We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
9
Omega-3s may lower hypertension mortality
Association between dietary intake of omega-3 polyunsaturated fatty acids and all-cause and cardiovascular mortality among hypertensive adults: Results from NHANES 1999-2018.
We explored the link between dietary omega-3 polyunsaturated fatty acids (N3-PUFA) and mortality in hypertensive adults through a thorough study involving over 26,000 participants from NHANES data spanning nearly two decades.
Our findings revealed that higher N3-PUFA intake, particularly from alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosapentaenoic acid (DPA), was associated with a lower risk of both overall and cardiovascular mortality.
This suggests that incorporating more omega-3 rich foods into the diet could be a valuable strategy for reducing health risks in those living with hypertension.
Read More
8
Fatty acids' effects on PIH
Fatty acids and pregnancy-induced hypertension: a Mendelian randomization study.
We investigated how fatty acids, particularly Omega-3 and Omega-6, affect pregnancy-induced hypertension (PIH). Our analysis utilized advanced statistical techniques on data gathered from Genome-Wide Association Studies.
The results suggest that higher levels of Omega-3 fatty acids, like DHA, might actually help protect against PIH. Conversely, an increased Omega-6 to Omega-3 ratio could raise the risk of developing this condition.
These insights could guide future clinical strategies aimed at reducing the risks associated with PIH in expectant mothers.
Read More
Most Useful Reviews
9
Improved blood pressure
3 people found this helpful
The best vascular protector! Without omega acids, our life in adulthood loses its pleasure: hypertension, stenocardia, and other issues. I take this medication year-round: my blood pressure is normal, my cardiovascular performance has improved, and even my joints have stopped grinding! I also give it to my elderly parents. The dosage and number of capsules are very convenient. I searched for a suitable mono drug for ages due to my allergy to multivitamins, and I found it only on this site. I recommend these drugs to all my relatives and friends, as well as to you, dear site users! Stay healthy and happy!
Association between dietary intake of omega-3 polyunsaturated fatty acids and all-cause and cardiovascular mortality among hypertensive adults: Results from NHANES 1999-2018.
We explored the link between dietary omega-3 polyunsaturated fatty acids (N3-PUFA) and mortality in hypertensive adults through a thorough study involving over 26,000 participants from NHANES data spanning nearly two decades.
Our findings revealed that higher N3-PUFA intake, particularly from alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosapentaenoic acid (DPA), was associated with a lower risk of both overall and cardiovascular mortality.
This suggests that incorporating more omega-3 rich foods into the diet could be a valuable strategy for reducing health risks in those living with hypertension.
Read More
9
Resolvin E1 reduces hypertension effects
Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
We explored the effects of Resolvin E1 (RvE1) in mice with hypertension induced by angiotensin II. By injecting RvE1, we observed significant reductions in blood pressure and improvements in vascular health, including decreased fibrosis and cell growth in blood vessels.
Importantly, the positive effects of RvE1 depended on the ChemR23 receptor—when this receptor was knocked down, the benefits were lost. Our findings suggest that targeting RvE1/ChemR23 could offer promising new ways to treat hypertension.
Read More
9
Eicosapentaenoic acid benefits hypertension
5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
9
Exercise aids hypertension-related BBB issues
Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries.
We investigated how hypertension affects the blood-brain barrier (BBB) and whether exercise training could improve its function. Our study involved spontaneously hypertensive rats (SHR) and Wistar rats, which we divided into groups that either underwent treadmill training or remained sedentary for four weeks. We found that hypertension led to an increase in blood pressure and heart rate, as well as a decrease in the protective Mfsd2a protein, which plays a crucial role in maintaining BBB integrity.
Interestingly, when the hypertensive rats participated in exercise training, we noticed a restoration of Mfsd2a levels, a reduction in another protein called caveolin-1, and importantly, a normalization of BBB permeability in the paraventricular nucleus of the hypothalamus. This change was also accompanied by improvements in heart rate and blood pressure variability, indicating enhanced autonomic control.
