Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 10 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Folic Acid Improves Cognitive Function
We explored how folic acid (FA) affects cognitive decline linked to hypothyroidism in a rat model. Over seven weeks, rats received PTU to induce hypothyroidism and were given varying doses of FA.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
Read More
8
We examined the impact of folic acid treatment on kidney function in rats with induced hypothyroidism. The study monitored biochemical and oxidative stress markers over six weeks. Results showed that hypothyroidism negatively affected kidney metrics, including urea and creatinine levels, and increased oxidative stress indicators.
Importantly, treatment with folic acid showed promise in mitigating these adverse effects. Histological analyses supported the notion that folic acid can enhance kidney health in this hypothyroid model, showcasing its potential therapeutic role.
Importantly, treatment with folic acid showed promise in mitigating these adverse effects. Histological analyses supported the notion that folic acid can enhance kidney health in this hypothyroid model, showcasing its potential therapeutic role.
Read More
7
We investigated how folic acid might help manage hypothyroidism by examining its effects on hypothalamic conditions in rats.
Our study involved 50 albino rats divided into five groups, including controls and those treated for hypothyroidism using a medication for six weeks.
Results showed that hypothyroid rats experienced significant biochemical changes and oxidative stress. However, our findings also indicated that while folic acid showed potential in improving these conditions, it was most effective when given after the rats returned to a normal thyroid state. Overall, the benefits of folic acid treatment were limited when administered during hypothyroidism.
Our study involved 50 albino rats divided into five groups, including controls and those treated for hypothyroidism using a medication for six weeks.
Results showed that hypothyroid rats experienced significant biochemical changes and oxidative stress. However, our findings also indicated that while folic acid showed potential in improving these conditions, it was most effective when given after the rats returned to a normal thyroid state. Overall, the benefits of folic acid treatment were limited when administered during hypothyroidism.
Read More
Most Useful Reviews
9
Highly absorbable
Highly absorbable and well tolerated, I am taking this supplement following a vitamin B9 deficiency linked to my hypothyroidism. Methylfolate is the active form of folic acid, directly assimilated by the body and crossing the blood-brain barrier. This product is of good quality and easy to take.
Read More
9
Essential for women
Folic acid is vital for women's health, especially for those planning a pregnancy. Its standard form is poorly absorbed by many, hence methylfolate is preferred. Doctors increasingly recognise this. I find this vitamin form effective, with excellent dosage and convenient capsules. I recommend it to all women.
Read More
9
Felt much better
I am suffering from hypothyroidism, and this supplement worked for me; I feel much better.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
- All Researches
9
Folic Acid Improves Cognitive Function
We explored how folic acid (FA) affects cognitive decline linked to hypothyroidism in a rat model. Over seven weeks, rats received PTU to induce hypothyroidism and were given varying doses of FA.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
Read More
9
We explored the impact of folic acid on heart changes in rats with hypothyroidism. The study included five groups of male albino rats, with some receiving folic acid while others did not. We found that hypothyroidism caused clear structural heart issues. However, folic acid seemed to help improve muscle fiber arrangement and overall heart architecture, especially when given as a post-treatment after restoring normal thyroid function. While folic acid showed promise, more research is needed to fully understand its benefits in humans.
Read More
9
We evaluated how folic acid impacts testicular function in hypothyroid rats. In this study, we observed that hypothyroidism led to significant disruptions in biochemical markers and sperm production.
Importantly, folic acid seemed to enhance spermatogenesis more effectively when administered after normal thyroid hormone levels were restored, suggesting a promising role for folic acid in supporting testicular health.
While our findings are promising, confirming these results in humans could pave the way for using folic acid as a complementary treatment alongside traditional therapies for hypothyroidism.
Importantly, folic acid seemed to enhance spermatogenesis more effectively when administered after normal thyroid hormone levels were restored, suggesting a promising role for folic acid in supporting testicular health.
While our findings are promising, confirming these results in humans could pave the way for using folic acid as a complementary treatment alongside traditional therapies for hypothyroidism.
Read More
8
We examined how B vitamins—especially folic acid—affect homocysteine levels in hypothyroid rats. By modeling thyroid dysfunction, we noticed that hypothyroidism led to reduced enzyme activity that helps process homocysteine, raising its levels in the blood.
