We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
Read More
9
Scallop oil significantly reduces cholesterol
Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice.
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Read More
9
Omega-3s improve cholesterol parameters
Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats.
We examined how swapping a saturated fat diet for omega-3 polyunsaturated fatty acids (n-3PUFAs) affects cholesterol and bone health in hypercholesterolemic rats.
In our study, rats that shifted to an n-3PUFA diet saw a notable decrease in serum lipids. While the diet appeared to positively impact their bone loss linked to periodontitis, rats on the n-3PUFA diet showed results similar to those on a commercial diet, indicating no major advantage of fish oil over a balanced diet.
Overall, our findings suggest that while omega-3s can help with cholesterol, they don't offer significant improvements over typical diets in these conditions.
Read More
Most Useful Reviews
9
Brain health benefit
114 people found this helpful
I highly recommend this excellent DHA and EPA composition for brain health. I'm very pleased with the 240 capsules. The price and quality are superb. If you don’t live near the sea, I suggest you and your children take it for at least 9-10 months a year to maintain health.
Read More
7.5
Effective cholesterol reduction
102 people found this helpful
Omega must be consumed as these acids are primarily obtained through food. I have been taking this brand's omega for a long time and am very satisfied with its quality. It lowers pressure and cholesterol levels, as confirmed by my tests.
Read More
9
Cholesterol plaque prevention
101 people found this helpful
Omega-3 acids help clear blood vessels of "bad" cholesterol, preventing cholesterol plaques. They improve blood viscosity and normalise blood pressure while boosting "good" cholesterol levels. I strongly recommend it.
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
Read More
9
CA-rich fish oils lower cholesterol
Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis.
We investigated whether cetoleic acid (CA), a healthy fat found in certain fish, can help lower cholesterol levels in rodents. Our systematic review included 12 studies, assessing how CA-rich fish oils influenced total cholesterol compared to regular diets.
The results showed a significant reduction in cholesterol levels in rodents that consumed CA-rich oils. However, it’s important to note that the risk of bias in the studies varied, making our conclusions tentative. Overall, these findings suggest CA-rich fish oils could play a beneficial role in heart health, but further research in humans is needed.
Read More
9
Scallop oil significantly reduces cholesterol
Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice.
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Read More
9
Omega-3 effective for heart risk
The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention.
We examined the role of eicosapentaenoic acid (EPA), specifically icosapent ethyl, in reducing cardiovascular disease risks. Approved by the FDA, this omega-3 treatment showed a notable 25% reduction in major heart events for high-risk patients. These patients already had controlled cholesterol but elevated triglyceride levels.
Importantly, while EPA proved effective, mixed omega-3 products lacking substantial evidence for heart health did not provide the same benefits. We believe adding EPA-only formulations to cardiovascular prevention guidelines is essential for at-risk individuals.
Read More
9
8-HEPE benefits cholesterol management
8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice.
We explored how 8-hydroxyeicosapentaenoic acid (8-HEPE), derived from Pacific krill, could improve cholesterol levels in mice commonly used for dyslipidemia studies.
Over eighteen weeks, mice on a high-cholesterol diet receiving 8-HEPE showed significantly higher levels of good HDL cholesterol, alongside lower levels of bad LDL cholesterol and liver triglycerides.
This suggests that 8-HEPE may enhance lipid profiles and liver health by influencing certain genes in macrophages. While promising, further research is needed to confirm these benefits in humans.
I highly recommend this excellent DHA and EPA composition for brain health. I'm very pleased with the 240 capsules. The price and quality are superb. If you don’t live near the sea, I suggest you and your children take it for at least 9-10 months a year to maintain health.
Read More
7.5
Effective cholesterol reduction
102 people found this helpful
Omega must be consumed as these acids are primarily obtained through food. I have been taking this brand's omega for a long time and am very satisfied with its quality. It lowers pressure and cholesterol levels, as confirmed by my tests.
Read More
9
Cholesterol plaque prevention
101 people found this helpful
Omega-3 acids help clear blood vessels of "bad" cholesterol, preventing cholesterol plaques. They improve blood viscosity and normalise blood pressure while boosting "good" cholesterol levels. I strongly recommend it.
Read More
7.5
Joint and cholesterol health
95 people found this helpful
This supplement lowers bad cholesterol, strengthens the cardiovascular system, and reduces the risk of blood clots. It positively affects the retina and protects joints and ligaments.
Read More
9
Cholesterol control
42 people found this helpful
This omega-3 is excellent for lowering cholesterol. I recommend it, especially considering the large jar size.
