Jarrow Formulas EPA-DHA Balance

Omega-3s reduce ischemic stroke risk

Based on 27 Researches

O'Keefe JH, Tintle NL, Harris WS, O'Keefe EL, Sala-Vila A, et al. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies. Stroke. 2024;55:50. doi:10.1161/STROKEAHA.123.044281

We dove into the connection between omega-3 fatty acids and stroke risks by analyzing data from 29 global cohorts, involving over 183,000 participants.

Our findings revealed that higher levels of omega-3s, particularly eicosapentaenoic acid and docosahexaenoic acid, are linked to a reduced risk of total and ischemic strokes. Specifically, those with the highest omega-3 levels experienced a 17% lower incidence of total stroke and an 18% reduced risk of ischemic stroke.

However, it's important to note that omega-3 levels showed no impact on hemorrhagic stroke risk.

Neurological health boost

Most Useful Review

125 people found this helpful

Regular intake of Omega-3 has led to improved memory, enhanced brain function, and reduced depression for women. These fatty acids assist in preventing neurological diseases, lowering the likelihood of stroke and vascular diseases, and normalising blood pressure.

Chronic Fatigue Syndrome details

Eicosapentaenoic acid shows potential

Based on 5 Researches

Puri BK. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome. Prostaglandins Leukot Essent Fatty Acids. 2004;70:399.

We assessed how eicosapentaenoic acid, an essential fatty acid, impacts chronic fatigue syndrome (CFS). A group of CFS patients took a specific supplement rich in this fatty acid. Remarkably, every participant reported symptom improvement within eight to twelve weeks.

These findings align with other research that shows the positive effects of eicosapentaenoic acid, hinting that it could be a promising treatment option for some individuals living with CFS.

Lessened symptoms

Most Useful Review

3 people found this helpful

This has significantly helped with my chronic mental illness, reducing symptoms and restoring peace. I took four pills daily to reach around 2000mg of EPA. Results appeared within two weeks. I initially started with one pill daily for menstrual cramps and mental fog, and I'm hopeful for further improvements.

Heart Attack details

Omega-3s' mixed effects on heart health

Based on 37 Researches

Rodriguez D, Lavie CJ, Elagizi A, Milani RV. Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health. Nutrients. 2022;14. doi:10.3390/nu14235146

We examined the impact of omega-3 fatty acids, often found in fish oil, on heart attack risks, particularly in patients with high triglyceride levels. The studies indicate that while omega-3s can effectively lower triglycerides and reduce certain cardiovascular disease outcomes, including fatal heart attacks, their overall benefit remains debated. Despite extensive research demonstrating some positive outcomes, many experts still question the magnitude of their effects on heart attack prevention. Improved guidance on omega-3 supplementation is still evolving as new evidence emerges.

Cardiologist avoidance

Most Useful Review

1 people found this helpful

Since I began taking Omega-3, I haven't needed to see the cardiologist. Combined with vitamin D3, it’s my favourite product for heart health. The pills are well-dosed, ensuring great quality.

Osteoporosis details

Li L, Wen Y, Liu D, Lan JP, Yang B. Causal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. Medicine (Baltimore). 2024;103:e38893. doi:10.1097/MD.0000000000038893

Based on 35 Researches

DHA linked to osteoporosis risk

We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.

Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.

However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.

Prevents osteoporosis

Most Useful Review

High-quality product made from natural ingredients, particularly vital for the elderly. Omega-3 fatty acids help prevent osteoporosis by maintaining healthy joints and alleviating pain during flare-ups. They combat bone loss, reduce inflammation, lessen rheumatoid arthritis symptoms, slow cartilage destruction during arthrosis, lower bad cholesterol, hydrate skin and hair, and promote heart health.

Arthritis details

Omega-3 benefits joint health in RA

Based on 37 Researches

Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. doi:10.1007/s10067-024-07040-0

We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.

However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.

