' 
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
Folate intake reduces migraine frequency
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Highly relevant to migraine research
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
8
Serum folate and migraines linked
Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study.
Focused study on folate association
We investigated the connection between serum folate levels and the occurrence of severe headaches or migraines using a large dataset from the National Health and Nutrition Examination Survey. In total, we analyzed information from 13,351 participants, with 2,742 of them reporting severe headaches or migraines within the last three months.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Read More
8
Folate metabolism's role in migraines
[The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].
Relevant but inconclusive findings
We explored the connection between genetic factors related to folate metabolism and the occurrence of migraines in children. Our study involved 54 children aged 7 to 18 who experienced migraines, alongside a control group of 115 children without neurological issues.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
Read More
Most Useful Reviews
0
Not suitable personally
These capsules are quite small, making them easy to swallow, which I appreciate. However, I began experiencing daily migraines from the very first dose. They might be beneficial for others, but they were a poor choice for me!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
- All Researches
8
Folate metabolism's role in migraines
[The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].
Relevant but inconclusive findings
We explored the connection between genetic factors related to folate metabolism and the occurrence of migraines in children. Our study involved 54 children aged 7 to 18 who experienced migraines, alongside a control group of 115 children without neurological issues.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
Read More
8
Folate intake reduces migraine frequency
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Highly relevant to migraine research
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
8
Serum folate and migraines linked
Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study.
Focused study on folate association
We investigated the connection between serum folate levels and the occurrence of severe headaches or migraines using a large dataset from the National Health and Nutrition Examination Survey. In total, we analyzed information from 13,351 participants, with 2,742 of them reporting severe headaches or migraines within the last three months.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
0
Not suitable personally
These capsules are quite small, making them easy to swallow, which I appreciate. However, I began experiencing daily migraines from the very first dose. They might be beneficial for others, but they were a poor choice for me!
