Last update
5/24/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Good
Based on 8 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Read More
8
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
Read More
7
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
Read More
Most Useful Reviews
9
Effective for hot flashes
4 people found this helpful
This product is effective and reasonably priced. I use it for hot flashes, even though I am past menopause, as my medications might also be causing them. It's been very effective; when I ran out, the hot flashes returned! The price is fair, so I’m satisfied.
Read More
9
Very effective folic acid
1 people found this helpful
This is quality folic acid that absorbs well. I recommend it for those planning to conceive or for women going through menopause.
Read More
9
Supports menopause symptoms
Excellent! This acid is especially necessary for women during pregnancy and menopause. Experts also recommend it for strengthening the immune, cardiovascular, and nervous systems.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
- All Researches
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Read More
8
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
Read More
7
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
Read More
7
We examined how folic acid supplements impact homocysteine levels in postmenopausal women over six months. Our findings suggest that after menopause, homocysteine levels rise significantly, presenting a cardiovascular risk.
While folic acid is a safe and affordable option, our study indicates that it may help lower homocysteine, potentially offering some protection against heart disease in this group. However, more research is needed to fully understand its effectiveness.
While folic acid is a safe and affordable option, our study indicates that it may help lower homocysteine, potentially offering some protection against heart disease in this group. However, more research is needed to fully understand its effectiveness.
Read More
7
Folate impacts menopause bone density
We investigated whether folates, vitamin B12, or homocysteine levels predict changes in bone density among postmenopausal women. Over five years, we measured these factors in 161 healthy volunteers, focusing on vertebral bone mineral density (BMD).
Our findings revealed that folates were significantly associated with BMD changes, indicating that low folate levels could contribute to bone density decline. However, we found no significant link between variations in BMD and homocysteine or vitamin B12 levels.
This highlights the potential importance of folate levels in supporting bone health during menopause.
Our findings revealed that folates were significantly associated with BMD changes, indicating that low folate levels could contribute to bone density decline. However, we found no significant link between variations in BMD and homocysteine or vitamin B12 levels.
This highlights the potential importance of folate levels in supporting bone health during menopause.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for hot flashes
4 people found this helpful
This product is effective and reasonably priced. I use it for hot flashes, even though I am past menopause, as my medications might also be causing them. It's been very effective; when I ran out, the hot flashes returned! The price is fair, so I’m satisfied.
Read More
9
Very effective folic acid
1 people found this helpful
This is quality folic acid that absorbs well. I recommend it for those planning to conceive or for women going through menopause.
Read More
9
Supports menopause symptoms
Excellent! This acid is especially necessary for women during pregnancy and menopause. Experts also recommend it for strengthening the immune, cardiovascular, and nervous systems.
Read More
7.5
Beneficial for menopause
This active form of folic acid is particularly useful for pregnant women and those planning to conceive. It has proven beneficial during menopause, as it is easily absorbed, stimulates the nervous system, and strengthens capillary walls. The packaging is also convenient.
Read More
7.5
Beneficial for menopause
1 people found this helpful
My functional doctor recommended methyl folate due to my poor vitamin B absorption. I found it highly effective and beneficial for managing menopause symptoms.
Read More
Frequently Asked Questions
7.5
Beneficial for menopause
This active form of folic acid is particularly useful for pregnant women and those planning to conceive. It has proven beneficial during menopause, as it is easily absorbed, stimulates the nervous system, and strengthens capillary walls. The packaging is also convenient.
7.5
Prevents Alzheimer's during menopause
For folic acid, I choose the methyl-activated form. After menopause, I focused on supplementing folic acid to help prevent Alzheimer’s. After comparing options, I'm pleased with this choice and will repurchase.
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
7
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
8
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
7
We examined how folic acid supplements impact homocysteine levels in postmenopausal women over six months. Our findings suggest that after menopause, homocysteine levels rise significantly, presenting a cardiovascular risk.
While folic acid is a safe and affordable option, our study indicates that it may help lower homocysteine, potentially offering some protection against heart disease in this group. However, more research is needed to fully understand its effectiveness.
While folic acid is a safe and affordable option, our study indicates that it may help lower homocysteine, potentially offering some protection against heart disease in this group. However, more research is needed to fully understand its effectiveness.
7
Folate impacts menopause bone density
We investigated whether folates, vitamin B12, or homocysteine levels predict changes in bone density among postmenopausal women. Over five years, we measured these factors in 161 healthy volunteers, focusing on vertebral bone mineral density (BMD).
Our findings revealed that folates were significantly associated with BMD changes, indicating that low folate levels could contribute to bone density decline. However, we found no significant link between variations in BMD and homocysteine or vitamin B12 levels.
This highlights the potential importance of folate levels in supporting bone health during menopause.
Our findings revealed that folates were significantly associated with BMD changes, indicating that low folate levels could contribute to bone density decline. However, we found no significant link between variations in BMD and homocysteine or vitamin B12 levels.
This highlights the potential importance of folate levels in supporting bone health during menopause.
7
We explored how folic acid might affect cardiovascular health during menopause, particularly concerning high levels of homocysteine, which can damage blood vessels. The study reviewed existing literature and found that folic acid supplementation is effective in reducing these high homocysteine levels. Additionally, it was noted that folate could improve endothelial function, helping to protect postmenopausal women from heart-related issues. This suggests that incorporating folic acid could be beneficial for cardiovascular health during and after menopause.
References
- Asadi M, Riazi H, Abbasinazari M, Majd HA, Montazeri A. Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial. J Sex Med. 2023;20:1180. 10.1093/jsxmed/qdad086
- Almassinokiani F, Kashanian M, Akbari P, Mossayebi E, Sadeghian E. Folic acid supplementation reduces plasma homocysteine in postmenopausal women. J Obstet Gynaecol. 2016;36:492. 10.3109/01443615.2015.1091811
- Bani S, Hasanpour S, Farzad Rik L, Hasankhani H, Sharami SH. The effect of folic Acid on menopausal hot flashes: a randomized clinical trial. J Caring Sci. 2013;2:131. 10.5681/jcs.2013.016
- Sultan N, Khan MA, Malik S. Effect of folic acid supplementation on homocysteine level in postmenopausal women. J Ayub Med Coll Abbottabad. 2007;19:78. PubMed
- Cagnacci A, Bagni B, Zini A, Cannoletta M, Generali M, et al. Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone. 2008;42:314. 10.1016/j.bone.2007.10.022
- Rejnmark L, Vestergaard P, Hermann AP, Brot C, Eiken P, et al. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women. Calcif Tissue Int. 2008;82:1. 10.1007/s00223-007-9087-0
- Villa P, Suriano R, Costantini B, Macrì F, Ricciardi L, et al. Hyperhomocysteinemia and cardiovascular risk in postmenopausal women: the role of folate supplementation. Clin Chem Lab Med. 2007;45:130. PubMed
- Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra Y, Planells E. Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population. J Trace Elem Med Biol. 2022;71:126942. 10.1016/j.jtemb.2022.126942
- Ewies A, Ahmed I, Al-Azzawi F, Pitkin J, Gupta P, et al. Folic acid supplementation in postmenopausal women with hot flushes: phase III randomised double-blind placebo-controlled trial. BJOG. 2021;128:2024. 10.1111/1471-0528.16739
