Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Calcium-Magnesium Inositol Hexaphosphate)
100 mg
8%
Inositol Hexaphosphate (from Calcium-Magnesium Inositol Hexaphosphate)
500 mg
†
The product is found useful for the following medical conditions
Lung Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 10 Reviews
8.9
9
Inositol’s role in lung cancer
The sodium/myo-inositol co-transporter SLC5A3 promotes non-small cell lung cancer cell growth.
Most Relevant Research
We explored the role of the sodium/myo-inositol co-transporter SLC5A3 in non-small cell lung cancer (NSCLC). Our research aimed to uncover how inositol impacts cancer cell growth and survival.
Through our analysis, we discovered that SLC5A3 levels were significantly higher in NSCLC tissues than in normal lung tissues. When we reduced SLC5A3 using specific techniques, we observed a notable decrease in cell growth, migration, and an increase in cell death. This suggests that SLC5A3 plays a pivotal role in maintaining cancer cell viability.
Furthermore, we found that adding myo-inositol or activating a related protein pathway helped reverse the effects seen with SLC5A3 depletion. In animal models, we noted that directly targeting SLC5A3 reduced tumor growth significantly, reinforcing the idea that it is a critical factor in NSCLC progression.
Overall, our findings highlight that SLC5A3 promotes cancer cell growth potentially by enhancing myo-inositol levels and activating specific signaling pathways. This offers new insights into potential treatment strategies targeting SLC5A3 for lung cancer patients.
Through our analysis, we discovered that SLC5A3 levels were significantly higher in NSCLC tissues than in normal lung tissues. When we reduced SLC5A3 using specific techniques, we observed a notable decrease in cell growth, migration, and an increase in cell death. This suggests that SLC5A3 plays a pivotal role in maintaining cancer cell viability.
Furthermore, we found that adding myo-inositol or activating a related protein pathway helped reverse the effects seen with SLC5A3 depletion. In animal models, we noted that directly targeting SLC5A3 reduced tumor growth significantly, reinforcing the idea that it is a critical factor in NSCLC progression.
Overall, our findings highlight that SLC5A3 promotes cancer cell growth potentially by enhancing myo-inositol levels and activating specific signaling pathways. This offers new insights into potential treatment strategies targeting SLC5A3 for lung cancer patients.
10
Optimal anti-cancer use
Most Useful Review
Number 1 anti-cancer supplement! Just make sure to take it with distilled or reverse osmosis water and at least 3 hours away from any food. It’s easiest to take first thing in the morning and then wait to eat for three hours.
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 28 Reviews
8.8
9
Myo-inositol affects prostate cancer cells
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line.
Most Relevant Research
We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
9.5
Significant cancer support
Most Useful Review
IP6 is an incredible supplement, significantly reducing the formation of harmful AGEs that damage our organs and contribute to diabetes complications. Its ability to lower these substances by a remarkable 40% is impressive. I recommend taking it before meals for optimal effects. IP6 is also a powerful anti-cancer agent. For those with diabetes and insulin resistance, I've found it synergistic with other supplements and providing substantial overall protection and energy boost.
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
USERS' SCORE
Good
Based on 10 Reviews
8.8
8
Inositol enhances rapeseed cold tolerance
Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.).
Most Relevant Research
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
9.5
Keeps shingles away
Most Useful Review
I take this daily to keep cold sores and shingles at bay!
Blood Clot details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 13 Reviews
8.7
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Most Relevant Research
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
10
Normalised iron levels
Most Useful Review
This supplement effectively reduces excess iron from the liver, particularly in men. I've been using it for a month, and my iron levels have returned to normal. It's crucial to follow the label instructions and not to take it for more than 4 to 6 weeks. I find it quite effective.
High Cholesterol details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 14 Reviews
8.7
9
IP6 improves cholesterol levels
Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane.
Most Relevant Research
We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.
Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
10
Significant ferritin reduction
Most Useful Review
This product helped me effectively reduce my ferritin levels, and my body’s inflammation vastly improved without affecting my sleep. Previously, I was troubled for two weeks by high ferritin levels that led to unrestful nights, even landing me in the emergency room. This product helps me absorb iron effectively, preventing bad retention that causes inflammation.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Improved sleep quality
Most Useful Review
Great product! I originally purchased this hoping to reduce the iron in my blood at 67, but to my surprise, it’s also excellent for my lifelong sleep issues! I’ve always struggled to fall asleep, but now I do so much faster. I take it at night, and rather than struggling to return to sleep after getting up to urinate, I no longer have a problem and am finally getting the sleep I require!
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.7
8
Myo-inositol aids gestational diabetes
Influence of myo-inositol on metabolic status for gestational diabetes: a meta-analysis of randomized controlled trials.
Most Relevant Research
We aimed to evaluate how myo-inositol supplementation affects women with gestational diabetes through a meta-analysis of randomized controlled trials. Our search included multiple databases, leading to the analysis of four studies involving 317 participants. The results showed that myo-inositol significantly reduced the need for insulin and improved insulin sensitivity. However, it did not influence birth weight, cesarean delivery rates, or NICU admissions. These findings suggest myo-inositol could be a helpful addition to managing gestational diabetes, but further research is needed.
9.8
Life-changing product
Most Useful Review
This product is almost a miracle for diabetes. I saw my fasting blood sugar levels drop dramatically, from 250 to 100, and I suspect that the FDA may soon take notice. This product truly works!
Anxiety details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
USERS' SCORE
Good
Based on 4 Reviews
8.6
8
Inositol reduces anxiety in hens
Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.
Most Relevant Research
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
9.5
Reduced anxiety significantly
Most Useful Review
Very excellent. It helped me greatly reduce obsessive-compulsive disorder, fear, and anxiety. It also assisted my wife in alleviating heavy menstrual cycles. Excellent results are observed when adhering to a healthy diet free from sugars, starches, and refined fats.
Brain Tumor details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.6
7
INPP5E's impact on medulloblastoma
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Most Relevant Research
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
8.8
Speedy delivery service
Most Useful Review
I ordered Jarrow Formulas IP6, and the immediate delivery impressed me. The capsules help chelate and remove the iron accumulation in my brain due to CCSVI, and I believe they are making a difference. I'm extremely happy with both the effectiveness and the swift service provided.
Cold Sores details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Prevents cold sores
Most Useful Review
They are large but effective for cold sores and canker sores! I find them easy to swallow despite their size. I take two, three times a day when dealing with an active cold sore, continuing this until the day after, and I've noticed my cold sore never fully formed, although I felt it trying to break through daily. I really appreciate these lozenges and intend to keep a bottle on hand at all times!
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.6
9.5
Short-lived colds
Most Useful Review
Bulletproof! I have taken IP6 for several years, and during this time, when exposed to various colds, they have either avoided me or their impact has been minimal and not severe. This has helped maintain a high level of immunity. Highly recommend!
Heart Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Inositol boosts heart protective adiponectin
Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
Most Relevant Research
Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
9.5
Improved cat health
Most Useful Review
I have two 13-year-old cats who recently required surgery and hospitalisation for bladder stones and kidney failure. I was surprised by this sudden event and stumbled upon inositol while seeking information. Although I was sceptical about its supposed miraculous effects, I purchased it out of hope, mixing it into their food. Remarkably, the operated cat has since regained her appetite, now enjoying life instead of hiding away. A vet confirmed that she no longer shows signs of severe renal failure, which astonished them. Following hospitalisation, successive blood tests revealed normal levels, and I look forward to our next appointment. Initially bought for my cat, I plan to use it myself and will recommend it for anyone over 40 to aid in preventing health issues.
Kidney Stones details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Inositol shows promise for nephropathies
Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies.
