages of 125 and 250 mg/kg in mice showed significant reduction in severe outcomes related to H1N1 pneumonia, suggesting that these doses could potentially enhance immune response during viral infections [5]. Another study indicated that Vitamin C could help shorten flu symptoms by approximately 9%, although the precise dosage was not highlighted [1].
Moreover, the effects of Vitamin C appear to be more pronounced when combined with other agents, such as red ginseng, to enhance immune response and combat inflammation [3]. Therefore, while higher doses might benefit some individuals, it's crucial to consult healthcare providers before commencing any supplementation, especially for treating flu, to determine a suitable approach tailored to individual health needs.
9
Instant flu relief
9 people found this helpful
They work quickly! I felt immediate relief from flu symptoms as soon as I took the first cap. I had been feeling unwell, weak, and mentally confused due to a virus. With each cap I took, I regained strength and clarity. I highly recommend these and have ordered additional products from this brand, including Madre Labs C. However, I believe GOL raw C is superior. It's wise to stock up during colder weather as these are raw and could be compromised in hot conditions.
9
Mild flu symptoms
1 people found this helpful
I see the effect! I ordered these vitamins in the autumn and took them for a month. After that, I fell ill with the flu but surprisingly suffered a very mild illness. In the early days of the illness, I took 1g each – four capsules. My husband, who doesn’t take vitamins, experienced a much harsher illness and was unwell for about a week and a half, but with vitamin C, it was considerably easier for me.
10
Cold prevention
The Best! I take higher doses of this vitamin at the first sign of any cold or flu, and it stops it from developing further. I generally adore Garden Of Life products, but this has saved me for many years now.
9
Flu protection
Super Vitamin C! I must sing its praises. Last winter, my entire family was sick with the flu, but I remained healthy thanks to my vitamin C—no runny nose whatsoever. I now drink it regularly and trust its effectiveness.
7.5
Immunity strength observed
This is the Vitamin C my whole family takes daily, and amidst the spread of RSV, flu, and other respiratory viruses, none of us have fallen ill. I am confident it strengthens our immunity and keeps us healthy. I’m very pleased with this product and will continue to use it.
9
Helpful for child
2 people found this helpful
I'm very pleased with this product. For the first time, I’ve seen a vitamin that helps my 3-year-old daughter with her ongoing flu during the autumn/winter season. I'm definitely repurchasing it.
9
Kid's flu relief
1 people found this helpful
Ever since my daughter started taking these vitamin C capsules, I haven’t heard her complain about the flu or a runny nose. They seem to be working well for her.
9
Boosts immunity effectively
The best vitamin C! This Raw Vitamin C is effective and safe for the entire family, formulated with unprocessed organic fruits, vegetables, probiotics, and enzymes for better absorption. I take two capsules daily, especially during flu season, as Vitamin C flushes out quickly. It's an irreplaceable supplement during colds; I notice a significant effect if taken at the first sign. The only downside is the cost, which is relatively high without discounts.
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
9
Immune booster for flu treatment
Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
References
Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. 10.1136/bmjgh-2020-003176
Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020;25. 10.3390/molecules25184248
Kim H, Jang M, Kim Y, Choi J, Jeon J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016;68:406. 10.1111/jphp.12529
Wang H, Xu R, Shi Y, Si L, Jiao P, et al. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur J Med Chem. 2016;110:376. 10.1016/j.ejmech.2016.01.005
Cai Y, Li YF, Tang LP, Tsoi B, Chen M, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. 10.1155/2015/675149