' 
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*
Top Medical Research Studies
9
DHA shows stroke protection potential
Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis.
Highly relevant assessment of DHA
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
Read More
9
DHA shows stroke protection potential
Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis.
Highly relevant assessment of DHA
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
Read More
9
DHA enhances stroke recovery efforts
Docosahexaenoic acid promotes M2 microglia phenotype via activating PPARγ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury.
Direct investigation of DHA effects
We set out to explore the impact of docosahexaenoic acid (DHA) on strokes, particularly how it influences microglia—those essential cells in our brain that can either harm or heal after an injury.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
Read More
Most Useful Reviews
8
Mood enhancement
I take this supplement each morning following a stroke three weeks ago. It has positively influenced my mood and aids my daily walking routine. Initially, I experienced a sleepless night when taken in the evening, but now I take it in the morning without feeling overstimulated.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
- All Researches
9
DHA shows stroke protection potential
Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis.
Highly relevant assessment of DHA
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
Read More
9
Docosahexaenoic acid reduces stroke risk
The association between fatty acids and atherosclerotic diseases: A mendelian randomization study.
Relevant but non-isolated factors
We examined the link between docosahexaenoic acid (DHA) and stroke incidence through a two-sample mendelian randomization analysis. The study utilized genome-wide association studies to uncover causal relationships at a genetic level.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
Our findings indicated that higher levels of DHA are associated with a significantly lower risk of strokes. Specifically, we observed a negative correlation, with an odds ratio of 0.800, suggesting that as DHA levels increase, the likelihood of experiencing a stroke decreases.
This evidence highlights the potential protective effect of DHA against stroke, providing important insights into dietary recommendations and therapeutic targets for reducing stroke risk. It's especially noteworthy that our results showed consistency without signs of heterogeneity, reinforcing the reliability of these findings.
Read More
9
DHA linked to reduced stroke risk
Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS.
Moderate relevance due to dietary factors
We examined the relationship between docosahexaenoic acid (DHA)—a type of omega-3 fatty acid—and the risk of experiencing an ischemic stroke. In our analysis, we utilized data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, focusing on how various plasma lipids could influence stroke incidents.
Our study tracked participants for an average of seven years and involved 1,075 individuals who suffered an ischemic stroke compared to 968 who did not. We found that a specific lipid factor, rich in DHA, was linked to a lower risk of stroke. In our findings, individuals with higher levels of this lipid exhibited an impressive 16% reduction in stroke risk.
Moreover, we discovered that those who consumed a healthier diet, particularly with significant fish intake, had higher levels of DHA. The data showed that DHA played a key role in mediating the connection between fish consumption and stroke risk reduction. Since DHA-rich lipids were consistently associated with better health outcomes, this suggests that incorporating more omega-3 fatty acids into our diets could be beneficial in protecting against stroke.
Overall, our findings highlight the importance of DHA in potentially lowering the risk of ischemic stroke, encouraging a greater emphasis on dietary choices that enhance omega-3 intake.
Our study tracked participants for an average of seven years and involved 1,075 individuals who suffered an ischemic stroke compared to 968 who did not. We found that a specific lipid factor, rich in DHA, was linked to a lower risk of stroke. In our findings, individuals with higher levels of this lipid exhibited an impressive 16% reduction in stroke risk.
Moreover, we discovered that those who consumed a healthier diet, particularly with significant fish intake, had higher levels of DHA. The data showed that DHA played a key role in mediating the connection between fish consumption and stroke risk reduction. Since DHA-rich lipids were consistently associated with better health outcomes, this suggests that incorporating more omega-3 fatty acids into our diets could be beneficial in protecting against stroke.
Overall, our findings highlight the importance of DHA in potentially lowering the risk of ischemic stroke, encouraging a greater emphasis on dietary choices that enhance omega-3 intake.
Read More
9
DHA enhances stroke recovery efforts
Docosahexaenoic acid promotes M2 microglia phenotype via activating PPARγ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury.
Direct investigation of DHA effects
We set out to explore the impact of docosahexaenoic acid (DHA) on strokes, particularly how it influences microglia—those essential cells in our brain that can either harm or heal after an injury.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
In our study, we administered DHA to rats who had undergone an ischemia-reperfusion injury, a condition that simulates a stroke. Over three days, we observed significant changes in the brain's response. DHA not only improved overall brain health but also swayed microglia towards a protective, anti-inflammatory M2 phenotype rather than a damaging, inflammatory M1 state.
We noted that DHA reduced markers associated with the harmful M1 phenotype and boosted those linked to the beneficial M2 phenotype. Additionally, it activated pathways involving PPARγ that further moderated brain inflammation, which is crucial for recovery after a stroke.
Overall, the results suggest that DHA holds promise as a therapeutic strategy to aid recovery from strokes by promoting healthier microglial behavior and reducing harmful inflammation, paving the way for improved neurological outcomes.
Read More
9
Docosahexaenoic acid enhances stroke recovery
Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury.
Combination effect complicates assessment
We explored a unique approach to treating cerebral ischemia-reperfusion injury (CI/RI), a major factor in stroke-related disabilities and deaths. The focus of our investigation was the combination of Ginkgolide B (GB) with docosahexaenoic acid (DHA). Together, these compounds show promise in improving recovery after a stroke by addressing various physiological challenges.
The study reported that when GB was conjugated with DHA, the resulting compound was better able to cross the blood-brain barrier, a significant hurdle in drug delivery for stroke patients. We observed that this new combination was encapsulated in liposomes, enhancing both its solubility and stability.
During the research, we noted that this combined treatment significantly reduced the size of brain infarcts in stroke-affected rats and improved their recovery behaviors. DHA, alongside GB, appeared to lower levels of damaging reactive oxygen species and support neuron survival. Importantly, it also encouraged a shift in microglia, the brain's immune cells, from a harmful to a healing state, thereby reducing inflammation.
Overall, our findings highlight DHA's role, particularly in enhancing the therapeutic effects of GB for stroke recovery, suggesting its potential in future treatments for this debilitating condition.
The study reported that when GB was conjugated with DHA, the resulting compound was better able to cross the blood-brain barrier, a significant hurdle in drug delivery for stroke patients. We observed that this new combination was encapsulated in liposomes, enhancing both its solubility and stability.
During the research, we noted that this combined treatment significantly reduced the size of brain infarcts in stroke-affected rats and improved their recovery behaviors. DHA, alongside GB, appeared to lower levels of damaging reactive oxygen species and support neuron survival. Importantly, it also encouraged a shift in microglia, the brain's immune cells, from a harmful to a healing state, thereby reducing inflammation.
Overall, our findings highlight DHA's role, particularly in enhancing the therapeutic effects of GB for stroke recovery, suggesting its potential in future treatments for this debilitating condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Mood enhancement
I take this supplement each morning following a stroke three weeks ago. It has positively influenced my mood and aids my daily walking routine. Initially, I experienced a sleepless night when taken in the evening, but now I take it in the morning without feeling overstimulated.
