5/30/2025
Last update
5/30/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Thiamin (as Thiamine Mononitrate)
25 mg
2,083%
Riboflavin
25 mg
1,923%
Niacin (as Nicotinic Acid)
25 mg NE§
156%
Vitamin B6 (as Pyridoxine HCl [25 mg] and Pyridoxal 5-Phosphate [10 mg])
35 mg
2,059%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
100 mcg
4,167%
Biotin (as d-Biotin)
300 mcg
1,000%
Pantothenic Acid (as Calcium D-Pantothenate)
100 mg
2,000%
Choline (as Choline Bitartrate)
50 mg
9%
Pantethine
25 mg
†
Inositol
50 mg
†
Top Medical Research Studies
7
We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Read More
9
We examined a unique case of a 58-year-old woman with recurrent endometrial cancer who showed signs of severe depression and attempted suicide. Initially, her symptoms were believed to be linked to major depressive disorder.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
Read More
8
Vitamin B12 aids specific sleep disorders
We looked into the effects of Vitamin B12 on two patients with long-standing sleep-wake rhythm disorders.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
Read More
Most Useful Reviews
9
Overall calmness achieved
4 people found this helpful
Over a year ago, I started taking this supplement, and it has been life-saving! It's an adaptogen that aids overall calm and tackles my insomnia and anxiety. I take it at night when I wake up, helping me to relax and return to sleep. I also take it during the day when needed, choosing a low dose that suits me perfectly.
Read More
7.5
Prevents insomnia symptoms
1 people found this helpful
These vitamins play a vital role in numerous processes within the human body, affecting many systems. I previously took B12 in liquid form, but now everything I need is in one tablet! I took it alongside my husband, who added zinc, D3, and omega 3 from the same company. The importance of these vitamins for the central nervous system cannot be overstated. Adequate intake acts as a significant preventative measure against fatigue, mood swings, insomnia, and decreased mental activity. The B vitamins collectively promote better sleep and cognitive function.
Read More
10
Calms insomnia issues
This is the best for stress and insomnia! I constantly buy and consume this product as B-Right provides the highest quality, easily digestible forms of B vitamins. They are excellent for alleviating bad moods, depression, irritability, and nervousness associated with insomnia. A deficiency in B vitamins may result in fatigue and weakness. I take them in the morning with breakfast and magnesium citrate in the evening, which helps me fall asleep like a baby. I feel much calmer during the day. I recommend it to everyone!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
- All Researches
9
We examined a unique case of a 58-year-old woman with recurrent endometrial cancer who showed signs of severe depression and attempted suicide. Initially, her symptoms were believed to be linked to major depressive disorder.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
Read More
8
In a 4-week open-label study involving 40 individuals with mild-to-moderate insomnia, we explored the effects of a combination formula containing melatonin and vitamin B6.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Read More
8
Vitamin B12 aids specific sleep disorders
We looked into the effects of Vitamin B12 on two patients with long-standing sleep-wake rhythm disorders.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
Read More
7
We evaluated the effectiveness of a nutritional supplement, SPINOFF, on sleep quality and mental health in a pilot study involving 41 participants. Initially, participants reported significant sleep issues and psychological distress.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
Read More
7
We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Overall calmness achieved
4 people found this helpful
Over a year ago, I started taking this supplement, and it has been life-saving! It's an adaptogen that aids overall calm and tackles my insomnia and anxiety. I take it at night when I wake up, helping me to relax and return to sleep. I also take it during the day when needed, choosing a low dose that suits me perfectly.
Read More
7.5
Prevents insomnia symptoms
1 people found this helpful
These vitamins play a vital role in numerous processes within the human body, affecting many systems. I previously took B12 in liquid form, but now everything I need is in one tablet! I took it alongside my husband, who added zinc, D3, and omega 3 from the same company. The importance of these vitamins for the central nervous system cannot be overstated. Adequate intake acts as a significant preventative measure against fatigue, mood swings, insomnia, and decreased mental activity. The B vitamins collectively promote better sleep and cognitive function.
Read More
10
Calms insomnia issues
This is the best for stress and insomnia! I constantly buy and consume this product as B-Right provides the highest quality, easily digestible forms of B vitamins. They are excellent for alleviating bad moods, depression, irritability, and nervousness associated with insomnia. A deficiency in B vitamins may result in fatigue and weakness. I take them in the morning with breakfast and magnesium citrate in the evening, which helps me fall asleep like a baby. I feel much calmer during the day. I recommend it to everyone!
Read More
9
Relaxes during insomnia
I began taking this over a year ago and it has been a lifesaver! As an adaptogen, it promotes overall calm. I experience insomnia and anxiety, but this gives me a sense of well-being. I take it at night when I wake up, and it relaxes me enough to fall back asleep. I also use it twice daily for anxiety or stress. I prefer a lower dose as it suits me best. I highly recommend this product.
Read More
Frequently Asked Questions
10
Calms insomnia issues
This is the best for stress and insomnia! I constantly buy and consume this product as B-Right provides the highest quality, easily digestible forms of B vitamins. They are excellent for alleviating bad moods, depression, irritability, and nervousness associated with insomnia. A deficiency in B vitamins may result in fatigue and weakness. I take them in the morning with breakfast and magnesium citrate in the evening, which helps me fall asleep like a baby. I feel much calmer during the day. I recommend it to everyone!
9
Relaxes during insomnia
I began taking this over a year ago and it has been a lifesaver! As an adaptogen, it promotes overall calm. I experience insomnia and anxiety, but this gives me a sense of well-being. I take it at night when I wake up, and it relaxes me enough to fall back asleep. I also use it twice daily for anxiety or stress. I prefer a lower dose as it suits me best. I highly recommend this product.
7.5
Prevents insomnia symptoms
1 people found this helpful
These vitamins play a vital role in numerous processes within the human body, affecting many systems. I previously took B12 in liquid form, but now everything I need is in one tablet! I took it alongside my husband, who added zinc, D3, and omega 3 from the same company. The importance of these vitamins for the central nervous system cannot be overstated. Adequate intake acts as a significant preventative measure against fatigue, mood swings, insomnia, and decreased mental activity. The B vitamins collectively promote better sleep and cognitive function.
7
We evaluated the effectiveness of a nutritional supplement, SPINOFF, on sleep quality and mental health in a pilot study involving 41 participants. Initially, participants reported significant sleep issues and psychological distress.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
8
In a 4-week open-label study involving 40 individuals with mild-to-moderate insomnia, we explored the effects of a combination formula containing melatonin and vitamin B6.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
References
- De Simone M, De Feo R, Choucha A, Ciaglia E, Fezeu F. Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin. Med Sci (Basel). 2023;12. 10.3390/medsci12010002
- Ishida M, Sato S, Sato I, Yoshioka A, Uchida N, et al. What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder. Palliat Support Care. 2024;22:205. 10.1017/S1478951523001128
- Lemoine P, Bablon JC, Da Silva C. A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Complement Ther Med. 2019;45:104. 10.1016/j.ctim.2019.05.024
- Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.
- Okawa M, Mishima K, Nanami T, Shimizu T, Iijima S, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13:15.
