We investigated the clinical safety and performance of a new magnesium scaffold known as DREAMS 3G. This innovative treatment aims to match the effectiveness of drug-eluting stents in coronary interventions.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
Read More
9
Magnesium nanoparticles enhance clotting time
Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis.
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
Read More
8
Magnesium scaffolds lower clotting risks
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
Read More
Most Useful Reviews
9.5
Improved cognitive functions
Excellent magnesium threonate; it works gently thanks to its dosage. I tried several options, and this one suits me perfectly. Threonate eliminates magnesium deficiency at the level "inside the brain", as it is the only form that can penetrate the blood-brain barrier. It dramatically enhances cognitive functions, including learning and memory. In situations of anxiety, it provides real and quick support. I have used threonate as an aid during recovery from trauma, where I faced severe anxiety and panic attacks. Despite the price, I always purchase it. It pairs well with malate and bisglycinate. However, I stress that in critical situations, seeking specialist advice is essential.
Read More
9.5
Calmed autistic child
I bought this for my 5-year-old autistic child for brain health and tranquillity. I dissolve the capsule in water and administer it with a syringe; it’s a tasteless white powder. It is the only magnesium type that crosses the blood-brain barrier, and it works wonderfully—the child is much calmer now. I highly recommend it!
Read More
9.5
Migraine relief
This product is great for those who struggle with brain fog in the mornings. I find my mind is much clearer after taking it the night before. A friend with chronic migraines was stunned; he didn't need his migraine medication after trying this magnesium. Only this form can penetrate the blood-brain barrier, and though I was sceptical initially, I'm now convinced it works, so I always keep a bottle at home.
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
Read More
8
Magnesium intake reduces RVO risk
Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis.
We explored whether magnesium intake could influence the risk of retinal vein occlusion (RVO), a leading cause of vision loss. Our analysis involved over 16,000 participants from a national health survey.
We discovered that sufficient magnesium intake was linked to a significant 64% reduced risk of RVO.
This finding was especially relevant for adults under 60, those with hypertension, and individuals without glaucoma. Further studies are needed to confirm magnesium's preventive benefits for RVO.
Read More
8
Effective clay-based hemostatic sponge
An Antibacterial, Antioxidant Adherent Sponge Constructed for Control of Arterial Bleeding Via Gallic Acid-Mediated Robust Assembly of Fibrous Clay in Collagen.
We examined a new sponge made from clay and collagen to control severe bleeding. Integrating palygorskite clay with collagen using gallic acid created a sponge that resists particle shedding and provides strong adhesion.
In our tests, this sponge demonstrated impressive results, reducing blood loss to 632 mg and achieving hemostasis in just 151 seconds, outperforming traditional gauze and even a well-known product called QuikClot.
With added antibacterial and antioxidant properties, this sponge could significantly enhance emergency bleeding management.
Read More
8
Magnesium scaffolds lower clotting risks
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
Read More
8
Bioresorbable stents' advancements noted
Coronary bioresorbable metallic stents: Advancements and future perspectives.
We explored the evolution of bioresorbable metallic stents as alternatives to traditional stents which can lead to complications like thrombosis and inflammation.
While bioresorbable polymeric stents face challenges, materials like zinc and magnesium show promise.
Specifically, magnesium-based stents have demonstrated successful absorption within a year and low rates of complications.
Continuing research will be essential to refine these innovations for better clinical outcomes.
Excellent magnesium threonate; it works gently thanks to its dosage. I tried several options, and this one suits me perfectly. Threonate eliminates magnesium deficiency at the level "inside the brain", as it is the only form that can penetrate the blood-brain barrier. It dramatically enhances cognitive functions, including learning and memory. In situations of anxiety, it provides real and quick support. I have used threonate as an aid during recovery from trauma, where I faced severe anxiety and panic attacks. Despite the price, I always purchase it. It pairs well with malate and bisglycinate. However, I stress that in critical situations, seeking specialist advice is essential.