Pain relief provided

Most Useful Review

This quality product, made from natural ingredients, is especially vital for older people. Omega-3 fatty acids help maintain healthy joints, relieve pain during flare-ups, and assist with rheumatoid arthritis.

Atrial Flutter details

Excellent! It effectively reduces the risk of atherosclerosis, improves blood circulation, and decreases thrombus formation. It has a beneficial impact on heart functionality while preventing the occurrence and development of arrhythmia.

Bone Pain details

Resolvin D1 alleviates bone cancer pain

Likely Very Effective

Flippen A, Khasabova IA, Simone DA, Khasabov SG. Systemic administration of Resolvin D1 reduces cancer-induced bone pain in mice: Lack of sex dependency in pain development and analgesia. Cancer Med. 2024;13:e70077. doi:10.1002/cam4.70077

We explored the potential of Resolvin D1 (RvD1) as a non-opioid treatment for bone cancer pain in a mouse model. RvD1 was administered intravenously, showing a remarkable ability to lessen pain effects similarly in both male and female mice.

We found that a single dose effectively reduced pain, while daily treatments eliminated it entirely. Notably, sex didn't influence the pain or treatment efficacy, opening doors for RvD1 as a viable alternative to opioids in managing bone cancer pain.

Pain relief observed

Most Useful Review

1 people found this helpful

The effect of this dietary supplement isn’t immediate, so patience is essential! After a few hours, I felt a lightness and a surge of energy. Omega-3 thins the blood, which may enhance circulation. By the end of the first month, my critical days became significantly less painful, and in the following month, there was no pain at all. Post-supplementation, I experienced a return of some pain, but it was less intense. I've also noticed remarkable nail hardness and new hair growth. Although I wish for more visible skin improvement, I appreciate the difference Omega-3 has made in my life.

Common Cold details

Imhoff-Kunsch B, Stein AD, Martorell R, Parra-Cabrera S, Romieu I, et al. Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. Pediatrics. 2011;128:e505. doi:10.1542/peds.2010-1386

Based on 3 Researches

DHA reduces infant cold symptoms

We conducted a double-blind randomized controlled trial to understand how prenatal supplementation of docosahexaenoic acid (DHA) might influence infant health, particularly concerning the common cold. Pregnant women were given either a daily dose of 400 mg of DHA or a placebo starting at 18 to 22 weeks of gestation until childbirth.

Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.

While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.

Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.

This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.

Boosts health

Most Useful Review

9 people found this helpful

I will definitely order again! Although the capsules are quite large, they are easy to swallow. This Omega-3 variant is perfect for children aged 4 to 12. My child's health improved remarkably; their skin feels better, and I've noticed they no longer suffer from the common cold as frequently as before.

Depression details

Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16213688

Based on 30 Researches

Omega-3 fatty acids show promise

We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.

Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.

Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness.

Antidepressant effect

Most Useful Review

8 people found this helpful

This product is fantastic for trying Omega-3 without taking multiple capsules. I've noticed a significant antidepressant effect, particularly in boosted dopamine levels, leading to reduced mental and physical fatigue. After just 5 capsules, I've cut back on other supplements for depression. I believe I had a long-standing Omega-3 deficiency.

Nausea details

Cerchietti LC, Navigante AH, Castro MA. Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer. Nutr Cancer. 2007;59:14.

Questionable

Based on 4 Researches

Omega-3s show symptom relief

We aimed to see how omega-3 fatty acids from fish oil could ease nausea and other symptoms in patients with advanced lung cancer suffering from Systemic Immune-Metabolic Syndrome (SIMS). The study involved a small group of patients divided into treatment groups, some receiving fish oil and others a combination of fish oil with celecoxib.

After six weeks, we noted improvements in appetite, fatigue, and lower inflammation markers in both fish oil groups. Interestingly, those who received fish oil alongside celecoxib showed even greater benefits in weight gain and muscle strength. These findings suggest that fish oil may help manage certain symptoms associated with nausea but not specifically reduce it alone.

