We explored the effects of Lactiplantibacillus plantarum Lb41 on nonalcoholic fatty liver disease (NAFLD) in mice fed a high-fat diet. After treatment with Lb41, we observed significant reductions in body weight and harmful serum lipids, indicating its potential benefits.
Additionally, Lb41 appeared to alleviate liver damage and improve metabolic markers, suggesting a protective effect against fatty liver disease. While results are promising, further research is necessary to fully understand the implications for human health.
Read More
9
MP108 benefits jaundice treatment
Oral administration of Lactobacillus rhamnosus MP108 ameliorates hemolytic jaundice in rats.
We examined how Lactobacillus rhamnosus MP108 affects hemolytic jaundice in rats. After one week of dietary MP108, we noted important improvements in body weight and liver function, indicated by normalized levels of various enzymes and bilirubin. Tissues from the liver and intestines showed healing effects, and our analysis revealed changes in gut bacteria that correlated with these health improvements. Overall, this study highlights the potential of MP108 to alleviate jaundice symptoms by supporting liver health through microbiome alterations.
Read More
8
Lactobacillus vesicles aid liver health
extracellular vesicles alleviate alcohol-induced liver injury in mice by regulating gut microbiota and activating the Nrf-2 signaling pathway.
We examined the effects of lactobacillus-derived extracellular vesicles (LAB-EVs) on liver health, especially in relation to alcohol-induced damage. Through a systematic study involving three different LAB-EVs, we observed significant reductions in liver injury, including improvements in liver function and inflammation.
Notably, these LAB-EVs also enhanced intestinal flora diversity and activated key liver proteins like Nrf-2. This suggests that LAB-EVs play a protective role, potentially making fermented foods an accessible way to support liver health.
Read More
Most Useful Reviews
0
Immediate relief
24 people found this helpful
I had high hopes for this drug due to the positive reviews I read. However, I began experiencing constant bloating and stabbing pain in my liver after a week. Initially, I thought it was a coincidence, but the discomfort persisted daily. I decided to stop taking the probiotics, and I immediately felt relief; the swelling and pain disappeared the very next day. It seems I have some idiosyncrasy, as prior to these probiotics, I had no such issues.
Read More
9
Normalised bowel function
8 people found this helpful
Six months post-appendectomy, I faced issues with bowel movements, but these probiotics have changed my life. After starting them, I found relief by the second week, and now my toilet visits are comfortable rather than distressing. My bowel function has normalised, and I’ve had no relapses since. I highly recommend them to others experiencing similar issues; they truly work wonders for me.
Read More
9
Effective treatment
1 people found this helpful
At last, a friend recommended Jarro to me. Initially, I was hesitant due to previous failures with similar products. However, after three to four weeks, the results were remarkable. I had endured stomach issues for years, but now I finally have a product that provides relief. I do not go without it anymore. Thank you to my friend and a massive thanks to Jarro.
We explored the effects of Lactiplantibacillus plantarum Lb41 on nonalcoholic fatty liver disease (NAFLD) in mice fed a high-fat diet. After treatment with Lb41, we observed significant reductions in body weight and harmful serum lipids, indicating its potential benefits.
Additionally, Lb41 appeared to alleviate liver damage and improve metabolic markers, suggesting a protective effect against fatty liver disease. While results are promising, further research is necessary to fully understand the implications for human health.
Read More
9
MP108 benefits jaundice treatment
Oral administration of Lactobacillus rhamnosus MP108 ameliorates hemolytic jaundice in rats.
We examined how Lactobacillus rhamnosus MP108 affects hemolytic jaundice in rats. After one week of dietary MP108, we noted important improvements in body weight and liver function, indicated by normalized levels of various enzymes and bilirubin. Tissues from the liver and intestines showed healing effects, and our analysis revealed changes in gut bacteria that correlated with these health improvements. Overall, this study highlights the potential of MP108 to alleviate jaundice symptoms by supporting liver health through microbiome alterations.
Read More
8
Lactobacillus effects on liver health
166, Derived from Yak Yogurt from Tibetan Areas of Sichuan, Improves High-Fat-Diet-Induced Hyperlipidemia by Modulating Gut Microbiota and Liver- and Gut-Related Pathways.