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has been widely discussed for its potential benefits in managing cardiovascular health, including high cholesterol. Research indicates that omega-3 fatty acids, particularly EPA and DHA found in fish oil, can help lower triglyceride levels—a type of fat in the blood that contributes to high cholesterol. In some cases, these fatty acids may also raise levels of HDL (high-density lipoprotein), often referred to as "good" cholesterol. However, while omega-3s can be a beneficial part of a heart-healthy diet, they are not a stand-alone solution for cholesterol management.
It's essential to understand that fish oil supplementation should not replace standard cholesterol-lowering medications or lifestyle changes like diet and exercise. Consult with a healthcare professional before adding omega-3 supplements to your regimen, especially if you have existing health conditions or are taking other medications. Keeping a balanced diet rich in omega-3s from sources like fatty fish, flaxseeds, and walnuts can also support overall health and align with cholesterol management goals.
Based on user reviews, many individuals report noticeable improvements in cholesterol levels after consistently taking Omega-3 supplements for a period ranging from two to six months. For example, one user noted a significant improvement within just three months of taking two capsules daily, bringing their cholesterol levels back to normal Read Review. Another user shared that after taking the capsules for six months, their cholesterol levels were normalized, highlighting the effectiveness of prolonged use Read Review.
It's worth noting that results can vary based on individual health conditions and adherence to a supplement regimen. Other reviewers mentioned positive changes in their lipid profiles and cardiovascular health, reinforcing the consensus that regular intake over several months can lead to significant health benefits Read ReviewRead Review. If you're considering this supplement for managing high cholesterol, patience and consistency appear to be key factors to achieving the desired results.
Scientific research supports the use of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in managing high cholesterol levels. Multiple studies indicate that these compounds, commonly found in fish oil and krill oil, can help lower triglyceride levels and improve cholesterol profiles. For instance, a study found that participants taking EPA saw a reduction in triglycerides by nearly 16% over 12 weeks ([11]). Additionally, another investigation showed that high-dose omega-3 supplementation resulted in significant reductions in both total cholesterol and low-density lipoprotein (LDL) levels among high-risk patients ([27]).
Furthermore, krill oil has been highlighted for its positive effects on cholesterol metabolism, with evidence suggesting it may help decrease fat accumulation and increase beneficial high-density lipoprotein (HDL) levels in mice studies ([1]). However, it's important to note that while these omega-3 fatty acids exhibit promising benefits, the evidence shows mixed results regarding their effects on overall cholesterol levels and cardiovascular health. Thus, while omega-3 supplementation can complement existing treatment strategies, more research is needed to fully understand its comprehensive impact on cholesterol management.
Based on user reviews, many individuals have reported significant improvements in their cholesterol levels and overall cardiovascular health after incorporating Omega-3 supplements into their daily regimen. One user specifically noted that their cholesterol levels returned to normal after just three months of taking two capsules daily, which exemplifies the potential efficacy of consistent use Read Review. Another family shared that their cholesterol improved markedly from being diagnosed with hyperlipidemia, citing nearly normal levels as a tangible health benefit Read Review.
Moreover, numerous reviewers emphasized the supplement's role in reducing "bad" cholesterol while enhancing "good" cholesterol levels, underscoring its dual action on lipid profiles Read Review. Many users attribute not only lower cholesterol to these supplements but also improvements in related areas like blood pressure management and heart health Read Review. However, it’s important to note that experiences can vary widely; one reviewer even reported adverse effects on their lipid profile despite a generally positive reception from others Read Review. As with any supplement, results may depend on individual health conditions and adherence to dosage recommendations.
Based on user reviews, many individuals report successfully combining Omega-3 supplements with other medications or supplements to manage high cholesterol effectively. For example, one user noted that they provide Omega-3 to their parents alongside other medications to support recovery following a stroke and aid in lowering cholesterol levels Read Review. Another reviewer shared that their doctor prescribed Omega-3 to help normalize both "good" and "bad" cholesterol levels, and after consistent use, they observed positive results Read Review.
Moreover, users emphasize the potential of Omega-3 to work in synergy with other interventions for cardiovascular health. One family reported significant improvements in cholesterol levels since incorporating Omega-3 into their regimen alongside other healthy lifestyle changes, ultimately resulting in near-normal cholesterol levels Read Review. However, it's crucial to note that experiences vary; one reviewer mentioned that this supplement led to a worsening of their lipid profile, indicating that combining Omega-3 with other treatments may not yield the same results for everyone Read Review. Overall, it appears that many users find Omega-3 beneficial when used alongside other health strategies.
