Last update
4/18/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Good
Based on 9 Reviews
8.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
7
Folic acid alleviates gastric hypersensitivity
We investigated how folic acid (FA) impacts gastric hypersensitivity caused by prenatal stress. Through a series of experiments involving nerve recordings and molecular analysis, we found that FA significantly alleviated symptoms related to gastric hypersensitivity.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
Read More
4
Methyl donors may increase allergy risk
We examined how late-gestation maternal supplementation with methyl donors impacts allergic sensitivity in offspring from pregnancies with restricted growth (IUGR).
Our study compared allergic responses in three groups of sheep: those from normal pregnancies, those from PR pregnancies without supplementation, and those whose mothers received the supplementation.
Interestingly, while the IUGR pregnancies showed protection against allergies, the methyl donor supplementation did not change this advantage. In fact, it resulted in more upper dermal mast cells but did not alter overall allergic reactions or birth size.
These findings indicate that while IUGR may limit allergy risk, adding methyl donors might potentially increase it instead.
Our study compared allergic responses in three groups of sheep: those from normal pregnancies, those from PR pregnancies without supplementation, and those whose mothers received the supplementation.
Interestingly, while the IUGR pregnancies showed protection against allergies, the methyl donor supplementation did not change this advantage. In fact, it resulted in more upper dermal mast cells but did not alter overall allergic reactions or birth size.
These findings indicate that while IUGR may limit allergy risk, adding methyl donors might potentially increase it instead.
Read More
Most Useful Reviews
10
No side effects noted
4 people found this helpful
The best form of folic acid, as suggested by my paediatrician for my child’s low hemoglobin during HV. I chose this form for myself as it digests better than the usual type. I did not notice any side effects or allergies, and the capsules are small and convenient to take.
Read More
9
No side effects
4 people found this helpful
The quality and ingredients are good. Folic acid is an excellent digestible form; I even give it to children. The taste is fine, and the capsules are small and easy to take. I experienced no allergies or side effects. This is a fantastic supplement for folate deficiency. During my pregnancy, everything was fine and I delivered a healthy baby. I liked the supplement and noticed great results.
Read More
9
No allergies noted
2 people found this helpful
Wonderful! This folic acid in the bioactive form of methylfolate is excellent. The capsules are small and easy to take, with a good dosage of 400 mcg. The manufacturer is reliable, and I experienced no allergies or side effects.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
- All Researches
7
Folic acid alleviates gastric hypersensitivity
We investigated how folic acid (FA) impacts gastric hypersensitivity caused by prenatal stress. Through a series of experiments involving nerve recordings and molecular analysis, we found that FA significantly alleviated symptoms related to gastric hypersensitivity.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
Read More
4
Methyl donors may increase allergy risk
We examined how late-gestation maternal supplementation with methyl donors impacts allergic sensitivity in offspring from pregnancies with restricted growth (IUGR).
Our study compared allergic responses in three groups of sheep: those from normal pregnancies, those from PR pregnancies without supplementation, and those whose mothers received the supplementation.
Interestingly, while the IUGR pregnancies showed protection against allergies, the methyl donor supplementation did not change this advantage. In fact, it resulted in more upper dermal mast cells but did not alter overall allergic reactions or birth size.
These findings indicate that while IUGR may limit allergy risk, adding methyl donors might potentially increase it instead.
Our study compared allergic responses in three groups of sheep: those from normal pregnancies, those from PR pregnancies without supplementation, and those whose mothers received the supplementation.
Interestingly, while the IUGR pregnancies showed protection against allergies, the methyl donor supplementation did not change this advantage. In fact, it resulted in more upper dermal mast cells but did not alter overall allergic reactions or birth size.
These findings indicate that while IUGR may limit allergy risk, adding methyl donors might potentially increase it instead.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
No side effects noted
4 people found this helpful
The best form of folic acid, as suggested by my paediatrician for my child’s low hemoglobin during HV. I chose this form for myself as it digests better than the usual type. I did not notice any side effects or allergies, and the capsules are small and convenient to take.
Read More
9
No side effects
4 people found this helpful
The quality and ingredients are good. Folic acid is an excellent digestible form; I even give it to children. The taste is fine, and the capsules are small and easy to take. I experienced no allergies or side effects. This is a fantastic supplement for folate deficiency. During my pregnancy, everything was fine and I delivered a healthy baby. I liked the supplement and noticed great results.
Read More
9
No allergies noted
2 people found this helpful
Wonderful! This folic acid in the bioactive form of methylfolate is excellent. The capsules are small and easy to take, with a good dosage of 400 mcg. The manufacturer is reliable, and I experienced no allergies or side effects.
Read More
9
Highly recommended
1 people found this helpful
The best form of folic acid to have during pregnancy and lactation. I experienced no allergies.
Read More
9
Easy to tolerate
1 people found this helpful
I find it easy to take, especially after previously experiencing allergies to folic acid.
Read More
Frequently Asked Questions
7.5
Reduction in allergies
1 people found this helpful
I noticed a reduction in my allergies after taking this. Additionally, there was an improvement in my gut motility.
9
No side effects
4 people found this helpful
The quality and ingredients are good. Folic acid is an excellent digestible form; I even give it to children. The taste is fine, and the capsules are small and easy to take. I experienced no allergies or side effects. This is a fantastic supplement for folate deficiency. During my pregnancy, everything was fine and I delivered a healthy baby. I liked the supplement and noticed great results.
10
No reported allergies
The natural digestible form of folic acid taken once daily does not lead to allergies or side effects, which is extremely important when planning for pregnancy and maintaining youth and beauty.
10
Works well
1 people found this helpful
I am usually allergic to folic acid found in pharmacies, but I have no issues with this folate. It works well for me.
10
Improved clarity
For women planning a pregnancy, keeping homocysteine levels below 7 is vital. I had levels around 9 and have a severe allergy to folic acid, so I ordered this. After a month, my levels dropped to 7, indicating effectiveness. Most importantly, I experience no allergies. Taking one capsule daily improved my clarity and cheerfulness, likely enhancing my overall performance. I recommend it highly!
References
- Wang HJ, Zhang FC, Xu TW, Xu YC, Tian YQ, et al. DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult offspring rats with prenatal maternal stress. CNS Neurosci Ther. 2023;29:1678. 10.1111/cns.14131
- Wooldridge AL, Bischof RJ, Liu H, Heinemann GK, Hunter DS, et al. Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR. Am J Physiol Regul Integr Comp Physiol. 2018;314:R22. 10.1152/ajpregu.00549.2016
