Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 2 Softgels
Serving Per Container: 60
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%‡
Cholesterol
11 mg
4%‡
Protein
<1 g
Fish Oil Concentrate^
2,000 mg
†
Omega-3 Fatty Acids^
1,200 mg
†
EPA (Eicosapentaenoic acid)^
800 mg
†
DHA (Docosahexaenoic acid)^
400 mg
†
Top Medical Research Studies
9
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
Read More
9
We explored the impact of omega 3 fatty acids (O3FA) on hypothyroidism triggered by bisphenol F (BPF), a chemical known to disrupt endocrine functions. The study involved 20 male Wistar rats, divided into groups to either receive BPF, O3FA, or a combination of both for a duration of 28 days. This design helped us assess the protective effects of O3FA against hypothyroidism-related testicular dysfunction.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Read More
8
Omega-3 benefits hypothyroid function
We explored the effects of eicosapentaenoic acid ethyl ester (EPA-E), a type of omega-3 fatty acid derived from fish oil, on hypothyroidism. This study used an animal model consisting of rats that were induced with hypothyroidism through a chemical called 1-methyl-2-imidazolethiol (MMI).
The results showed that oral administration of EPA-E helped to inhibit the reduction of thyroid hormone levels in these rats. Additionally, it also prevented changes in the structure of thyroid follicles that are typically associated with hypothyroidism.
Interestingly, we found that plasma free fatty acid (FFA) concentrations were sometimes elevated in some hypothyroid patients, which suggested a potential link between FFA levels and thyroid function. This means that variations in fatty acid levels may influence how the thyroid gland operates.
Overall, our findings suggest that omega-3 fatty acids like EPA-E could offer a protective effect against hypothyroidism, making them worth further exploration in human studies.
The results showed that oral administration of EPA-E helped to inhibit the reduction of thyroid hormone levels in these rats. Additionally, it also prevented changes in the structure of thyroid follicles that are typically associated with hypothyroidism.
Interestingly, we found that plasma free fatty acid (FFA) concentrations were sometimes elevated in some hypothyroid patients, which suggested a potential link between FFA levels and thyroid function. This means that variations in fatty acid levels may influence how the thyroid gland operates.
Overall, our findings suggest that omega-3 fatty acids like EPA-E could offer a protective effect against hypothyroidism, making them worth further exploration in human studies.
Read More
Most Useful Reviews
9
Improved skin appearance
1 people found this helpful
After two years of use, I can see visible results. They still work well and are tolerated excellently, making them a regular purchase. The effect lasted for three months after the can, improving my skin and reducing cellulite and varicose veins. I initially took two capsules but have now increased to three daily. For hypothyroidism, a minimum of 2000 units is essential; I may increase to four. I purposely bought a second large jar due to the positive results I've observed and continue to buy regularly, as I am satisfied with the effect.
Read More
7.5
Energising and effective
I have been purchasing these for three years due to their great effect and visible results. This is one of my few regular purchases, and I take them several times a year with short breaks. My dosage is typically 4-6 capsules daily, ideally taken in the morning as they are invigorating; they should not be taken before bedtime. This dosage works well for my hypothyroidism.
Read More
7.5
Hydrated skin
With hypothyroidism, my skin was very dry. After using omega supplements, I noticed that my skin became much more hydrated.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
- All Researches
9
We explored the impact of omega 3 fatty acids (O3FA) on hypothyroidism triggered by bisphenol F (BPF), a chemical known to disrupt endocrine functions. The study involved 20 male Wistar rats, divided into groups to either receive BPF, O3FA, or a combination of both for a duration of 28 days. This design helped us assess the protective effects of O3FA against hypothyroidism-related testicular dysfunction.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Read More
9
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
Read More
9
We investigated the potential benefits of omega-3 fatty acids in a model of hypothyroidism. This study used a group of pregnant and lactating rats whose offspring experienced thyroid hormone deficiency due to induced hypothyroidism.
We found that supplementing the mothers with omega-3 fatty acids, specifically a blend of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), significantly altered the levels of apoptosis—cell death—occurring in the developing brains of their pups.