Most Relevant Research
We explored the potential of inositol hexakisphosphate (IP6) and its analogues as a treatment for calcium oxalate (CaOx) nephropathies, conditions often linked to kidney stones. Our study utilized a new machine learning approach that helped screen various chemical modifications of IP6 to find a particularly effective compound.
This innovative method led us to identify a divalent inositol phosphate that demonstrated remarkable activity. In our findings, this molecule completely inhibited the crystallization of CaOx crystals at very low concentrations. Additionally, it significantly reduced the interaction between crystals and kidney cells, preventing harmful changes in gene expression related to kidney damage.
We observed that, in a mouse model experiencing increased levels of oxalate, the IP6 analogue reduced crystal formation and subsequent kidney injury. With these promising results, we believe that these inositol analogues may offer a new therapeutic option for those suffering from calcium oxalate-related kidney issues.
This innovative method led us to identify a divalent inositol phosphate that demonstrated remarkable activity. In our findings, this molecule completely inhibited the crystallization of CaOx crystals at very low concentrations. Additionally, it significantly reduced the interaction between crystals and kidney cells, preventing harmful changes in gene expression related to kidney damage.
We observed that, in a mouse model experiencing increased levels of oxalate, the IP6 analogue reduced crystal formation and subsequent kidney injury. With these promising results, we believe that these inositol analogues may offer a new therapeutic option for those suffering from calcium oxalate-related kidney issues.
9.5
Reversed kidney failure
Most Useful Review
I was taken aback when my two cats suddenly required surgery for bladder stones and kidney failure. In my search for remedies, I discovered inositol. Though initially sceptical, I decided to sprinkle it over their food. Remarkably, the operated cat has regained her appetite and is behaving normally again. The vet was surprised by her recovery from renal failure, stating it was the first such occurrence for them. Regular blood tests have shown normal results, so now, I'll consider using it for myself and family too. It's definitely something I'd recommend for those over 40 years old.
Prostate Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
IP6 potentially prevents prostate cancer
Stage-Specific Effect of Inositol Hexaphosphate on Cancer Stem Cell Pool during Growth and Progression of Prostate Tumorigenesis in TRAMP Model.
Most Relevant Research
We evaluated how inositol hexaphosphate (IP6), a natural compound found in various foods, influences the growth and development of prostate cancer in a special group of mice known as TRAMP. The study involved feeding these male mice either regular water or water containing 2% IP6 at different stages of their growth – starting at 4, 12, 20, and 30 weeks of age – for a period of about 8 to 15 weeks.
Pathological evaluations at the end of the study revealed some encouraging results. The IP6 treatment seemed to halt tumor progression earlier on, and it significantly reduced the incidence of more severe forms of the disease by around 55% to 70%. This finding suggests that IP6 could have a crucial role in preventing prostate cancer from advancing in severity.
Furthermore, we explored the effects of IP6 on cancer stem cells (CSCs), a small group of cells within tumors that can drive cancer growth. The results indicated that IP6 might help in reducing these CSCs in prostate tumors. In laboratory tests, we also found that IP6 treatment dramatically decreased the number of floating prostate cancer stem cell clusters by approximately 90%.
Overall, these findings suggest that IP6 holds significant promise as a preventive measure against prostate cancer, particularly at earlier stages of the disease.
Pathological evaluations at the end of the study revealed some encouraging results. The IP6 treatment seemed to halt tumor progression earlier on, and it significantly reduced the incidence of more severe forms of the disease by around 55% to 70%. This finding suggests that IP6 could have a crucial role in preventing prostate cancer from advancing in severity.
Furthermore, we explored the effects of IP6 on cancer stem cells (CSCs), a small group of cells within tumors that can drive cancer growth. The results indicated that IP6 might help in reducing these CSCs in prostate tumors. In laboratory tests, we also found that IP6 treatment dramatically decreased the number of floating prostate cancer stem cell clusters by approximately 90%.