Calms cravings

Most Useful Review

3 people found this helpful

No nausea... It seems to calm me down a little... I quit smoking and needed something to manage the intense cravings. I have tried many other fish oils, and this one does not make me feel queasy.

Adenoiditis details

Reduced dryness noticeably

9 people found this helpful

I will definitely order more, as I am thoroughly pleased with everything! The capsules are quite large but easy to swallow without getting stuck. This Omega-3 formula provides an optimal dosage of EPA and DHA for children aged 4 to 12, making it an excellent choice. I give my child one capsule with a meal. The effects of fish oil have been remarkable for me: my skin quality has improved across my entire body; dryness and tightness have disappeared, and healing has become noticeably quicker. I no longer feel cold all the time, particularly in winter. My overall health has improved significantly.

Adhd details

Significant improvement

1 people found this helpful

My child has attention deficit hyperactivity disorder (ADHD), and I bought this to supplement EPA. There has been a significant improvement in the child's hyperactivity.

Allergies details

Hirakata T, Lee HC, Ohba M, Saeki K, Okuno T, et al. Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T2 immune responses. FASEB J. 2019;33:3392. doi:10.1096/fj.201801805R

Based on 37 Researches

Omega-3s reduce allergic symptoms

We discovered that a diet enriched with omega-3 fatty acids can effectively reduce symptoms of allergic conjunctivitis (AC) in mice. This reduction occurred without influencing the typical immune responses usually associated with allergies. Instead, omega-3s worked by changing the lipid molecules linked to inflammation.

Notably, these fatty acids completely suppressed itching near the eyes and significantly decreased the presence of eosinophils, cells commonly involved in allergic reactions. However, total serum IgE levels and T2 cytokine expression remained unchanged, suggesting that omega-3s tackle AC symptoms in a unique way.

Pleasant allergy experience

Most Useful Review

I’ve had no allergies from this product and enjoy taking it.

Anxiety details

Omega-3s improve mental health outcomes

Based on 26 Researches

Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. doi:10.3390/nu16234065

We explored the impact of polyunsaturated fatty acids (PUFAs), particularly omega-3s, on anxiety and depression in over 102,000 participants from the UK Biobank.

The study revealed that higher levels of omega-3 PUFAs were linked to lower risks of developing anxiety and depressive disorders, alongside improvement in adverse psychological symptoms.

Additionally, the research highlighted significant associations between these fatty acids and brain white matter structure, providing valuable insights into how omega-3s might support mental wellness.

Reduces inflammation

Most Useful Review

1 people found this helpful

Ideal for immunity and beautiful skin and hair. Fish oil was mandated in childhood for a reason. Back then, we didn't understand polyunsaturated fatty acids (PUFAs) or omega-3's vital role, yet children taking fish oil were found to be healthier, with stable nervous systems. Sufficient omega-3 consumption leads to good immunity, delayed ageing, and a clear mind. Fish oil promotes a healthy emotional state and significantly reduces anxiety. Despite my limited fish intake, I’ve appreciated the visible improvements in my skin and hair after using this Omega-3 supplement. I recommend it for a great EPA/DHA ratio!

Back Pain details

Eicosapentaenoic acid alleviates back pain

Based on 9 Researches

Lin Z, Ni L, Teng C, Zhang Z, Wu L, et al. Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis. Front Cell Dev Biol. 2021;9:745621. doi:10.3389/fcell.2021.745621

We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.

Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.

In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.

7.5

Joint pain improvement

Most Useful Review

1 people found this helpful

This Omega-3 is good and economical. I have been taking two capsules daily for three months, and I’ve noticed softer skin and a significant reduction in joint and lower back pain. The only downside is the chemical smell of the strawberry flavouring, but the benefits outweigh this flaw.

Flu details

Dramatic skin improvement

1 people found this helpful

Initially, I had low expectations for this omega supplement, especially after experiencing hair loss and dry skin post-childbirth. Taking these capsules with enzymes has transformed my experience! The dryness, especially on my legs, had persisted all my life, yet after just three days of use, I stopped using creams as my skin became remarkably moist. Adding vitamin D and iron has also improved my hair growth, revitalising my desire to live and work. I am genuinely delighted with the results!