Remarkably, when we administered folic acid along with other B vitamins, we observed a significant drop in those homocysteine levels. This suggests that these vitamins may play a vital role in preventing endothelial dysfunction associated with hypothyroidism. However, we should remember this study was performed in rats, and further research is needed in humans.
Remarkably, when we administered folic acid along with other B vitamins, we observed a significant drop in those homocysteine levels. This suggests that these vitamins may play a vital role in preventing endothelial dysfunction associated with hypothyroidism. However, we should remember this study was performed in rats, and further research is needed in humans.
Read More
8
In our double-blinded clinical trial, we evaluated how folic acid affects serum homocysteine levels in patients with hypothyroidism when taken alongside levothyroxine.
We followed sixty participants for two months, dividing them into two groups—one receiving just levothyroxine, and the other, levothyroxine plus folic acid.
Results were promising; while both treatments lowered homocysteine levels, the group taking folic acid experienced a more significant drop. This suggests that combining folic acid with levothyroxine could enhance treatment outcomes for hypothyroidism.
We followed sixty participants for two months, dividing them into two groups—one receiving just levothyroxine, and the other, levothyroxine plus folic acid.
Results were promising; while both treatments lowered homocysteine levels, the group taking folic acid experienced a more significant drop. This suggests that combining folic acid with levothyroxine could enhance treatment outcomes for hypothyroidism.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Highly absorbable
Highly absorbable and well tolerated, I am taking this supplement following a vitamin B9 deficiency linked to my hypothyroidism. Methylfolate is the active form of folic acid, directly assimilated by the body and crossing the blood-brain barrier. This product is of good quality and easy to take.
Read More
9
Essential for women
Folic acid is vital for women's health, especially for those planning a pregnancy. Its standard form is poorly absorbed by many, hence methylfolate is preferred. Doctors increasingly recognise this. I find this vitamin form effective, with excellent dosage and convenient capsules. I recommend it to all women.
Read More
9
Felt much better
I am suffering from hypothyroidism, and this supplement worked for me; I feel much better.
Read More
9
Good brand trust
I really like Jarrow Formulas. My endocrinologist prescribed it for hypothyroidism. The small capsules are easy to swallow and help reduce homocysteine levels.
Read More
7.5
Satisfactory quality
I frequently order this supplement for my hypothyroidism and am satisfied. The quality is good, the capsules are small, and the price is reasonable. This is folic acid in the form of methylfolate, which shows results. The brand’s packaging has improved, making it more convenient.
Read More
Frequently Asked Questions
9
Felt much better
I am suffering from hypothyroidism, and this supplement worked for me; I feel much better.
7.5
Observed improvement
This is the best form of folate, necessary for all women. I take it due to hypothyroidism and have noticed an improvement!
7.5
Satisfactory quality
I frequently order this supplement for my hypothyroidism and am satisfied. The quality is good, the capsules are small, and the price is reasonable. This is folic acid in the form of methylfolate, which shows results. The brand’s packaging has improved, making it more convenient.
9
Good brand trust
I really like Jarrow Formulas. My endocrinologist prescribed it for hypothyroidism. The small capsules are easy to swallow and help reduce homocysteine levels.
7.5
Helps with symptoms
I took this along with other B vitamins, and it helps with my hypothyroidism.
7.5
Restoration aid
2 people found this helpful
Recommended for restoring the intestines and thyroid gland, particularly with AIT and hypothyroidism. I take it along with other B vitamins.
9
Folic Acid Improves Cognitive Function
We explored how folic acid (FA) affects cognitive decline linked to hypothyroidism in a rat model. Over seven weeks, rats received PTU to induce hypothyroidism and were given varying doses of FA.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
8
In our double-blinded clinical trial, we evaluated how folic acid affects serum homocysteine levels in patients with hypothyroidism when taken alongside levothyroxine.
We followed sixty participants for two months, dividing them into two groups—one receiving just levothyroxine, and the other, levothyroxine plus folic acid.
Results were promising; while both treatments lowered homocysteine levels, the group taking folic acid experienced a more significant drop. This suggests that combining folic acid with levothyroxine could enhance treatment outcomes for hypothyroidism.
We followed sixty participants for two months, dividing them into two groups—one receiving just levothyroxine, and the other, levothyroxine plus folic acid.
