Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Read More
9
We explored the connection between dietary vitamin B6 intake and stroke risk, looking at data collected from the National Health and Nutrition Examination Survey (NHANES) over a span of several years. This analysis involved 24,214 participants, with 921 having been diagnosed with stroke, allowing us to evaluate how varying levels of vitamin B6 might influence the likelihood of experiencing a stroke.
Our findings reveal that individuals who consumed higher amounts of vitamin B6 had a significantly lower risk of stroke compared to those with lower intake levels. Specifically, we found that those in the highest quartile of vitamin B6 consumption had an odds ratio of 0.48 for stroke risk when fully adjusted, indicating a clear protective benefit. Additionally, those engaging in moderate-intensity physical activity experienced even more pronounced effects.
We also investigated the relationship between vitamin B6 intake and stroke using advanced modeling techniques which demonstrated a non-linear, L-shaped connection. This suggests that as vitamin B6 intake increases, the risk of stroke decreases—especially after a certain threshold of consumption.
Overall, our study suggests that boosting dietary intake of vitamin B6 might be an effective strategy for reducing stroke risk, underscoring the nutrient's importance in maintaining our health.
Our findings reveal that individuals who consumed higher amounts of vitamin B6 had a significantly lower risk of stroke compared to those with lower intake levels. Specifically, we found that those in the highest quartile of vitamin B6 consumption had an odds ratio of 0.48 for stroke risk when fully adjusted, indicating a clear protective benefit. Additionally, those engaging in moderate-intensity physical activity experienced even more pronounced effects.
We also investigated the relationship between vitamin B6 intake and stroke using advanced modeling techniques which demonstrated a non-linear, L-shaped connection. This suggests that as vitamin B6 intake increases, the risk of stroke decreases—especially after a certain threshold of consumption.
Overall, our study suggests that boosting dietary intake of vitamin B6 might be an effective strategy for reducing stroke risk, underscoring the nutrient's importance in maintaining our health.
Read More
9
We explored the cost-effectiveness of different folic acid supplementation strategies aimed at preventing strokes in hypertensive individuals in China. By examining four policy options, we aimed to find the best approach to support stroke prevention while considering potential complications from undetected vitamin B12 deficiencies.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
Read More
Most Useful Reviews
8.5
Effective B vitamins
83 people found this helpful
This excellent formulation contains three crucial B vitamins. It dissolves under the tongue for quick absorption, aiding in the prevention of heart disease and stroke by lowering homocysteine levels.
Read More
4
Quality of life
12 people found this helpful
Great price and quality. This strong methylfolate product significantly aids my MTHFR mutation, improving my quality of life. I no longer worry as much about the risk of stroke or blood clots, as it has helped me immensely.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.4
- All Researches
9
We explored the connection between dietary vitamin B6 intake and stroke risk, looking at data collected from the National Health and Nutrition Examination Survey (NHANES) over a span of several years. This analysis involved 24,214 participants, with 921 having been diagnosed with stroke, allowing us to evaluate how varying levels of vitamin B6 might influence the likelihood of experiencing a stroke.
Our findings reveal that individuals who consumed higher amounts of vitamin B6 had a significantly lower risk of stroke compared to those with lower intake levels. Specifically, we found that those in the highest quartile of vitamin B6 consumption had an odds ratio of 0.48 for stroke risk when fully adjusted, indicating a clear protective benefit. Additionally, those engaging in moderate-intensity physical activity experienced even more pronounced effects.
We also investigated the relationship between vitamin B6 intake and stroke using advanced modeling techniques which demonstrated a non-linear, L-shaped connection. This suggests that as vitamin B6 intake increases, the risk of stroke decreases—especially after a certain threshold of consumption.
Overall, our study suggests that boosting dietary intake of vitamin B6 might be an effective strategy for reducing stroke risk, underscoring the nutrient's importance in maintaining our health.
Our findings reveal that individuals who consumed higher amounts of vitamin B6 had a significantly lower risk of stroke compared to those with lower intake levels. Specifically, we found that those in the highest quartile of vitamin B6 consumption had an odds ratio of 0.48 for stroke risk when fully adjusted, indicating a clear protective benefit. Additionally, those engaging in moderate-intensity physical activity experienced even more pronounced effects.