Headache details

EPA shows promise for migraine relief

Based on 20 Researches

Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. doi:10.1016/j.bbi.2024.03.019

We examined the effects of eicosapentaenoic acid (EPA) on episodic migraine patients through a 12-week randomized double-blind trial. Seventy participants were divided into two groups, one receiving EPA and the other a placebo.

Those taking the EPA experienced significant decreases in migraine frequency, medication use, headache severity, and improvements in overall quality of life.

Notably, women benefitted particularly from this treatment. Overall, high-dose EPA showed promise as an effective preventive option for episodic migraines, with no major side effects observed.

Migraine relief

Most Useful Review

The migraine is gone; headaches have ceased entirely. Smoker's must-try.

Acne details

Conforti C, Agozzino M, Emendato G, Fai A, Fichera F, et al. Acne and diet: a review. Int J Dermatol. 2022;61:930. doi:10.1111/ijd.15862

Questionable

Based on 18 Researches

Omega-3 may improve acne

We observed that acne is a common skin condition, particularly affecting individuals under 30. Our exploration into the role of diet revealed that nutrition significantly influences acne development. Among the various dietary components, omega-3 fatty acids stood out due to their potential anti-inflammatory properties.

The research indicates that foods rich in omega-3 can help reduce the production of inflammatory substances that may contribute to acne. Additionally, specific fatty acids, such as docosapentaenoic acid and γ-linolenic acid, have shown promise in improving acne lesions.

By integrating omega-3 into the diet, we might be able to mitigate some of the troublesome symptoms associated with acne. While the evidence is still unfolding, the link between omega-3 fatty acids and reduced acne severity offers a hopeful avenue worth considering for those battling breakouts.

Affordable and effective

Most Useful Review

11 people found this helpful

The best value for money! My dermatologist prescribed omega-3 for my acne, suggesting a total of 3000 mg per day. This brand is the cheapest available and only requires five capsules daily, lasting 48 days at just 26 rubles a day. It's essential to check the quality by freezing a capsule; if it remains clear, it’s good quality. I highly recommend this omega–you won't find anything better!

Cold details

Reduced cold symptoms

10 people found this helpful

I am extremely pleased with this Excellent Omega, which contains 60% Omega-3 fatty acids. In my local pharmacies, I found only one more product with such a high concentration, at a significantly higher price. I bought 240 capsules, taking one each morning with my husband. We haven’t contracted colds since starting this regimen, and the quality of my skin has improved. Whenever I feel a hint of a runny nose or sore throat, we immediately increase to 2-3 capsules a day alongside a high dose of Vitamin C until we feel better.

Hypothyroidism details

Abd Allah ES, Gomaa AM, Sayed MM. The effect of omega-3 on cognition in hypothyroid adult male rats. Acta Physiol Hung. 2014;101:362. doi:10.1556/APhysiol.101.2014.3.11

Based on 11 Researches

Omega-3 aids hypothyroid cognition

We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.

The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.

However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.

All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.

Improved skin appearance

Most Useful Review

1 people found this helpful

After two years of use, I can see visible results. They still work well and are tolerated excellently, making them a regular purchase. The effect lasted for three months after the can, improving my skin and reducing cellulite and varicose veins. I initially took two capsules but have now increased to three daily. For hypothyroidism, a minimum of 2000 units is essential; I may increase to four. I purposely bought a second large jar due to the positive results I've observed and continue to buy regularly, as I am satisfied with the effect.

Leg Cramps details

Circulation improvement

6 people found this helpful

My legs often cramped in the middle of the night. I thought I was deficient in minerals, so I took calcium and magnesium supplements, but they had no effect. After a hospital examination, it was found that poor blood circulation due to cold sensitivity was the cause. I was prescribed Opalmon, a blood smoothing medication. Had I known the cause, I would have discarded the supplement and switched to this medication earlier. Now my leg cramps have completely disappeared. This product is excellent!

