Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 18 Reviews
8.1
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*

Top Medical Research Studies

We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.

After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.

Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.

Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
8
Memory enhancement through tuna oil
We set out to explore the effects of omega-3-rich tuna oil, particularly its docosahexaenoic acid (DHA) component, on memory in rats that underwent ovariectomy—a common model for studying menopause. Over a period of 28 days before and 21 days after the surgery, female rats were given various doses of tuna oil to assess its impact on cognitive performance.

Our findings showed that all doses of tuna oil improved memory performance. We also observed increases in beneficial substances like DHA and improvements in enzyme activities linked to brain health, such as superoxide dismutase (SOD) and glutathione peroxidase (GPx). At the same time, harmful factors such as cortisol and inflammatory cytokines decreased, which suggests that tuna oil may help to reduce stress and inflammation in the brain.

Moreover, medium and high doses of tuna oil managed to suppress monoamine oxidase, while a high dose also moderated gamma-aminotransferase, highlighting its intricate role in neurotransmitter regulation. Interestingly, no notable changes in telomere length or estrogen levels were observed, indicating that the benefits of tuna oil in this context may primarily arise from its antioxidant and anti-inflammatory effects.

Overall, our findings indicate that tuna oil could have a positive influence on memory in the context of menopause, primarily through mechanisms that alleviate oxidative stress and inflammation.
9
DHA improves lipid profiles modestly
We conducted a study to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid found in fish oil, affects plasma lipid levels in healthy pre-menopausal women. This randomized, double-blind, placebo-controlled trial included 53 participants who were given either 0, 0.35, 0.7, or 1 gram of DHA-rich tuna oil, or a placebo for eight weeks.

Our findings showed that only the highest dose of DHA at 1 gram per day significantly reduced plasma triglycerides—by about 23%. This reduction was particularly noted in the very-low-density lipoprotein triglycerides. Additionally, although we identified a slight increase in HDL particle size with DHA supplementation, we did not observe any significant changes in LDL levels.

Overall, our research underscores that while DHA-rich supplementation can lower triglycerides and possibly improve certain lipid profiles in pre-menopausal women, the effects don’t specifically address menopause symptoms.

Most Useful Reviews

9
Stops hot flashes
5 people found this helpful
I purchase it frequently and recommend it to friends experiencing menopause symptoms. It helped me stop hot flashes, lifted my mood, and I was initially worried I’d feel this way due to age. Thankfully, I feel happier, socialise more, and enjoy restful sleep. It's truly remarkable.
8
Reduces anxiety
1 people found this helpful
I began taking this during menopause because I was struggling with symptoms like poor sleep, joint pain, and anxiety. Since starting, I’ve slept better, experienced less joint pain, and noticed a significant reduction in anxiety. I prefer these solidified powder tablets over capsule supplements for peace of mind.
9
Balances hot flashes
I discovered this product to manage hot flashes associated with menopause. It's very effective and helps balance my symptoms.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
  • All Researches
We explored the relationship between docosahexaenoic acid (DHA), a type of omega-3 fatty acid, and breast density among postmenopausal women, particularly focusing on those who are obese. Our study aimed to understand how DHA might differentially affect breast density in obese versus nonobese women, using a method called iTRAQ to analyze plasma samples over two years.

During the study, we identified 173 proteins in the plasma samples. Some of these proteins showed different levels of expression based on whether women were obese or lean. Notably, proteins like the vitamin D binding protein and fibronectin were altered, which suggests a connection between DHA intake and reduced inflammation in obese women.

Our findings indicated that there is an inverse relationship between DHA levels and breast density specifically in postmenopausal obese women. This suggests that greater DHA intake could potentially reduce breast density and may decrease breast cancer risk in this demographic. However, it’s important to note that the effect was not observed in nonobese women.

Overall, this research highlights DHA's role in impacting breast health during menopause, particularly for those with obesity. It opens up further discussions on how dietary changes could play a role in cancer prevention strategies for women going through menopause.
9
DHA improves lipid profiles modestly
We conducted a study to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid found in fish oil, affects plasma lipid levels in healthy pre-menopausal women. This randomized, double-blind, placebo-controlled trial included 53 participants who were given either 0, 0.35, 0.7, or 1 gram of DHA-rich tuna oil, or a placebo for eight weeks.

Our findings showed that only the highest dose of DHA at 1 gram per day significantly reduced plasma triglycerides—by about 23%. This reduction was particularly noted in the very-low-density lipoprotein triglycerides. Additionally, although we identified a slight increase in HDL particle size with DHA supplementation, we did not observe any significant changes in LDL levels.