However, we saw no significant changes in the Wistar group between training and sedentary states, suggesting that the exercise's effects were specific to the hypertensive condition. This highlights that while docosahexaenoic acid (DHA) transport through Mfsd2a is beneficial, the direct impact of DHA alone on hypertension wasn't the focus of our study.
Ultimately, we concluded that exercise training is an effective way to improve both the BBB function and autonomic regulation in hypertensive individuals. It emphasizes the potential therapeutic benefits of lifestyle interventions, like regular exercise, in managing hypertension-related complications.
Read More
8
Resolvin D2 aids hypertension prevention
Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors.
We investigated whether resolvin D2 (RvD2) could prevent vascular damage caused by obesity and hypertension. In mice exposed to a high-fat diet and angiotensin II, RvD2 administration showed promise in reducing obesity-related inflammation and vascular remodeling.
While RvD2 helped improve endothelial function and reduce inflammatory markers, the study didn’t indicate a complete reversal of hypertension.
Our findings suggest RvD2 might be a protective agent against vascular damage linked to hypertension, primarily affecting immune and vascular cells.
The best vascular protector! Without omega acids, our life in adulthood loses its pleasure: hypertension, stenocardia, and other issues. I take this medication year-round: my blood pressure is normal, my cardiovascular performance has improved, and even my joints have stopped grinding! I also give it to my elderly parents. The dosage and number of capsules are very convenient. I searched for a suitable mono drug for ages due to my allergy to multivitamins, and I found it only on this site. I recommend these drugs to all my relatives and friends, as well as to you, dear site users! Stay healthy and happy!
Read More
9
Effective for seniors
Great for those over 55 and with hypertension.
Read More
9
Hypertension reduction
Reduces hypertension.
Read More
6
Inconsistent evidence
There is qualified information about health benefits. Preliminary research suggests that EPA and DHA may lower coronary heart disease risk. They help reduce blood pressure and hypertension risk for many. However, the FDA found the evidence to be inconsistent. One serving of EPA-DHA Balance contains 1.2 grams of EPA and DHA. This is a good hair supplement, and the large packaging features excellent ingredients.
Read More
6
Substitute for fish
1 people found this helpful
Supplied with fish without the need to consume large amounts of it. When on a low carbohydrate diet, we turn to this product instead of eating fish. I recommend it to those who do not eat fish in Europe and America. It seems to soften blood vessels and improve hypertension, although individual differences exist. The capsule size could be a slight challenge, hence the four-star rating.
Hypertension, commonly known as high blood pressure, is a medical condition characterized by the consistent elevation of blood pressure in the arteries. Blood pressure readings consist of two numbers: systolic pressure (the pressure in the arteries when the heart beats) over diastolic pressure (the pressure when the heart rests between beats). A normal blood pressure reading is typically around 120/80 mmHg. Hypertension is generally diagnosed when readings consistently exceed 130/80 mmHg, a level that increases the risk of serious health issues like heart disease, stroke, and kidney damage.
Since hypertension often develops silently without noticeable symptoms, regular monitoring of blood pressure is crucial, especially for those at higher risk due to factors like age, family history, obesity, or sedentary lifestyle. Effective management can significantly lower health risks and often includes lifestyle changes such as a balanced diet, regular exercise, reduced sodium intake, and, if necessary, medication prescribed by a healthcare provider. Early detection and consistent management of hypertension can lead to better health outcomes, making it important to stay informed about your blood pressure levels.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has been studied for its potential benefits in managing hypertension, or high blood pressure. Research suggests that the omega-3 fatty acids found in fish oil—particularly EPA and DHA—may help lower blood pressure in some individuals. The exact mechanism is not fully understood, but it is believed that omega-3s can improve vascular function and reduce inflammation, which are both factors that can contribute to elevated blood pressure levels.
