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Infographics 
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
7
We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Read More
9
We explored the potential connection between red blood cell (RBC) folate levels and diabetic nephropathy (DN) in individuals with type 2 diabetes mellitus. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018, we carried out a cross-sectional analysis involving 3,070 adults diagnosed with type 2 diabetes.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
Read More
8
We examined the impact of folate, a water-soluble vitamin, on glycemic control and insulin resistance in individuals with type 2 diabetes. By systematically reviewing various studies, we uncovered that supplementing with folic acid could enhance insulin sensitivity.
Our analysis included a range of systematic reviews and meta-analyses focusing on the effects of different water-soluble vitamins, like B-1, B-3, biotin, B-9 (folate), and vitamin C. The findings highlighted that vitamin C also shows positive outcomes in managing blood sugar levels, but we observed that folic acid stood out in its ability to combat insulin resistance effectively.
Overall, while folic acid supplementation appears promising, we emphasized the need for further high-quality randomized controlled trials. This will help solidify our understanding and ensure that we can rely on folate as an effective treatment option for diabetes management.
Our analysis included a range of systematic reviews and meta-analyses focusing on the effects of different water-soluble vitamins, like B-1, B-3, biotin, B-9 (folate), and vitamin C. The findings highlighted that vitamin C also shows positive outcomes in managing blood sugar levels, but we observed that folic acid stood out in its ability to combat insulin resistance effectively.
Overall, while folic acid supplementation appears promising, we emphasized the need for further high-quality randomized controlled trials. This will help solidify our understanding and ensure that we can rely on folate as an effective treatment option for diabetes management.
Read More
Most Useful Reviews
9
Improves feline health
I purchased methylfolate for my diabetic cat, which developed diabetic neuropathy. After four months on a regimen of methylcobalamin and methylfolate, the improvement was noticeable within a month. I plan to continue this treatment for my cat's ongoing health.
Read More
9
Restores nutrient balance
I take methylfolate because I have been diagnosed with diabetes mellitus. Long-term diabetes disrupts the metabolism of water-soluble vitamins, including B12, B6, and folic acid, which I now supplement. This is an excellent supplement, and I recommend it.
Read More
7.5
Reduces diabetes risk
This helps preserve memory, reduces the risk of Alzheimer's disease, improves sleep, and stabilises blood pressure while maintaining skin and hair health and preventing anaemia. It is effective in lowering the risk of diabetes.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
- All Researches
9
We evaluated the impact of 5-methyltetrahydrofolate (5-MTHF) and an aqueous extract on diabetes by examining their effects in a rat model with induced diabetes. Our findings were based on a combination of in silico docking studies and in vitro assays, which indicated that folates bind effectively with proteins that regulate glucose metabolism.
In our tests, we observed that 5-MTHF demonstrated stronger inhibitory action on alpha-amylase than folic acid, indicating its potential for managing blood sugar levels. When we administered 5-MTHF and the aqueous extract to diabetic Wistar rats, both supplements contributed to significant reductions in fasting blood glucose and improvements in glucose tolerance.
Furthermore, alongside controlling blood sugar, we noted that supplementation helped reduce obesity, address hyperlipidemia, and enhance antioxidant enzyme levels. Remarkably, the higher dosage of 5-MTHF provided better results than the aqueous extract and higher doses of folic acid, suggesting its effectiveness as a treatment option. By incorporating the aqueous extract, we also found an increase in serum folate levels, indicating its role as a folate source enriched with other beneficial phytochemicals.
Overall, we highlighted the promising effects of both the aqueous extract and 5-MTHF, emphasizing their potential as dietary supplements for diabetes management and its associated complications.
In our tests, we observed that 5-MTHF demonstrated stronger inhibitory action on alpha-amylase than folic acid, indicating its potential for managing blood sugar levels. When we administered 5-MTHF and the aqueous extract to diabetic Wistar rats, both supplements contributed to significant reductions in fasting blood glucose and improvements in glucose tolerance.
Furthermore, alongside controlling blood sugar, we noted that supplementation helped reduce obesity, address hyperlipidemia, and enhance antioxidant enzyme levels. Remarkably, the higher dosage of 5-MTHF provided better results than the aqueous extract and higher doses of folic acid, suggesting its effectiveness as a treatment option. By incorporating the aqueous extract, we also found an increase in serum folate levels, indicating its role as a folate source enriched with other beneficial phytochemicals.
Overall, we highlighted the promising effects of both the aqueous extract and 5-MTHF, emphasizing their potential as dietary supplements for diabetes management and its associated complications.
Read More
9
We explored the potential connection between red blood cell (RBC) folate levels and diabetic nephropathy (DN) in individuals with type 2 diabetes mellitus. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018, we carried out a cross-sectional analysis involving 3,070 adults diagnosed with type 2 diabetes.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
Read More
8
We examined the impact of folate, a water-soluble vitamin, on glycemic control and insulin resistance in individuals with type 2 diabetes. By systematically reviewing various studies, we uncovered that supplementing with folic acid could enhance insulin sensitivity.