We assessed the impact of LF-166, a probiotic from yak yogurt, on liver health in mice fed a high-fat diet. Our findings showed that LF-166 not only reduced body weight and blood lipid levels but also alleviated liver steatosis and improved gut health. Furthermore, we noticed changes in gut microbiota composition, revealing an enhanced diversity. However, while LF-166 shows promise in managing hyperlipidemia, further studies are needed to firmly establish its effectiveness and applicability in humans.
Read More
8
JCF enhances liver disease treatment
JiGuCao capsule formula alleviates metabolic fatty liver disease by regulating the gut-liver axis and lipid metabolism.
We investigated how JiGuCao Capsule formula (JCF) can help treat metabolic-associated fatty liver disease (MAFLD). Using a mouse model, we observed that JCF positively influences liver health by enhancing intestinal function and adjusting gut bacteria. The mice that received JCF showed reduced liver fat and improved metabolism compared to those without treatment. While our findings are promising, more clinical studies on humans are essential to confirm JCF's effectiveness in managing MAFLD.
Read More
8
Probiotics provide potential NASH treatment
In Vitro, In Vivo, and In Silico Investigation of Synbiotic-Mediated Activation of PPAR- Curtails Nonalcoholic Steatohepatitis (NASH) in Wistar Rats by Inhibiting PNPLA3/SREBP1-c Lead Inflammatory Injury of Hepatic Cells.
We investigated the potential of a probiotic and aged garlic extract combination to treat nonalcoholic steatohepatitis (NASH), a serious liver condition. Using a rat model, our study employed both laboratory and animal tests to look at inflammation levels and various biochemical markers in liver tissues.
The results showed that this synbiotic therapy reduced liver inflammation by impacting key proteins related to fatty liver disease. However, while there was a reduction in some inflammatory signals, the overall benefits for treating NASH are still unclear.
I had high hopes for this drug due to the positive reviews I read. However, I began experiencing constant bloating and stabbing pain in my liver after a week. Initially, I thought it was a coincidence, but the discomfort persisted daily. I decided to stop taking the probiotics, and I immediately felt relief; the swelling and pain disappeared the very next day. It seems I have some idiosyncrasy, as prior to these probiotics, I had no such issues.
Read More
9
Normalised bowel function
8 people found this helpful
Six months post-appendectomy, I faced issues with bowel movements, but these probiotics have changed my life. After starting them, I found relief by the second week, and now my toilet visits are comfortable rather than distressing. My bowel function has normalised, and I’ve had no relapses since. I highly recommend them to others experiencing similar issues; they truly work wonders for me.
Read More
9
Effective treatment
1 people found this helpful
At last, a friend recommended Jarro to me. Initially, I was hesitant due to previous failures with similar products. However, after three to four weeks, the results were remarkable. I had endured stomach issues for years, but now I finally have a product that provides relief. I do not go without it anymore. Thank you to my friend and a massive thanks to Jarro.
Read More
9
Noteworthy relief
I felt completely bewildered but had a surprising experience. Yesterday, I faced severe constipation during my pregnancy and ate something, leading to an unexpected result. This morning, I was finally able to use the bathroom! It’s incredible how this product assists with my constipation, allowing me a sense of comfort I had been missing.
Read More
7.5
Preventive measures
10 people found this helpful
I've dealt with diverticulitis for years and have suffered significant pain. To help prevent flare-ups, I take this probiotic as part of my health regimen. It's become vital in managing my intestinal environment and constipation, supporting my overall gut health. While not all individuals might experience the same results, it has helped me to maintain control over my condition effectively.
Liver disease encompasses a variety of conditions that affect the liver's ability to function effectively. The liver is a vital organ responsible for many important tasks, including metabolizing nutrients, detoxifying harmful substances, and producing bile for digestion. Common forms of liver disease include hepatitis, fatty liver disease, cirrhosis, and liver cancer. Each of these conditions can significantly impact liver function and overall health, leading to symptoms that range from fatigue and jaundice to more serious complications requiring urgent medical attention.
The causes of liver disease are diverse and can include chronic alcohol abuse, viral infections, autoimmune disorders, and metabolic conditions like obesity and diabetes. Early detection is key to managing liver disease effectively, often involving lifestyle changes, medications, and sometimes surgical interventions. Regular check-ups and liver function tests are recommended for individuals at higher risk, such as those with a family history of liver disease or those who lead certain lifestyle habits. Adopting a balanced diet and reducing alcohol intake can greatly aid in liver health and help prevent the onset of these conditions.
