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SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6
USERS' SCORE
Good
Based on 16 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
7
Folic acid positively affects sexual health
Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial.
Highly relevant to folate efficacy
We aimed to understand how folic acid might influence sexual function in postmenopausal women, a group that often experiences sexual dysfunction. For this investigation, we conducted a solid triple-blind randomized controlled trial in Tehran, Iran, involving 100 participants recruited from health centers. Each woman in the study received either 5 mg of folic acid or a placebo daily for eight weeks, always on an empty stomach.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
Read More
4
Folic acid shows no significant benefits
Folic acid supplementation in postmenopausal women with hot flushes: phase III randomised double-blind placebo-controlled trial.
Direct evaluation of folic acid
We conducted a phase III double-blind, placebo-controlled trial to assess the effects of folic acid supplementation on hot flushes in postmenopausal women. This study, which took place across nine hospitals in England, involved 164 women who reported experiencing at least 50 hot flushes each week. Participants were randomly assigned to take either a daily 5 mg folic acid tablet or a placebo for 12 weeks.
Throughout this period, we asked participants to document the frequency and severity of their hot flushes using a Sloan Diary, along with answering questions from validated quality of life scales at regular intervals. When we analyzed the data, we found that while women taking folic acid experienced a mean reduction in their Hot Flush Score, this decrease was not statistically significant compared to those on placebo.
Specifically, the difference in improvement between the folic acid group and the placebo group was marginal, indicating no clear advantage of folic acid in alleviating hot flushes over the study duration. However, some enhancements were noted in emotional and overall quality of life scores among the folic acid group at week 8, suggesting potential benefits that may require further exploration.
Ultimately, this study did not establish folic acid as a proven treatment for reducing hot flushes in postmenopausal women, highlighting the need for more comprehensive research to confirm its effects.
Throughout this period, we asked participants to document the frequency and severity of their hot flushes using a Sloan Diary, along with answering questions from validated quality of life scales at regular intervals. When we analyzed the data, we found that while women taking folic acid experienced a mean reduction in their Hot Flush Score, this decrease was not statistically significant compared to those on placebo.
Specifically, the difference in improvement between the folic acid group and the placebo group was marginal, indicating no clear advantage of folic acid in alleviating hot flushes over the study duration. However, some enhancements were noted in emotional and overall quality of life scores among the folic acid group at week 8, suggesting potential benefits that may require further exploration.
Ultimately, this study did not establish folic acid as a proven treatment for reducing hot flushes in postmenopausal women, highlighting the need for more comprehensive research to confirm its effects.
Read More
7
Zinc supplementation improves menopause nutrients
Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population.
Moderate relevance to folate effects
In our exploration into the effects of zinc supplementation on postmenopausal women, we examined how it influences key nutrients like folate and homocysteine levels. Within an 8-week study involving 51 women aged 44 to 76, participants were divided into two groups: one received a daily zinc supplement of 50 mg, while the other took a placebo.
After the study period, we observed significant improvements in folate levels among those who received zinc. In fact, this group showed a marked increase in folate compared to their initial levels. Additionally, we noticed a decrease in homocysteine levels when comparing results across both groups, suggesting a positive outcome from the zinc intervention.
Although we found that zinc had a beneficial impact on folate and also influenced homocysteine levels, it’s important to note that the zinc treatment didn’t exclusively affect vitamin B levels, as improvements were observed in both groups equally. While the connection between folate and lower homocysteine levels was strong, further research is necessary to understand the implications fully.
Overall, our findings highlight the potential of zinc supplementation in enhancing nutrient status during menopause, but we recognize the necessity for larger studies with optimized dosages to confirm these outcomes.
After the study period, we observed significant improvements in folate levels among those who received zinc. In fact, this group showed a marked increase in folate compared to their initial levels. Additionally, we noticed a decrease in homocysteine levels when comparing results across both groups, suggesting a positive outcome from the zinc intervention.
Although we found that zinc had a beneficial impact on folate and also influenced homocysteine levels, it’s important to note that the zinc treatment didn’t exclusively affect vitamin B levels, as improvements were observed in both groups equally. While the connection between folate and lower homocysteine levels was strong, further research is necessary to understand the implications fully.
Overall, our findings highlight the potential of zinc supplementation in enhancing nutrient status during menopause, but we recognize the necessity for larger studies with optimized dosages to confirm these outcomes.
Read More
Most Useful Reviews
9
Improved PMS symptoms
Folic acid is crucial for women's health, especially after 30 and during menopause. It's also beneficial when combined with MyoInositol for those planning a pregnancy. The tablets are small and easy to take. Since starting this supplement on my doctor's advice, I've noticed an improvement in my PMS symptoms.
Read More
8.8
Supports menopause health
Methyl folate is vital for women during pregnancy and menopause. It strengthens the immune and cardiovascular systems. This form can cross the blood-brain barrier for better absorption. It's essential to restore folic acid levels to avoid fatigue, headaches, and other symptoms related to its deficiency.
Read More
9.5
Effective for hot flashes
This product is effective and reasonably priced. I use it for hot flashes, even though I am past menopause, as my medications might also be causing them. It's been very effective; when I ran out, the hot flashes returned! The price is fair, so I’m satisfied.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6
7
Folic acid positively affects sexual health
Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial.
