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SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
USERS' SCORE
Good
Based on 28 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin)
250 mg
†
Top Medical Research Studies
9
Lactoferrin reduces acne inflammation
Lactoferrin regulates sebogenesis and inflammation in SZ95 human sebocytes and mouse model of acne.
Highly relevant study on lactoferrin
We aimed to explore how lactoferrin affects acne by testing its anti-inflammatory and anti-lipid properties on human sebaceous gland cells and a mouse model. Using SZ95 cells, we treated them with varying concentrations of lactoferrin to observe its impact on cell viability, lipid content, and gene expression related to fat metabolism and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
Read More
9
Lactoferrin reduces acne inflammation
Influence of lactoferrin on Propionibacterium acnes-induced inflammation in vitro and in vivo.
High relevance to acne treatment
We explored the effects of lactoferrin (LF) on inflammation caused by Propionibacterium acnes, a key player in acne development. In our investigation, we treated human skin cells with heat-killed P. acnes and observed that LF significantly reduced the production of inflammatory cytokines, such as IL-8.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
Read More
9
Lactoferrin improves acne treatment
Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris.
Highly relevant acne treatment findings
We examined the potential benefits of lactoferrin-enriched fermented milk on acne vulgaris, a common inflammatory skin condition. In our study, young adults between 18 and 30 years old participated in a 12-week trial. They were divided into two groups: one took fermented milk with 200 mg of lactoferrin daily, while the other consumed only fermented milk without the supplement.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
Read More
Most Useful Reviews
9.5
Significant reduction
Possibly the solution for chronic adult acne. I'm in my late twenties and have been very prone to acne consistently since my teenage years. When I say I've tried everything, I truly mean it. Up until now, the only treatment that ever worked was prescription Accutane, which is harmful to the liver and has unpleasant side effects. After six months on Accutane, my skin stayed relatively clear for about six months, but soon after, serious acne returned. Since then, I have tested many supplements and creams, none of which helped. I eventually discovered a study indicating that acne was reduced in participants using lactoferrin enriched fermented milk. After beginning this product, my acne has significantly reduced within just two weeks.
Read More
8.5
Improvement in acne
As a fashion model, my skin health is crucial. After battling Lyme disease for a year, I switched to alternative therapies, including Jarrow Lactoferrin and Colostrum. The results have been remarkable! My energy increased, I can climb stairs without getting winded, and my skin has improved significantly; it's more hydrated and plump. My acne is clearing up remarkably well after several weeks of usage!
Read More
9.5
Clearing acne effectively
Clears adult acne. Studies show lactoferrin can reduce sebum production by at least 30% in 12 weeks. I've noticed my skin is becoming less oily, and acne is clearing up. This is particularly noteworthy, as no other treatment I know of can achieve this without side effects. Lactoferrin has no adverse effects. As a 26-year-old male, I'm very pleased with the results.
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
9.5
Lactoferrin effectively reduces acne
A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris.
Study evaluates combined treatment
In a well-structured study, we investigated the combined effects of lactoferrin, vitamin E, and zinc as a treatment for mild to moderate acne. This randomized, double-blind, placebo-controlled trial included 168 participants aged between 13 and 40, all of whom were assigned to either receive the treatment or a placebo for three months.
Throughout the study, we observed that those taking the lactoferrin combination began experiencing a noticeable reduction in their acne lesions as soon as two weeks into the treatment. By the tenth week, participants using the lactoferrin formulation had an impressive average reduction of 28.5% in total lesions when compared to those receiving the placebo.
Furthermore, we found significant improvements in both comedones and inflammatory lesions at the ten-week mark. Throughout this research, there were no reported adverse events, highlighting the safety of this treatment regimen. Overall, our findings suggest that a twice-daily intake of lactoferrin combined with vitamin E and zinc can significantly reduce acne lesions in those suffering from mild to moderate acne vulgaris.
Throughout the study, we observed that those taking the lactoferrin combination began experiencing a noticeable reduction in their acne lesions as soon as two weeks into the treatment. By the tenth week, participants using the lactoferrin formulation had an impressive average reduction of 28.5% in total lesions when compared to those receiving the placebo.
Furthermore, we found significant improvements in both comedones and inflammatory lesions at the ten-week mark. Throughout this research, there were no reported adverse events, highlighting the safety of this treatment regimen. Overall, our findings suggest that a twice-daily intake of lactoferrin combined with vitamin E and zinc can significantly reduce acne lesions in those suffering from mild to moderate acne vulgaris.
Read More
9
Lactoferrin reduces acne inflammation
Lactoferrin regulates sebogenesis and inflammation in SZ95 human sebocytes and mouse model of acne.