Read More
9.5
Calmed autistic child
I bought this for my 5-year-old autistic child for brain health and tranquillity. I dissolve the capsule in water and administer it with a syringe; it’s a tasteless white powder. It is the only magnesium type that crosses the blood-brain barrier, and it works wonderfully—the child is much calmer now. I highly recommend it!
Read More
9.5
Migraine relief
This product is great for those who struggle with brain fog in the mornings. I find my mind is much clearer after taking it the night before. A friend with chronic migraines was stunned; he didn't need his migraine medication after trying this magnesium. Only this form can penetrate the blood-brain barrier, and though I was sceptical initially, I'm now convinced it works, so I always keep a bottle at home.
Read More
8.8
Lowered blood pressure
The quality is excellent, and this magnesium combination is the best as it enters the mitochondria and corrects the imbalance. After using it, my cousin's blood pressure decreased significantly, allowing her to stop taking blood pressure medications. However, she does need to take B6 pills to enhance absorption.
Read More
8
Reduced convulsions
I have sought this particular form of magnesium for ages, as it can pass the blood-brain barrier. I only take it at night; my sleep has slightly improved, and the convulsions have lessened somewhat. Remarkably, I have not experienced a headache during the two-month intake, a common issue for me in autumn. It is good magnesium, though a bit pricey, so I will likely purchase it once a year.
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Based on user reviews, the timeline for seeing results when taking magnesium threonate for blood health can vary significantly among individuals. Some users have reported immediate improvements in cognitive functions, such as enhanced clarity and memory, within the first few days of use (Read Review). Others have experienced a gradual decline in symptoms over a two-month period, particularly in terms of sleep improvement and seizure control (Read Review).
In general, many users express that consistent intake is crucial to notice significant benefits. Improvements regarding anxiety and cognitive support were also reported, often suggesting that users felt results after a couple of weeks (Read Review). Individuals seeking to address blood-related issues may want to consider taking the supplement regularly while keeping in mind that consulting a healthcare professional is advisable for tailored advice.
The link between magnesium and blood clotting is increasingly supported by scientific research. One significant study identified that increasing magnesium levels could effectively lower the risk of conditions linked with blood clotting, specifically retinal vein occlusion (RVO), demonstrating a notable 64% lower risk among those with adequate magnesium intake [1]. Another pivotal research highlighted how a deficiency in magnesium transporter 1 (MAGT1) could enhance platelet activity and increase clot formation, indicating that maintaining sufficient magnesium levels is crucial for vascular health [8].
Additionally, innovative magnesium scaffolds, like the Magmaris, have shown to exhibit lower thrombogenicity compared to traditional stainless steel stents, promising to enhance patient safety in cardiovascular treatments [3]. Various studies on bioresorbable magnesium scaffolds reveal not only their effectiveness in cardiovascular interventions but also their potential to mitigate complications such as thrombosis [4]. Overall, increasing the intake of magnesium and exploring its applications in medical devices hold promise for managing blood clot risks effectively and warrants further investigation for clinical effectiveness.
Based on user reviews, many individuals have reported notable improvements in cognitive function after using magnesium threonate. Users highlight enhancements in memory, clarity, and overall brain health. One user shared a dramatic change, stating that even their friend, who suffered from chronic migraines, no longer needed medication after starting this supplement (Read Review). Additionally, parents of children with autism mentioned significant calming effects, with one parent noting that their child became much calmer after administration (Read Review).
Moreover, participants reported positive experiences regarding anxiety management and sleep improvement. Users indicated that magnesium threonate provided quick support during anxious moments, while others noticed a reduction in insomnia and fatigue (Read Review). It is important to remember that individual results can vary, and while many users experienced these benefits, they also stressed the significance of professional consultation for personal health concerns.
Users report that magnesium threonate can be effectively combined with other magnesium forms, such as malate and bisglycinate, to enhance its benefits. One user highlighted this synergy, stating that they have experienced excellent results while utilizing threonate alongside these other forms to tackle magnesium deficiency inside the brain (Read Review). However, they still emphasize the importance of seeking professional advice in critical health situations, indicating that a tailored approach could be beneficial.