When it comes to effectively managing high cholesterol with omega-3 fish oil, recent research has pinpointed that higher doses are generally more beneficial. Specifically, a systematic review of various studies found that daily intakes of around 4 grams of eicosapentaenoic acid (EPA) can lead to significant reductions in triglycerides and improvements in overall cholesterol profiles for patients at high risk for cardiovascular issues [27]. For instance, participants who consumed 4 grams of EPA experienced a drop in triglycerides from an average of 2.97 mmol/L to 1.75 mmol/L over three months, showcasing its potency in cholesterol management.
Moreover, another study elaborates on the specific advantages of eicosapentaenoic acid in lowering both total cholesterol and non-high-density lipoprotein cholesterol, which is crucial for heart health [37]. While doses can vary based on individual health conditions, this research indicates that higher daily dosages of EPA—especially when combined with docosahexaenoic acid (DHA)—can significantly contribute to better lipid profiles and reduced cardiovascular risks. This reaffirms the growing consensus among health professionals that a tailored approach incorporating omega-3 fatty acids can be a powerful ally in the ongoing battle against high cholesterol.
9
Regulated cholesterol
8 people found this helpful
Taking two tablets daily significantly improved my cholesterol levels within three months, bringing them back to normal. I continue to use this product as it's helped maintain my levels effectively.
9
Normalised cholesterol
2 people found this helpful
My doctor prescribed Omega-3 to normalise my “good” and “bad” cholesterol. I took the EPA-DHA Balance capsules for six months and am pleased with the results; my cholesterol is now normal. They have a lovely aroma, easy to consume, and last for eight months.
9
Lower triglycerides
11 people found this helpful
I used to have high triglycerides and poor cholesterol levels but switched to this natural Jarrow EPA/DHA fish oil. It has significantly improved my blood work, lowering my triglycerides effectively without any fishy aftertaste. I highly recommend this brand.
9
Reduces blood cholesterol
2 people found this helpful
This excellent dietary supplement contains concentrated fish oil with guaranteed benefits. It helps reduce cholesterol and supports heart health while being suitable for all ages. The sealed packaging preserves the product, and the price is lower than local options.
9
Family health improvement
7 people found this helpful
Our family's cholesterol has improved significantly since using this Omega-3. Initially diagnosed with hyperlipidemia, we noticed nearly normal cholesterol levels now, showing tangible benefits for everyone's health.
9
Cholesterol plaque prevention
101 people found this helpful
Omega-3 acids help clear blood vessels of "bad" cholesterol, preventing cholesterol plaques. They improve blood viscosity and normalise blood pressure while boosting "good" cholesterol levels. I strongly recommend it.
7.5
Joint and cholesterol health
95 people found this helpful
This supplement lowers bad cholesterol, strengthens the cardiovascular system, and reduces the risk of blood clots. It positively affects the retina and protects joints and ligaments.
0
Worsened results
36 people found this helpful
The Omega worsened my lipidogram results. Despite evaluating many brands for EPA/DHA ratios and raw material quality, this one caused declines in good cholesterol (HDL). After using it, triglycerides improved, but overall results were disappointing.
7.5
Cholesterol reduction
6 people found this helpful
Very profitable Omega! I regularly give it to my parents to lower their cholesterol levels alongside other medications, helping them recover following a stroke.
9
Omega-3 EPA+DHA improves cholesterol
EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
9
High-purity EPA benefits cholesterol
Pleiotropic beneficial cardiometabolic actions of a high-purity eicosapentaenoic acid product in high cardiovascular risk individuals.
We examined the impact of a highly purified eicosapentaenoic acid (EPA) formulation on cholesterol levels and overall heart health in individuals considered at high risk for cardiovascular issues. The study involved 226 patients who had high triglycerides and one or more cardiovascular risk factors, such as hypertension or diabetes.
Participants received 4 grams of EPA daily for three months alongside regular nutritional counseling. By tracking key health markers, we noted significant improvements in cholesterol levels, particularly in triglycerides and low-density lipoprotein (LDL). For instance, triglyceride levels dropped from an average of 2.97 mmol/L to 1.75 mmol/L in just three months.
Additionally, we found improvements in other important metrics, including total cholesterol and glucose levels, indicating that EPA supplementation may have broad benefits for cardiometabolic health. Although apolipoprotein A levels did not change significantly, the overall trend suggests that incorporating EPA could play a role in achieving better heart health outcomes.