Our results demonstrated that omega-3 supplementation reduced DNA fragmentation and the activation of a protein linked to apoptosis, suggesting that these fatty acids play a protective role. They appeared to counteract the effects of hypothyroidism by bringing back the balance of pro-and anti-apoptotic proteins in the cerebellum.
Notably, omega-3 fatty acids helped restore vital signaling pathways that connect to cell survival without interfering with thyroid hormone-responsive gene expression. This highlights the complex role omega-3s could play in brain health during critical developmental phases, especially under stress such as thyroid hormone deficiency.
We found that supplementing the mothers with omega-3 fatty acids, specifically a blend of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), significantly altered the levels of apoptosis—cell death—occurring in the developing brains of their pups.
Our results demonstrated that omega-3 supplementation reduced DNA fragmentation and the activation of a protein linked to apoptosis, suggesting that these fatty acids play a protective role. They appeared to counteract the effects of hypothyroidism by bringing back the balance of pro-and anti-apoptotic proteins in the cerebellum.
Notably, omega-3 fatty acids helped restore vital signaling pathways that connect to cell survival without interfering with thyroid hormone-responsive gene expression. This highlights the complex role omega-3s could play in brain health during critical developmental phases, especially under stress such as thyroid hormone deficiency.
Read More
8
Omega-3 benefits hypothyroid function
We explored the effects of eicosapentaenoic acid ethyl ester (EPA-E), a type of omega-3 fatty acid derived from fish oil, on hypothyroidism. This study used an animal model consisting of rats that were induced with hypothyroidism through a chemical called 1-methyl-2-imidazolethiol (MMI).
The results showed that oral administration of EPA-E helped to inhibit the reduction of thyroid hormone levels in these rats. Additionally, it also prevented changes in the structure of thyroid follicles that are typically associated with hypothyroidism.
Interestingly, we found that plasma free fatty acid (FFA) concentrations were sometimes elevated in some hypothyroid patients, which suggested a potential link between FFA levels and thyroid function. This means that variations in fatty acid levels may influence how the thyroid gland operates.
Overall, our findings suggest that omega-3 fatty acids like EPA-E could offer a protective effect against hypothyroidism, making them worth further exploration in human studies.
The results showed that oral administration of EPA-E helped to inhibit the reduction of thyroid hormone levels in these rats. Additionally, it also prevented changes in the structure of thyroid follicles that are typically associated with hypothyroidism.
Interestingly, we found that plasma free fatty acid (FFA) concentrations were sometimes elevated in some hypothyroid patients, which suggested a potential link between FFA levels and thyroid function. This means that variations in fatty acid levels may influence how the thyroid gland operates.
Overall, our findings suggest that omega-3 fatty acids like EPA-E could offer a protective effect against hypothyroidism, making them worth further exploration in human studies.
Read More
8
We examined the effects of omega-3 fatty acids on heart muscle function in hypothyroid rats through a detailed investigation involving both hypothyroid and euthyroid (normal thyroid) groups. The rats were fed diets rich in either n-6 or n-3 fatty acids to observe how these dietary fats influenced their heart's response to beta-adrenoceptor agonists—substances that stimulate heart contraction.
Our findings revealed that in hypothyroid rats on an n-6 diet, the heart's maximum contractile strength was significantly reduced compared to euthyroid controls. Specifically, their ability to develop tension in response to stimulation was only 54% above resting levels, while euthyroid rats showed a far better response at 160%. Interestingly, hypothyroid rats on the n-3 diet did experience an improvement, with tension levels rising to 105% above resting levels, but this was still lower than the 399% seen in healthy controls.
We also evaluated how the heart's beta-adrenoceptors—the sites that respond to hormones like adrenaline—behaved differently. While the overall number of receptors remained constant regardless of thyroid state or diet, their function appeared to be altered, particularly in hypothyroid rats on the n-6 diet.
Importantly, our observation indicates that incorporating n-3 fatty acids in the diet can enhance heart muscle function in hypothyroid conditions, showing potential for dietary interventions in managing this condition. However, it's clear that other factors also play a significant role in heart health in hypothyroidism.
