' 
SCIENTIFIC SCORE
Possibly Effective
Based on 47 Researches
7.5
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
Supplement Facts
Serving Size: 2 Softgels
Serving Per Container: 60
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%‡
Cholesterol
11 mg
4%‡
Protein
<1 g
Fish Oil Concentrate^
2,000 mg
†
Omega-3 Fatty Acids^
1,200 mg
†
EPA (Eicosapentaenoic acid)^
800 mg
†
DHA (Docosahexaenoic acid)^
400 mg
†
Top Medical Research Studies
8
Resolvin D1 impacts lupus progression
Resolvin D1 inhibits T follicular helper cell expansion in systemic lupus erythematosus.
High relevance for autoimmunity research
We focused on how Resolvin D1 (RvD1), a pro-resolving lipid, impacts systemic lupus erythematosus (SLE). Our study measured RvD1 levels and T follicular helper (Tfh) cell counts in SLE patients versus healthy individuals.
We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.
Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.
We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.
Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.
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8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Directly addresses eicosapentaenoic acid
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
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7
Omega-3 shows mixed RA benefits
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Relevant as a nutritional intervention
We analyzed data from 18 randomized controlled trials involving 1018 rheumatoid arthritis (RA) patients to understand the effects of omega-3 supplementation. Our findings revealed that omega-3 significantly increased beneficial fatty acids, EPA, and DHA, while also decreasing harmful triglycerides and tender joint counts.
However, while some inflammation markers showed slight improvements, these changes were not statistically significant. Overall, omega-3 may help manage certain symptoms of RA, but the evidence remains mixed regarding its broader impact on inflammation.
However, while some inflammation markers showed slight improvements, these changes were not statistically significant. Overall, omega-3 may help manage certain symptoms of RA, but the evidence remains mixed regarding its broader impact on inflammation.
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Most Useful Reviews
8.8
Improved hemostasis
This omega has a great composition with good EPA and DHA percentages. There’s no fishy aftertaste, making it enjoyable to take. I started it to regulate my hemostasis, which has worked wonderfully. My hair and nails have greatly improved, and I believe it aids in treating autoimmune disorders effectively.
Read More
5
Tasty and effective
I've enjoyed this omega for several years due to its quality and pleasant taste without an aftertaste. I take two after breakfast, and I've seen obvious benefits, including reduced inflammation and healthier hair. It's essential for anyone focusing on managing their autoimmune disorder.
Read More
5
Reduced inflammation
This omega does not smell like fish; instead, it has a light strawberry fragrance. I ordered it to take regularly, and it seems effective in reducing inflammation. I personally find it beneficial when dealing with autoimmune disorders.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 47 Researches
7.5
- All Researches
9
Stable resolvin analogue shows promise
The chemically stable analogue of resolvin D1 ameliorates experimental autoimmune encephalomyelitis by mediating the resolution of inflammation.
High relevance for autoimmune treatment
We explored the effects of a new, stable form of resolvin D1, called p-MPPF, on autoimmune encephalomyelitis, a condition affecting the nervous system. In our research, both p-MPPF and its unstable counterpart, RvD1, showed significant promise in reducing inflammation and improving symptoms.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
Read More
9
Eicosapentaenoic Acid aids autoimmunity
ω-3 polyunsaturated fatty acid alleviates systemic lupus erythematosus by suppressing autoimmunity in a murine model.
Highly relevant autoimmune research
We explored the effect of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on systemic lupus erythematosus (SLE), a complex autoimmune disease that causes widespread inflammation in the body. In a carefully designed study using a mouse model of SLE, we discovered that dietary supplementation with EPA-rich fish oil significantly improved various autoimmune symptoms.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Read More
9
Combination therapy shows promise
Omega-3 Polyunsaturated Fatty Acid: A Pharmaco-Nutraceutical Approach to Improve the Responsiveness to Ursodeoxycholic Acid.
Moderate relevance to autoimmune treatment
We set out to understand if adding eicosapentaenoic acid (EPA) to ursodeoxycholic acid (UDCA) could improve outcomes for patients with autoimmune disorders and cholestatic liver diseases. By evaluating how this combination affects key factors like bile acid management, cell apoptosis, and inflammation, we aimed to see if EPA could bolster the effects of UDCA, especially in patients who typically do not respond well to this treatment.
Interestingly, we found that when EPA was combined with a lower dose of UDCA, the results were quite appealing. The combination helped reduce the expression of certain inflammatory genes and showed a notable decrease in cell damage caused by bile acids, even when compared to higher doses of UDCA alone. This means that with EPA, we could potentially achieve better therapeutic outcomes without escalating the drug dosage.