9
Antarctic krill oil aids cholesterol
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
8
Omega-3 reduces high cholesterol
Efficacy and safety of omega-3-acid ethyl acetate 90 capsules in severe hypertriglyceridemia: A randomized, controlled, multicenter study.
We assessed the effectiveness of omega-3-acid ethyl acetate, which includes docosahexaenoic acid (DHA), in managing high cholesterol, particularly focusing on patients with severe hypertriglyceridemia. In a carefully designed randomized, double-blind, placebo-controlled study, 239 participants were assigned to receive either omega-3 capsules or a placebo for 12 weeks.
Throughout the study period, we measured various cholesterol-related indicators at the start and after 4, 8, and 12 weeks. We observed significant reductions in triacylglycerols, total cholesterol, non-high-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and apolipoprotein C-III in the omega-3 group compared to the placebo. These findings suggest that the combined omega-3 treatment, which prominently features DHA, can enhance lipid profiles in patients struggling with severe hypertriglyceridemia.
However, it’s important to note that there was no significant change observed in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or the LDL-C/HDL-C ratio between the two groups. Furthermore, the safety profile was similar across both groups, indicating that omega-3 capsules are generally well-tolerated. Overall, while DHA is part of the treatment, we could not isolate its specific impact on cholesterol levels due to the study’s design, which considered the effects of the omega-3 formulation collectively.
References
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Hirako S, Kim H, Iizuka Y, Matsumoto A. Fish oil consumption prevents hepatic lipid accumulation induced by high-cholesterol feeding in obese KK mice. Biomed Res. 2024;45:33. 10.2220/biomedres.45.33
Mjaatveit M, Oldernes H, Gudbrandsen OA. Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis. Br J Nutr. 2024;131:606. 10.1017/S0007114523002118
Zhang C, Wang X, Sun S, Fu Y, Wu Y, et al. Fat-1 expression alleviates atherosclerosis in transgenic rabbits. J Cell Mol Med. 2022;26:1306. 10.1111/jcmm.17188
Sugimoto K, Hosomi R, Shimono T, Kanda S, Nishiyama T, et al. Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice. J Oleo Sci. 2021;70:965. 10.5650/jos.ess21032
Jaca A, Durão S, Harbron J. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. S Afr Med J. 2020;110:1158. 10.7196/SAMJ.2020.v110i12.14730
Trivedi K, Le V, Nelson JR. The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention. Postgrad Med. 2021;133:28. 10.1080/00325481.2020.1783937
Saito M, Ishida N, Yamada H, Ibi M, Hirose M. 8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice. Biol Pharm Bull. 2020;43:919. 10.1248/bpb.b20-00162
Llop-Talaveron J, Badía-Tahull M, Lozano-Andreu T, Rigo-Bonnin R, Virgili-Casas N, et al. Phytosterolemia and γ-glutamyl transferase in adults with parenteral nutrition: Fish versus vegetal lipids: A randomized clinical trial. Nutrition. 2020;70:110587. 10.1016/j.nut.2019.110587
Antona ME, Ramos C, Stranges A, Monteiro AF, Gonzales Chaves MM, et al. Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats. Arch Oral Biol. 2020;109:104553. 10.1016/j.archoralbio.2019.104553
Zhou Q, Zhang Z, Wang P, Zhang B, Chen C, et al. EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Mol Nutr Food Res. 2019;63:e1801157. 10.1002/mnfr.201801157
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, et al. Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT. J Am Coll Cardiol. 2019;73:2791. 10.1016/j.jacc.2019.02.032
Preston Mason R. New Insights into Mechanisms of Action for Omega-3 Fatty Acids in Atherothrombotic Cardiovascular Disease. Curr Atheroscler Rep. 2019;21:2. 10.1007/s11883-019-0762-1
Vikøren LA, Drotningsvik A, Bergseth MT, Mjøs SA, Austgulen MH, et al. Intake of Baked Cod Fillet Resulted in Lower Serum Cholesterol and Higher Long Chain -3 PUFA Concentrations in Serum and Tissues in Hypercholesterolemic Obese Zucker fa/fa Rats. Nutrients. 2018;10. 10.3390/nu10070840