Lactobacillus is a genus of bacteria that plays a crucial role in the fermentation of various foods and is found naturally in the human gut. Known for their probiotic properties, strains of Lactobacillus are commonly utilized in the production of yogurt, sauerkraut, and other fermented products. They are characterized by their rod-shaped structure and ability to convert sugars into lactic acid, which not only helps preserve food but also contributes to the tangy flavor of fermented foods.
In addition to their culinary uses, Lactobacillus bacteria can offer several health benefits. They are known to support gut health by enhancing the balance of beneficial bacteria in the microbiome, potentially aiding in digestion and alleviating symptoms of issues like irritable bowel syndrome (IBS). Regular consumption of Lactobacillus-containing foods or supplements may also bolster the immune system and improve overall digestive health. With a growing interest in gut health, Lactobacillus remains a key player in both dietary and therapeutic contexts.
Lactobacillus, a type of beneficial bacteria commonly found in fermented foods and probiotics, has garnered interest for its potential role in liver health. Some studies suggest that certain strains of Lactobacillus may help improve liver function and reduce liver inflammation, particularly in patients with conditions like non-alcoholic fatty liver disease (NAFLD). This effect is thought to occur through the modulation of gut microbiota and inflammation, which can indirectly support liver health. However, the research is ongoing, and while preliminary data is promising, definitive conclusions about the efficacy and specific mechanisms are still under investigation.
It’s important to note that while incorporating Lactobacillus through dietary means or supplements may be beneficial as part of an overall health strategy, it should not be viewed as a standalone treatment for liver disease. If you or someone you know is dealing with liver concerns, consulting a healthcare provider is crucial to understand the best approach tailored to individual health needs.
Based on user reviews, the time it typically takes to see results from probiotics can vary significantly. Many users report noticeable improvements within two to four weeks of consistent use. For instance, one reviewer highlighted that after three to four weeks of taking the supplement, they experienced remarkable results, significantly alleviating long-standing stomach issues Read Review. Another user mentioned finding relief by the second week, indicating that if the product suits your system, benefits might appear relatively quickly Read Review.
However, it's also crucial to consider that individual experiences can vary widely. Some users expressed no immediate relief and noted a slight easing of symptoms after nearly a month of use Read Review. Additionally, while certain users felt improvements right from the first use, the overall consensus suggests that one may need to maintain patience, as the timing for results can depend on personal health conditions and the specific probiotic formula Read Review. In conclusion, while many have experienced positive changes within weeks, some may take longer to notice any substantial benefits.
The research surrounding various supplements and their effects on liver disease presents a mixed bag of promising findings, primarily from animal studies. For instance, Lactiplantibacillus plantarum Lb41 has shown potential in combating nonalcoholic fatty liver disease (NAFLD) by improving metabolic markers and reducing liver damage in mice exposed to high-fat diets [1]. Similarly, another study demonstrated that a probiotic from yak yogurt, LF-166, not only improved liver health but also positively affected gut microbiota composition [2]. These findings suggest that certain probiotics may indeed contribute beneficially to liver health, particularly under conditions of dietary stress.
However, it is crucial to note that the research predominantly focuses on animal models, and there's a clear need for clinical studies involving human subjects to definitively establish the efficacy of these supplements. For instance, while JiGuCao Capsules showed improved liver health in a mouse model of metabolic-associated fatty liver disease (MAFLD) [3], further validation in humans is essential to ascertain their therapeutic potential. Overall, while there is promising evidence pointing to the benefits of certain probiotics and dietary supplements in managing liver disease, the lack of extensive human trials indicates a cautious approach is warranted.
Based on user reviews, many individuals have reported notable improvements in their digestive health after using probiotics. For instance, one user shared that after struggling with bowel issues post-surgery, they experienced significant relief within just two weeks of starting the probiotics, transforming their discomforting toilet visits into a more pleasant experience Read Review. Another reviewer highlighted a remarkable turnaround, stating that after three to four weeks of consistent use, long-standing stomach issues were alleviated, and they found a product that works for them after years of searching Read Review.
Users facing chronic conditions, such as diverticulitis and Crohn's disease, also reported positive changes, with one user feeling their intestinal environment was significantly better controlled, which contributed to a reduction in painful flare-ups Read Review. Another reviewer noted experiencing an immediate easing effect after taking the product, which reinforces the idea that effective results can vary widely among individuals Read Review. While many users found considerable benefits from probiotics, others mentioned mixed results, with some reporting only slight improvements over time Read Review. As such, it's important to remember that individual experiences may differ.
