Last update
3/9/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 42 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
8
We explored how the treatment with JB-1—a type of probiotic bacteria—affects anxiety during chronic stress in rats. In our study, half of the twenty rats received JB-1 while the other half got a placebo over eight weeks of stress exposure.
The results were telling! Rats on JB-1 showed less anxiety and were more willing to explore their environment compared to the placebo group, which largely avoided exploration. Additionally, measurements of brain metabolites indicated that JB-1 helped maintain stability in brain chemistry, even in stressful conditions.
This suggests that lactobacillus rhamnosus might play a beneficial role in reducing anxiety during prolonged stress.
The results were telling! Rats on JB-1 showed less anxiety and were more willing to explore their environment compared to the placebo group, which largely avoided exploration. Additionally, measurements of brain metabolites indicated that JB-1 helped maintain stability in brain chemistry, even in stressful conditions.
This suggests that lactobacillus rhamnosus might play a beneficial role in reducing anxiety during prolonged stress.
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9
We investigated the impact of Lactobacillus acidophilus and Bifidobacterium adolescentis on anxiety levels in rats facing acute hypoxia. In our study, 64 male Wistar rats were divided into four groups for comparison. The results showed that rats receiving probiotics exhibited lower oxidative stress and anxiety levels compared to those who did not. Notably, those treated with probiotics went through behavioral tests indicating increased exploratory behavior and decreased anxiety. Overall, our findings suggest that these probiotics offer both antioxidant and anxiety-reducing effects in stressful conditions.
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8
We examined how colonizing newborn mice with probiotics, specifically Lactobacillus rhamnosus GG (LGG), influences anxiety in adulthood. By administering live LGG during pregnancy and early life, we observed significant changes to the gut microbiome and protective effects on the intestinal barrier. Notably, the adult mice with LGG colonization showed reduced anxiety-like behaviors in tests designed to measure stress responses. This indicates that early life probiotics could play an important role in regulating the gut-brain axis and improving mental health in later life.
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Most Useful Reviews
9
Stomach issue relief
6 people found this helpful
Got rid of my acid reflux! This product is exceptional, the only probiotic that truly helped my stomach problems. I often experience acid reflux linked to anxiety, which had become almost daily. After seeing a YouTuber discuss its benefits, I purchased it immediately. This has been a game changer!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 42 Researches
7.3
- All Researches
9
We investigated the impact of Lactobacillus acidophilus and Bifidobacterium adolescentis on anxiety levels in rats facing acute hypoxia. In our study, 64 male Wistar rats were divided into four groups for comparison. The results showed that rats receiving probiotics exhibited lower oxidative stress and anxiety levels compared to those who did not. Notably, those treated with probiotics went through behavioral tests indicating increased exploratory behavior and decreased anxiety. Overall, our findings suggest that these probiotics offer both antioxidant and anxiety-reducing effects in stressful conditions.
Read More
9
We investigated how probiotics, specifically Lactobacillus rhamnosus and Bifidobacterium BB-12, can affect anxiety in a mouse model of Alzheimer’s disease. In our study, we found that mice treated with these probiotics exhibited significantly reduced anxiety-like behaviors compared to those exposed to aluminum chloride alone.
Through various behavioral tests, it was evident that this probiotic combination also improved memory functions. Our results suggest that leveraging the gut-brain axis through these probiotics could offer a promising approach for alleviating anxiety and cognitive deficits in neurodegenerative conditions like Alzheimer's.
Through various behavioral tests, it was evident that this probiotic combination also improved memory functions. Our results suggest that leveraging the gut-brain axis through these probiotics could offer a promising approach for alleviating anxiety and cognitive deficits in neurodegenerative conditions like Alzheimer's.
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We conducted a study to assess how well the probiotic CECT 7347 (ES1) and the heat-treated version (HT-ES1) helped alleviate diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms in adults. Over 84 days, participants took either the probiotic, the postbiotic, or a placebo, reporting significant improvement in key measures like symptom severity, quality of life, and even anxiety levels. The results demonstrated a notable reduction in IBS symptoms, making it one of the first trials to show such effectiveness in this area.
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9
Bifidobacterium longum may ease anxiety
We examined the impact of a probiotic blend, Bifidobacterium longum strains 1714® and 35642®, on anxiety and irritable bowel syndrome (IBS) symptoms in patients. Over eight weeks, we observed that the treatment helped restore the stress response and improved IBS symptoms and psychometric scores for anxiety and depression.
Interestingly, the benefits continued after stopping treatment, suggesting a lasting positive effect. The findings indicate that managing stress can significantly influence IBS symptoms and associated mood disturbances.
Interestingly, the benefits continued after stopping treatment, suggesting a lasting positive effect. The findings indicate that managing stress can significantly influence IBS symptoms and associated mood disturbances.
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9
Bifidobacterium lactis reduces anxiety significantly
We conducted a thorough investigation into the effects of Bifidobacterium lactis, known as Probio-M8, on anxiety and overall well-being in patients with coronary artery disease (CAD). Over six months, we compared a group receiving the probiotic with a placebo group.
Notably, those in the probiotic group reported significant improvements in anxiety levels and other markers of mental health. This suggests that enhancing gut health can also positively influence our mood and emotional states.
With ongoing research, it’s becoming clearer how beneficial our gut bacteria can be for our overall mental and physical wellness.
Notably, those in the probiotic group reported significant improvements in anxiety levels and other markers of mental health. This suggests that enhancing gut health can also positively influence our mood and emotional states.