Our findings suggest that incorporating EPA alongside UDCA not only enhances the benefits but could also widen the therapeutic window for patients struggling with liver issues linked to autoimmune disorders. This exciting pharmaco-nutraceutical approach may pave the way for more effective treatments in the future.
Interestingly, we found that when EPA was combined with a lower dose of UDCA, the results were quite appealing. The combination helped reduce the expression of certain inflammatory genes and showed a notable decrease in cell damage caused by bile acids, even when compared to higher doses of UDCA alone. This means that with EPA, we could potentially achieve better therapeutic outcomes without escalating the drug dosage.
Our findings suggest that incorporating EPA alongside UDCA not only enhances the benefits but could also widen the therapeutic window for patients struggling with liver issues linked to autoimmune disorders. This exciting pharmaco-nutraceutical approach may pave the way for more effective treatments in the future.
Read More
9
Eicosapentaenoic acid aids lupus management
Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity.
Highly relevant to autoimmune research
We sought to understand how dietary fatty acids, specifically eicosapentaenoic acid (EPA), influence autoimmune diseases like lupus. Through our research on both drug-induced and spontaneous mouse models of lupus, we observed that supplementing with EPA significantly eased symptoms associated with the disease.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Read More
9
Eicosapentaenoic acid's role in arthritis
CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota.
Relevant but not conclusive effects
We aimed to understand how eicosapentaenoic acid, among other metabolites, plays a role in managing autoimmune disorders like rheumatoid arthritis (RA). We tested two specific strains of probiotics, CCFM1074 and CCFM1075, on rats with collagen-induced arthritis to evaluate their impact on immune responses and gut health.
Our findings showed that CCFM1074 significantly eased symptoms of arthritis, while CCFM1075 did not offer similar benefits. Interestingly, both strains helped reduce inflammation markers, notably lowering plasma levels of IL-6 and decreasing the proportion of harmful Th17 cells. However, CCFM1074 stood out by increasing beneficial Treg cells in the mesenteric lymph nodes.
One of the highlights of our study was the role of eicosapentaenoic acid—a metabolite that was notably regulated by CCFM1074. This fatty acid is linked to improving unsaturated fatty acids metabolism, which may contribute to reducing arthritis symptoms. Additionally, CCFM1074 positively influenced the gut microbiota, altering community structures and enhancing beneficial bacteria populations.
Overall, we observed that eicosapentaenoic acid, alongside other factors, could help alleviate arthritis by promoting a healthier gut environment and balancing immune responses.
Our findings showed that CCFM1074 significantly eased symptoms of arthritis, while CCFM1075 did not offer similar benefits. Interestingly, both strains helped reduce inflammation markers, notably lowering plasma levels of IL-6 and decreasing the proportion of harmful Th17 cells. However, CCFM1074 stood out by increasing beneficial Treg cells in the mesenteric lymph nodes.
One of the highlights of our study was the role of eicosapentaenoic acid—a metabolite that was notably regulated by CCFM1074. This fatty acid is linked to improving unsaturated fatty acids metabolism, which may contribute to reducing arthritis symptoms. Additionally, CCFM1074 positively influenced the gut microbiota, altering community structures and enhancing beneficial bacteria populations.
Overall, we observed that eicosapentaenoic acid, alongside other factors, could help alleviate arthritis by promoting a healthier gut environment and balancing immune responses.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved hemostasis
This omega has a great composition with good EPA and DHA percentages. There’s no fishy aftertaste, making it enjoyable to take. I started it to regulate my hemostasis, which has worked wonderfully. My hair and nails have greatly improved, and I believe it aids in treating autoimmune disorders effectively.
Read More
5
Tasty and effective
I've enjoyed this omega for several years due to its quality and pleasant taste without an aftertaste. I take two after breakfast, and I've seen obvious benefits, including reduced inflammation and healthier hair. It's essential for anyone focusing on managing their autoimmune disorder.
Read More
5
Reduced inflammation
This omega does not smell like fish; instead, it has a light strawberry fragrance. I ordered it to take regularly, and it seems effective in reducing inflammation. I personally find it beneficial when dealing with autoimmune disorders.
4.5
Avoided fish aftertaste
I tested this omega for my sister but found an unnatural aftertaste and fish burps unpleasant. While the capsules are easy enough to swallow, I've used a different product that I preferred for managing my autoimmune disorder effectively. This one did not suit me.