Overall, our research underscores that while DHA-rich supplementation can lower triglycerides and possibly improve certain lipid profiles in pre-menopausal women, the effects don’t specifically address menopause symptoms.
We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.

After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.

Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.

Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
8
DHA linked to delayed menopause
We explored the impact of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on the timing of menopause. Utilizing a two-sample Mendelian randomization approach, we sought to determine whether DHA could influence female reproductive longevity by examining age at menarche and age at natural menopause.

Our study analyzed data from a large number of participants, including over 200,000 European women and nearly 44,000 East Asian women, to gauge the effects of plasma levels of various polyunsaturated fatty acids on reproductive milestones.

The findings revealed that higher levels of DHA in the blood are linked to a delayed onset of natural menopause, while they did not seem to influence the age of first menstruation. This suggests that DHA could be an important factor for women looking to extend their reproductive lifespan, providing a potential target for future health interventions.
8
Memory enhancement through tuna oil
We set out to explore the effects of omega-3-rich tuna oil, particularly its docosahexaenoic acid (DHA) component, on memory in rats that underwent ovariectomy—a common model for studying menopause. Over a period of 28 days before and 21 days after the surgery, female rats were given various doses of tuna oil to assess its impact on cognitive performance.

Our findings showed that all doses of tuna oil improved memory performance. We also observed increases in beneficial substances like DHA and improvements in enzyme activities linked to brain health, such as superoxide dismutase (SOD) and glutathione peroxidase (GPx). At the same time, harmful factors such as cortisol and inflammatory cytokines decreased, which suggests that tuna oil may help to reduce stress and inflammation in the brain.

Moreover, medium and high doses of tuna oil managed to suppress monoamine oxidase, while a high dose also moderated gamma-aminotransferase, highlighting its intricate role in neurotransmitter regulation. Interestingly, no notable changes in telomere length or estrogen levels were observed, indicating that the benefits of tuna oil in this context may primarily arise from its antioxidant and anti-inflammatory effects.

Overall, our findings indicate that tuna oil could have a positive influence on memory in the context of menopause, primarily through mechanisms that alleviate oxidative stress and inflammation.

User Reviews

USERS' SCORE
Good
Based on 18 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Stops hot flashes
5 people found this helpful
I purchase it frequently and recommend it to friends experiencing menopause symptoms. It helped me stop hot flashes, lifted my mood, and I was initially worried I’d feel this way due to age. Thankfully, I feel happier, socialise more, and enjoy restful sleep. It's truly remarkable.
8
Reduces anxiety
1 people found this helpful
I began taking this during menopause because I was struggling with symptoms like poor sleep, joint pain, and anxiety. Since starting, I’ve slept better, experienced less joint pain, and noticed a significant reduction in anxiety. I prefer these solidified powder tablets over capsule supplements for peace of mind.
9
Balances hot flashes
I discovered this product to manage hot flashes associated with menopause. It's very effective and helps balance my symptoms.
9
Reduces stress
This is amazing; I feel less stressed when taking this. It's a wonderful product of great quality and definitely enhances my mood during menopause.
9
Alleviates problems
Ashwagandha supports the Guggul! It helps me reduce issues related to menopause. Thank you very much!

Frequently Asked Questions

6
Improves mood
I purchased this to alleviate menopause discomfort. After a few days, my mood became much more peaceful. Although the improvement in sleep isn't dramatic, I appreciate the pleasant taste and intend to continue taking it.
9
Enhances well-being
I’ve been taking this regularly for over a year to help with menopause and stress at home, and it works wonderfully. I highly recommend it for general well-being and stable behaviour.
9
Increases energy
Although the scent is earthy, I feel it works effectively. The quality is excellent. During menopause, I get tired easily, but after taking one pill, I was energetic all day. Thank you very much!
9
Stops hot flashes
5 people found this helpful
I purchase it frequently and recommend it to friends experiencing menopause symptoms. It helped me stop hot flashes, lifted my mood, and I was initially worried I’d feel this way due to age. Thankfully, I feel happier, socialise more, and enjoy restful sleep. It's truly remarkable.
8
Reduces anxiety
1 people found this helpful
I began taking this during menopause because I was struggling with symptoms like poor sleep, joint pain, and anxiety. Since starting, I’ve slept better, experienced less joint pain, and noticed a significant reduction in anxiety. I prefer these solidified powder tablets over capsule supplements for peace of mind.
9
Reduces stress
This is amazing; I feel less stressed when taking this. It's a wonderful product of great quality and definitely enhances my mood during menopause.
9
Alleviates problems
Ashwagandha supports the Guggul! It helps me reduce issues related to menopause. Thank you very much!
7.5
Must-have supplement
Good for menopause; Ashwagandha is essential if you’re over 40. It helps navigate the challenges of menopause.
7.5
Eases sickness
Excellent! After reading the yoga teacher's blog, I started drinking this to reduce feelings of sickness during menopause. It's a supplement that seems effective.
9
Improves sleep quality
2 people found this helpful
I take one tablet before dinner due to sleep issues from menopause. I’ve tried various supplements, but ashwagandha works best for me. It appears effective without a strong taste, and the small size makes it easy to consume. I intend to repurchase once I run out.
8
DHA linked to delayed menopause
We explored the impact of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on the timing of menopause. Utilizing a two-sample Mendelian randomization approach, we sought to determine whether DHA could influence female reproductive longevity by examining age at menarche and age at natural menopause.