While some studies have shown promising results, the evidence is not universally conclusive. The effects of omega-3 supplementation can vary depending on the individual and the dosage. Therefore, if you are considering adding omega-3 fish oil to your regimen for managing hypertension, it's essential to consult with a healthcare professional first. They can help determine whether it’s appropriate for your specific health needs and how it might interact with any medications you may be taking.
Based on user reviews, those taking this supplement for hypertension have reported varying timelines for experiencing noticeable results. Some users have experienced improvements in their blood pressure and overall vascular health shortly after starting the supplement, indicating that within a few weeks of consistent use, one may notice positive changes. For instance, one reviewer noted significant cardiovascular benefits and stabilization of blood pressure during year-round usage (Read Review), while another emphasized that the supplement is particularly beneficial for those over 55 with hypertension (Read Review).
However, it's important to recognize that individual responses may vary greatly. For example, while several users mentioned effective results in reducing hypertension, the timeline for these benefits isn't uniformly consistent across all individuals. Some reviews highlighted that it might take dedicated use over several weeks to months to assess the full effects, suggesting a prudence in managing expectations (Read Review, Read Review). Ultimately, it's advised to consult with a healthcare provider to tailor any supplementation plan effectively for your specific health conditions.
Extensive scientific research supports the use of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in managing hypertension. Numerous studies have indicated that regular consumption of omega-3s can lead to significant reductions in blood pressure and contribute positively to overall cardiovascular health. For instance, a meta-analysis involving nearly 5,000 participants revealed that moderate daily doses of omega-3 fatty acids effectively lowered both systolic and diastolic blood pressure, especially in older adults and those already experiencing hypertension [25]. Additionally, another study demonstrated that dietary EPA was associated with reduced prevalence of hypertension among U.S. adults, emphasizing its beneficial role in blood pressure management [14].
Moreover, findings have suggested that these fatty acids might provide additional protective benefits against heart-related conditions and mortality in people living with hypertension, pointing towards a broader positive impact of omega-3s beyond just lowering blood pressure. However, while the evidence is compelling, variations in individual responses and the need for further research to isolate effects from other dietary components make it clear that omega-3s should be considered as part of a comprehensive approach to managing hypertension [8]. Overall, adding omega-3-rich foods to your diet seems like a wise move for anyone aiming to manage their blood pressure effectively.
Users report a variety of improvements in their cardiovascular health and blood pressure regulation after using this supplement. Many have noted a reduction in hypertension, with some experiencing sustained normal blood pressure levels as a result of long-term use. For instance, one user described enhanced cardiovascular performance, along with improved joint health, indicating broad systemic benefits from daily usage (Read Review). Additionally, reviews highlight that this supplement may be particularly beneficial for those over the age of 55, as one user specifically endorsed it for individuals dealing with hypertension in this age group (Read Review).
While a majority of users report positive outcomes, it's important to remember that individual experiences can differ significantly. Some users have noted that while the supplement aids in lowering blood pressure, results may take time and the degree of effectiveness can vary by person (Read Review). Comments from multiple reviewers underscore that supplementation of omega-3 fatty acids does appear to reduce hypertension risk for most individuals, especially when taken consistently (Read Review). As always, it is prudent to consult a healthcare professional to find the right approach tailored to personal health needs.
Users report positive experiences when combining this supplement with other supplements for managing hypertension. Many have noted that taking omega-3 fatty acids, specifically EPA and DHA, can be particularly effective in reducing blood pressure levels. One user mentioned that this supplement "softens blood vessels and improves hypertension," highlighting its beneficial vaso-relaxation properties, which can augment other hypertension management strategies (Read Review, Read Review) . Additionally, healthcare providers recommend this supplement for patients dealing with cardiovascular issues, including hypertension and arrhythmias, indicating that it may complement pharmaceutical approaches effectively (Read Review).
