' 
![]()
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
USERS' SCORE
Good
Based on 26 Reviews
8.8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
Folate's role in depression treatment
Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses.
High relevance to topic
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Read More
7
Folate biomarkers indicate depression
Serum molecules of the folate-driven one-carbon cycle as indicators of depressive tendencies in the elderly.
Highly relevant to depression study
We explored how important substances in the folate-driven one-carbon cycle might serve as indicators of depression in the elderly. By analyzing serum samples from 95 older adults, we aimed to reveal whether certain folate-related biomarkers could help identify those with depressive tendencies.
We measured levels of key metabolites such as folate, S-adenosylmethionine (SAM), and total bile acids, among others. We categorized participants based on their scores from the Hamilton Depression Rating Scale (HAMD-17), comparing those with low depression levels to those with higher scores.
Our findings showed significant differences in serum folate concentrations and SAM/SAH ratios between groups. We found critical thresholds for serum folate and SAM/SAH ratios that could indicate greater depressive tendencies: a folate level below 15.5 nmol/L and a SAM/SAH ratio below 13.0 were associated with higher depression scores.
Overall, our study suggests that measuring these folate-related biomarkers could be useful in recognizing depressive tendencies in older individuals.
We measured levels of key metabolites such as folate, S-adenosylmethionine (SAM), and total bile acids, among others. We categorized participants based on their scores from the Hamilton Depression Rating Scale (HAMD-17), comparing those with low depression levels to those with higher scores.
Our findings showed significant differences in serum folate concentrations and SAM/SAH ratios between groups. We found critical thresholds for serum folate and SAM/SAH ratios that could indicate greater depressive tendencies: a folate level below 15.5 nmol/L and a SAM/SAH ratio below 13.0 were associated with higher depression scores.
Overall, our study suggests that measuring these folate-related biomarkers could be useful in recognizing depressive tendencies in older individuals.
Read More
7
Depression linked to low folate
Evaluating the association of depressive symptoms on serum folate and erythrocyte folate levels based on the 2017-2020 NHANES database.
Direct association with dietary needs
We explored how different levels of depressive symptoms could influence folate levels in the body, focusing on findings from the NHANES database collected between 2017 and 2020. Our analysis involved nearly 5,000 participants and examined their serum and erythrocyte folate levels in relation to the severity of their depressive symptoms.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Read More
Most Useful Reviews
9.5
Potential depression aid
Methylfolate, or (6S)-5-MTHF, is the most effective form of folate, easily absorbed and critical for human health. It helps control homocysteine levels, supports cell growth, and reduces risks of developmental defects in infants. Methylfolate also positively influences cognitive functions, making it valuable for depression treatment. Studies show it can lower homocysteine levels, which, when elevated, is linked to cardiovascular diseases. It's crucial to choose methylfolate over standard folic acid, which is poorly absorbed and can hinder essential nutrient absorption from food.
Read More
9.5
Supports depression recovery
Jarrow Formulas' Methyl Folate is one of the most active forms of folic acid. It’s crucial for human health but is poorly absorbed in its raw form, requiring transformation by enzymes. A B9 deficiency raises homocysteine levels, damaging cells, particularly in the nervous and cardiovascular systems. Women considering pregnancy should take folate supplements before conception to lower homocysteine levels. Methylfolate helps prevent pregnancy-related health issues and supports men’s health as well.
Read More
8.8
Critical for pregnancy
The active form of vitamin B9 is essential for pregnancy. A deficiency in the mother can lead to severe fetal malformations. It’s crucial to address this deficiency at least three months before conception. B9 absorption affects iron, and deficits can lead to anaemia, resulting in apathy or depression. Men must also consider methylfolate to reduce homocysteine levels, especially smokers. I've felt balanced and noticed significant improvements in my hair health since taking B vitamins.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
8
Folate's role in depression treatment
Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses.
High relevance to topic
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Read More
8
Chlorzoxazone and folate improve mood
A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice.
Folate's role in depression unclear.
We explored how a combination of chlorzoxazone, a medication that activates potassium channels, and folic acid affects anxiety and depression in a mouse model of spinocerebellar ataxia type 3 (SCA3). Specifically, we investigated whether this combination could improve mood and cognitive function in SCA3-84Q mice, which are known to exhibit symptoms linked to cerebellar cognitive affective syndrome.
Our results indicated that both chlorzoxazone and the combination with folic acid positively influenced motor coordination and cerebellar function. However, it was only the combination treatment that significantly alleviated anxiety and depressive symptoms, while also enhancing recognition memory in these mice. This suggests that while chlorzoxazone alone has benefits, the added folic acid plays a crucial role in addressing mood-related issues.
Overall, our findings underline the importance of combining therapies to target both motor and non-motor symptoms in complex conditions like SCA3. This combination approach could be beneficial for developing future treatments that address the full spectrum of the disease's impact on individuals.
Our results indicated that both chlorzoxazone and the combination with folic acid positively influenced motor coordination and cerebellar function. However, it was only the combination treatment that significantly alleviated anxiety and depressive symptoms, while also enhancing recognition memory in these mice. This suggests that while chlorzoxazone alone has benefits, the added folic acid plays a crucial role in addressing mood-related issues.