Overall, these findings suggest that IP6 holds significant promise as a preventive measure against prostate cancer, particularly at earlier stages of the disease.
9.5
Cancer management support
Most Useful Review
I have been taking IP6 for four years after my cancer operation. My initial outlook was grim, but following a friend's recommendation, I continued taking them. I’m still cancer-free, so I’ll keep using them as a precaution.
Autoimmune Disorder details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.6
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Myo-inositol enhances vitamin D effects
The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study.
Most Relevant Research
Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
8.8
Improved sugar levels
Most Useful Review
This company has the best quality. I bought it for my mother to tackle insulin resistance and reduce sugar levels and high inflammatory ferritin. Our attending physician prescribed this specific drug in combination, stating that it binds and removes iron. Assigned to take it for 6 months, 1 capsule 3 times a day, for best results. Mom has been taking it for 3 months, and her sugar level has decreased from 7 to 5. She doesn’t complain about the taste and, as the doctor advised, follows the diet. A useful product yielding great results. We are still taking it and have ordered a second bottle.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9.5
Effective pain relief
Most Useful Review
IP-6 is fantastic! It aids me in overcoming various health issues I regularly face. It completely alleviates the pain!
Cardiovascular Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 7 Reviews
8.5
9
Inositol protects against cardiac damage
Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.
Most Relevant Research
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
8.3
Remarkable results obtained
Most Useful Review
I took this to chelate excess iron from my liver, and I was astonished to find that it alleviated my palmar erythema almost immediately. Research reveals that low-dose IP6 (500-1000mg daily) reduces inflammatory TNF-a cytokines linked to liver disease and leaky gut. I am overjoyed daily to have discovered IP6, and I always take it on an empty stomach with a full glass of water.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.3
Restored menstrual cycle
Most Useful Review
This product has been beneficial for my polycystic ovary syndrome and I continue to purchase it regularly. Before starting it, I experienced amenorrhea, but my menstrual cycle has now returned and ovulation seems to have resumed. Additionally, IP6 is known to help prevent cancer, so I ensure to buy it alongside this supplement. It is advisable to take it on an empty stomach. Inositol truly appears to be effective for my PCOS. I hope this review assists others.
Constipation details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
BZYQD enhances motility and reduces inflammation
Buzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats.
Most Relevant Research
We aimed to understand the effects of Buzhongyiqi decoction (BZYQD) on constipation, particularly how it influences various metabolic pathways. In our exploration, we conducted experiments on rats experiencing loperamide-induced constipation. Following treatment with BZYQD, we observed a notable increase in the small intestinal transit rate, suggesting improved digestive movement.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
10
Cured constipation entirely
Most Useful Review
Excellent! After six days of taking this, my stomach feels better, and I am no longer constipated. My IBS-M seems stable now, and I will soon check my high ferritin levels. I’ll return to review more of this fantastic IP6. Highly recommended!
Knee Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
7.5
Joint pain relief
Most Useful Review
I purchased this to avoid the hassle of juicing cabbage as part of my programme to reduce excessive iron in my body. Taking pills or capsules is undoubtedly more convenient. I can now feel considerable improvement in my joint and shoulder pain, thanks to this IP6 supplement. I also recommend considering activated rice bran, which I herb sells as well, although it was out of stock when I ordered Jarrow's IP6. I'll definitely consider adding activated rice bran to my shopping cart next time.
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
Myo-inositol improves insulin resistance
The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD.
Most Relevant Research
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
8.8
Ferritin levels decreased
Most Useful Review
I purchased it for my mother, who suffers from high ferritin levels due to liver issues. Fortunately, after starting this supplement, her ferritin levels decreased from 102 to 80. My husband is also looking to try it, as his analysis revealed dangerously high ferritin at 275.
Shingles details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
8.8
Preventive supplement
Most Useful Review
I take this daily to keep cold sores and shingles at bay!