However, users also caution that individual reactions can vary significantly. While the majority agree on the positive impact of omega-3s on blood pressure, they acknowledge that results may differ based on personal health and dietary habits. Some reviews encouraged consistent usage over time for optimal benefits, suggesting that those on low-carbohydrate diets or who do not consume fish may particularly benefit from supplementation (Read Review, Read Review). As always, it’s advisable to consult with healthcare professionals to customize supplement regimens regarding hypertension management.
Research suggests that the optimal dose of Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for managing hypertension is in the range of 2 to 3 grams per day. A comprehensive analysis of randomized controlled trials indicated that this moderate intake is associated with significant decreases in both systolic and diastolic blood pressure—approximately 2.61 mm Hg for systolic and 1.64 mm Hg for diastolic pressure [25]. It's worth noting that while these dosages are effective, exceeding 3 grams daily can be beneficial, especially for individuals at higher risk for cardiovascular issues.
Additionally, higher intake of Omega-3s has been linked with a reduced prevalence of hypertension, with participants consuming in the highest quartile of polyunsaturated fatty acid intake showing less likelihood of being hypertensive [14]. This underscores the importance of integrating Omega-3 fatty acids into the diet—obtained from sources like fish oil—within the recommended dosages to potentially support blood pressure regulation and overall cardiovascular health.
9
Improved blood pressure
3 people found this helpful
The best vascular protector! Without omega acids, our life in adulthood loses its pleasure: hypertension, stenocardia, and other issues. I take this medication year-round: my blood pressure is normal, my cardiovascular performance has improved, and even my joints have stopped grinding! I also give it to my elderly parents. The dosage and number of capsules are very convenient. I searched for a suitable mono drug for ages due to my allergy to multivitamins, and I found it only on this site. I recommend these drugs to all my relatives and friends, as well as to you, dear site users! Stay healthy and happy!
9
Effective for seniors
Great for those over 55 and with hypertension.
6
Substitute for fish
1 people found this helpful
Supplied with fish without the need to consume large amounts of it. When on a low carbohydrate diet, we turn to this product instead of eating fish. I recommend it to those who do not eat fish in Europe and America. It seems to soften blood vessels and improve hypertension, although individual differences exist. The capsule size could be a slight challenge, hence the four-star rating.
7.5
Reduced hypertension risk
Good dosage and excellent quality. Taking EPA with DHA helps lower blood pressure and the likelihood of developing hypertension in most individuals. I recommend it.
7.5
Effective for arrhythmias
Works wonderfully! Ultra Omega-3 has proved effective. The capsule contains 600 mg of acids. I prescribe it to my patients with cardiovascular issues, including arrhythmias and hypertension, as well as dyslipidemia and atherosclerosis. However, individual intolerance to any drug components must be considered.
7.5
Mixed feelings
Great but expensive. Consuming the omega-3 fatty acids EPA and DHA may lessen the risk of coronary heart disease. The combination helps reduce blood pressure and the risk of hypertension in the majority. It’s the ideal Omega-3 ratio for health; however, it is costly for me.
8
Eicosapentaenoic acid lowers blood pressure
Omega-3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials.
We explored how eicosapentaenoic acid, often combined with docosahexaenoic acid, impacts hypertension. Our analysis focused on a robust collection of randomized controlled trials involving nearly 5,000 participants, which provided us with valuable insights into the relationship between omega-3 fatty acids and blood pressure.
From our findings, we noted the most effective daily intake of omega-3s for lowering blood pressure appeared to be between 2 and 3 grams. This moderate intake showed promising results in reducing both systolic and diastolic blood pressure. Interestingly, we discovered that this effect was particularly pronounced in groups that were older, had hypertension, or suffered from high cholesterol.
However, we also observed a J-shaped dose-response curve, which suggests that while lower doses are effective, higher doses might not yield additional benefits and could even be less effective for some people. This emphasizes the importance of adhering to recommended doses, especially for those at risk for cardiovascular diseases.