We also investigated the relationship between vitamin B6 intake and stroke using advanced modeling techniques which demonstrated a non-linear, L-shaped connection. This suggests that as vitamin B6 intake increases, the risk of stroke decreases—especially after a certain threshold of consumption.
Overall, our study suggests that boosting dietary intake of vitamin B6 might be an effective strategy for reducing stroke risk, underscoring the nutrient's importance in maintaining our health.
Read More
9
We explored the cost-effectiveness of different folic acid supplementation strategies aimed at preventing strokes in hypertensive individuals in China. By examining four policy options, we aimed to find the best approach to support stroke prevention while considering potential complications from undetected vitamin B12 deficiencies.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
Read More
9
We explored the connection between folate levels, homocysteine, and the outcomes of ischemic stroke. In a study involving 3,530 patients, we measured serum folate and homocysteine levels at the time of hospital admission.
Our findings revealed that higher folate levels were linked to a significantly lower risk of death and major disability three months after a stroke. Specifically, patients in the highest quartile of folate had a 29% reduced risk of experiencing adverse outcomes compared to those with the lowest levels.
On the flip side, elevated homocysteine levels seemed to indicate a higher risk; those in the top quartile had a 52% increased chance of facing the primary outcome. After adjusting for various factors, the results still highlighted that while folate may offer protective benefits, some of these effects might be mediated through homocysteine.
In summary, maintaining high levels of folate could be beneficial for stroke patients, potentially reducing their chances of serious complications.
Our findings revealed that higher folate levels were linked to a significantly lower risk of death and major disability three months after a stroke. Specifically, patients in the highest quartile of folate had a 29% reduced risk of experiencing adverse outcomes compared to those with the lowest levels.
On the flip side, elevated homocysteine levels seemed to indicate a higher risk; those in the top quartile had a 52% increased chance of facing the primary outcome. After adjusting for various factors, the results still highlighted that while folate may offer protective benefits, some of these effects might be mediated through homocysteine.
In summary, maintaining high levels of folate could be beneficial for stroke patients, potentially reducing their chances of serious complications.
Read More
9
We explored the impact of folic acid supplementation on stroke prevention through an extensive look at 21 randomized clinical trials from around the world. This analysis involved over 115,000 participants, providing a comprehensive picture of how folate might influence stroke risk.
The findings revealed a noteworthy 10% reduction in stroke risk for those taking folic acid, suggesting that this vitamin plays a beneficial role in safeguarding against strokes. Interestingly, the effectiveness varied depending on whether the participants lived in areas where grains were fortified with folate. We observed a more significant impact in regions without fortified grains, highlighting that the local dietary context matters.
Furthermore, our analysis indicated that individuals without a prior history of stroke or heart issues experienced the most benefits from folic acid. These results emphasize the importance of individualized approaches to stroke prevention, considering both diet and personal health history. Overall, this substantial collection of trials supports the notion that folic acid could be a valuable component in stroke prevention strategies.
The findings revealed a noteworthy 10% reduction in stroke risk for those taking folic acid, suggesting that this vitamin plays a beneficial role in safeguarding against strokes. Interestingly, the effectiveness varied depending on whether the participants lived in areas where grains were fortified with folate. We observed a more significant impact in regions without fortified grains, highlighting that the local dietary context matters.
Furthermore, our analysis indicated that individuals without a prior history of stroke or heart issues experienced the most benefits from folic acid. These results emphasize the importance of individualized approaches to stroke prevention, considering both diet and personal health history. Overall, this substantial collection of trials supports the notion that folic acid could be a valuable component in stroke prevention strategies.
Read More
9
We explored the impact of tetrahydrofolate (THF) on cognitive impairment resulting from intracerebral hemorrhage (ICH), a common type of hemorrhagic stroke. This research is particularly important because ICH can lead to cognitive challenges and significant psychological burdens for patients.
Our findings revealed that administering THF helps restore cognitive function after ICH. By using specially designed Nestin-GFP mice, we observed that THF not only spurs the growth of neural stem cells in the hippocampus but also promotes the creation of new neurons. This enhancement in neurogenesis is crucial for cognitive health.
