' 
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.9
USERS' SCORE
Medium or Average
Based on 13 Reviews
6.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
9
LC-STH-13 counters lupus effects
LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.
High relevance, promising findings
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production.
High relevance for autoimmune treatment
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models.
Study shows viable celiac treatment potential.
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
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Most Useful Reviews
8.3
Did not help
After years of dealing with intestinal dysfunction and an autoimmune disorder, I decided to try various probiotics, but unfortunately, they were ineffective for me. I even experienced negative side effects from one of them. Despite my efforts, I did not find relief and would suggest testing different options first to determine what works for you.
Read More
9.5
Highly recommended
Taking this probiotic has greatly aided my autoimmune disorder, particularly with its Lactobacillus rhamnosus strain, which is known to combat c. difficile infections. I used it before, during, and after my surgery while on antibiotics, and thankfully experienced no issues. I've since made it a part of my daily routine. It deserves its 5-star rating, and I wholeheartedly recommend it.
Read More
9.5
Life-changing results
This is the best probiotic for my autoimmune disorder! Suggested by my doctor, it helped reduce my reliance on Immodium within just two days. My gastrointestinal issues have significantly improved, allowing me to lead a normal life. I'm eagerly awaiting my next order to continue the improvements.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.9
- All Researches
9
Probiotic IRT5 reduces diabetes effects
Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics.
Relevant for diabetes research
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Read More
9
Synbiotics improve rheumatoid arthritis symptoms
Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial.
High relevance; significant findings
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production.
High relevance for autoimmune treatment
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
Probiotics may aid rheumatoid arthritis
The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages.
High relevance to autoimmune treatment
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
9
LC-STH-13 counters lupus effects
LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.
High relevance, promising findings
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 13 Reviews
6.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Did not help
After years of dealing with intestinal dysfunction and an autoimmune disorder, I decided to try various probiotics, but unfortunately, they were ineffective for me. I even experienced negative side effects from one of them. Despite my efforts, I did not find relief and would suggest testing different options first to determine what works for you.
Read More
9.5
Highly recommended
Taking this probiotic has greatly aided my autoimmune disorder, particularly with its Lactobacillus rhamnosus strain, which is known to combat c. difficile infections. I used it before, during, and after my surgery while on antibiotics, and thankfully experienced no issues. I've since made it a part of my daily routine. It deserves its 5-star rating, and I wholeheartedly recommend it.
Read More
9.5
Life-changing results
This is the best probiotic for my autoimmune disorder! Suggested by my doctor, it helped reduce my reliance on Immodium within just two days. My gastrointestinal issues have significantly improved, allowing me to lead a normal life. I'm eagerly awaiting my next order to continue the improvements.
Read More
0
Adverse reaction
Initially encouraged by positive reviews, I found that after two doses of this probiotic, my symptoms severely worsened, resembling poisoning. I cannot recommend it for anyone with an autoimmune disorder.
8.8
Capsule variety availability
I am new to Primal Defense and grateful this product does not contain the S. Thermophilus strain, which irritates my autoimmune disorder (ankylosing spondylitis). These products are necessary for those with incurable autoimmune disorders. I appreciate the larger 216-cap bottle and hope the price remains accessible for those of us needing these essentials consistently. I’m looking for improvements in symptoms and skin quality.
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