Additionally, another user mentioned taking B6 supplements to improve the absorption of magnesium threonate, suggesting that combining supplements with proper guidance can lead to more pronounced effects, especially in managing conditions like high blood pressure (Read Review). This highlights the importance of understanding individual health needs when considering supplement combinations.
9.5
Migraine relief
This product is great for those who struggle with brain fog in the mornings. I find my mind is much clearer after taking it the night before. A friend with chronic migraines was stunned; he didn't need his migraine medication after trying this magnesium. Only this form can penetrate the blood-brain barrier, and though I was sceptical initially, I'm now convinced it works, so I always keep a bottle at home.
8
Reduced convulsions
I have sought this particular form of magnesium for ages, as it can pass the blood-brain barrier. I only take it at night; my sleep has slightly improved, and the convulsions have lessened somewhat. Remarkably, I have not experienced a headache during the two-month intake, a common issue for me in autumn. It is good magnesium, though a bit pricey, so I will likely purchase it once a year.
9.5
Calmed autistic child
I bought this for my 5-year-old autistic child for brain health and tranquillity. I dissolve the capsule in water and administer it with a syringe; it’s a tasteless white powder. It is the only magnesium type that crosses the blood-brain barrier, and it works wonderfully—the child is much calmer now. I highly recommend it!
8.8
Improved sleep quality
Great supplement! It benefits blood vessels and helps me combat insomnia and constant fatigue. I take it regularly and feel the difference.
9.5
Improved cognitive functions
Excellent magnesium threonate; it works gently thanks to its dosage. I tried several options, and this one suits me perfectly. Threonate eliminates magnesium deficiency at the level "inside the brain", as it is the only form that can penetrate the blood-brain barrier. It dramatically enhances cognitive functions, including learning and memory. In situations of anxiety, it provides real and quick support. I have used threonate as an aid during recovery from trauma, where I faced severe anxiety and panic attacks. Despite the price, I always purchase it. It pairs well with malate and bisglycinate. However, I stress that in critical situations, seeking specialist advice is essential.
8.8
Lowered blood pressure
The quality is excellent, and this magnesium combination is the best as it enters the mitochondria and corrects the imbalance. After using it, my cousin's blood pressure decreased significantly, allowing her to stop taking blood pressure medications. However, she does need to take B6 pills to enhance absorption.
8
Magnesium intake reduces RVO risk
Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis.
We explored whether magnesium intake could influence the risk of retinal vein occlusion (RVO), a leading cause of vision loss. Our analysis involved over 16,000 participants from a national health survey.
We discovered that sufficient magnesium intake was linked to a significant 64% reduced risk of RVO.
This finding was especially relevant for adults under 60, those with hypertension, and individuals without glaucoma. Further studies are needed to confirm magnesium's preventive benefits for RVO.
8
MAGT1 deficiency increases thrombosis risk
MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
We studied how a lack of magnesium transporter 1 (MAGT1) impacts blood clot formation and the risk of stroke. Using various laboratory and animal models, we observed that MAGT1 deficiency leads to enhanced platelet activity and quicker clotting. This deficiency resulted in faster artery blockage and severe brain damage during strokes. Interestingly, restoring magnesium levels or blocking certain channels helped normalize platelet behavior. Overall, we found that MAGT1's function is crucial for vascular health, indicating its deficiency could elevate risks for thrombosis and ischemic stroke.
8
Magnesium scaffolds lower clotting risks
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
8
Bioresorbable stents' advancements noted
Coronary bioresorbable metallic stents: Advancements and future perspectives.
We explored the evolution of bioresorbable metallic stents as alternatives to traditional stents which can lead to complications like thrombosis and inflammation.
While bioresorbable polymeric stents face challenges, materials like zinc and magnesium show promise.
Specifically, magnesium-based stents have demonstrated successful absorption within a year and low rates of complications.
Continuing research will be essential to refine these innovations for better clinical outcomes.