Our study analyzed data from a large number of participants, including over 200,000 European women and nearly 44,000 East Asian women, to gauge the effects of plasma levels of various polyunsaturated fatty acids on reproductive milestones.

The findings revealed that higher levels of DHA in the blood are linked to a delayed onset of natural menopause, while they did not seem to influence the age of first menstruation. This suggests that DHA could be an important factor for women looking to extend their reproductive lifespan, providing a potential target for future health interventions.
We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.

After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.

Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.

Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
8
DHA in enriched milk benefits heart health
We aimed to understand how docosahexaenoic acid (DHA), found in specially enriched milk, affects postmenopausal women, particularly regarding heart health and bone density. The study involved 117 healthy postmenopausal women, divided into two groups.

One group consumed 0.5 liters of low-lactose skimmed milk enhanced with DHA, eicosapentaenoic acid (EPA), oleic acid, vitamins, and calcium each day. The other group drank regular semiskimmed milk, enriched with vitamins A and D, for the same duration.

After 12 months, our findings showed promising improvements in the group that consumed the enriched milk. This group saw notable decreases in various cardiovascular risk markers, such as total cholesterol and low-density lipoprotein (LDL) levels. However, there were no significant changes observed in bone turnover markers or other relevant bone health indicators.

Overall, while we noted beneficial effects on heart health, we did not find substantial evidence that DHA, on its own or in combination with other nutrients, significantly impacted bone metabolism in postmenopausal women. Nonetheless, regularly drinking this enriched dairy product may support cardiovascular health during menopause.
7
DHA potentially supports mental health
We explored the link between docosahexaenoic acid (DHA), a type of omega-3 fatty acid, and depression among postmenopausal women, especially those undergoing hormone therapy (HT). By examining a group of 214 women, we wanted to understand whether higher levels of DHA in their erythrocytes, or red blood cells, could correlate with lower levels of depression.

Our findings revealed something quite interesting. Among women who were using hormone therapy, we observed significant negative relationships between erythrocyte levels of DHA and indicators of depression. In other words, as the levels of DHA increased, depression scores tended to decrease. However, this positive association was not seen in women who were not using hormone therapy, indicating that DHA's effectiveness might be enhanced when combined with HT.

While this suggests that incorporating DHA could potentially support mental health for those on hormone therapy, it is essential to note that the study primarily focuses on women using HT. Therefore, the benefit of DHA on its own, separate from hormone therapy, remains unclear based on our research.
We set out to understand how docosahexaenoic acid (DHA), along with other supplements, impacts oxidative stress in the livers of rats following ovariectomy—a procedure used to mimic menopause. By treating the rats with DHA for 16 weeks, we focused on its potential to alleviate oxidative damage commonly associated with menopause.

Throughout our exploration, we observed that while serum estrogen levels dropped after ovariectomy, these levels remained unaffected by dietary treatments. However, we found that DHA played a crucial role in enhancing the antioxidant defenses in the liver. This was shown by a recovery in the activity of important antioxidant enzymes, which help protect the body from oxidative stress.

Interestingly, despite the benefits in protein antioxidant activity, we noticed that DHA treatment also led to an increase in malondialdehyde levels, a marker of lipid peroxidation. This contrasted with our expectations and suggested that while DHA positively impacted certain areas, it also unveiled complexities in how it interacts with the oxidative processes in the liver.

Overall, our findings indicate that DHA may provide some antioxidant properties, but the mixed results highlight the need for further research to fully understand its role in managing oxidative stress during menopause.