Results were promising; while both treatments lowered homocysteine levels, the group taking folic acid experienced a more significant drop. This suggests that combining folic acid with levothyroxine could enhance treatment outcomes for hypothyroidism.
8
We examined the impact of folic acid treatment on kidney function in rats with induced hypothyroidism. The study monitored biochemical and oxidative stress markers over six weeks. Results showed that hypothyroidism negatively affected kidney metrics, including urea and creatinine levels, and increased oxidative stress indicators.
Importantly, treatment with folic acid showed promise in mitigating these adverse effects. Histological analyses supported the notion that folic acid can enhance kidney health in this hypothyroid model, showcasing its potential therapeutic role.
Importantly, treatment with folic acid showed promise in mitigating these adverse effects. Histological analyses supported the notion that folic acid can enhance kidney health in this hypothyroid model, showcasing its potential therapeutic role.
7
We explored the impact of folic acid on hypothyroidism, particularly its effects on the testes of male rats. Our study involved 50 rats divided into five groups, including controls, hypothyroid subjects, and those treated with folic acid.
We observed that hypothyroidism led to significant changes in testicular structure and reduced sperm count. Importantly, folic acid showed promise in alleviating some of these testicular changes, especially when combined with thyroid hormone treatment.
Overall, while folic acid can help restore some aspects of reproductive health in hypothyroid conditions, we recognized that it works best as an additional therapy rather than a standalone solution.
We observed that hypothyroidism led to significant changes in testicular structure and reduced sperm count. Importantly, folic acid showed promise in alleviating some of these testicular changes, especially when combined with thyroid hormone treatment.
Overall, while folic acid can help restore some aspects of reproductive health in hypothyroid conditions, we recognized that it works best as an additional therapy rather than a standalone solution.
References
- Kakhki S, Goodarzi M, Abbaszade-Cheragheali A, Rajabi M, Masoumipour AH, et al. Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring. Int J Dev Neurosci. 2023;83:615. 10.1002/jdn.10289
- Amirahmadi S, Hosseini M, Ahmadabady S, Akbarian M, Abrari K, et al. Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats. Metab Brain Dis. 2021;36:2393. 10.1007/s11011-021-00815-3
- Nechyporuk V, Korda M, Pentiuk L, Dmytrenko I, Bulko I. The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats. Pol Merkur Lekarski. 2020;48:55.
- Ziaee A, Hajibagher Tehrani N, Hosseinkhani Z, Kazemifar A, Javadi A, et al. Effects of folic acid plus levothyroxine on serum homocysteine level in hypothyroidism. Caspian J Intern Med. 2012;3:417.
- Massoud AA, El-Atrash A, Tousson E, Ibrahim W, Abou-Harga H. Light and ultrastructural study in the propylthiouracil-induced hypothyroid rat heart ventricles and the ameliorating role of folic acid. Toxicol Ind Health. 2012;28:262. 10.1177/0748233711410915
- Salama AF, Tousson E, Ibrahim W, Hussein WM. Biochemical and histopathological studies of the PTU-induced hypothyroid rat kidney with reference to the ameliorating role of folic acid. Toxicol Ind Health. 2013;29:600. 10.1177/0748233711432577
- Tousson E, Ali EM, Ibrahim W, Mansour MA. Treatment with folic acid ameliorated the histopathological alterations caused by propylthiouracil-induced hypothyroid rat testes. Toxicol Ind Health. 2012;28:566. 10.1177/0748233711420469
- Ibrahim W, Tousson E, El-Masry T, Arafa N, Akela M. The effect of folic acid as an antioxidant on the hypothalamic monoamines in experimentally induced hypothyroid rat. Toxicol Ind Health. 2012;28:253. 10.1177/0748233711410913
- Ibrahim W, Tousson E, Ali EM, Mansour MA. Folic acid alleviates oxidative stress and hyperhomocysteinemia involved in testicular dysfunction of hypothyroid rats. Gen Comp Endocrinol. 2011;174:143. 10.1016/j.ygcen.2011.08.012
- Tousson E, Ibrahim W, Arafa N, Akela MA. Monoamine concentrations changes in the PTU-induced hypothyroid rat brain and the ameliorating role of folic acid. Hum Exp Toxicol. 2012;31:282. 10.1177/0960327111405863