With ongoing research, it’s becoming clearer how beneficial our gut bacteria can be for our overall mental and physical wellness.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Stomach issue relief
6 people found this helpful
Got rid of my acid reflux! This product is exceptional, the only probiotic that truly helped my stomach problems. I often experience acid reflux linked to anxiety, which had become almost daily. After seeing a YouTuber discuss its benefits, I purchased it immediately. This has been a game changer!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Chan HHY, Siu PLK, Choy CT, Chan UK, Zhou J, et al. Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health Symptoms and Sleep Quality in Hong Kong Chinese. Nutrients. 2023;15. 10.3390/nu15245037
- Haghighat N, Mohammadshahi M, Shayanpour S, Haghighizadeh MH, Rahmdel S, et al. The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial. Indian J Nephrol. 2021;31:149. 10.4103/ijn.IJN_341_19
- Kozin SV, Kravtsov AA, Kravchenko SV, Ivashchenko LI. [Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia]. Vopr Pitan. 2021;90:63. 10.33029/0042-8833-2021-90-2-63-72
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- Al Kassaa I, Fuad M. Effects of HN001 on Happiness and Mental Well-Being: Findings from a Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16172936
- Ruiz-Gonzalez C, Cardona D, Rueda-Ruzafa L, Rodriguez-Arrastia M, Ropero-Padilla C, et al. Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double-Blind Randomized Placebo-Controlled Crossover Trial. Probiotics Antimicrob Proteins. 2024. 10.1007/s12602-024-10315-2
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- Schell M, Wardelmann K, Hauffe R, Rath M, Chopra S, et al. Sex-Specifically Attenuates Depressive-like Behavior and Mitigates Metabolic Consequences in Obesity. Biol Psychiatry Glob Open Sci. 2023;3:651. 10.1016/j.bpsgos.2023.02.011
- Jadhav G, Dudhabhate BB, Kokare DM, Sakharkar AJ. Gut Microbiota Regulates Epigenetic Remodelling in the Amygdala: A Role in Repeated Mild Traumatic Brain Injury (rMTBI)-Induced Anxiety. Mol Neurobiol. 2024;61:9892. 10.1007/s12035-023-03697-x
- Walden KE, Moon JM, Hagele AM, Allen LE, Gaige CJ, et al. A randomized controlled trial to examine the impact of a multi-strain probiotic on self-reported indicators of depression, anxiety, mood, and associated biomarkers. Front Nutr. 2023;10:1219313. 10.3389/fnut.2023.1219313
- Hamid M, Zahid S. Ameliorative effects of probiotics in AlCl-induced mouse model of Alzheimer's disease. Appl Microbiol Biotechnol. 2023;107:5803. 10.1007/s00253-023-12686-y
- Chudzik A, Słowik T, Kochalska K, Pankowska A, Łazorczyk A, et al. Continuous Ingestion of JB-1 during Chronic Stress Ensures Neurometabolic and Behavioural Stability in Rats. Int J Mol Sci. 2022;23. 10.3390/ijms23095173
- Wauters L, Van Oudenhove L, Accarie A, Geboers K, Geysen H, et al. CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial. Gut Microbes. 2022;14:2031695. 10.1080/19490976.2022.2031695
- Zhou B, Jin G, Pang X, Mo Q, Bao J, et al. Lactobacillus rhamnosus GG colonization in early life regulates gut-brain axis and relieves anxiety-like behavior in adulthood. Pharmacol Res. 2022;177:106090. 10.1016/j.phrs.2022.106090
- Liu Y, Sanderson D, Mian MF, McVey Neufeld KA, Forsythe P. Loss of vagal integrity disrupts immune components of the microbiota-gut-brain axis and inhibits the effect of Lactobacillus rhamnosus on behavior and the corticosterone stress response. Neuropharmacology. 2021;195:108682. 10.1016/j.neuropharm.2021.108682
- Foroozan P, Koushkie Jahromi M, Nemati J, Sepehri H, Safari MA, et al. Probiotic Supplementation and High-Intensity Interval Training Modify Anxiety-Like Behaviors and Corticosterone in High-Fat Diet-Induced Obesity Mice. Nutrients. 2021;13. 10.3390/nu13061762
- Quero CD, Manonelles P, Fernández M, Abellán-Aynés O, López-Plaza D, et al. Differential Health Effects on Inflammatory, Immunological and Stress Parameters in Professional Soccer Players and Sedentary Individuals after Consuming a Synbiotic. A Triple-Blinded, Randomized, Placebo-Controlled Pilot Study. Nutrients. 2021;13. 10.3390/nu13041321
- Tamayo M, Agusti A, Molina-Mendoza GV, Rossini V, Frances-Cuesta C, et al. Bifidobacterium longum CECT 30763 improves depressive- and anxiety-like behavior in a social defeat mouse model through the immune and dopaminergic systems. Brain Behav Immun. 2025;125:35. 10.1016/j.bbi.2024.12.028
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- Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. 10.1080/19490976.2024.2338322
- Boehme M, Rémond-Derbez N, Lerond C, Lavalle L, Keddani S, et al. subsp. Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial. Nutrients. 2023;15. 10.3390/nu15143122
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- Haghighat N, Rajabi S, Mohammadshahi M. Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial. Nutr Neurosci. 2021;24:490. 10.1080/1028415X.2019.1646975
Data last updated:
