Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 16 Reviews
8.2
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*
Top Medical Research Studies
9
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in a study designed to understand its role in overcoming hypothyroidism-induced neuronal apoptosis, especially during crucial cerebellar development. Our research involved supplementing pregnant and lactating rats with a mixture of DHA and eicosapentaenoic acid (EPA) while inducing hypothyroidism using methimazole.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
Read More
7
We explored the effects of hypothyroidism on phospholipids in the sarcoplasmic reticulum of fast skeletal muscle in rats. Through comparing hypothyroid rats with control (euthyroid) rats, we observed notable changes in the levels of specific phospholipids, particularly phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Hypothyroidism led to a 24% decrease in PE and an increase in PC, while levels of other phospholipids and cholesterol remained steady.
Our study examined the fatty acyl composition of these phospholipids as well. We found that both PE and PC compositions were quantitatively distinct, with hypothyroid conditions causing shifts in fatty acids. Specifically, we noted an increased presence of docosahexaenoic acid (22:6(n - 3)), as well as arachidonic acid (20:4(n - 6)), among others. Conversely, there were decreases in linoleic (18:2(n - 6)), palmitic (16:0), and oleic (18:1(n - 9)) acids.
Interestingly, a 14-day treatment with thyroid hormone significantly reversed the changes in phospholipid distribution and fatty acyl composition, bringing many values back to those seen in euthyroid rats. However, while some improvements were observed for docosahexaenoic acid, others such as linoleic and certain fatty acids in PC did not fully return to baseline levels. This indicates that, while there are changes associated with hypothyroidism that involve docosahexaenoic acid, the treatment does not completely restore the fatty acid profile.
Our study examined the fatty acyl composition of these phospholipids as well. We found that both PE and PC compositions were quantitatively distinct, with hypothyroid conditions causing shifts in fatty acids. Specifically, we noted an increased presence of docosahexaenoic acid (22:6(n - 3)), as well as arachidonic acid (20:4(n - 6)), among others. Conversely, there were decreases in linoleic (18:2(n - 6)), palmitic (16:0), and oleic (18:1(n - 9)) acids.
Interestingly, a 14-day treatment with thyroid hormone significantly reversed the changes in phospholipid distribution and fatty acyl composition, bringing many values back to those seen in euthyroid rats. However, while some improvements were observed for docosahexaenoic acid, others such as linoleic and certain fatty acids in PC did not fully return to baseline levels. This indicates that, while there are changes associated with hypothyroidism that involve docosahexaenoic acid, the treatment does not completely restore the fatty acid profile.
Read More
Most Useful Reviews
9
Optimises thyroid function
7 people found this helpful
Ashwagandha is renowned for stimulating the thyroid gland and promoting its optimal function, which is beneficial for those with hypothyroidism. Additionally, it effectively reduces stress and anxiety, helping individuals manage cortisol levels and maintain calm throughout the day. Its antioxidant properties also assist in detoxifying the body.
Read More
9
Beneficial herbs
6 people found this helpful
I recommend this to anyone with hypothyroidism. I have benefited immensely from these herbs, and the results of my analyses exceeded my expectations after three months of continued use.
Read More
9
Boosted energy levels
3 people found this helpful
This product works well for my hypothyroidism. I previously struggled with depression and anxiety, but I noticed these symptoms diminishing in the first week of use. My mood improved, and I had more energy, making it easier to arise in the morning without the overwhelming exhaustion I experienced earlier. Although I'm on other medications, I feel a noticeable difference and will reorder. I've also recommended it to my brother, who has experienced similar improvements in just a week. Individual results may vary, but I believe it's worthwhile to try.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
9
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in a study designed to understand its role in overcoming hypothyroidism-induced neuronal apoptosis, especially during crucial cerebellar development. Our research involved supplementing pregnant and lactating rats with a mixture of DHA and eicosapentaenoic acid (EPA) while inducing hypothyroidism using methimazole.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
Read More
7
We explored the effects of hypothyroidism on phospholipids in the sarcoplasmic reticulum of fast skeletal muscle in rats. Through comparing hypothyroid rats with control (euthyroid) rats, we observed notable changes in the levels of specific phospholipids, particularly phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Hypothyroidism led to a 24% decrease in PE and an increase in PC, while levels of other phospholipids and cholesterol remained steady.
Our study examined the fatty acyl composition of these phospholipids as well. We found that both PE and PC compositions were quantitatively distinct, with hypothyroid conditions causing shifts in fatty acids. Specifically, we noted an increased presence of docosahexaenoic acid (22:6(n - 3)), as well as arachidonic acid (20:4(n - 6)), among others. Conversely, there were decreases in linoleic (18:2(n - 6)), palmitic (16:0), and oleic (18:1(n - 9)) acids.
Interestingly, a 14-day treatment with thyroid hormone significantly reversed the changes in phospholipid distribution and fatty acyl composition, bringing many values back to those seen in euthyroid rats. However, while some improvements were observed for docosahexaenoic acid, others such as linoleic and certain fatty acids in PC did not fully return to baseline levels. This indicates that, while there are changes associated with hypothyroidism that involve docosahexaenoic acid, the treatment does not completely restore the fatty acid profile.
Our study examined the fatty acyl composition of these phospholipids as well. We found that both PE and PC compositions were quantitatively distinct, with hypothyroid conditions causing shifts in fatty acids. Specifically, we noted an increased presence of docosahexaenoic acid (22:6(n - 3)), as well as arachidonic acid (20:4(n - 6)), among others. Conversely, there were decreases in linoleic (18:2(n - 6)), palmitic (16:0), and oleic (18:1(n - 9)) acids.
Interestingly, a 14-day treatment with thyroid hormone significantly reversed the changes in phospholipid distribution and fatty acyl composition, bringing many values back to those seen in euthyroid rats. However, while some improvements were observed for docosahexaenoic acid, others such as linoleic and certain fatty acids in PC did not fully return to baseline levels. This indicates that, while there are changes associated with hypothyroidism that involve docosahexaenoic acid, the treatment does not completely restore the fatty acid profile.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Optimises thyroid function
7 people found this helpful
Ashwagandha is renowned for stimulating the thyroid gland and promoting its optimal function, which is beneficial for those with hypothyroidism. Additionally, it effectively reduces stress and anxiety, helping individuals manage cortisol levels and maintain calm throughout the day. Its antioxidant properties also assist in detoxifying the body.
Read More
9
Beneficial herbs
6 people found this helpful
I recommend this to anyone with hypothyroidism. I have benefited immensely from these herbs, and the results of my analyses exceeded my expectations after three months of continued use.
Read More
9
Boosted energy levels
3 people found this helpful
This product works well for my hypothyroidism. I previously struggled with depression and anxiety, but I noticed these symptoms diminishing in the first week of use. My mood improved, and I had more energy, making it easier to arise in the morning without the overwhelming exhaustion I experienced earlier. Although I'm on other medications, I feel a noticeable difference and will reorder. I've also recommended it to my brother, who has experienced similar improvements in just a week. Individual results may vary, but I believe it's worthwhile to try.
Read More
9
Helps balance stress
2 people found this helpful
Ashwagandha is an adaptogen facilitating the body’s response to stress by lowering cortisol levels and balancing thyroid hormone T4. Clinical trials indicate that after eight weeks, patients with hypothyroidism saw significant increases in thyroxine levels, diminishing the severity of the condition. I highly recommend it!
Read More
9
Revitalised health observed
2 people found this helpful
After years of carbohydrate restriction, I developed hypothyroidism and was in terrible health until I found this product. It has revitalised me, allowing for restful sleep and resulting in energy throughout the day. I noticed no side effects, and my thyroid function improved during tests. I’m truly grateful for this product.
Read More
Frequently Asked Questions
9
Boosted energy levels
3 people found this helpful
This product works well for my hypothyroidism. I previously struggled with depression and anxiety, but I noticed these symptoms diminishing in the first week of use. My mood improved, and I had more energy, making it easier to arise in the morning without the overwhelming exhaustion I experienced earlier. Although I'm on other medications, I feel a noticeable difference and will reorder. I've also recommended it to my brother, who has experienced similar improvements in just a week. Individual results may vary, but I believe it's worthwhile to try.
9
Beneficial herbs
6 people found this helpful
I recommend this to anyone with hypothyroidism. I have benefited immensely from these herbs, and the results of my analyses exceeded my expectations after three months of continued use.
7.5
Alleviates depression effectively
2 people found this helpful
I ordered ashwagandha due to my hypothyroidism and found it beneficial in stimulating adrenal function. After three months of morning use, my depression and anxiety levels decreased markedly. The product's quality is commendable, and I find the smell and taste acceptable. Overall, this small capsule has made a positive impact on my well-being.
9
Helps balance stress
2 people found this helpful
Ashwagandha is an adaptogen facilitating the body’s response to stress by lowering cortisol levels and balancing thyroid hormone T4. Clinical trials indicate that after eight weeks, patients with hypothyroidism saw significant increases in thyroxine levels, diminishing the severity of the condition. I highly recommend it!
6
Reduced anxiety levels
9 people found this helpful
Ashwagandha alleviated my nervousness but did not boost my energy. This year has been stressful, and I'm seeking remedies for nervousness and depression. Although I'm aware that many adaptogens are unsuitable for my hypothyroidism, I found that this product diminished my anxiety and negative thoughts significantly. While I did not experience increased energy, the reduction in nervousness has been essential for me, and I'm content with the results. I noticed no side effects while taking it on an empty stomach each morning.
7.5
Calms anxiety
This is amazing for individuals with anxiety and tension, as it calms the mind. It has a pleasant scent and is suitable for hypothyroidism. I’ve noticed it significantly improves my sleep quality.
7.5
Improved hair quality
4 people found this helpful
I started taking this as a trial for my hypothyroidism. Rather than rely on medication, I stopped taking Thyradin and switched to this alone. I haven't yet had a blood test, so I don't know my current levels, but my hair is noticeably less frizzy than when I was on medication. Having adequate hormones genuinely improves my hair quality, and I can really feel the difference. After having my hormones tested, I noticed an improvement. I'm grateful for this and wish to continue taking it.
7.5
Stress relief
I took this supplement for prophylaxis and as an adaptogen. Much has been said about ashwagandha in traditional medicine. I was advised to use it as it can protect against ageing, increase fatigue resistance, enhance mental clarity, and even support thyroid function in asymptomatic hypothyroidism. Since taking it along with other supplements, I've noticed the stress manifestations in my body have lessened, and I feel almost healthy.
9
Enhanced energy levels
1 people found this helpful
Ashwagandha for hypothyroidism helps to normalise thyroid hormones, which I experienced personally. My T3 levels reached the top of the reference range, resulting in boosts to my energy and mood. I have struggled with hypothyroidism for two years now, and this supplement also lowers cortisol levels. However, it's important to note that it might exacerbate symptoms of hyperthyroidism.
9
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in a study designed to understand its role in overcoming hypothyroidism-induced neuronal apoptosis, especially during crucial cerebellar development. Our research involved supplementing pregnant and lactating rats with a mixture of DHA and eicosapentaenoic acid (EPA) while inducing hypothyroidism using methimazole.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
7
We explored the effects of hypothyroidism on phospholipids in the sarcoplasmic reticulum of fast skeletal muscle in rats. Through comparing hypothyroid rats with control (euthyroid) rats, we observed notable changes in the levels of specific phospholipids, particularly phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Hypothyroidism led to a 24% decrease in PE and an increase in PC, while levels of other phospholipids and cholesterol remained steady.
Our study examined the fatty acyl composition of these phospholipids as well. We found that both PE and PC compositions were quantitatively distinct, with hypothyroid conditions causing shifts in fatty acids. Specifically, we noted an increased presence of docosahexaenoic acid (22:6(n - 3)), as well as arachidonic acid (20:4(n - 6)), among others. Conversely, there were decreases in linoleic (18:2(n - 6)), palmitic (16:0), and oleic (18:1(n - 9)) acids.
Interestingly, a 14-day treatment with thyroid hormone significantly reversed the changes in phospholipid distribution and fatty acyl composition, bringing many values back to those seen in euthyroid rats. However, while some improvements were observed for docosahexaenoic acid, others such as linoleic and certain fatty acids in PC did not fully return to baseline levels. This indicates that, while there are changes associated with hypothyroidism that involve docosahexaenoic acid, the treatment does not completely restore the fatty acid profile.
Our study examined the fatty acyl composition of these phospholipids as well. We found that both PE and PC compositions were quantitatively distinct, with hypothyroid conditions causing shifts in fatty acids. Specifically, we noted an increased presence of docosahexaenoic acid (22:6(n - 3)), as well as arachidonic acid (20:4(n - 6)), among others. Conversely, there were decreases in linoleic (18:2(n - 6)), palmitic (16:0), and oleic (18:1(n - 9)) acids.
Interestingly, a 14-day treatment with thyroid hormone significantly reversed the changes in phospholipid distribution and fatty acyl composition, bringing many values back to those seen in euthyroid rats. However, while some improvements were observed for docosahexaenoic acid, others such as linoleic and certain fatty acids in PC did not fully return to baseline levels. This indicates that, while there are changes associated with hypothyroidism that involve docosahexaenoic acid, the treatment does not completely restore the fatty acid profile.
References
- Sinha RA, Khare P, Rai A, Maurya SK, Pathak A, et al. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci. 2009;27:377. doi:10.1016/j.ijdevneu.2009.02.003
- Simonides WS, van Hardeveld C. Effects of hypothyroidism on the distribution and fatty acyl composition of phospholipids in sarcoplasmic reticulum of fast skeletal muscle of the rat. Biochim Biophys Acta. 1987;924:204.
