' 
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Folic acid combats insomnia effects
Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP).
Highly relevant to insomnia
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Read More
8
Folic acid may improve sleep
The association between serum total folic acid concentration and severe difficulty falling asleep in US adults: NHANES 2005-2008.
Significant correlation with insomnia
We explored how serum total folic acid levels might influence the experience of severe difficulty falling asleep among adults in the United States. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) across two cycles, we divided participants into two groups: those with severe difficulty falling asleep and those without.
Our findings revealed that higher levels of folic acid in the blood were associated with lower odds of experiencing severe difficulty in falling asleep. Specifically, those in the highest quartile of folic acid levels had significantly reduced odds of insomnia symptoms. This trend was more pronounced among specific subgroups, such as males, smokers, and people without diabetes, suggesting that they may benefit the most from adequate folate levels.
Overall, these results indicate that folic acid might play a protective role against insomnia. We suggest that folic acid supplementation could be a valuable option for preventing and potentially treating sleep difficulties.
Our findings revealed that higher levels of folic acid in the blood were associated with lower odds of experiencing severe difficulty in falling asleep. Specifically, those in the highest quartile of folic acid levels had significantly reduced odds of insomnia symptoms. This trend was more pronounced among specific subgroups, such as males, smokers, and people without diabetes, suggesting that they may benefit the most from adequate folate levels.
Overall, these results indicate that folic acid might play a protective role against insomnia. We suggest that folic acid supplementation could be a valuable option for preventing and potentially treating sleep difficulties.
Read More
7
Folate's link to sleep disturbances
Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys.
Moderate relevance to sleep research
We delved into how folate could potentially influence insomnia, focusing on data from the National Health and Nutrition Examination Surveys. This research highlighted the relationship between various nutritional biomarkers and sleep disturbances, particularly in adults aged 20 to 85.
Among the findings, we observed that folate was independently linked to instances of sleep disturbance. This suggests that higher levels of folate in the serum could be associated with reduced sleep disruptions. However, we didn't find conclusive evidence that increasing folate directly translates to improved sleep quality or duration.
It’s essential to keep in mind that while our findings are noteworthy, they indicate a correlation rather than a guaranteed causative effect. This means more research is needed to thoroughly explore how folate influences sleep patterns and whether it might be beneficial in treating insomnia effectively.
Among the findings, we observed that folate was independently linked to instances of sleep disturbance. This suggests that higher levels of folate in the serum could be associated with reduced sleep disruptions. However, we didn't find conclusive evidence that increasing folate directly translates to improved sleep quality or duration.
It’s essential to keep in mind that while our findings are noteworthy, they indicate a correlation rather than a guaranteed causative effect. This means more research is needed to thoroughly explore how folate influences sleep patterns and whether it might be beneficial in treating insomnia effectively.
Read More
Most Useful Reviews
9.5
Improved sleep quality
My doctor recommended 5-MTHF due to high homocysteine levels that link to inflammation and insomnia. After just three days of taking it, I was sleeping through the night.
Read More
8.8
Less insomnia
Very good. These are tiny capsules that I take alongside methylated B12. After about six weeks, I have great results – less insomnia, reduced fatigue, and clearer thinking.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
- All Researches
9
Folic acid combats insomnia effects
Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP).
Highly relevant to insomnia
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Read More
8
Folic acid may improve sleep
The association between serum total folic acid concentration and severe difficulty falling asleep in US adults: NHANES 2005-2008.
Significant correlation with insomnia
We explored how serum total folic acid levels might influence the experience of severe difficulty falling asleep among adults in the United States. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) across two cycles, we divided participants into two groups: those with severe difficulty falling asleep and those without.
Our findings revealed that higher levels of folic acid in the blood were associated with lower odds of experiencing severe difficulty in falling asleep. Specifically, those in the highest quartile of folic acid levels had significantly reduced odds of insomnia symptoms. This trend was more pronounced among specific subgroups, such as males, smokers, and people without diabetes, suggesting that they may benefit the most from adequate folate levels.
Overall, these results indicate that folic acid might play a protective role against insomnia. We suggest that folic acid supplementation could be a valuable option for preventing and potentially treating sleep difficulties.
Our findings revealed that higher levels of folic acid in the blood were associated with lower odds of experiencing severe difficulty in falling asleep. Specifically, those in the highest quartile of folic acid levels had significantly reduced odds of insomnia symptoms. This trend was more pronounced among specific subgroups, such as males, smokers, and people without diabetes, suggesting that they may benefit the most from adequate folate levels.
Overall, these results indicate that folic acid might play a protective role against insomnia. We suggest that folic acid supplementation could be a valuable option for preventing and potentially treating sleep difficulties.
Read More
7
Folate's link to sleep disturbances
Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys.
Moderate relevance to sleep research
We delved into how folate could potentially influence insomnia, focusing on data from the National Health and Nutrition Examination Surveys. This research highlighted the relationship between various nutritional biomarkers and sleep disturbances, particularly in adults aged 20 to 85.
Among the findings, we observed that folate was independently linked to instances of sleep disturbance. This suggests that higher levels of folate in the serum could be associated with reduced sleep disruptions. However, we didn't find conclusive evidence that increasing folate directly translates to improved sleep quality or duration.
It’s essential to keep in mind that while our findings are noteworthy, they indicate a correlation rather than a guaranteed causative effect. This means more research is needed to thoroughly explore how folate influences sleep patterns and whether it might be beneficial in treating insomnia effectively.
Among the findings, we observed that folate was independently linked to instances of sleep disturbance. This suggests that higher levels of folate in the serum could be associated with reduced sleep disruptions. However, we didn't find conclusive evidence that increasing folate directly translates to improved sleep quality or duration.
It’s essential to keep in mind that while our findings are noteworthy, they indicate a correlation rather than a guaranteed causative effect. This means more research is needed to thoroughly explore how folate influences sleep patterns and whether it might be beneficial in treating insomnia effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved sleep quality
My doctor recommended 5-MTHF due to high homocysteine levels that link to inflammation and insomnia. After just three days of taking it, I was sleeping through the night.
8.8
Less insomnia
Very good. These are tiny capsules that I take alongside methylated B12. After about six weeks, I have great results – less insomnia, reduced fatigue, and clearer thinking.
