Last update
5/25/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.6
USERS' SCORE
Medium or Average
Based on 8 Reviews
6.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
7
We examined the effects of folic acid on 16 children suffering from migraines linked to certain gene variants. These children also had hyperhomocysteinemia, a condition that can elevate migraine risk.
After the folic acid supplementation, we noted a reduction in migraine attacks. However, the reasons behind this improvement remain unclear. Consequently, we recommend further research, ideally through a randomized double-blind trial, to truly validate these promising initial findings.
After the folic acid supplementation, we noted a reduction in migraine attacks. However, the reasons behind this improvement remain unclear. Consequently, we recommend further research, ideally through a randomized double-blind trial, to truly validate these promising initial findings.
Read More
8
We investigated how folic acid, along with other B vitamins, impacts migraines by looking at specific gene variations. In a 6-month study with 206 women suffering from migraines, those who received vitamin supplementation showed decreased homocysteine levels and less severe headaches compared to those on placebo.
Interestingly, genetic factors mattered. Women with certain gene variants experienced greater headache relief and lower disability levels. Overall, our findings suggest that B vitamin supplementation can reduce migraine symptoms, influenced by individual genetic profiles.
Interestingly, genetic factors mattered. Women with certain gene variants experienced greater headache relief and lower disability levels. Overall, our findings suggest that B vitamin supplementation can reduce migraine symptoms, influenced by individual genetic profiles.
Read More
Most Useful Reviews
10
Migraine relief
I take inositol, 4000mg daily, with my husband, and the migraines that tormented me for six years have vanished. I'm amazed by this response to the medication; it has given me a surge of energy. I'm delighted I eventually tried it for my migraines, although it was originally recommended by my gynecologist for pregnancy planning.
Read More
9
Effective for headaches
I am grateful it was once recommended to me. This irreplaceable thing must be taken continuously. Thanks to methyl folate, I have gotten rid of headaches and migraines.
Read More
7.5
Hope it helps
I drink on the advice of an endocrinologist for my migraine. I was previously worried about frequent attacks. The doctor advised folic acid, fish oil, and more to drink. Hope it helps, as life with migraines is not a life at all.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.6
- All Researches
8
We investigated how folic acid, along with other B vitamins, impacts migraines by looking at specific gene variations. In a 6-month study with 206 women suffering from migraines, those who received vitamin supplementation showed decreased homocysteine levels and less severe headaches compared to those on placebo.
Interestingly, genetic factors mattered. Women with certain gene variants experienced greater headache relief and lower disability levels. Overall, our findings suggest that B vitamin supplementation can reduce migraine symptoms, influenced by individual genetic profiles.
Interestingly, genetic factors mattered. Women with certain gene variants experienced greater headache relief and lower disability levels. Overall, our findings suggest that B vitamin supplementation can reduce migraine symptoms, influenced by individual genetic profiles.
Read More
8
We conducted a randomized, double-blind study to explore how vitamin supplementation affects migraine patients, particularly focusing on folic acid's role in reducing homocysteine levels.
Our results showed that daily intake of folic acid, along with other vitamins, reduced homocysteine significantly and halved migraine disability over six months.
Notably, those with a specific genetic marker experienced even more pronounced benefits. While these findings are promising, further research is needed to confirm the effectiveness of vitamin therapy for everyone.
Our results showed that daily intake of folic acid, along with other vitamins, reduced homocysteine significantly and halved migraine disability over six months.
Notably, those with a specific genetic marker experienced even more pronounced benefits. While these findings are promising, further research is needed to confirm the effectiveness of vitamin therapy for everyone.
Read More
8
We explored the connection between genetic factors related to folate metabolism and the occurrence of migraines in children. Our study involved 54 children aged 7 to 18 who experienced migraines, alongside a control group of 115 children without neurological issues.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
Read More
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
7
We explored how serum folate levels relate to migraines by looking at data from over 13,000 participants in a nationwide health study.
Folic acid showed a negative association with severe headaches, meaning higher levels of folate may lead to fewer migraines.
This connection was particularly strong among women, younger adults, and non-Hispanic White individuals.
However, more research is necessary to confirm these findings and further investigate the influence of folate on migraine prevention.
Folic acid showed a negative association with severe headaches, meaning higher levels of folate may lead to fewer migraines.
This connection was particularly strong among women, younger adults, and non-Hispanic White individuals.
However, more research is necessary to confirm these findings and further investigate the influence of folate on migraine prevention.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 8 Reviews
6.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Migraine relief
I take inositol, 4000mg daily, with my husband, and the migraines that tormented me for six years have vanished. I'm amazed by this response to the medication; it has given me a surge of energy. I'm delighted I eventually tried it for my migraines, although it was originally recommended by my gynecologist for pregnancy planning.
Read More
9
Effective for headaches
I am grateful it was once recommended to me. This irreplaceable thing must be taken continuously. Thanks to methyl folate, I have gotten rid of headaches and migraines.
Read More
7.5
Hope it helps
I drink on the advice of an endocrinologist for my migraine. I was previously worried about frequent attacks. The doctor advised folic acid, fish oil, and more to drink. Hope it helps, as life with migraines is not a life at all.