Users have reported a mixed experience when combining this supplement with other treatments for liver disease and related conditions. Some individuals, like one reviewer, experienced discomfort, specifically constant bloating and stabbing pain in the liver after starting the probiotic. Upon ceasing the supplement, they noted an immediate relief from these symptoms, suggesting that it may not be suitable for everyone when used in conjunction with their existing health conditions Read Review.
Conversely, others have found the probiotic beneficial alongside their health regimens. For instance, users managing chronic conditions such as diverticulitis and Crohn's disease reported significant improvements in their symptoms, indicating that the probiotic could effectively complement their treatment plans Read ReviewRead Review. This underscores the importance of individual response to probiotics, suggesting that while they may be a helpful addition for some, others might experience adverse effects. As always, it's advisable to consult a healthcare provider before combining supplements, especially when managing specific health conditions.
9
Effective treatment
1 people found this helpful
At last, a friend recommended Jarro to me. Initially, I was hesitant due to previous failures with similar products. However, after three to four weeks, the results were remarkable. I had endured stomach issues for years, but now I finally have a product that provides relief. I do not go without it anymore. Thank you to my friend and a massive thanks to Jarro.
9
Normalised bowel function
8 people found this helpful
Six months post-appendectomy, I faced issues with bowel movements, but these probiotics have changed my life. After starting them, I found relief by the second week, and now my toilet visits are comfortable rather than distressing. My bowel function has normalised, and I’ve had no relapses since. I highly recommend them to others experiencing similar issues; they truly work wonders for me.
6
Gentle effect
I believe this product is somewhat effective. I purchased it because I do not usually consume well-known products, and after nearly a month, I do feel a slight easing of my symptoms, which is a positive change.
7.5
Effective probiotic benefits
43 people found this helpful
This probiotic has proven to be remarkably effective right from the first use. I was hesitant due to the cost, but it has improved my digestive health significantly. The strength and type of beneficial bacteria it contains have led to better immunity, enhanced skin condition, and an uplift in my mood overall. I'm truly delighted to have discovered and incorporated this into my routine.
7.5
Preventive measures
10 people found this helpful
I've dealt with diverticulitis for years and have suffered significant pain. To help prevent flare-ups, I take this probiotic as part of my health regimen. It's become vital in managing my intestinal environment and constipation, supporting my overall gut health. While not all individuals might experience the same results, it has helped me to maintain control over my condition effectively.
9
Quick effects
1 people found this helpful
The product acts immediately! I can feel a notable easing effect shortly after taking it, which has been very beneficial.
0
Immediate relief
24 people found this helpful
I had high hopes for this drug due to the positive reviews I read. However, I began experiencing constant bloating and stabbing pain in my liver after a week. Initially, I thought it was a coincidence, but the discomfort persisted daily. I decided to stop taking the probiotics, and I immediately felt relief; the swelling and pain disappeared the very next day. It seems I have some idiosyncrasy, as prior to these probiotics, I had no such issues.
6
Improve Crohn's disease
2 people found this helpful
I find this probiotic helpful for managing my Crohn's disease. It complements my overall treatment well. I've noticed significant improvements in my condition, encouraging me to continue using it consistently.
9
Lb41 may protect liver health
Probiotic Lactiplantibacillus plantarum Lb41 alleviates high-fat diet-induced nonalcoholic fatty liver disease in mice.
We explored the effects of Lactiplantibacillus plantarum Lb41 on nonalcoholic fatty liver disease (NAFLD) in mice fed a high-fat diet. After treatment with Lb41, we observed significant reductions in body weight and harmful serum lipids, indicating its potential benefits.
Additionally, Lb41 appeared to alleviate liver damage and improve metabolic markers, suggesting a protective effect against fatty liver disease. While results are promising, further research is necessary to fully understand the implications for human health.
8
Lactobacillus effects on liver health
166, Derived from Yak Yogurt from Tibetan Areas of Sichuan, Improves High-Fat-Diet-Induced Hyperlipidemia by Modulating Gut Microbiota and Liver- and Gut-Related Pathways.
We assessed the impact of LF-166, a probiotic from yak yogurt, on liver health in mice fed a high-fat diet. Our findings showed that LF-166 not only reduced body weight and blood lipid levels but also alleviated liver steatosis and improved gut health. Furthermore, we noticed changes in gut microbiota composition, revealing an enhanced diversity. However, while LF-166 shows promise in managing hyperlipidemia, further studies are needed to firmly establish its effectiveness and applicability in humans.
