Medical Researches
Possibly Effective
Based on 9 Researches
Probiotic may stabilize estrogen levelsSupplementation with a Probiotic Formula Having β-Glucuronidase Activity Modulates Serum Estrogen Levels in Healthy Peri- and Postmenopausal Women.
High relevance for menopausal research
We examined whether a probiotic containing the strain KABP052 could help stabilize estrogen levels in peri- and postmenopausal women. In a thorough randomized, double-blind study, we compared women taking the probiotic to those given a placebo.
Over 12 weeks, those who received KABP052 showed notably higher estradiol and estrone levels, suggesting that this probiotic can effectively modulate estrogen during menopause. This promising finding opens new avenues for using probiotics to support menopausal health.
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Probiotics improve vaginal well-beingEfficacy of PBS067, subsp. BL050, and LRH020 in the Amelioration of Vaginal Microbiota in Post-Menopausal Women: A Prospective Observational Clinical Trial.
Study shows significant positive outcomes
This clinical trial investigated how probiotics could improve vaginal health in post-menopausal women.
We enrolled 50 healthy participants, aged 45 to 65, who took a specific probiotic supplement for 28 days.
Our results showed a remarkable 50% increase in the Vaginal Health Index and significant declines in inflammatory markers.
Notably, probiotics helped boost lactobacilli levels, indicating a positive shift in vaginal microbiota during the menopausal transition.
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Probiotics improve vaginal floraRandomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of postmenopausal women.
Highly relevant therapeutic insight.
We investigated how orally administered probiotics, particularly Lactobacillus rhamnosus, can impact the vaginal flora of postmenopausal women. In a randomized, double-blind study, participants received either probiotic capsules or a placebo for 14 days.
Our findings revealed that 60% of the women taking the probiotics experienced a significant improvement in their vaginal flora, compared to just 16% in the placebo group. This suggests that Lactobacillus rhamnosus may effectively support vaginal health during menopause.
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Probiotics may enhance BV treatmentNucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic lactobacilli.
Moderately relevant findings for management
We investigated how Lactobacillus rhamnosus could help manage bacterial vaginosis (BV) in postmenopausal women. In our study, 55 vaginal samples from 11 women revealed a common bacterial imbalance linked to BV. Notably, when we conducted a two-month randomized trial, the women who took Lactobacillus rhamnosus GR-1, along with Lactobacillus fermentum RC-14, showed a restoration of healthy vaginal bacteria. This suggests that probiotics can positively impact BV management, offering a potentially effective alternative to traditional treatments.
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Gut Tregs, probiotics aid bone healthGut-resident Tregs (GTregs) play a pivotal role in maintaining bone health under post-menopausal osteoporotic conditions.
Significant findings on osteoporosis
We explored the essential role of gut-resident regulatory T cells (GTregs) in maintaining bone health during post-menopausal osteoporosis. Our research reveals that these immune cells not only promote the formation of bone-building cells called osteoblasts but also inhibit bone-resorbing cells known as osteoclasts.
Through our investigation, we found that the presence of short-chain fatty acids is critical for gut health and GTreg function. When we administered probiotics such as Lactobacillus rhamnosus, we observed improved regulation of GTregs, supporting bone health and alleviating inflammation in osteoporosis.
This innovative link demonstrates the potential for probiotics to play a vital part in managing bone health during menopause.
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