Our findings revealed that in hypothyroid rats on an n-6 diet, the heart's maximum contractile strength was significantly reduced compared to euthyroid controls. Specifically, their ability to develop tension in response to stimulation was only 54% above resting levels, while euthyroid rats showed a far better response at 160%. Interestingly, hypothyroid rats on the n-3 diet did experience an improvement, with tension levels rising to 105% above resting levels, but this was still lower than the 399% seen in healthy controls.
We also evaluated how the heart's beta-adrenoceptors—the sites that respond to hormones like adrenaline—behaved differently. While the overall number of receptors remained constant regardless of thyroid state or diet, their function appeared to be altered, particularly in hypothyroid rats on the n-6 diet.
Importantly, our observation indicates that incorporating n-3 fatty acids in the diet can enhance heart muscle function in hypothyroid conditions, showing potential for dietary interventions in managing this condition. However, it's clear that other factors also play a significant role in heart health in hypothyroidism.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved skin appearance
1 people found this helpful
After two years of use, I can see visible results. They still work well and are tolerated excellently, making them a regular purchase. The effect lasted for three months after the can, improving my skin and reducing cellulite and varicose veins. I initially took two capsules but have now increased to three daily. For hypothyroidism, a minimum of 2000 units is essential; I may increase to four. I purposely bought a second large jar due to the positive results I've observed and continue to buy regularly, as I am satisfied with the effect.
Read More
7.5
Energising and effective
I have been purchasing these for three years due to their great effect and visible results. This is one of my few regular purchases, and I take them several times a year with short breaks. My dosage is typically 4-6 capsules daily, ideally taken in the morning as they are invigorating; they should not be taken before bedtime. This dosage works well for my hypothyroidism.
Read More
7.5
Hydrated skin
With hypothyroidism, my skin was very dry. After using omega supplements, I noticed that my skin became much more hydrated.
Read More
6
Reduces inflammation
I highly recommend fish oil for both PCOS and hypothyroidism, as both are hormone-related conditions. Fish oil significantly reduces inflammation in the body, which in turn alleviates my symptoms. The ingredients are of high quality. If you found my review helpful, please give it a like. 👍
Read More
Frequently Asked Questions
9
Improved skin appearance
1 people found this helpful
After two years of use, I can see visible results. They still work well and are tolerated excellently, making them a regular purchase. The effect lasted for three months after the can, improving my skin and reducing cellulite and varicose veins. I initially took two capsules but have now increased to three daily. For hypothyroidism, a minimum of 2000 units is essential; I may increase to four. I purposely bought a second large jar due to the positive results I've observed and continue to buy regularly, as I am satisfied with the effect.
7.5
Energising and effective
I have been purchasing these for three years due to their great effect and visible results. This is one of my few regular purchases, and I take them several times a year with short breaks. My dosage is typically 4-6 capsules daily, ideally taken in the morning as they are invigorating; they should not be taken before bedtime. This dosage works well for my hypothyroidism.
7.5
Hydrated skin
With hypothyroidism, my skin was very dry. After using omega supplements, I noticed that my skin became much more hydrated.
6
Reduces inflammation
I highly recommend fish oil for both PCOS and hypothyroidism, as both are hormone-related conditions. Fish oil significantly reduces inflammation in the body, which in turn alleviates my symptoms. The ingredients are of high quality. If you found my review helpful, please give it a like. 👍
8
Omega-3 benefits hypothyroid function
We explored the effects of eicosapentaenoic acid ethyl ester (EPA-E), a type of omega-3 fatty acid derived from fish oil, on hypothyroidism. This study used an animal model consisting of rats that were induced with hypothyroidism through a chemical called 1-methyl-2-imidazolethiol (MMI).
The results showed that oral administration of EPA-E helped to inhibit the reduction of thyroid hormone levels in these rats. Additionally, it also prevented changes in the structure of thyroid follicles that are typically associated with hypothyroidism.
Interestingly, we found that plasma free fatty acid (FFA) concentrations were sometimes elevated in some hypothyroid patients, which suggested a potential link between FFA levels and thyroid function. This means that variations in fatty acid levels may influence how the thyroid gland operates.
Overall, our findings suggest that omega-3 fatty acids like EPA-E could offer a protective effect against hypothyroidism, making them worth further exploration in human studies.