References
Kim J, Kim M, Lee CS, Choi EY. Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis. Nutrients. 2025;17. doi:10.3390/nu17071285
Guo X, Zeng X, He Y, Zhang X, Shi W, et al. An Antibacterial, Antioxidant Adherent Sponge Constructed for Control of Arterial Bleeding Via Gallic Acid-Mediated Robust Assembly of Fibrous Clay in Collagen. ACS Appl Mater Interfaces. 2025;17:16489. doi:10.1021/acsami.4c19209
Müller M, Ludwig L, Englert H, Riedl KA, Müller MC, et al. A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds. Sci Rep. 2024;14:26691. doi:10.1038/s41598-024-77266-0
Zhang J, Chen Z, Rao L, He Y. Coronary bioresorbable metallic stents: Advancements and future perspectives. J Cardiol. 2025;85:69. doi:10.1016/j.jjcc.2024.08.003
Włodarczak A, Rola P, Włodarczak S, Szudrowicz M, Giniewicz K, et al. Two-Year Outcomes for Patients with Non-ST-Elevation Acute Coronary Syndrome Treated with Magmaris and Absorb Bioresorbable Scaffolds in Large-Vessel Lesions. J Pers Med. 2024;14. doi:10.3390/jpm14050540
Galli S, Troiano S, Palloshi A, Rapetto C, Pisano F, et al. Comparison of acute versus stable coronary syndrome in patients treated with the Magmaris scaffold: Two-year results from the Magmaris Multicenter Italian Registry. Cardiovasc Revasc Med. 2023;57:53. doi:10.1016/j.carrev.2023.06.022
Włodarczak A, Rola P, Barycki M, Furtan Ł, Łanocha M, et al. Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort. Diab Vasc Dis Res. 2023;20:14791641231188705. doi:10.1177/14791641231188705
Gotru SK, Mammadova-Bach E, Sogkas G, Schuhmann MK, Schmitt K, et al. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Arterioscler Thromb Vasc Biol. 2023;43:1494. doi:10.1161/ATVBAHA.122.318115
Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. A new resorbable magnesium scaffold for de novo coronary lesions (DREAMS 3): one-year results of the BIOMAG-I first-in-human study. EuroIntervention. 2023;19:e414. doi:10.4244/EIJ-D-23-00326
Wlodarczak A, Montorsi P, Torzewski J, Bennett J, Starmer G, et al. One- and two-year clinical outcomes of treatment with resorbable magnesium scaffolds for coronary artery disease: the prospective, international, multicentre BIOSOLVE-IV registry. EuroIntervention. 2023;19:232. doi:10.4244/EIJ-D-22-01069
Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. Safety and performance of the third-generation drug-eluting resorbable coronary magnesium scaffold system in the treatment of subjects with de novo coronary artery lesions: 6-month results of the prospective, multicenter BIOMAG-I first-in-human study. EClinicalMedicine. 2023;59:101940. doi:10.1016/j.eclinm.2023.101940
Pompei G, Campo G, Ruggiero R, Maffeo D, Sgura F, et al. Long-term outcomes of patients treated with sirolimus-eluting resorbable magnesium scaffolds: Insights from the SHERPA-MAGIC study. Int J Cardiol. 2023;383:1. doi:10.1016/j.ijcard.2023.04.029
Fedele G, Castiglioni S, Maier JAM, Locatelli L. The Effects of Sirolimus and Magnesium on Primary Human Coronary Endothelial Cells: An In Vitro Study. Int J Mol Sci. 2023;24. doi:10.3390/ijms24032930
Tonai K, Katayama S, Koyama K, Sata N, Tomioka Y, et al. Association between hypomagnesemia and coagulopathy in sepsis: a retrospective observational study. BMC Anesthesiol. 2022;22:359. doi:10.1186/s12871-022-01903-2
Seguchi M, Aytekin A, Lenz T, Nicol P, Alvarez-Covarrubias HA, et al. Challenges of the newer generation of resorbable magnesium scaffolds: Lessons from failure mechanisms of the past generation. J Cardiol. 2023;81:179. doi:10.1016/j.jjcc.2022.09.003
Venkatappa MM, Udagani C, Hanumegowda SM, Pramod SN, Venkataramaiah S, et al. Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis. Molecules. 2022;27. doi:10.3390/molecules27165162