Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
USERS' SCORE
Good
Based on 28 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin)
250 mg
†
Top Medical Research Studies
9
We aimed to explore how lactoferrin affects acne by testing its anti-inflammatory and anti-lipid properties on human sebaceous gland cells and a mouse model. Using SZ95 cells, we treated them with varying concentrations of lactoferrin to observe its impact on cell viability, lipid content, and gene expression related to fat metabolism and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
Read More
9
We explored the effects of lactoferrin (LF) on inflammation caused by Propionibacterium acnes, a key player in acne development. In our investigation, we treated human skin cells with heat-killed P. acnes and observed that LF significantly reduced the production of inflammatory cytokines, such as IL-8.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
Read More
9
We examined the potential benefits of lactoferrin-enriched fermented milk on acne vulgaris, a common inflammatory skin condition. In our study, young adults between 18 and 30 years old participated in a 12-week trial. They were divided into two groups: one took fermented milk with 200 mg of lactoferrin daily, while the other consumed only fermented milk without the supplement.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
Read More
Most Useful Reviews
9
Significant reduction
194 people found this helpful
Possibly the solution for chronic adult acne. I'm in my late twenties and have been very prone to acne consistently since my teenage years. When I say I've tried everything, I truly mean it. Up until now, the only treatment that ever worked was prescription Accutane, which is harmful to the liver and has unpleasant side effects. After six months on Accutane, my skin stayed relatively clear for about six months, but soon after, serious acne returned. Since then, I have tested many supplements and creams, none of which helped. I eventually discovered a study indicating that acne was reduced in participants using lactoferrin enriched fermented milk. After beginning this product, my acne has significantly reduced within just two weeks.
Read More
7
Improvement in acne
129 people found this helpful
As a fashion model, my skin health is crucial. After battling Lyme disease for a year, I switched to alternative therapies, including Jarrow Lactoferrin and Colostrum. The results have been remarkable! My energy increased, I can climb stairs without getting winded, and my skin has improved significantly; it's more hydrated and plump. My acne is clearing up remarkably well after several weeks of usage!
Read More
9
Clearing acne effectively
41 people found this helpful
Clears adult acne. Studies show lactoferrin can reduce sebum production by at least 30% in 12 weeks. I've noticed my skin is becoming less oily, and acne is clearing up. This is particularly noteworthy, as no other treatment I know of can achieve this without side effects. Lactoferrin has no adverse effects. As a 26-year-old male, I'm very pleased with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
- All Researches
9.5
Lactoferrin effectively reduces acne
In a well-structured study, we investigated the combined effects of lactoferrin, vitamin E, and zinc as a treatment for mild to moderate acne. This randomized, double-blind, placebo-controlled trial included 168 participants aged between 13 and 40, all of whom were assigned to either receive the treatment or a placebo for three months.
Throughout the study, we observed that those taking the lactoferrin combination began experiencing a noticeable reduction in their acne lesions as soon as two weeks into the treatment. By the tenth week, participants using the lactoferrin formulation had an impressive average reduction of 28.5% in total lesions when compared to those receiving the placebo.
Furthermore, we found significant improvements in both comedones and inflammatory lesions at the ten-week mark. Throughout this research, there were no reported adverse events, highlighting the safety of this treatment regimen. Overall, our findings suggest that a twice-daily intake of lactoferrin combined with vitamin E and zinc can significantly reduce acne lesions in those suffering from mild to moderate acne vulgaris.
Throughout the study, we observed that those taking the lactoferrin combination began experiencing a noticeable reduction in their acne lesions as soon as two weeks into the treatment. By the tenth week, participants using the lactoferrin formulation had an impressive average reduction of 28.5% in total lesions when compared to those receiving the placebo.
Furthermore, we found significant improvements in both comedones and inflammatory lesions at the ten-week mark. Throughout this research, there were no reported adverse events, highlighting the safety of this treatment regimen. Overall, our findings suggest that a twice-daily intake of lactoferrin combined with vitamin E and zinc can significantly reduce acne lesions in those suffering from mild to moderate acne vulgaris.
Read More
9
We aimed to explore how lactoferrin affects acne by testing its anti-inflammatory and anti-lipid properties on human sebaceous gland cells and a mouse model. Using SZ95 cells, we treated them with varying concentrations of lactoferrin to observe its impact on cell viability, lipid content, and gene expression related to fat metabolism and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
Read More
9
We explored the effects of lactoferrin (LF) on inflammation caused by Propionibacterium acnes, a key player in acne development. In our investigation, we treated human skin cells with heat-killed P. acnes and observed that LF significantly reduced the production of inflammatory cytokines, such as IL-8.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
Read More
9
We examined the potential benefits of lactoferrin-enriched fermented milk on acne vulgaris, a common inflammatory skin condition. In our study, young adults between 18 and 30 years old participated in a 12-week trial. They were divided into two groups: one took fermented milk with 200 mg of lactoferrin daily, while the other consumed only fermented milk without the supplement.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
Read More
We conducted a 12-week multicenter trial examining how well a specific cream, containing retinoid molecules and Iris Florentina root extract, works for adult female acne, as well as the impact of combining it with a prebiotic supplement that includes lactoferrin. The study included 184 women, assessing not just the number of acne lesions, but also scoring the severity of their condition using recognized tools.