Our analysis included a range of systematic reviews and meta-analyses focusing on the effects of different water-soluble vitamins, like B-1, B-3, biotin, B-9 (folate), and vitamin C. The findings highlighted that vitamin C also shows positive outcomes in managing blood sugar levels, but we observed that folic acid stood out in its ability to combat insulin resistance effectively.
Overall, while folic acid supplementation appears promising, we emphasized the need for further high-quality randomized controlled trials. This will help solidify our understanding and ensure that we can rely on folate as an effective treatment option for diabetes management.
Our analysis included a range of systematic reviews and meta-analyses focusing on the effects of different water-soluble vitamins, like B-1, B-3, biotin, B-9 (folate), and vitamin C. The findings highlighted that vitamin C also shows positive outcomes in managing blood sugar levels, but we observed that folic acid stood out in its ability to combat insulin resistance effectively.
Overall, while folic acid supplementation appears promising, we emphasized the need for further high-quality randomized controlled trials. This will help solidify our understanding and ensure that we can rely on folate as an effective treatment option for diabetes management.
Read More
8
We investigated the potential benefits of folate treatment in connection with diabetes, particularly focusing on how it can influence cognitive function. Our research involved comparing the fatty acid levels and homocysteine levels in diabetic individuals both with and without cognitive dysfunction.
We found that low levels of n-3 polyunsaturated fatty acids (PUFAs), alongside high serum homocysteine, significantly raised the risk of cognitive impairment in those with diabetes. Treating mice with a mix of fish oil, folate, and vitamin B led to notable improvements in their cognitive function and brain structure.
Folic acid, along with vitamin B, aids in transporting beneficial compounds like docosahexaenoic acid (DHA) to the brain. This transport is particularly crucial as it helps lower harmful homocysteine levels, protecting the brain from neuronal damage. Moreover, these vitamins contribute to maintaining healthy DNA functioning in diabetic brains by enhancing active DNA demethylation processes.
Overall, our study highlights the promising role that combining fish oil, folate, and B vitamins can play in preventing cognitive decline associated with diabetes. It's a significant step in understanding how these nutrients can work together to support brain health in those affected by diabetes.
We found that low levels of n-3 polyunsaturated fatty acids (PUFAs), alongside high serum homocysteine, significantly raised the risk of cognitive impairment in those with diabetes. Treating mice with a mix of fish oil, folate, and vitamin B led to notable improvements in their cognitive function and brain structure.
Folic acid, along with vitamin B, aids in transporting beneficial compounds like docosahexaenoic acid (DHA) to the brain. This transport is particularly crucial as it helps lower harmful homocysteine levels, protecting the brain from neuronal damage. Moreover, these vitamins contribute to maintaining healthy DNA functioning in diabetic brains by enhancing active DNA demethylation processes.
Overall, our study highlights the promising role that combining fish oil, folate, and B vitamins can play in preventing cognitive decline associated with diabetes. It's a significant step in understanding how these nutrients can work together to support brain health in those affected by diabetes.
Read More
7
We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves feline health
I purchased methylfolate for my diabetic cat, which developed diabetic neuropathy. After four months on a regimen of methylcobalamin and methylfolate, the improvement was noticeable within a month. I plan to continue this treatment for my cat's ongoing health.
Read More
9
Restores nutrient balance
I take methylfolate because I have been diagnosed with diabetes mellitus. Long-term diabetes disrupts the metabolism of water-soluble vitamins, including B12, B6, and folic acid, which I now supplement. This is an excellent supplement, and I recommend it.
Read More
7.5
Reduces diabetes risk
This helps preserve memory, reduces the risk of Alzheimer's disease, improves sleep, and stabilises blood pressure while maintaining skin and hair health and preventing anaemia. It is effective in lowering the risk of diabetes.
Read More
7.5
Supports overall health
Methylfolate, a B vitamin (B9), addresses folic acid deficiency. It aids in pregnancy-related anaemia, unbalanced nutrition, and supports the immune system and heart health. After 40, sufficient folic acid helps memory, stabilises blood pressure, positively affects the nervous system, and reduces diabetes risk while maintaining skin and hair health.
Read More
Frequently Asked Questions
9
Improves feline health
I purchased methylfolate for my diabetic cat, which developed diabetic neuropathy. After four months on a regimen of methylcobalamin and methylfolate, the improvement was noticeable within a month. I plan to continue this treatment for my cat's ongoing health.
9
Restores nutrient balance
I take methylfolate because I have been diagnosed with diabetes mellitus. Long-term diabetes disrupts the metabolism of water-soluble vitamins, including B12, B6, and folic acid, which I now supplement. This is an excellent supplement, and I recommend it.
7.5
Reduces diabetes risk
This helps preserve memory, reduces the risk of Alzheimer's disease, improves sleep, and stabilises blood pressure while maintaining skin and hair health and preventing anaemia. It is effective in lowering the risk of diabetes.
7.5
Supports overall health
Methylfolate, a B vitamin (B9), addresses folic acid deficiency. It aids in pregnancy-related anaemia, unbalanced nutrition, and supports the immune system and heart health. After 40, sufficient folic acid helps memory, stabilises blood pressure, positively affects the nervous system, and reduces diabetes risk while maintaining skin and hair health.