The results showed that oral administration of EPA-E helped to inhibit the reduction of thyroid hormone levels in these rats. Additionally, it also prevented changes in the structure of thyroid follicles that are typically associated with hypothyroidism.
Interestingly, we found that plasma free fatty acid (FFA) concentrations were sometimes elevated in some hypothyroid patients, which suggested a potential link between FFA levels and thyroid function. This means that variations in fatty acid levels may influence how the thyroid gland operates.
Overall, our findings suggest that omega-3 fatty acids like EPA-E could offer a protective effect against hypothyroidism, making them worth further exploration in human studies.
9
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
4
We examined the fatty acid composition in blood serum and erythrocyte membrane lipids of 38 patients suffering from hypothyroidism, with a specific focus on those who also had left ventricular diastolic dysfunction. Our findings revealed that patients had an increased level of saturated fatty acids, particularly myristic and palmitic acids, while the levels of unsaturated fatty acids were notably decreased.
Moreover, we observed a significant reduction in arachidonic levels in both blood serum and erythrocyte membranes before treatment and throughout the hormonal therapy process. Additionally, the content of omega-3 fatty acids in the erythrocyte membrane lipids showed a decline during standard therapeutic interventions.
This pattern indicates that while omega-3 fatty acids decline with conventional therapy, they may have a role to play in managing hypothyroidism as they might deserve consideration for inclusion in combined treatment approaches. However, our examination does not establish a definitive benefit of omega-3 fatty acids as a standalone treatment for hypothyroidism.
Moreover, we observed a significant reduction in arachidonic levels in both blood serum and erythrocyte membranes before treatment and throughout the hormonal therapy process. Additionally, the content of omega-3 fatty acids in the erythrocyte membrane lipids showed a decline during standard therapeutic interventions.
This pattern indicates that while omega-3 fatty acids decline with conventional therapy, they may have a role to play in managing hypothyroidism as they might deserve consideration for inclusion in combined treatment approaches. However, our examination does not establish a definitive benefit of omega-3 fatty acids as a standalone treatment for hypothyroidism.
References
- Odetayo AF, Olayaki LA. Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities. JBRA Assist Reprod. 2024;28:471. 10.5935/1518-0557.20240033
- Abd Allah ES, Gomaa AM, Sayed MM. The effect of omega-3 on cognition in hypothyroid adult male rats. Acta Physiol Hung. 2014;101:362. 10.1556/APhysiol.101.2014.3.11
- Sinha RA, Khare P, Rai A, Maurya SK, Pathak A, et al. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci. 2009;27:377. 10.1016/j.ijdevneu.2009.02.003
- Walter R, Dunn ME, d'Anjou MA, Lécuyer M. Nonsurgical resolution of gallbladder mucocele in two dogs. J Am Vet Med Assoc. 2008;232:1688. 10.2460/javma.232.11.1688
- Serebriakova OV, Govorin AV, Prosianik VI, Baksheeva EV. [Fatty acid composition of the blood serum and erythrocyte membrane lipids in patients with hypothyroidism and left ventricular diastolic dysfunction]. Klin Med (Mosk). 2008;86:40.
- Makino M, Oda N, Miura N, Imamura S, Yamamoto K, et al. Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. J Endocrinol. 2001;171:259.
- Pehowich DJ. Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak. Biochim Biophys Acta. 1999;1411:192.
- Pehowich DJ. Hypothyroid state and membrane fatty acid composition influence cardiac mitochondrial pyruvate oxidation. Biochim Biophys Acta. 1995;1235:231.
- Awumey EM, Paton DM, Pehowich DJ. Thyroid status and dietary fatty acids affect beta-adrenoceptor agonist stimulation of tension development in rat myocardium. J Auton Pharmacol. 1995;15:73.
- Awumey EM, Pehowich DJ. N-3 and N-6 fatty acids modulate the inotropic response to calcium in hypothyroid rat papillary muscle. J Cardiovasc Pharmacol. 1995;25:473.
- Simonides WS, van Hardeveld C. Effects of hypothyroidism on the distribution and fatty acyl composition of phospholipids in sarcoplasmic reticulum of fast skeletal muscle of the rat. Biochim Biophys Acta. 1987;924:204.
