Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
7
Carnitine supplementation shows promise
We explored the potential benefits of carnitine supplementation in individuals with type 2 diabetes over a 12-week period. Our study involved 32 participants taking 2970 mg of L-carnitine daily, while we measured insulin sensitivity and acetylcarnitine levels in their muscles.
The results showed that carnitine treatment improved insulin sensitivity and increased acetylcarnitine concentrations in muscle. Additionally, there were hints of lower fasting plasma glucose levels and reduced liver fat content.
Although the benefits are promising, further research is essential to solidify these findings.
The results showed that carnitine treatment improved insulin sensitivity and increased acetylcarnitine concentrations in muscle. Additionally, there were hints of lower fasting plasma glucose levels and reduced liver fat content.
Although the benefits are promising, further research is essential to solidify these findings.
Read More
4
We examined the effects of acetyl-L-carnitine (ALC) on diabetic peripheral neuropathy (DPN) through a comprehensive review of four studies involving nearly 1,000 participants.
While ALC seemed to provide some pain relief at higher doses above 1500 mg/day, the overall evidence was deemed very low certainty, making it challenging to draw firm conclusions.
Additionally, we found limited data on functional improvements and adverse events, leaving us uncertain about ALC's safety. In essence, while ALC may show promise, more robust research is necessary to fully understand its effectiveness in treating DPN.
While ALC seemed to provide some pain relief at higher doses above 1500 mg/day, the overall evidence was deemed very low certainty, making it challenging to draw firm conclusions.
Additionally, we found limited data on functional improvements and adverse events, leaving us uncertain about ALC's safety. In essence, while ALC may show promise, more robust research is necessary to fully understand its effectiveness in treating DPN.
Read More
8
This study examined how acetyl-l-carnitine affects heart function in diabetic male Wistar rats. We induced diabetes and treated the rats with acetyl-l-carnitine or oxfenicine for eight weeks.
Our findings highlighted that acetyl-l-carnitine helped to maintain heart mechanics by preventing deterioration in cardiac contractility, unlike oxfenicine. This suggests that acetyl-l-carnitine could support heart health in diabetes, offering insights for future treatments.
Our findings highlighted that acetyl-l-carnitine helped to maintain heart mechanics by preventing deterioration in cardiac contractility, unlike oxfenicine. This suggests that acetyl-l-carnitine could support heart health in diabetes, offering insights for future treatments.
Read More
Most Useful Reviews
9
Lowered ALC level
3 people found this helpful
I began taking two of these capsules while avoiding vinegar, and my diabetic A1C number dropped to 5.9, nearly in the normal range. I was absolutely overjoyed! I highly recommend these capsules, especially for those who have diabetes.
Read More
10
Cured fatty liver
This product effectively cured my fatty liver as well as my diabetes. How excellent are these two effects?
Read More
9
Weight loss success
This really works! I struggled with weight, and before diabetes, neither sports nor diet helped me shed fat around my waist. Following a recommendation, I took 2 capsules of L-Carnitine each morning before meals to enhance fat metabolism. Miraculously, I lost 3 kg in a week and felt more energetic! I regret not starting this sooner!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
- All Researches
8
Acetyl L-Carnitine aids diabetic neuropathy
We investigated the effects of a combination treatment that includes Acetyl L-Carnitine on diabetic neuropathy in patients with Type 2 diabetes. In a 12-month, double-blind, placebo-controlled study involving 85 participants, we observed that those receiving the combination treatment showed significant improvements in several measures of nerve function, pain, and quality of life. However, results for cardiovascular reflex tests and certain screening instruments did not show significant benefits. Overall, the combination appears promising for managing diabetic neuropathy.
Read More
8
This study examined how acetyl-l-carnitine affects heart function in diabetic male Wistar rats. We induced diabetes and treated the rats with acetyl-l-carnitine or oxfenicine for eight weeks.
Our findings highlighted that acetyl-l-carnitine helped to maintain heart mechanics by preventing deterioration in cardiac contractility, unlike oxfenicine. This suggests that acetyl-l-carnitine could support heart health in diabetes, offering insights for future treatments.
Our findings highlighted that acetyl-l-carnitine helped to maintain heart mechanics by preventing deterioration in cardiac contractility, unlike oxfenicine. This suggests that acetyl-l-carnitine could support heart health in diabetes, offering insights for future treatments.
Read More
7
Carnitine supplementation shows promise
We explored the potential benefits of carnitine supplementation in individuals with type 2 diabetes over a 12-week period. Our study involved 32 participants taking 2970 mg of L-carnitine daily, while we measured insulin sensitivity and acetylcarnitine levels in their muscles.
The results showed that carnitine treatment improved insulin sensitivity and increased acetylcarnitine concentrations in muscle. Additionally, there were hints of lower fasting plasma glucose levels and reduced liver fat content.
