Medical Researches
Moderately Effective
Based on 6 Researches
We explored how the probiotic Bifidobacterium longum 5(1A) can affect pneumonia caused by Klebsiella pneumoniae in mice. Our study showed that this treatment led to a quicker resolution of lung inflammation and significantly reduced the bacterial load, ultimately saving 100% of the mice from death.
This protective effect was linked to the activation of the Toll-like receptor signaling pathway. In particular, B. longum 5(1A) helped balance the body's inflammatory response, promoting a faster recovery in the lungs. Overall, our findings suggest that this probiotic could play a beneficial role in enhancing lung health during infections.
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Probiotics lower postoperative complicationsA Four-Probiotics Regimen Reduces Postoperative Complications After Colorectal Surgery: A Randomized, Double-Blind, Placebo-Controlled Study.
Strong evidence of probiotic effectiveness.
We conducted a double-blind, placebo-controlled study to explore the benefits of a probiotic formulation in patients undergoing colorectal surgery. Patients received either placebo or probiotics containing Lactobacillus acidophilus, L. plantarum, Bifidobacterium lactis, and Saccharomyces boulardii, starting a day before surgery for 15 days afterward.
The results were promising; the probiotics significantly reduced postoperative complications like pneumonia, surgical site infections, and anastomotic leakage. With a lower complication rate and shorter hospital stays for those taking probiotics, the study highlights their potential to enhance recovery after surgery.
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Probiotics reduce lung inflammationLactobacillus rhamnosus GG and Bifidobacterium longum attenuate lung injury and inflammatory response in experimental sepsis.
Promising for sepsis treatment
We evaluated whether Lactobacillus rhamnosus GG and Bifidobacterium longum can protect against lung injury during infections in mice. In our experiment, young mice received either probiotic treatment or a placebo before being subjected to a sepsis-inducing procedure.
The results indicated that both probiotics helped reduce lung damage and inflammation. Notably, less inflammation in the lungs was linked to lower levels of certain immune response markers. This suggests that probiotics might be a promising approach to mitigate lung injuries caused by infections and sepsis.
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Probiotics reduce pneumonia riskA four-probiotic preparation for ventilator-associated pneumonia in multi-trauma patients: results of a randomized clinical trial.
Moderate significance for clinical settings
We explored the effectiveness of a probiotic regimen in preventing ventilator-associated pneumonia (VAP) for mechanically ventilated multi-trauma patients. In a randomized, placebo-controlled trial, 112 patients were split into two groups—one receiving probiotics and the other a placebo.
The results showed that those on probiotics had a significantly lower incidence of VAP and sepsis compared to the placebo group. Additionally, their stay in the intensive care unit and overall hospital stay were also reduced.
This suggests that probiotics could be a valuable addition to care for patients facing long-term mechanical ventilation.
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Probiotics reduce pneumonia in childrenPrebiotic and probiotic fortified milk in prevention of morbidities among children: community-based, randomized, double-blind, controlled trial.
Significant in pneumonia prevention
We explored the role of adding Bifidobacterium lactis and prebiotic oligosaccharides to milk in preventing pneumonia in children aged 1-4 years. In a community-based, randomized controlled trial, children received either control milk or fortified milk over a year.
Our findings revealed a 24% reduction in pneumonia incidence and a 35% decrease in severe acute lower respiratory infections among those receiving the fortified milk. However, while there were positive trends, the overall impact on diarrhea wasn’t significant.
This study highlights the potential benefits of using milk as a delivery system for probiotics in fighting respiratory illnesses in young children.
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