On a mechanistic level, we discovered that THF reduces elevated levels of the protein PTEN, which is known to inhibit cell growth, while simultaneously increasing the levels of phosphorylated AKT and mTOR—proteins essential for cell survival and growth. Additionally, by conditionally removing PTEN from hippocampal neural stem cells, we noticed a reduction in the negative effects ICH typically has on the proliferation of these cells and on neurogenesis.
Overall, our study sheds light on the potential of THF as a therapeutic option for those recovering from hemorrhagic strokes, providing valuable insights into how we might help improve recovery for affected individuals.
Our findings revealed that administering THF helps restore cognitive function after ICH. By using specially designed Nestin-GFP mice, we observed that THF not only spurs the growth of neural stem cells in the hippocampus but also promotes the creation of new neurons. This enhancement in neurogenesis is crucial for cognitive health.
On a mechanistic level, we discovered that THF reduces elevated levels of the protein PTEN, which is known to inhibit cell growth, while simultaneously increasing the levels of phosphorylated AKT and mTOR—proteins essential for cell survival and growth. Additionally, by conditionally removing PTEN from hippocampal neural stem cells, we noticed a reduction in the negative effects ICH typically has on the proliferation of these cells and on neurogenesis.
Overall, our study sheds light on the potential of THF as a therapeutic option for those recovering from hemorrhagic strokes, providing valuable insights into how we might help improve recovery for affected individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8.5
Effective B vitamins
83 people found this helpful
This excellent formulation contains three crucial B vitamins. It dissolves under the tongue for quick absorption, aiding in the prevention of heart disease and stroke by lowering homocysteine levels.
Read More
4
Quality of life
12 people found this helpful
Great price and quality. This strong methylfolate product significantly aids my MTHFR mutation, improving my quality of life. I no longer worry as much about the risk of stroke or blood clots, as it has helped me immensely.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Zhang M, Zhong J, Peng Y, Hao L, Xiao B. Pyridoxal 5'-phosphate and risk of stroke: triangulation of evidence from a nationally representative cohort and bidirectional Mendelian randomization analysis. EPMA J. 2025;16:95. 10.1007/s13167-024-00392-2
- Dong G, Xu W, Xu L. Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study. Nutrients. 2024;16. 10.3390/nu16172818
- Wang C, Li B, Zhu Q, Zhang Q, Xie Z, et al. Dietary vitamin B6 intake and stroke are negatively associated in adults: A cross-sectional study from the NHANES. Heliyon. 2024;10:e31125. 10.1016/j.heliyon.2024.e31125
- Zhang N, Wu Z, Bai X, Song Y, Li P, et al. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119:821. 10.1016/j.ajcnut.2023.12.021
- Rafay A, Abdul Fatir C, Hiba HT, Jamil M, Talha Awan M. Hyperhomocysteinemia Presenting as Stroke in a Young Individual: A Case Report. Cureus. 2024;16:e52381. 10.7759/cureus.52381
- Li ZC, Huang M, Yao QY, Lin CH, Hong BC, et al. Association between Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia. J Integr Neurosci. 2024;23:3. 10.31083/j.jin2301003
- An X, Du X, Yang B, Zhai N, Cui L. Prognostic Impact of Serum Homocysteine-Lowering Therapy on Patients with Hemorrhagic Stroke and Its Influence on National Institutes of Health Stroke Scale and China Stroke Scale Scores. Altern Ther Health Med. 2024;30:381.