Liver Disease details

Zhang H, Lu Y, Zhang Y, Dong J, Jiang S, et al. DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis. Int Immunopharmacol. 2024;140:112895. doi:10.1016/j.intimp.2024.112895

Based on 28 Researches

DHA-PS promotes liver recovery

We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.

Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.

Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.

Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.

7.5

Reduces inflammation

Most Useful Review

This is a basic health supplement. Omega reduces inflammation in the body and is essential for the health of the cardiovascular system, nervous system, brain, and liver.

Rash details

Rhodes LE, White SI. Dietary fish oil as a photoprotective agent in hydroa vacciniforme. Br J Dermatol. 1998;138:173.

Questionable

Based on 3 Researches

Promising results for fish oil

We investigated the impact of dietary fish oil, rich in omega-3 fatty acids, on hydroa vacciniforme, a challenging photosensitivity disorder. Three boys with the condition took five capsules of MaxEPA daily for three months. During follow-up tests, we observed that all boys had lower sensitivity to UVA light, indicating a positive response to the treatment.

While one child demonstrated a significant improvement, another showed mild progress, and the third did not improve but later responded well to another medication. Overall, fish oil may reduce UV sensitivity and improve rash outcomes for some patients.

No more rash

Most Useful Review

2 people found this helpful

Worthy rival of famous brands. My son, who has autism, has taken it multiple times. We require these essential acids consistently, ideally in a 2:1 ratio. Although the recommendation is to take one capsule, my son often requests two a day, which isn't an issue. Upon opening the capsule, a strawberry scent is noticeable. I'm unsure of the scientific background, but compared to expensive chemist brands that caused allergic reactions, this has worked wonderfully; there’s no more belching or rash on his cheeks. The composition offers excellent value for money! Highly recommend!

Blurred Vision details

1 people found this helpful

I drink omega all year round on the advice of a trichologist. After three visits this year, my hair condition has markedly improved. I've noticed a decrease in hair loss and an increase in thickness. My facial skin looks better, dryness has disappeared, and the rough skin on my elbows and heels has become much softer. Most importantly, my eye fatigue has decreased and my vision has improved! I used to struggle to look at gadgets for long without discomfort. Thankfully, I don't have this problem anymore.

Hypertension details

Eicosapentaenoic acid benefits hypertension

Based on 28 Researches

Asulin M, Gorodetzer N, Fridman R, Shelly Ben-Shushan R, Cohen Z, et al. 5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway. Biochem Biophys Res Commun. 2024;700:149585. doi:10.1016/j.bbrc.2024.149585

We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.

Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.

Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.

Improved blood pressure

Most Useful Review

3 people found this helpful

The best vascular protector! Without omega acids, our life in adulthood loses its pleasure: hypertension, stenocardia, and other issues. I take this medication year-round: my blood pressure is normal, my cardiovascular performance has improved, and even my joints have stopped grinding! I also give it to my elderly parents. The dosage and number of capsules are very convenient. I searched for a suitable mono drug for ages due to my allergy to multivitamins, and I found it only on this site. I recommend these drugs to all my relatives and friends, as well as to you, dear site users! Stay healthy and happy!

Autoimmune Disorder details

Resolvin D1 impacts lupus progression

Based on 38 Researches

Huang L, Wu J, Cao J, Sheng X, Wang M, et al. Resolvin D1 inhibits T follicular helper cell expansion in systemic lupus erythematosus. Scand J Rheumatol. 2024;53:276. doi:10.1080/03009742.2024.2344906

We focused on how Resolvin D1 (RvD1), a pro-resolving lipid, impacts systemic lupus erythematosus (SLE). Our study measured RvD1 levels and T follicular helper (Tfh) cell counts in SLE patients versus healthy individuals.

We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.

Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.

