Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Nicomide shows notable acne improvement
We conducted a study to evaluate how effective Nicomide, which includes folic acid, is for treating acne and rosacea. Over eight weeks, 198 patients tracked their progress. Remarkably, 79% reported noticeable improvements after just four weeks, with many seeing over 50% reduction in lesions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
Read More
9
We evaluated the effectiveness of Tracnil™, a blend of myo-inositol, folic acid, and vitamin D3, in treating acne among 33 overweight women with normal hormone levels. This single-arm study monitored acne severity, hirsutism, and menstrual irregularities over eight weeks.
Results revealed significant reductions in acne lesions and improvements in hirsutism and menstrual cycles, all with minimal side effects. Although the subjects had normal hormone levels, Tracnil™ seemed to enhance receptor sensitivity to sex hormones, positioning it as a promising first-line treatment for acne linked to PCOS.
Results revealed significant reductions in acne lesions and improvements in hirsutism and menstrual cycles, all with minimal side effects. Although the subjects had normal hormone levels, Tracnil™ seemed to enhance receptor sensitivity to sex hormones, positioning it as a promising first-line treatment for acne linked to PCOS.
Read More
9
We examined the impact of adding a new dietary supplement, NicAzel, to existing acne treatments in 235 patients with inflammatory acne vulgaris over an 8-week period.
The study showed promising results, with 88% of participants reporting a reduction in inflammatory lesions after using NicAzel. Moreover, 81% felt their complexion improved significantly, and many rated this supplement as effective as previous antibiotic treatments.
However, it's essential to note that while these findings are encouraging, further studies are needed to fully understand its long-term efficacy and safety.
The study showed promising results, with 88% of participants reporting a reduction in inflammatory lesions after using NicAzel. Moreover, 81% felt their complexion improved significantly, and many rated this supplement as effective as previous antibiotic treatments.
However, it's essential to note that while these findings are encouraging, further studies are needed to fully understand its long-term efficacy and safety.
Read More
Most Useful Reviews
9
Decreased acne spots
1 people found this helpful
Very good. Excellent for the skin; since I started using it, I have noticed a decrease in acne spots. Additionally, my hair feels shinier, falls out less, and my hair and nails have grown faster.
Read More
7.5
Reduced facial rashes
I take it as prescribed by my dermatologist. It turns out a low level of folic acid also influences acne. After a month of taking it, I can observe a reduction in rashes on my face.
Read More
7.5
Helpful for acne
I believe folic acid is beneficial for the skin. It works wonders for acne.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
- All Researches
9
We evaluated the effectiveness of Tracnil™, a blend of myo-inositol, folic acid, and vitamin D3, in treating acne among 33 overweight women with normal hormone levels. This single-arm study monitored acne severity, hirsutism, and menstrual irregularities over eight weeks.
Results revealed significant reductions in acne lesions and improvements in hirsutism and menstrual cycles, all with minimal side effects. Although the subjects had normal hormone levels, Tracnil™ seemed to enhance receptor sensitivity to sex hormones, positioning it as a promising first-line treatment for acne linked to PCOS.
Results revealed significant reductions in acne lesions and improvements in hirsutism and menstrual cycles, all with minimal side effects. Although the subjects had normal hormone levels, Tracnil™ seemed to enhance receptor sensitivity to sex hormones, positioning it as a promising first-line treatment for acne linked to PCOS.
Read More
9
We examined the impact of adding a new dietary supplement, NicAzel, to existing acne treatments in 235 patients with inflammatory acne vulgaris over an 8-week period.
The study showed promising results, with 88% of participants reporting a reduction in inflammatory lesions after using NicAzel. Moreover, 81% felt their complexion improved significantly, and many rated this supplement as effective as previous antibiotic treatments.
However, it's essential to note that while these findings are encouraging, further studies are needed to fully understand its long-term efficacy and safety.
The study showed promising results, with 88% of participants reporting a reduction in inflammatory lesions after using NicAzel. Moreover, 81% felt their complexion improved significantly, and many rated this supplement as effective as previous antibiotic treatments.
However, it's essential to note that while these findings are encouraging, further studies are needed to fully understand its long-term efficacy and safety.
Read More
9
Nicomide shows notable acne improvement
We conducted a study to evaluate how effective Nicomide, which includes folic acid, is for treating acne and rosacea. Over eight weeks, 198 patients tracked their progress. Remarkably, 79% reported noticeable improvements after just four weeks, with many seeing over 50% reduction in lesions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
Read More
9
We've discovered that folate supplementation may play a role in managing musculoskeletal pain associated with isotretinoin, a medication commonly used for acne treatment. In our investigation involving six patients suffering from nodulocystic acne, we closely observed their experiences after starting isotretinoin. Each patient reported developing pain in their muscles and joints, a side effect that can significantly affect quality of life.
The patients were treated with daily doses of folic acid and vitamin B12, leading to successful pain relief. This suggests that these supplements could be beneficial in alleviating discomfort without halting the use of isotretinoin itself. It’s important to note that while our findings are promising, extensive trials with larger sample sizes are still necessary to confirm these results.
As we move forward, we encourage our peers to consider offering B12 and folate to patients experiencing musculoskeletal pain from isotretinoin. This could help maintain treatment effectiveness while addressing uncomfortable side effects. Our study sheds light on an important aspect of acne treatment and patient care, urging further investigation into the benefits of these vitamins for overall treatment satisfaction.