References

  1. Gao H, Ying Y, Sun J, Huang Y, Li X, et al. Genetically Determined Plasma Docosahexaenoic Acid Showed a Causal Association with Female Reproductive Longevity-Related Phenotype: A Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16234103
  2. Wattanathorn J, Thukham-Mee W. Omega-3-Rich Tuna Oil Derived from By-Products of the Canned Tuna Industry Enhances Memory in an Ovariectomized Rat Model of Menopause. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13060637
  3. Félix-Soriano E, Martínez-Gayo A, Cobo MJ, Pérez-Chávez A, Ibáñez-Santos J, et al. Effects of DHA-Rich n-3 Fatty Acid Supplementation and/or Resistance Training on Body Composition and Cardiometabolic Biomarkers in Overweight and Obese Post-Menopausal Women. Nutrients. 2021;13. doi:10.3390/nu13072465
  4. Konuri A, Bhat KMR, Rai KS, Gourishetti K, Phaneendra M YS. Supplementation of fenugreek with choline-docosahexaenoic acid attenuates menopause induced memory loss, BDNF and dendritic arborization in ovariectomized rats. Anat Sci Int. 2021;96:197. doi:10.1007/s12565-020-00574-8
  5. Sun YW, Xu H, Benitez G, Chen KM, Stanley A, et al. Omega-3 Fatty Acids Responsive Proteins and Reduction in Breast Density in Obese Postmenopausal Women. J Proteome Res. 2019;18:3461. doi:10.1021/acs.jproteome.9b00356
  6. Putti JS, Engers VK, Heemann FM, Salomon TB, Benfato MS, et al. Effects of lipoic acid and ω-3 long-chain polyunsaturated fatty acids on the kidney in the ovariectomized rat model of menopause. Nutrition. 2019;66:173. doi:10.1016/j.nut.2019.05.003
  7. Marinho PM, Salomon TB, Andrade AS, Behling CS, Putti JS, et al. The effect of n-3 long-chain polyunsaturated fatty acids and lipoic acid on the heart in the ovariectomized rat model of menopause. Free Radic Res. 2019;53:669. doi:10.1080/10715762.2019.1620938
  8. Abshirini M, Siassi F, Koohdani F, Qorbani M, Khosravi S, et al. Higher intake of dietary n-3 PUFA and lower MUFA are associated with fewer menopausal symptoms. Climacteric. 2019;22:195. doi:10.1080/13697137.2018.1547700
  9. Sparkes C, Gibson R, Sinclair A, Else PL, Meyer BJ. Effect of Low Dose Docosahexaenoic Acid-Rich Fish Oil on Plasma Lipids and Lipoproteins in Pre-Menopausal Women: A Dose⁻Response Randomized Placebo-Controlled Trial. Nutrients. 2018;10. doi:10.3390/nu10101460
  10. Schüller ÁK, Mena Canata DA, Hackenhaar FS, Engers VK, Heemann FM, et al. Effects of lipoic acid and n-3 long-chain polyunsaturated fatty acid on the liver ovariectomized rat model of menopause. Pharmacol Rep. 2018;70:263. doi:10.1016/j.pharep.2017.10.006
  11. Cianci A, Maiolino L, Giunta G, Rapisarda AMC, Di Mauro P, et al. Neurovegetative disorders of perimenopausal women treated with docosahexaenoic acid (DHA, 625 mg). Gynecol Endocrinol. 2017;33:980. doi:10.1080/09513590.2017.1334200
  12. Fonolla-Joya J, Reyes-García R, García-Martín A, López-Huertas E, Muñoz-Torres M. Daily Intake of Milk Enriched with n-3 Fatty Acids, Oleic Acid, and Calcium Improves Metabolic and Bone Biomarkers in Postmenopausal Women. J Am Coll Nutr. 2016;35:529.
  13. Jin Y, Kim TH, Park Y. Association between erythrocyte levels of n-3 polyunsaturated fatty acids and depression in postmenopausal women using or not using hormone therapy. Menopause. 2016;23:1012. doi:10.1097/GME.0000000000000667
  14. Alves Luzia L, Mendes Aldrighi J, Teixeira Damasceno NR, Rodrigues Sampaio G, Aparecida Manólio Soares R, et al. FISH OIL AND VITAMIN E CHANGE LIPID PROFILES AND ANTI-LDL-ANTIBODIES IN TWO DIFFERENT ETHNIC GROUPS OF WOMEN TRANSITIONING THROUGH MENOPAUSE. Nutr Hosp. 2015;32:165. doi:10.3305/nh.2015.32.1.9079
  15. Dong H, Hutchins-Wiese H, Kleppinger A, Annis K, Liva E, et al. Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Turnover in Older Women. Int J Vitam Nutr Res. 2014;84:124. doi:10.1024/0300-9831/a000199
image