Blom WAM, Koppenol WP, Hiemstra H, Stojakovic T, Scharnagl H, et al. A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia. Eur J Nutr. 2019;58:1615. 10.1007/s00394-018-1706-1
Shen J, Rastogi R, Guan L, Li F, Du H, et al. Omega-3 fatty acid supplement reduces activation of NADPH oxidase in intracranial atherosclerosis stenosis. Neurol Res. 2018;40:499. 10.1080/01616412.2018.1451290
Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. 10.3390/jcdd12020060
Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
Uthaiah NM, Venkataramareddy SR, Mudhol S, Sheikh AY. EPA-rich Nannochloropsis oceanica biomass regulates gut microbiota, alleviates inflammation and ameliorates liver fibrosis in rats. Food Res Int. 2025;202:115733. 10.1016/j.foodres.2025.115733
Yoshikiyo K, Shimizu H, Nagato EG, Ishizuka S, Yamamoto T. Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels. Molecules. 2025;30. 10.3390/molecules30020281
Lamantia V, Bissonnette S, Beaudry M, Cyr Y, Rosiers CD, et al. EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors. Sci Rep. 2024;14:27146. 10.1038/s41598-024-73672-6
Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. 10.3389/fnut.2024.1423228
Bashir B, Schofield J, Downie P, France M, Ashcroft DM, et al. Beyond LDL-C: unravelling the residual atherosclerotic cardiovascular disease risk landscape-focus on hypertriglyceridaemia. Front Cardiovasc Med. 2024;11:1389106. 10.3389/fcvm.2024.1389106
Lin YL, Wang CL, Chiang TI. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients. Front Nephrol. 2024;4:1365809. 10.3389/fneph.2024.1365809
Omari M, Alkhalil M. Atherosclerosis Residual Lipid Risk-Overview of Existing and Future Pharmacotherapies. J Cardiovasc Dev Dis. 2024;11. 10.3390/jcdd11040126
Szarek M, Bhatt DL, Miller M, Brinton EA, Jacobson TA, et al. Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl. J Am Coll Cardiol. 2024;83:1529. 10.1016/j.jacc.2024.02.016
Liakos CI, Lanaras L, Bristianou M, Papadopoulos DP. Pleiotropic beneficial cardiometabolic actions of a high-purity eicosapentaenoic acid product in high cardiovascular risk individuals. Lipids. 2024;59:67. 10.1002/lipd.12391
Ganuza E, Etomi EH, Olson M, Whisner CM. Omega-3 eicosapentaenoic polar-lipid rich extract from microalgae decreases plasma triglycerides and cholesterol in a real-world normolipidemic supplement consumer population. Front Nutr. 2024;11:1293909. 10.3389/fnut.2024.1293909
Kobayashi Y, Fujikawa T, Haruna A, Kawano R, Ozawa M, et al. Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study. Medicina (Kaunas). 2023;60. 10.3390/medicina60010075
Mueller PA, Bergstrom P, Rosario S, Heard M, Pamir N. Fish Oil Supplementation Modifies the Proteome, Lipidome, and Function of High-Density Lipoprotein: Findings from a Trial in Young Healthy Adults. J Nutr. 2024;154:1130. 10.1016/j.tjnut.2024.01.007
Chang Y, Xuan Y, Zhang R, Ding X, Zeng Q, et al. Effects of Dietary Schizochytrium Algae as ω-3 PUFA Source on the Egg-Laying Quail Performance, Serum Indexes, and Egg Yolk Fatty Acids Contents. Animals (Basel). 2024;15. 10.3390/ani15010021
Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. 10.1039/d4fo04961f
Coelho-Júnior HJ, Álvarez-Bustos A, Picca A, Calvani R, Rodriguez-Mañas L, et al. Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults. Nutrients. 2024;16. 10.3390/nu16234087
Cabrita ARJ, Barroso C, Fontes-Sousa AP, Correia A, Teixeira L, et al. Assessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota. Front Vet Sci. 2024;11:1449141. 10.3389/fvets.2024.1449141
Zhang D, Wang Z, Guo S, Sun Y, Zhou D, et al. F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol. Exp Gerontol. 2024;196:112577. 10.1016/j.exger.2024.112577
Zhao W, Wang Y, Li J, Chen T, Yin D, et al. Efficacy and safety of omega-3-acid ethyl acetate 90 capsules in severe hypertriglyceridemia: A randomized, controlled, multicenter study. Lipids. 2024;59:145. 10.1002/lipd.12406
Li P, Khan S, Huang Y, Lu S, Zhou P, et al. Effect of Perilla seeds inclusion on the performance, egg quality characteristics, biochemical parameters and egg yolk fatty acid composition of laying hens. Trop Anim Health Prod. 2024;56:147. 10.1007/s11250-024-03983-3