Although the benefits are promising, further research is essential to solidify these findings.
The results showed that carnitine treatment improved insulin sensitivity and increased acetylcarnitine concentrations in muscle. Additionally, there were hints of lower fasting plasma glucose levels and reduced liver fat content.
Although the benefits are promising, further research is essential to solidify these findings.
Read More
7
We investigated how acetyl-L-carnitine (ALC) compares to methylcobalamin (MC) in treating diabetic peripheral neuropathy. In this rigorous clinical trial involving 232 patients, we found that both ALC and MC led to noticeable improvements in nerve function and symptoms over 24 weeks.
Importantly, there was no significant difference in the effectiveness between the two treatments. This suggests that ALC is just as good as MC for managing this condition, with both options being well-tolerated by patients.
Importantly, there was no significant difference in the effectiveness between the two treatments. This suggests that ALC is just as good as MC for managing this condition, with both options being well-tolerated by patients.
Read More
7
We explored how acetyl-L-carnitine affects nerve regeneration in patients with diabetic neuropathy (DN). In a year-long study, we reviewed various data from nearly 500 DN patients to identify factors influencing nerve health. We discovered that higher levels of HbA1c, a marker of blood glucose control, were linked to poorer nerve fiber performance.
Unfortunately, the data did not indicate significant benefits from acetyl-L-carnitine in nerve regeneration compared to blood sugar management. This highlights the importance of keeping blood sugar levels stable to protect nerve function.
Unfortunately, the data did not indicate significant benefits from acetyl-L-carnitine in nerve regeneration compared to blood sugar management. This highlights the importance of keeping blood sugar levels stable to protect nerve function.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Lowered ALC level
3 people found this helpful
I began taking two of these capsules while avoiding vinegar, and my diabetic A1C number dropped to 5.9, nearly in the normal range. I was absolutely overjoyed! I highly recommend these capsules, especially for those who have diabetes.
Read More
10
Cured fatty liver
This product effectively cured my fatty liver as well as my diabetes. How excellent are these two effects?
Read More
9
Weight loss success
This really works! I struggled with weight, and before diabetes, neither sports nor diet helped me shed fat around my waist. Following a recommendation, I took 2 capsules of L-Carnitine each morning before meals to enhance fat metabolism. Miraculously, I lost 3 kg in a week and felt more energetic! I regret not starting this sooner!
Read More
9
Supports liver function
I really appreciate this product along with hepatoprotectors. It supports the liver with a high-quality form of L-carnitine and aids in detoxification processes for those with diabetes.
Read More
9
Controls diabetes well
Now Foods offers the highest quality I've encountered in all their products. This form of L-carnitine effectively manages my diabetes without requiring any medications from my doctor.
Read More
Frequently Asked Questions
9
Lowered ALC level
3 people found this helpful
I began taking two of these capsules while avoiding vinegar, and my diabetic A1C number dropped to 5.9, nearly in the normal range. I was absolutely overjoyed! I highly recommend these capsules, especially for those who have diabetes.
6
Blood sugar improvement
Most of the cells in one's body contain carnitine, synthesised by the liver and kidneys. Carnitine aids in energy production. Acetyl-L-carnitine (ALC) is a form of carnitine available as a supplement. Research indicates that people with prediabetes experienced improvements in blood sugar levels after taking ALC for 2 months. The ingredients are pure, and the quality is excellent from iHerb—good dosage and size, with no taste since it’s in capsule form.
7.5
Stabilised diabetes effects
This product has helped stabilise and reduce my diabetes side effects. At my next doctor's visit, I plan to discuss the possibility of lowering my medication or possibly stopping one or more altogether!
9
Weight loss success
This really works! I struggled with weight, and before diabetes, neither sports nor diet helped me shed fat around my waist. Following a recommendation, I took 2 capsules of L-Carnitine each morning before meals to enhance fat metabolism. Miraculously, I lost 3 kg in a week and felt more energetic! I regret not starting this sooner!
9
Controls diabetes well
Now Foods offers the highest quality I've encountered in all their products. This form of L-carnitine effectively manages my diabetes without requiring any medications from my doctor.
9
Supports liver function
I really appreciate this product along with hepatoprotectors. It supports the liver with a high-quality form of L-carnitine and aids in detoxification processes for those with diabetes.
6
Effective for Type 2
1 people found this helpful
Good for diabetes type 2 when paired with Super R-Lipoic. This is the second bottle for my mum.
4
We examined the effects of acetyl-L-carnitine (ALC) on diabetic peripheral neuropathy (DPN) through a comprehensive review of four studies involving nearly 1,000 participants.
While ALC seemed to provide some pain relief at higher doses above 1500 mg/day, the overall evidence was deemed very low certainty, making it challenging to draw firm conclusions.