8
PUFAs linked to lower hypertension risk
Association between dietary intake of polyunsaturated fatty acid and prevalence of hypertension in U.S. adults: A cross-sectional study using data from NHANES 2009-2016.
We aimed to understand how consuming polyunsaturated fatty acids (PUFAs), especially from fish oil, relates to hypertension in U.S. adults. Analyzing data from over 17,000 participants, we discovered that higher intake of PUFAs, including omega-3s, was linked to a significantly lower prevalence of hypertension.
Specifically, our findings showed that those in the highest quartiles of PUFA intake had notably reduced odds of high blood pressure. This suggests that including more omega-3 fatty acids in our diet could be beneficial for blood pressure management.
7
Omega-3s' uncertain hypertension effects
Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?
We explored the impact of omega-3 fatty acids on hypertension through various clinical studies and large-scale trials. The findings revealed that while omega-3s, such as EPA and DHA, show promising potential in regulating blood pressure, the results are not consistent.
Many studies indicate these fatty acids can benefit vascular health, but the overall effect on high blood pressure remains unclear. Omega-3s may help manage vascular tone and reduce cardiovascular risks, yet more research is needed to solidify their role against hypertension.
References
Li ZH, Song WQ, Qiu CS, Li HM, Tang XL, et al. Fish oil supplementation, genetic susceptibility and risk of new-onset hypertension. Prev Med. 2024;189:108152. doi:10.1016/j.ypmed.2024.108152
Xi C, Zhang J, Liu H, Tao S, Xie Y, et al. Can Omega-3 prevent the accidence of stroke: a mendelian randomization study. Hereditas. 2024;161:30. doi:10.1186/s41065-024-00329-9
Rodrigues-Diez R, Ballesteros-Martinez C, Moreno-Carriles RM, Nistal F, Díaz Del Campo LS, et al. Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors. Biomed Pharmacother. 2024;174:116564. doi:10.1016/j.biopha.2024.116564
Song Y, Wang Q, Jia L. Omega-3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approach. J Clin Hypertens (Greenwich). 2024;26:382. doi:10.1111/jch.14782
Chen H, Leng X, Liu S, Zeng Z, Huang F, et al. Association between dietary intake of omega-3 polyunsaturated fatty acids and all-cause and cardiovascular mortality among hypertensive adults: Results from NHANES 1999-2018. Clin Nutr. 2023;42:2434. doi:10.1016/j.clnu.2023.09.011
Zhang J, Yin Z, Xu Y, Wei C, Peng S, et al. Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice. Hypertension. 2023;80:2650. doi:10.1161/HYPERTENSIONAHA.123.21348
Ma Z, He W. Fatty acids and pregnancy-induced hypertension: a Mendelian randomization study. Lipids Health Dis. 2023;22:131. doi:10.1186/s12944-023-01889-x
Brosolo G, Da Porto A, Marcante S, Picci A, Capilupi F, et al. Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?. Int J Mol Sci. 2023;24. doi:10.3390/ijms24119520
Ma T, He L, Luo Y, Zhang G, Cheng X, et al. Use of fish oil and mortality of patients with cardiometabolic multimorbidity: A prospective study of UK biobank. Nutr Metab Cardiovasc Dis. 2022;32:2751. doi:10.1016/j.numecd.2022.09.016
Gharraee N, Wang Z, Pflum A, Medina-Hernandez D, Herrington D, et al. Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats. J Lipid Res. 2022;63:100292. doi:10.1016/j.jlr.2022.100292