- Zhang P, Xie X, Zhang Y. Associations between homocysteine and B vitamins and stroke: a cross-sectional study. Front Neurol. 2023;14:1184141. 10.3389/fneur.2023.1184141
- Yuan S, Mason AM, Carter P, Burgess S, Larsson SC. Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study. BMC Med. 2021;19:97. 10.1186/s12916-021-01977-8
- Zhang Y, Wang L, Li X, Geng J. Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats. Exp Ther Med. 2021;21:483. 10.3892/etm.2021.9914
- Chen L, Li Q, Fang X, Wang X, Min J, et al. Dietary Intake of Homocysteine Metabolism-Related B-Vitamins and the Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies. Adv Nutr. 2020;11:1510. 10.1093/advances/nmaa061
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. 10.3390/nu17010159
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. 10.1186/s12889-024-21005-7
- Gonçalves-Pereira J, Mergulhão P, Froes F. Medications to Modify Aspiration Risk: Those That Add to Risk and Those That May Reduce Risk. Semin Respir Crit Care Med. 2024;45:694. 10.1055/s-0044-1791827
- Shi M, Zheng J, Liu Y, Mao X, Wu X, et al. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke. J Am Heart Assoc. 2024;13:e036527. 10.1161/JAHA.124.036527
- Yaldiko A, Coonrod S, Marella P, Hurley L, Jadavji NM. Maternal dietary deficiencies in folic acid or choline reduce primary neuron viability after exposure to hypoxia through increased levels of apoptosis. Nutr Neurosci. 2024. 10.1080/1028415X.2024.2398365
- Yang J, Wang J, Li B, Zhang Y. Folic acid for the primary prevention of stroke: a systematic review and meta-analysis. Front Nutr. 2024;11:1288417. 10.3389/fnut.2024.1288417
- Zhou L, Wang J, Wu H, Yu P, He Z, et al. Serum levels of vitamin B12 combined with folate and plasma total homocysteine predict ischemic stroke disease: a retrospective case-control study. Nutr J. 2024;23:76. 10.1186/s12937-024-00977-7
- Moti Wala S, AlEdani EM, Samuel EA, Ahmad K, Manongi NJ, et al. Exploring the Nexus: A Systematic Review on the Interplay of the Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T Genotype, Hyperhomocysteinemia, and Spontaneous Cervical/Vertebral Artery Dissection in Young Adults. Cureus. 2024;16:e60878. 10.7759/cureus.60878
- Zhang N, Zhou Z, Chi X, Fan F, Li S, et al. Folic acid supplementation for stroke prevention: A systematic review and meta-analysis of 21 randomized clinical trials worldwide. Clin Nutr. 2024;43:1706. 10.1016/j.clnu.2024.05.034
- Zhang X, Zhang Q, Zhang Q, Wang H, Yin Y, et al. Tetrahydrofolate Attenuates Cognitive Impairment after Hemorrhagic Stroke by Promoting Hippocampal Neurogenesis via PTEN Signaling. eNeuro. 2024;11. 10.1523/ENEURO.0021-24.2024
- Shi Y, Zhang Z, Wang B, Wang Y, Kong X, et al. Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention. Signal Transduct Target Ther. 2024;9:110. 10.1038/s41392-024-01817-0
- Hu X, Jiang Y. The impact of SLCO1B1 polymorphisms on homocysteine concentrations: evidence for a stronger association in men. Front Nephrol. 2024;4:1465380. 10.3389/fneph.2024.1465380
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. 10.2147/NDT.S480417
- Atam V, Srivastava S, Sharma A, Atam I, Tewari J, et al. Serum Vitamin B12 Levels as a Risk Factor and Prognostic Marker in Patients With Acute Ischemic Stroke at a Tertiary Care Center in Northern India: A Case-Control Study. Cureus. 2024;16:e70473. 10.7759/cureus.70473
- Jung E, Kook HY, Ryu SJ, Ryu HH, Kim HG. The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex. J Nutr. 2024;154:3012. 10.1016/j.tjnut.2024.08.002
- Ge Y, Yang C, Zadeh M, Sprague SM, Lin YD, et al. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice. iScience. 2024;27:109480. 10.1016/j.isci.2024.109480
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. 10.12968/bjcn.2024.29.3.137
- Park EJ. Association between vitamin B12 status and heart rate variability in patients with ischemic stroke. Medicine (Baltimore). 2023;102:e33428. 10.1097/MD.0000000000033428
- Rasyid A, Mesiano T, Kurniawan M, Hidayat R, Eddy Yunus R, et al. Comprehensive Management of Acute Ischemic Stroke in Psoriatic Patient. Case Rep Dermatol Med. 2023;2023:6580971. 10.1155/2023/6580971