8
JCF enhances liver disease treatment
JiGuCao capsule formula alleviates metabolic fatty liver disease by regulating the gut-liver axis and lipid metabolism.
We investigated how JiGuCao Capsule formula (JCF) can help treat metabolic-associated fatty liver disease (MAFLD). Using a mouse model, we observed that JCF positively influences liver health by enhancing intestinal function and adjusting gut bacteria. The mice that received JCF showed reduced liver fat and improved metabolism compared to those without treatment. While our findings are promising, more clinical studies on humans are essential to confirm JCF's effectiveness in managing MAFLD.
References
Lee NK, Lee Y, Shin DS, Park E, Paik HD. Probiotic Lactiplantibacillus plantarum Lb41 alleviates high-fat diet-induced nonalcoholic fatty liver disease in mice. Nutrition. 2025;134:112735. doi:10.1016/j.nut.2025.112735
Zhang S, Xu L, Zhu C, Li J, Fu Y, et al. 166, Derived from Yak Yogurt from Tibetan Areas of Sichuan, Improves High-Fat-Diet-Induced Hyperlipidemia by Modulating Gut Microbiota and Liver- and Gut-Related Pathways. Foods. 2025;14. doi:10.3390/foods14050867
Qi W, Cao X, Chen Y, Chen H, Zhang N, et al. JiGuCao capsule formula alleviates metabolic fatty liver disease by regulating the gut-liver axis and lipid metabolism. Phytomedicine. 2025;140:156559. doi:10.1016/j.phymed.2025.156559
Sharma D, Patel D, Mandal P. In Vitro, In Vivo, and In Silico Investigation of Synbiotic-Mediated Activation of PPAR- Curtails Nonalcoholic Steatohepatitis (NASH) in Wistar Rats by Inhibiting PNPLA3/SREBP1-c Lead Inflammatory Injury of Hepatic Cells. Mediators Inflamm. 2025;2025:9948679. doi:10.1155/mi/9948679
Liu C, Wang Y, Sheng L, Zhang Y, Luo G, et al. 3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury. Phytomedicine. 2025;139:156445. doi:10.1016/j.phymed.2025.156445
Wu G, Ai Q, Shi Y. Oral administration of Lactobacillus rhamnosus MP108 ameliorates hemolytic jaundice in rats. J Food Sci. 2025;90:e17671. doi:10.1111/1750-3841.17671
Lv Y, Chu J, Zhang X, Li X, Yin A. Synbiotics effects of d-tagatose and Lactobacillus rhamnosus GG on the inflammation and oxidative stress reaction of Gallus gallus based on the genus of cecal bacteria and their metabolites. PLoS One. 2025;20:e0317825. doi:10.1371/journal.pone.0317825
Jiao Q, Liu J, Zhou L, McClements DJ, Liu W, et al. extracellular vesicles alleviate alcohol-induced liver injury in mice by regulating gut microbiota and activating the Nrf-2 signaling pathway. Food Funct. 2025;16:1284. doi:10.1039/d4fo04364b
Zhu Y, Pan Y, Wang X, Wei L, Zhu L, et al. GG Combined with Metformin Alleviates Alcohol-Induced Liver Inflammation in Mice by Maintaining the Intestinal Barrier and Regulating Treg/Th1 Cells. J Med Food. 2025. doi:10.1089/jmf.2024.k.0184
Jang H, Joung H, Chu J, Cho M, Kim YW, et al. subsp. CKDB001 Ameliorates Metabolic Complications in High-Fat Diet-Induced Obese Mice. Nutrients. 2024;16. doi:10.3390/nu16244260
Kurakawa T, Kani K, Chudan S, Nishikawa M, Tabuchi Y, et al. Rice Kefiran Ameliorates Obesity and Hepatic Steatosis Through the Change in Gut Microbiota. Microorganisms. 2024;12. doi:10.3390/microorganisms12122495
Hewady S, Manuel CR, Pasquali C, Koya J, Reznik SE. OM-85 attenuates high-fat diet-induced obesity, insulin resistance, gut dysbiosis and nonalcoholic steatohepatitis in a murine model. Biomed Pharmacother. 2024;181:117710. doi:10.1016/j.biopha.2024.117710