While the primary cream formulation showed effectiveness and was well tolerated, the combination with the prebiotic supplement resulted in additional benefits, particularly in reducing inflammatory lesions. Although lactoferrin was part of this combination, the study did not isolate its effects, so we cannot definitively assess its specific role in acne treatment.
Overall, our findings indicate that the cream is beneficial for managing adult female acne, and the added prebiotic aspect seems to enhance results—especially for inflammation. Still, without isolating lactoferrin, its individual impact on acne remains unclear.
While the primary cream formulation showed effectiveness and was well tolerated, the combination with the prebiotic supplement resulted in additional benefits, particularly in reducing inflammatory lesions. Although lactoferrin was part of this combination, the study did not isolate its effects, so we cannot definitively assess its specific role in acne treatment.
Overall, our findings indicate that the cream is beneficial for managing adult female acne, and the added prebiotic aspect seems to enhance results—especially for inflammation. Still, without isolating lactoferrin, its individual impact on acne remains unclear.
Read More
User Reviews
USERS' SCORE
Good
Based on 28 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant reduction
194 people found this helpful
Possibly the solution for chronic adult acne. I'm in my late twenties and have been very prone to acne consistently since my teenage years. When I say I've tried everything, I truly mean it. Up until now, the only treatment that ever worked was prescription Accutane, which is harmful to the liver and has unpleasant side effects. After six months on Accutane, my skin stayed relatively clear for about six months, but soon after, serious acne returned. Since then, I have tested many supplements and creams, none of which helped. I eventually discovered a study indicating that acne was reduced in participants using lactoferrin enriched fermented milk. After beginning this product, my acne has significantly reduced within just two weeks.
Read More
7
Improvement in acne
129 people found this helpful
As a fashion model, my skin health is crucial. After battling Lyme disease for a year, I switched to alternative therapies, including Jarrow Lactoferrin and Colostrum. The results have been remarkable! My energy increased, I can climb stairs without getting winded, and my skin has improved significantly; it's more hydrated and plump. My acne is clearing up remarkably well after several weeks of usage!
Read More
9
Clearing acne effectively
41 people found this helpful
Clears adult acne. Studies show lactoferrin can reduce sebum production by at least 30% in 12 weeks. I've noticed my skin is becoming less oily, and acne is clearing up. This is particularly noteworthy, as no other treatment I know of can achieve this without side effects. Lactoferrin has no adverse effects. As a 26-year-old male, I'm very pleased with the results.
Read More
9
Improved acne condition
14 people found this helpful
Excellent! After seeing the reviews, I purchased lactoferrin. It has significantly improved my acne, which I didn’t expect, along with enhancing my iron absorption and relieving symptoms of anaemia.
Read More
7.5
Improving skin
11 people found this helpful
It helps with my acne; I've noticed an improvement in just two days of taking this brand. I was a bit sceptical at first, but now my face is less inflamed, and even my ulcers are healing. If the progress continues, I might consider updating my review to five stars.
Read More
Frequently Asked Questions
9
We aimed to explore how lactoferrin affects acne by testing its anti-inflammatory and anti-lipid properties on human sebaceous gland cells and a mouse model. Using SZ95 cells, we treated them with varying concentrations of lactoferrin to observe its impact on cell viability, lipid content, and gene expression related to fat metabolism and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
9.5
Lactoferrin effectively reduces acne
In a well-structured study, we investigated the combined effects of lactoferrin, vitamin E, and zinc as a treatment for mild to moderate acne. This randomized, double-blind, placebo-controlled trial included 168 participants aged between 13 and 40, all of whom were assigned to either receive the treatment or a placebo for three months.
Throughout the study, we observed that those taking the lactoferrin combination began experiencing a noticeable reduction in their acne lesions as soon as two weeks into the treatment. By the tenth week, participants using the lactoferrin formulation had an impressive average reduction of 28.5% in total lesions when compared to those receiving the placebo.
Furthermore, we found significant improvements in both comedones and inflammatory lesions at the ten-week mark. Throughout this research, there were no reported adverse events, highlighting the safety of this treatment regimen. Overall, our findings suggest that a twice-daily intake of lactoferrin combined with vitamin E and zinc can significantly reduce acne lesions in those suffering from mild to moderate acne vulgaris.
Throughout the study, we observed that those taking the lactoferrin combination began experiencing a noticeable reduction in their acne lesions as soon as two weeks into the treatment. By the tenth week, participants using the lactoferrin formulation had an impressive average reduction of 28.5% in total lesions when compared to those receiving the placebo.