Additionally, we found limited data on functional improvements and adverse events, leaving us uncertain about ALC's safety. In essence, while ALC may show promise, more robust research is necessary to fully understand its effectiveness in treating DPN.
While ALC seemed to provide some pain relief at higher doses above 1500 mg/day, the overall evidence was deemed very low certainty, making it challenging to draw firm conclusions.
Additionally, we found limited data on functional improvements and adverse events, leaving us uncertain about ALC's safety. In essence, while ALC may show promise, more robust research is necessary to fully understand its effectiveness in treating DPN.
7
We investigated how acetyl-L-carnitine (ALC) compares to methylcobalamin (MC) in treating diabetic peripheral neuropathy. In this rigorous clinical trial involving 232 patients, we found that both ALC and MC led to noticeable improvements in nerve function and symptoms over 24 weeks.
Importantly, there was no significant difference in the effectiveness between the two treatments. This suggests that ALC is just as good as MC for managing this condition, with both options being well-tolerated by patients.
Importantly, there was no significant difference in the effectiveness between the two treatments. This suggests that ALC is just as good as MC for managing this condition, with both options being well-tolerated by patients.
7
Carnitine supplementation shows promise
We explored the potential benefits of carnitine supplementation in individuals with type 2 diabetes over a 12-week period. Our study involved 32 participants taking 2970 mg of L-carnitine daily, while we measured insulin sensitivity and acetylcarnitine levels in their muscles.
The results showed that carnitine treatment improved insulin sensitivity and increased acetylcarnitine concentrations in muscle. Additionally, there were hints of lower fasting plasma glucose levels and reduced liver fat content.
Although the benefits are promising, further research is essential to solidify these findings.
The results showed that carnitine treatment improved insulin sensitivity and increased acetylcarnitine concentrations in muscle. Additionally, there were hints of lower fasting plasma glucose levels and reduced liver fat content.
Although the benefits are promising, further research is essential to solidify these findings.
7
We explored how acetyl-L-carnitine affects nerve regeneration in patients with diabetic neuropathy (DN). In a year-long study, we reviewed various data from nearly 500 DN patients to identify factors influencing nerve health. We discovered that higher levels of HbA1c, a marker of blood glucose control, were linked to poorer nerve fiber performance.
Unfortunately, the data did not indicate significant benefits from acetyl-L-carnitine in nerve regeneration compared to blood sugar management. This highlights the importance of keeping blood sugar levels stable to protect nerve function.
Unfortunately, the data did not indicate significant benefits from acetyl-L-carnitine in nerve regeneration compared to blood sugar management. This highlights the importance of keeping blood sugar levels stable to protect nerve function.
8
Acetyl L-Carnitine aids diabetic neuropathy
We investigated the effects of a combination treatment that includes Acetyl L-Carnitine on diabetic neuropathy in patients with Type 2 diabetes. In a 12-month, double-blind, placebo-controlled study involving 85 participants, we observed that those receiving the combination treatment showed significant improvements in several measures of nerve function, pain, and quality of life. However, results for cardiovascular reflex tests and certain screening instruments did not show significant benefits. Overall, the combination appears promising for managing diabetic neuropathy.
References
- Op den Kamp-Bruls YMH, Op den Kamp YJM, Veeraiah P, Zapata Perez R, Phielix E, et al. Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in patients with type 2 diabetes. Diabetes Obes Metab. 2025. doi:10.1111/dom.16298
- Didangelos T, Karlafti E, Kotzakioulafi E, Kontoninas Z, Margaritidis C, et al. Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy. Nutrients. 2020;12. doi:10.3390/nu12113254
- Rolim LC, da Silva EM, Flumignan RL, Abreu MM, Dib SA. Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy. Cochrane Database Syst Rev. 2019;6:CD011265. doi:10.1002/14651858.CD011265.pub2
- Li S, Chen X, Li Q, Du J, Liu Z, et al. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. J Diabetes Investig. 2016;7:777. doi:10.1111/jdi.12493
- Hur J, Sullivan KA, Callaghan BC, Pop-Busui R, Feldman EL. Identification of factors associated with sural nerve regeneration and degeneration in diabetic neuropathy. Diabetes Care. 2013;36:4043. doi:10.2337/dc12-2530
- Wang CH, Wang SS, Ko WJ, Chen YS, Chang CY, et al. Acetyl-l-carnitine and oxfenicine on cardiac pumping mechanics in streptozotocin-induced diabetes in male Wistar rats. PLoS One. 2013;8:e69977. doi:10.1371/journal.pone.0069977
- Fernandez IC, Del Carmen Camberos M, Passicot GA, Martucci LC, Cresto JC. Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide - case reports. J Pediatr Endocrinol Metab. 2013;26:347. doi:10.1515/jpem-2012-0128