The patients were treated with daily doses of folic acid and vitamin B12, leading to successful pain relief. This suggests that these supplements could be beneficial in alleviating discomfort without halting the use of isotretinoin itself. It’s important to note that while our findings are promising, extensive trials with larger sample sizes are still necessary to confirm these results.
As we move forward, we encourage our peers to consider offering B12 and folate to patients experiencing musculoskeletal pain from isotretinoin. This could help maintain treatment effectiveness while addressing uncomfortable side effects. Our study sheds light on an important aspect of acne treatment and patient care, urging further investigation into the benefits of these vitamins for overall treatment satisfaction.
Read More
7
Combination therapy benefits PCOS management
We explored the impact of a combination therapy on women with polycystic ovary syndrome (PCOS), which includes insulin sensitizers, antioxidants, and vitamins. This observational study found that after 12 weeks of treatment, both obese and non-obese participants showed significant improvements in menstrual cycles, acne, and hirsutism.
Additionally, there was a notable reduction in body weight and BMI among obese subjects, though lean participants did not show changes in these measures. Overall, this combination therapy appears to be a safe and effective strategy for managing PCOS symptoms.
Additionally, there was a notable reduction in body weight and BMI among obese subjects, though lean participants did not show changes in these measures. Overall, this combination therapy appears to be a safe and effective strategy for managing PCOS symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Decreased acne spots
1 people found this helpful
Very good. Excellent for the skin; since I started using it, I have noticed a decrease in acne spots. Additionally, my hair feels shinier, falls out less, and my hair and nails have grown faster.
Read More
7.5
Reduced facial rashes
I take it as prescribed by my dermatologist. It turns out a low level of folic acid also influences acne. After a month of taking it, I can observe a reduction in rashes on my face.
Read More
7.5
Helpful for acne
I believe folic acid is beneficial for the skin. It works wonders for acne.
Read More
Frequently Asked Questions
7.5
Reduced facial rashes
I take it as prescribed by my dermatologist. It turns out a low level of folic acid also influences acne. After a month of taking it, I can observe a reduction in rashes on my face.
9
Decreased acne spots
1 people found this helpful
Very good. Excellent for the skin; since I started using it, I have noticed a decrease in acne spots. Additionally, my hair feels shinier, falls out less, and my hair and nails have grown faster.
7.5
Helpful for acne
I believe folic acid is beneficial for the skin. It works wonders for acne.
9
We evaluated the effectiveness of Tracnil™, a blend of myo-inositol, folic acid, and vitamin D3, in treating acne among 33 overweight women with normal hormone levels. This single-arm study monitored acne severity, hirsutism, and menstrual irregularities over eight weeks.
Results revealed significant reductions in acne lesions and improvements in hirsutism and menstrual cycles, all with minimal side effects. Although the subjects had normal hormone levels, Tracnil™ seemed to enhance receptor sensitivity to sex hormones, positioning it as a promising first-line treatment for acne linked to PCOS.
Results revealed significant reductions in acne lesions and improvements in hirsutism and menstrual cycles, all with minimal side effects. Although the subjects had normal hormone levels, Tracnil™ seemed to enhance receptor sensitivity to sex hormones, positioning it as a promising first-line treatment for acne linked to PCOS.
9
Nicomide shows notable acne improvement
We conducted a study to evaluate how effective Nicomide, which includes folic acid, is for treating acne and rosacea. Over eight weeks, 198 patients tracked their progress. Remarkably, 79% reported noticeable improvements after just four weeks, with many seeing over 50% reduction in lesions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
References
- Ramanan EA, Ravi S, Anbu KRR, Michael M. Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study. Dermatol Res Pract. 2020;2020:7019126. doi:10.1155/2020/7019126
- Advani K, Batra M, Tajpuriya S, Gupta R, Saraswat A, et al. Efficacy of combination therapy of inositols, antioxidants and vitamins in obese and non-obese women with polycystic ovary syndrome: an observational study. J Obstet Gynaecol. 2020;40:96. doi:10.1080/01443615.2019.1604644
- Ghiasi M, Mortazavi H, Jafari M. Efficacy of Folic Acid and Vitamin B Replacement Therapies in the Reduction of Adverse Effects of Isotretinoin: A Randomized Controlled Trial. Skinmed. 2018;16:239.
- Tolino E, Skroza N, Mambrin A, Bernardini N, Zuber S, et al. Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment. G Ital Dermatol Venereol. 2018;153:866. doi:10.23736/S0392-0488.18.05710-3
- Shalita AR, Falcon R, Olansky A, Iannotta P, Akhavan A, et al. Inflammatory acne management with a novel prescription dietary supplement. J Drugs Dermatol. 2012;11:1428.
- Niren NM, Torok HM. The Nicomide Improvement in Clinical Outcomes Study (NICOS): results of an 8-week trial. Cutis. 2006;77:17.
- Ahmed SH, El-Kelish AA, Hafeez NA, El-Bakry ST. Influential Factors of Depression in Patients with Moderate and Severe Acne. J Clin Aesthet Dermatol. 2020;13:13.
- Feily A. Successful Treatment of Isotretinoin Induced Musculoskeletal Pain by Vitamin B12 and Folic Acid. Open Access Maced J Med Sci. 2019;7:3726. doi:10.3889/oamjms.2019.799