Highly relevant study on lactoferrin
We aimed to explore how lactoferrin affects acne by testing its anti-inflammatory and anti-lipid properties on human sebaceous gland cells and a mouse model. Using SZ95 cells, we treated them with varying concentrations of lactoferrin to observe its impact on cell viability, lipid content, and gene expression related to fat metabolism and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.
We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
Read More
9
Lactoferrin reduces acne inflammation
Influence of lactoferrin on Propionibacterium acnes-induced inflammation in vitro and in vivo.
High relevance to acne treatment
We explored the effects of lactoferrin (LF) on inflammation caused by Propionibacterium acnes, a key player in acne development. In our investigation, we treated human skin cells with heat-killed P. acnes and observed that LF significantly reduced the production of inflammatory cytokines, such as IL-8.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
To dig deeper, we looked at how LF influenced specific proteins linked to inflammation. Results showed that LF helped lower the levels of proteins associated with inflammatory responses in these skin cells. This suggests that LF is capable of moderating the skin's response to P. acnes.
Additionally, we conducted tests on mice, injecting them with activated P. acnes to induce inflammation. When we treated one ear of the mice with LF, results indicated a noticeable reduction in inflammation compared to the untreated ear. These findings further support LF's potential in managing acne-related skin issues.
Overall, our study reveals that lactoferrin can play a vital role in reducing inflammation linked to acne, thus presenting a promising avenue for acne treatment.
Read More
9
Lactoferrin improves acne treatment
Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris.
Highly relevant acne treatment findings
We examined the potential benefits of lactoferrin-enriched fermented milk on acne vulgaris, a common inflammatory skin condition. In our study, young adults between 18 and 30 years old participated in a 12-week trial. They were divided into two groups: one took fermented milk with 200 mg of lactoferrin daily, while the other consumed only fermented milk without the supplement.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
Throughout the study, we monitored changes in their acne lesions, skin hydration, sebum levels, and skin surface lipids. Our findings revealed that participants in the lactoferrin group experienced a noteworthy 38.6% reduction in inflammatory lesions and a decrease in overall acne grade by about 20.3% compared to the placebo group. We also noted a significant 31.1% cut in sebum content in the lactoferrin group, suggesting an effective link between lactoferrin consumption and improved skin conditions.
Interestingly, both groups showed a decrease in total skin surface lipids, but the lactoferrin group specifically reduced triacylglycerols, which is correlated with their improved acne scores. Overall, our research suggests that incorporating lactoferrin-enriched fermented milk into one's diet can positively affect acne vulgaris by targeting lipid levels in the skin.
Read More
8
Retinoid cream shows effectiveness
Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women.
Combination treatment benefits explored
We conducted a 12-week multicenter trial examining how well a specific cream, containing retinoid molecules and Iris Florentina root extract, works for adult female acne, as well as the impact of combining it with a prebiotic supplement that includes lactoferrin. The study included 184 women, assessing not just the number of acne lesions, but also scoring the severity of their condition using recognized tools.
While the primary cream formulation showed effectiveness and was well tolerated, the combination with the prebiotic supplement resulted in additional benefits, particularly in reducing inflammatory lesions. Although lactoferrin was part of this combination, the study did not isolate its effects, so we cannot definitively assess its specific role in acne treatment.
Overall, our findings indicate that the cream is beneficial for managing adult female acne, and the added prebiotic aspect seems to enhance results—especially for inflammation. Still, without isolating lactoferrin, its individual impact on acne remains unclear.
While the primary cream formulation showed effectiveness and was well tolerated, the combination with the prebiotic supplement resulted in additional benefits, particularly in reducing inflammatory lesions. Although lactoferrin was part of this combination, the study did not isolate its effects, so we cannot definitively assess its specific role in acne treatment.
Overall, our findings indicate that the cream is beneficial for managing adult female acne, and the added prebiotic aspect seems to enhance results—especially for inflammation. Still, without isolating lactoferrin, its individual impact on acne remains unclear.
Read More
User Reviews
USERS' SCORE
Good
Based on 28 Reviews
8.6
9.5
Improved acne condition
Excellent! After seeing the reviews, I purchased lactoferrin. It has significantly improved my acne, which I didn’t expect, along with enhancing my iron absorption and relieving symptoms of anaemia.
9.5
Clear skin benefit
It has worked wonders for my acne-prone skin, keeping it clear with continuous use.
9.5
Chronic acne relief
I’ve struggled with hormonal acne for almost 4 years. After taking this, I noticed a significant improvement in redness on my face by the same day. Now, after nearly a month, I barely have any breakouts.
9.5
Acne cessation
I can no longer get acne, and my communication during high temperatures has improved. However, I hesitate to continue due to the use of colostrum ingredients, which raises ethical concerns for me.
9.5
Diminished acne
I found a study showing acne reduction with lactoferrin-fortified milk. After just two weeks of using this supplement, my acne has significantly diminished and continues to improve.