Highly relevant to folate efficacy
We aimed to understand how folic acid might influence sexual function in postmenopausal women, a group that often experiences sexual dysfunction. For this investigation, we conducted a solid triple-blind randomized controlled trial in Tehran, Iran, involving 100 participants recruited from health centers. Each woman in the study received either 5 mg of folic acid or a placebo daily for eight weeks, always on an empty stomach.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
Read More
7
Zinc supplementation improves menopause nutrients
Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population.
Moderate relevance to folate effects
In our exploration into the effects of zinc supplementation on postmenopausal women, we examined how it influences key nutrients like folate and homocysteine levels. Within an 8-week study involving 51 women aged 44 to 76, participants were divided into two groups: one received a daily zinc supplement of 50 mg, while the other took a placebo.
After the study period, we observed significant improvements in folate levels among those who received zinc. In fact, this group showed a marked increase in folate compared to their initial levels. Additionally, we noticed a decrease in homocysteine levels when comparing results across both groups, suggesting a positive outcome from the zinc intervention.
Although we found that zinc had a beneficial impact on folate and also influenced homocysteine levels, it’s important to note that the zinc treatment didn’t exclusively affect vitamin B levels, as improvements were observed in both groups equally. While the connection between folate and lower homocysteine levels was strong, further research is necessary to understand the implications fully.
Overall, our findings highlight the potential of zinc supplementation in enhancing nutrient status during menopause, but we recognize the necessity for larger studies with optimized dosages to confirm these outcomes.
After the study period, we observed significant improvements in folate levels among those who received zinc. In fact, this group showed a marked increase in folate compared to their initial levels. Additionally, we noticed a decrease in homocysteine levels when comparing results across both groups, suggesting a positive outcome from the zinc intervention.
Although we found that zinc had a beneficial impact on folate and also influenced homocysteine levels, it’s important to note that the zinc treatment didn’t exclusively affect vitamin B levels, as improvements were observed in both groups equally. While the connection between folate and lower homocysteine levels was strong, further research is necessary to understand the implications fully.
Overall, our findings highlight the potential of zinc supplementation in enhancing nutrient status during menopause, but we recognize the necessity for larger studies with optimized dosages to confirm these outcomes.
Read More
4
Folic acid shows no significant benefits
Folic acid supplementation in postmenopausal women with hot flushes: phase III randomised double-blind placebo-controlled trial.
Direct evaluation of folic acid
We conducted a phase III double-blind, placebo-controlled trial to assess the effects of folic acid supplementation on hot flushes in postmenopausal women. This study, which took place across nine hospitals in England, involved 164 women who reported experiencing at least 50 hot flushes each week. Participants were randomly assigned to take either a daily 5 mg folic acid tablet or a placebo for 12 weeks.
Throughout this period, we asked participants to document the frequency and severity of their hot flushes using a Sloan Diary, along with answering questions from validated quality of life scales at regular intervals. When we analyzed the data, we found that while women taking folic acid experienced a mean reduction in their Hot Flush Score, this decrease was not statistically significant compared to those on placebo.
Specifically, the difference in improvement between the folic acid group and the placebo group was marginal, indicating no clear advantage of folic acid in alleviating hot flushes over the study duration. However, some enhancements were noted in emotional and overall quality of life scores among the folic acid group at week 8, suggesting potential benefits that may require further exploration.
Ultimately, this study did not establish folic acid as a proven treatment for reducing hot flushes in postmenopausal women, highlighting the need for more comprehensive research to confirm its effects.
Throughout this period, we asked participants to document the frequency and severity of their hot flushes using a Sloan Diary, along with answering questions from validated quality of life scales at regular intervals. When we analyzed the data, we found that while women taking folic acid experienced a mean reduction in their Hot Flush Score, this decrease was not statistically significant compared to those on placebo.
Specifically, the difference in improvement between the folic acid group and the placebo group was marginal, indicating no clear advantage of folic acid in alleviating hot flushes over the study duration. However, some enhancements were noted in emotional and overall quality of life scores among the folic acid group at week 8, suggesting potential benefits that may require further exploration.
Ultimately, this study did not establish folic acid as a proven treatment for reducing hot flushes in postmenopausal women, highlighting the need for more comprehensive research to confirm its effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.6
9.5
Very effective folic acid
This is quality folic acid that absorbs well. I recommend it for those planning to conceive or for women going through menopause.
9.5
Protects against menopause
Methyl folate is a superior alternative to synthetic folic acid, playing a crucial role in heart health and preventing early menopause. It is vital during pregnancy planning and offers essential support for women's health throughout all life stages.
9.5
Supports menopause symptoms
Excellent! This acid is especially necessary for women during pregnancy and menopause. Experts also recommend it for strengthening the immune, cardiovascular, and nervous systems.
9.5
Effective for hot flashes
This product is effective and reasonably priced. I use it for hot flashes, even though I am past menopause, as my medications might also be causing them. It's been very effective; when I ran out, the hot flashes returned! The price is fair, so I’m satisfied.
9
Improved PMS symptoms
Folic acid is crucial for women's health, especially after 30 and during menopause. It's also beneficial when combined with MyoInositol for those planning a pregnancy. The tablets are small and easy to take. Since starting this supplement on my doctor's advice, I've noticed an improvement in my PMS symptoms.
Read More