Overall, our findings underline the importance of combining therapies to target both motor and non-motor symptoms in complex conditions like SCA3. This combination approach could be beneficial for developing future treatments that address the full spectrum of the disease's impact on individuals.
Read More
7
Depression linked to low folate
Evaluating the association of depressive symptoms on serum folate and erythrocyte folate levels based on the 2017-2020 NHANES database.
Direct association with dietary needs
We explored how different levels of depressive symptoms could influence folate levels in the body, focusing on findings from the NHANES database collected between 2017 and 2020. Our analysis involved nearly 5,000 participants and examined their serum and erythrocyte folate levels in relation to the severity of their depressive symptoms.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Read More
7
Methylfolate enhances depression treatment
Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder.
Combination therapy evaluated for depression
We conducted a study aiming to explore how low-dose methylfolate could improve treatment outcomes for patients struggling with depressive disorder when paired with standard antidepressants. In our open-label clinical trial, we involved 44 participants who received one of several evidence-based antidepressant treatments over four weeks.
Those in the experimental group also received 800 µg of methylfolate daily. Throughout the study, we measured improvements in depressive symptoms using the Patient Health Questionnaire-9 at various intervals. This approach allowed us to gauge changes in their scores over time, as well as remission rates and other important factors.
The results indicated that combining methylfolate with antidepressants could be a promising and safe strategy for treating depression. We noticed improvements, suggesting that this combination might help enhance the effectiveness of traditional antidepressants. However, it's essential to remember that as we continued our research, we couldn't isolate the effects of methylfolate alone, making it hard to draw definitive conclusions about its standalone benefits.
Those in the experimental group also received 800 µg of methylfolate daily. Throughout the study, we measured improvements in depressive symptoms using the Patient Health Questionnaire-9 at various intervals. This approach allowed us to gauge changes in their scores over time, as well as remission rates and other important factors.
The results indicated that combining methylfolate with antidepressants could be a promising and safe strategy for treating depression. We noticed improvements, suggesting that this combination might help enhance the effectiveness of traditional antidepressants. However, it's essential to remember that as we continued our research, we couldn't isolate the effects of methylfolate alone, making it hard to draw definitive conclusions about its standalone benefits.
Read More
7
Folate's complex impact on depression
Association of serum total folate and serum vitamin D concentrations with W-shape in depressed older adults with cognitive dysfunction: A cross-sectional observational study.
Moderate relevance; unclear isolated effect
In our investigation, we aimed to understand how serum total folate and vitamin D levels relate to depression in older adults, particularly those experiencing cognitive dysfunction. By analyzing data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2011 to 2014, we examined over 2,000 participants aged 60 and above.
Utilizing recognized assessment tools like the Patient Health Questionnaire for depression and cognitive tests for cognitive function, we looked for associations between nutrient levels and mental health outcomes. Our findings revealed a notable W-shaped relationship, suggesting that both low and high levels of folate might be linked to increased depression symptoms, whereas moderate levels could be beneficial.
This highlights the potential for folic acid supplementation, especially within a particular range, to aid in combating depression in this demographic. However, it’s essential to perform further clinical studies to confirm these insights and understand the nuances behind the role of nutrition in mental health management.
Utilizing recognized assessment tools like the Patient Health Questionnaire for depression and cognitive tests for cognitive function, we looked for associations between nutrient levels and mental health outcomes. Our findings revealed a notable W-shaped relationship, suggesting that both low and high levels of folate might be linked to increased depression symptoms, whereas moderate levels could be beneficial.
This highlights the potential for folic acid supplementation, especially within a particular range, to aid in combating depression in this demographic. However, it’s essential to perform further clinical studies to confirm these insights and understand the nuances behind the role of nutrition in mental health management.
Read More
User Reviews
USERS' SCORE
Good
Based on 26 Reviews
8.8
9.5
Potential depression aid
Methylfolate, or (6S)-5-MTHF, is the most effective form of folate, easily absorbed and critical for human health. It helps control homocysteine levels, supports cell growth, and reduces risks of developmental defects in infants. Methylfolate also positively influences cognitive functions, making it valuable for depression treatment. Studies show it can lower homocysteine levels, which, when elevated, is linked to cardiovascular diseases. It's crucial to choose methylfolate over standard folic acid, which is poorly absorbed and can hinder essential nutrient absorption from food.
Read More
9.5
Supports depression recovery
Jarrow Formulas' Methyl Folate is one of the most active forms of folic acid. It’s crucial for human health but is poorly absorbed in its raw form, requiring transformation by enzymes. A B9 deficiency raises homocysteine levels, damaging cells, particularly in the nervous and cardiovascular systems. Women considering pregnancy should take folate supplements before conception to lower homocysteine levels. Methylfolate helps prevent pregnancy-related health issues and supports men’s health as well.
Read More
9.5
Mood improvement
Methylfolate is essential for producing happiness hormones and improving mood. It's crucial for cell division, growth, and immune function. A deficiency can lead to symptoms like depression, anxiety, and memory issues. I find methylfolate to be one of the best forms for assimilation.
Read More
9.5
Effective against anxiety
I quickly noticed that this methylfolate helped with my anxiety and depression. I felt its positive effects within a couple of weeks.
9.5
Mood regulation
Methylfolate is crucial for producing neurotransmitters like serotonin, dopamine, and norepinephrine, which greatly affect mood regulation and are linked to depression.