7.5

Improved hemostasis

Most Useful Review

4 people found this helpful

This omega has a great composition with good EPA and DHA percentages. There’s no fishy aftertaste, making it enjoyable to take. I started it to regulate my hemostasis, which has worked wonderfully. My hair and nails have greatly improved, and I believe it aids in treating autoimmune disorders effectively.

Heart Disease details

Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. doi:10.1016/j.mayocp.2024.08.007

Based on 38 Researches

Omega-3 reduces heart disease risk

We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.

For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.

Strengthening heart

Most Useful Review

4 people found this helpful

I was prescribed Hard 5 Omega-3 by my cardiologist to help strengthen my heart. I used to take omeganol, but this Omega is much more affordable and lasts a long time. Its composition is far superior! I recommend it highly. I take 2 capsules daily and give my 7-year-old daughter 1 capsule.

Cardiovascular Disease details

Omega-3 levels reduce heart failure

Based on 33 Researches

We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.

For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.

Convenient dosage

Most Useful Review

3 people found this helpful

I continuously take omega-3, which has improved my blood pressure and cardiovascular health. This supplement has also alleviated joint issues. Its dosage is convenient, and I recommend it to my family and friends for overall wellness.

Pelvic Pain details

Omega-3 fish oil alleviates menstrual pain

Based on 14 Researches

Moghadamnia AA, Mirhosseini N, Abadi MH, Omranirad A, Omidvar S. Effect of Clupeonella grimmi (anchovy/kilka) fish oil on dysmenorrhoea. East Mediterr Health J. 2010;16:408.

We explored the effects of omega-3 fatty acids from Clupeonella grimmi fish oil on dysmenorrhoea through a clinical trial involving 36 young women. Participants were split into two groups; one received fish oil while the other received a placebo.

After three months, those taking fish oil reported significantly less pain, with visual analogue scale scores showing a marked improvement. Notably, there was also a reduction in low back and abdominal pain, and less reliance on ibuprofen.

Overall, omega-3 fish oil appears to effectively reduce pelvic pain associated with menstrual cycles.

Joint pain relief

Most Useful Review

4 people found this helpful

This is the best Omega-3 supplement I've tried. It contains 600 mg of omega-3 per capsule, which is sufficient for prevention and support. I experienced a significant reduction in joint pain within days of taking 3 g (around 3-4 capsules). I recommend it for anyone dealing with pelvic pain or inflammation.

Diabetes details

Sugasini D, Yalagala PCR, Park JC, Ma G, Farooq Z, et al. Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2024;65:39. doi:10.1167/iovs.65.14.39

Based on 16 Researches

Reduced retina DHA in diabetes

We investigated the impact of diabetes on the levels of docosahexaenoic acid (DHA), an essential omega 3 fatty acid, in the retina of humans and mice. Our findings revealed that diabetic individuals had significantly lower DHA levels—40% less in peripheral regions and 25% less in the macula—compared to those without diabetes.

Additionally, we observed a reduction of retinal thickness and function in diabetic mice. Although there’s potential for dietary DHA to help with diabetic retinopathy, the current study suggests that diabetes is linked to reduced DHA and related retinal defects.

7.5

Reduces systemic inflammation

Most Useful Review

A good, high-quality omega that lowers cholesterol, alleviates systemic inflammation, and reduces triglycerides in the blood, particularly beneficial for type 2 diabetes.

High Cholesterol details

Omega-3 EPA+DHA improves cholesterol

Based on 38 Researches

Zhou Q, Zhang Z, Wang P, Zhang B, Chen C, et al. EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Mol Nutr Food Res. 2019;63:e1801157. doi:10.1002/mnfr.201801157

We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.

Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.

Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.

Brain health benefit

Most Useful Review

114 people found this helpful

I highly recommend this excellent DHA and EPA composition for brain health. I'm very pleased with the 240 capsules. The price and quality are superb. If you don’t live near the sea, I suggest you and your children take it for at least 9-10 months a year to maintain health.

Blood Clot details