Ma T, He L, Luo Y, Li J, Zhang G, et al. Associations of baseline use of fish oil with progression of cardiometabolic multimorbidity and mortality among patients with hypertension: a prospective study of UK Biobank. Eur J Nutr. 2022;61:3461. doi:10.1007/s00394-022-02889-w
Arvizu M, Minguez-Alarcon L, Wang S, Mitsunami M, Stuart JJ, et al. Pre-pregnancy fat intake in relation to hypertensive disorders of pregnancy. Am J Clin Nutr. 2022;116:750. doi:10.1093/ajcn/nqac145
Shi HH, Zhang LY, Chen LP, Yang JY, Wang CC, et al. EPA-Enriched Phospholipids Alleviate Renal Interstitial Fibrosis in Spontaneously Hypertensive Rats by Regulating TGF-β Signaling Pathways. Mar Drugs. 2022;20. doi:10.3390/md20020152
Ni S, Zhong Z, Wei J, Zhou J, Cai L, et al. Association between dietary intake of polyunsaturated fatty acid and prevalence of hypertension in U.S. adults: A cross-sectional study using data from NHANES 2009-2016. Hypertens Res. 2022;45:516. doi:10.1038/s41440-021-00849-1
Egan Benova T, Viczenczova C, Szeiffova Bacova B, Zurmanova J, Knezl V, et al. Omacor Protects Normotensive and Hypertensive Rats Exposed to Continuous Light from Increased Risk to Malignant Cardiac Arrhythmias. Mar Drugs. 2021;19. doi:10.3390/md19120659
Olivares-Silva F, De Gregorio N, Espitia-Corredor J, Espinoza C, Vivar R, et al. Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension. Biochim Biophys Acta Mol Basis Dis. 2021;1867:166241. doi:10.1016/j.bbadis.2021.166241
Arghavani H, Bilodeau JF, Rudkowska I. Association Between Circulating Fatty Acids and Blood Pressure: A Review. Curr Nutr Rep. 2025;14:15. doi:10.1007/s13668-024-00602-3
Kujawska A, Bromage S, Simoes JA, Zupkauskienė J, McMahon N, et al. The impact of dietary supplements on blood pressure in older adults: A network meta-analysis of randomized controlled trials. Heliyon. 2024;10:e25615. doi:10.1016/j.heliyon.2024.e25615
Asulin M, Gorodetzer N, Fridman R, Shelly Ben-Shushan R, Cohen Z, et al. 5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway. Biochem Biophys Res Commun. 2024;700:149585. doi:10.1016/j.bbrc.2024.149585
Pipingas A, Reddan JM, Gauci S, Young LM, Kennedy G, et al. Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study. Nutrients. 2023;15. doi:10.3390/nu15092198
Imig JD. Bioactive lipids in hypertension. Adv Pharmacol. 2023;97:1. doi:10.1016/bs.apha.2023.01.001
Bercea C, Limbu R, Behnam K, Ng KE, Aziz Q, et al. Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels. Front Physiol. 2022;13:1033216. doi:10.3389/fphys.2022.1033216
Zavala MR, Longarzo ML, Vázquez RF, Vélez Rueda O, Maté SM, et al. Polyunsaturated ω3 fatty acids prevent the cardiac hypertrophy in hypertensive rats. Biochim Biophys Acta Gen Subj. 2023;1867:130278. doi:10.1016/j.bbagen.2022.130278
Pinhas S, Amram E, Slutsky-Smith E, Ertracht O, Atar S, et al. Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation. Prostaglandins Other Lipid Mediat. 2022;162:106665. doi:10.1016/j.prostaglandins.2022.106665
Zhang X, Ritonja JA, Zhou N, Chen BE, Li X. Omega-3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2022;11:e025071. doi:10.1161/JAHA.121.025071
Barsheshet M, Ertracht O, Boginya A, Reuveni T, Atar S, et al. Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:159031. doi:10.1016/j.bbalip.2021.159031
Nestel PJ, Mori TA. Diet to Stop Hypertension: Should Fats be Included?. Curr Hypertens Rep. 2024;26:409. doi:10.1007/s11906-024-01310-7
Perego SM, Raquel HA, Candido VB, Masson GS, Martins MM, et al. Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries. Am J Physiol Regul Integr Comp Physiol. 2023;325:R299. doi:10.1152/ajpregu.00049.2023