8
We examined the impact of folate, a water-soluble vitamin, on glycemic control and insulin resistance in individuals with type 2 diabetes. By systematically reviewing various studies, we uncovered that supplementing with folic acid could enhance insulin sensitivity.
Our analysis included a range of systematic reviews and meta-analyses focusing on the effects of different water-soluble vitamins, like B-1, B-3, biotin, B-9 (folate), and vitamin C. The findings highlighted that vitamin C also shows positive outcomes in managing blood sugar levels, but we observed that folic acid stood out in its ability to combat insulin resistance effectively.
Overall, while folic acid supplementation appears promising, we emphasized the need for further high-quality randomized controlled trials. This will help solidify our understanding and ensure that we can rely on folate as an effective treatment option for diabetes management.
Our analysis included a range of systematic reviews and meta-analyses focusing on the effects of different water-soluble vitamins, like B-1, B-3, biotin, B-9 (folate), and vitamin C. The findings highlighted that vitamin C also shows positive outcomes in managing blood sugar levels, but we observed that folic acid stood out in its ability to combat insulin resistance effectively.
Overall, while folic acid supplementation appears promising, we emphasized the need for further high-quality randomized controlled trials. This will help solidify our understanding and ensure that we can rely on folate as an effective treatment option for diabetes management.
9
We evaluated the impact of 5-methyltetrahydrofolate (5-MTHF) and an aqueous extract on diabetes by examining their effects in a rat model with induced diabetes. Our findings were based on a combination of in silico docking studies and in vitro assays, which indicated that folates bind effectively with proteins that regulate glucose metabolism.
In our tests, we observed that 5-MTHF demonstrated stronger inhibitory action on alpha-amylase than folic acid, indicating its potential for managing blood sugar levels. When we administered 5-MTHF and the aqueous extract to diabetic Wistar rats, both supplements contributed to significant reductions in fasting blood glucose and improvements in glucose tolerance.
Furthermore, alongside controlling blood sugar, we noted that supplementation helped reduce obesity, address hyperlipidemia, and enhance antioxidant enzyme levels. Remarkably, the higher dosage of 5-MTHF provided better results than the aqueous extract and higher doses of folic acid, suggesting its effectiveness as a treatment option. By incorporating the aqueous extract, we also found an increase in serum folate levels, indicating its role as a folate source enriched with other beneficial phytochemicals.
Overall, we highlighted the promising effects of both the aqueous extract and 5-MTHF, emphasizing their potential as dietary supplements for diabetes management and its associated complications.
In our tests, we observed that 5-MTHF demonstrated stronger inhibitory action on alpha-amylase than folic acid, indicating its potential for managing blood sugar levels. When we administered 5-MTHF and the aqueous extract to diabetic Wistar rats, both supplements contributed to significant reductions in fasting blood glucose and improvements in glucose tolerance.
Furthermore, alongside controlling blood sugar, we noted that supplementation helped reduce obesity, address hyperlipidemia, and enhance antioxidant enzyme levels. Remarkably, the higher dosage of 5-MTHF provided better results than the aqueous extract and higher doses of folic acid, suggesting its effectiveness as a treatment option. By incorporating the aqueous extract, we also found an increase in serum folate levels, indicating its role as a folate source enriched with other beneficial phytochemicals.
Overall, we highlighted the promising effects of both the aqueous extract and 5-MTHF, emphasizing their potential as dietary supplements for diabetes management and its associated complications.
9
We explored the potential connection between red blood cell (RBC) folate levels and diabetic nephropathy (DN) in individuals with type 2 diabetes mellitus. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018, we carried out a cross-sectional analysis involving 3,070 adults diagnosed with type 2 diabetes.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
References
- Chai Y, Chen C, Yin X, Wang X, Yu W, et al. Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses. Asia Pac J Clin Nutr. 2025;34:118. 10.6133/apjcn.202502_34(1).0012
- Chen L, Liu R, He X, Fang J, Zhou L, et al. Synergistically effects of n-3 PUFA and B vitamins prevent diabetic cognitive dysfunction through promoting TET2-mediated active DNA demethylation. Clin Nutr. 2025;45:111. 10.1016/j.clnu.2025.01.002
- Pathikkal A, Bhaskar TK, Prasanthan A, Haritha PK, Puthusseri B, et al. 5-Methyltetrahydrofolate and aqueous extract of () ameliorate diabetes and associated complications in STZ-induced diabetic rats. 3 Biotech. 2025;15:15. 10.1007/s13205-024-04170-9
- Liang Y, Ding L, Tao M, Zhu Y. The association of metabolic profile of folate with diabetic kidney disease: evidence from 2011-2020 cycles of the NHANES. Ren Fail. 2024;46:2420830. 10.1080/0886022X.2024.2420830
- Yu P, Ji Y, Wang H, Liu K. Association between RBC folate and diabetic nephropathy in Type2 diabetes mellitus patients: a cross-sectional study. Sci Rep. 2024;14:24692. 10.1038/s41598-024-76456-0