Furthermore, we found significant improvements in both comedones and inflammatory lesions at the ten-week mark. Throughout this research, there were no reported adverse events, highlighting the safety of this treatment regimen. Overall, our findings suggest that a twice-daily intake of lactoferrin combined with vitamin E and zinc can significantly reduce acne lesions in those suffering from mild to moderate acne vulgaris.
9
We explored the effects of lactoferrin (LF) on inflammation caused by Propionibacterium acnes, a key player in acne development. In our investigation, we treated human skin cells with heat-killed P. acnes and observed that LF significantly reduced the production of inflammatory cytokines, such as IL-8.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
9
We examined the potential benefits of lactoferrin-enriched fermented milk on acne vulgaris, a common inflammatory skin condition. In our study, young adults between 18 and 30 years old participated in a 12-week trial. They were divided into two groups: one took fermented milk with 200 mg of lactoferrin daily, while the other consumed only fermented milk without the supplement.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
7
We examined the potential of lactoferrin as a treatment option for acne, driven by its known antimicrobial and anti-inflammatory properties. The review focused on analyzing six clinical studies to better understand how effective lactoferrin can be in addressing this common skin condition.
Although the evidence gathered is encouraging, especially regarding its positive effects, we noted that the studies did not isolate lactoferrin's impact from other treatments. This means we still need more targeted research to confidently say that lactoferrin is an effective stand-alone therapy for acne.
Overall, while lactoferrin shows promise in managing acne, further studies are needed to clarify its effectiveness when used independently in clinical practice.
Although the evidence gathered is encouraging, especially regarding its positive effects, we noted that the studies did not isolate lactoferrin's impact from other treatments. This means we still need more targeted research to confidently say that lactoferrin is an effective stand-alone therapy for acne.
Overall, while lactoferrin shows promise in managing acne, further studies are needed to clarify its effectiveness when used independently in clinical practice.
7
We set out to understand how lactoferrin, a naturally occurring protein known for its antimicrobial and anti-inflammatory properties, can help treat mild to moderate acne vulgaris. In our open-label study, we had 43 participants, including adolescents and young adults, who took chewable tablets containing bovine lactoferrin twice daily for eight weeks.
Our main focus was to see if this supplementation would lead to a reduction in acne lesion counts compared to the starting point. By the end of the study, we observed some promising results: participants experienced a noticeable drop in both inflammatory and non-inflammatory lesion counts. Specifically, non-inflammatory lesions decreased by 23.5%, and total lesions were down by 22.5%.
Additionally, about 76.9% of our subjects reported fewer total lesions by the end of the eight weeks. Importantly, none of the participants experienced significant side effects related to lactoferrin, indicating that it was well tolerated throughout the study. While these findings are encouraging, we recognize the limitations of our uncontrolled design and suggest that more rigorous, randomized trials would help solidify these results.
Our main focus was to see if this supplementation would lead to a reduction in acne lesion counts compared to the starting point. By the end of the study, we observed some promising results: participants experienced a noticeable drop in both inflammatory and non-inflammatory lesion counts. Specifically, non-inflammatory lesions decreased by 23.5%, and total lesions were down by 22.5%.
Additionally, about 76.9% of our subjects reported fewer total lesions by the end of the eight weeks. Importantly, none of the participants experienced significant side effects related to lactoferrin, indicating that it was well tolerated throughout the study. While these findings are encouraging, we recognize the limitations of our uncontrolled design and suggest that more rigorous, randomized trials would help solidify these results.
References
- Su YT, Zouboulis CC, Cui W, Zhang AP. Lactoferrin regulates sebogenesis and inflammation in SZ95 human sebocytes and mouse model of acne. J Cosmet Dermatol. 2023;22:1361. doi:10.1111/jocd.15577
- Kazandjieva J, Dimitrova J, Sankeva M, Yankov D, Bocheva V, et al. Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women. J Cosmet Dermatol. 2022;21:5716. doi:10.1111/jocd.15074
- Su Y, Cui W, Wei H. Influence of lactoferrin on Propionibacterium acnes-induced inflammation in vitro and in vivo. Dermatol Ther. 2020;33:e14483. doi:10.1111/dth.14483
- Chan H, Chan G, Santos J, Dee K, Co JK. A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris. Int J Dermatol. 2017;56:686. doi:10.1111/ijd.13607
- Hassoun LA, Sivamani RK. A systematic review of lactoferrin use in dermatology. Crit Rev Food Sci Nutr. 2017;57:3632. doi:10.1080/10408398.2015.1137859
- Mueller EA, Trapp S, Frentzel A, Kirch W, Brantl V. Efficacy and tolerability of oral lactoferrin supplementation in mild to moderate acne vulgaris: an exploratory study. Curr Med Res Opin. 2011;27:793. doi:10.1185/03007995.2011.557720
- Kim J, Ko Y, Park YK, Kim NI, Ha WK, et al. Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition. 2010;26:902. doi:10.1016/j.nut.2010.05.011