Read More
0
Not suitable personally
2 people found this helpful
These capsules are quite small, making them easy to swallow, which I appreciate. However, I began experiencing daily migraines from the very first dose. They might be beneficial for others, but they were a poor choice for me!
Read More
7.5
Noticed improvement
Got better! I drank a course for migraines, as advised by the endocrinologist.
Read More
Frequently Asked Questions
9
Effective for headaches
I am grateful it was once recommended to me. This irreplaceable thing must be taken continuously. Thanks to methyl folate, I have gotten rid of headaches and migraines.
10
Migraine relief
I take inositol, 4000mg daily, with my husband, and the migraines that tormented me for six years have vanished. I'm amazed by this response to the medication; it has given me a surge of energy. I'm delighted I eventually tried it for my migraines, although it was originally recommended by my gynecologist for pregnancy planning.
0
Negative experience
I’m homozygous for an MTHFR mutation, and this was recommended by my practitioner. Unfortunately, I had a poor reaction. My anxiety shot up, and I began experiencing panic attacks and migraines. It took two weeks to recover after discontinuing it.
7.5
Hope it helps
I drink on the advice of an endocrinologist for my migraine. I was previously worried about frequent attacks. The doctor advised folic acid, fish oil, and more to drink. Hope it helps, as life with migraines is not a life at all.
7.5
Noticed improvement
Got better! I drank a course for migraines, as advised by the endocrinologist.
0
Waste of money
This product was not what I expected; folate is different from folic acid. After switching to folate, my migraines disappeared, but this product brought them back. It was a complete waste of money for me.
7
We explored how serum folate levels relate to migraines by looking at data from over 13,000 participants in a nationwide health study.
Folic acid showed a negative association with severe headaches, meaning higher levels of folate may lead to fewer migraines.
This connection was particularly strong among women, younger adults, and non-Hispanic White individuals.
However, more research is necessary to confirm these findings and further investigate the influence of folate on migraine prevention.
Folic acid showed a negative association with severe headaches, meaning higher levels of folate may lead to fewer migraines.
This connection was particularly strong among women, younger adults, and non-Hispanic White individuals.
However, more research is necessary to confirm these findings and further investigate the influence of folate on migraine prevention.
4
We explored the link between migraine and certain vitamins, particularly B6, folate, and B12, which may help lower homocysteine levels.
Our systematic review of twelve studies found that these vitamins showed promise in preventing migraine with aura, while their effectiveness in treating acute migraine attacks was not significant.
Although folate alone was ineffective, using B6 in various combinations did show benefits. While the overall safety was good, more high-quality studies are needed for clearer conclusions, especially concerning migraine without aura.
Our systematic review of twelve studies found that these vitamins showed promise in preventing migraine with aura, while their effectiveness in treating acute migraine attacks was not significant.
Although folate alone was ineffective, using B6 in various combinations did show benefits. While the overall safety was good, more high-quality studies are needed for clearer conclusions, especially concerning migraine without aura.
8
We investigated how folic acid, along with other B vitamins, impacts migraines by looking at specific gene variations. In a 6-month study with 206 women suffering from migraines, those who received vitamin supplementation showed decreased homocysteine levels and less severe headaches compared to those on placebo.
Interestingly, genetic factors mattered. Women with certain gene variants experienced greater headache relief and lower disability levels. Overall, our findings suggest that B vitamin supplementation can reduce migraine symptoms, influenced by individual genetic profiles.
Interestingly, genetic factors mattered. Women with certain gene variants experienced greater headache relief and lower disability levels. Overall, our findings suggest that B vitamin supplementation can reduce migraine symptoms, influenced by individual genetic profiles.
2
We explored the effects of 1 mg of folic acid, combined with Vitamins B6 and B12, on migraine symptoms in 300 women diagnosed with migraine with aura.
Over a six-month period, participants received either the vitamin supplement or a placebo. Unfortunately, we did not observe a significant decline in migraine severity, frequency, or overall disability among those taking the lower dosage of folic acid.
This suggests that the reduced dosage is less effective than previous studies where higher doses were administered.
Over a six-month period, participants received either the vitamin supplement or a placebo. Unfortunately, we did not observe a significant decline in migraine severity, frequency, or overall disability among those taking the lower dosage of folic acid.
This suggests that the reduced dosage is less effective than previous studies where higher doses were administered.
8
We conducted a randomized, double-blind study to explore how vitamin supplementation affects migraine patients, particularly focusing on folic acid's role in reducing homocysteine levels.
Our results showed that daily intake of folic acid, along with other vitamins, reduced homocysteine significantly and halved migraine disability over six months.
Notably, those with a specific genetic marker experienced even more pronounced benefits. While these findings are promising, further research is needed to confirm the effectiveness of vitamin therapy for everyone.
Our results showed that daily intake of folic acid, along with other vitamins, reduced homocysteine significantly and halved migraine disability over six months.
Notably, those with a specific genetic marker experienced even more pronounced benefits. While these findings are promising, further research is needed to confirm the effectiveness of vitamin therapy for everyone.
References
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. 10.1097/MD.0000000000040458
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. 10.1186/s10194-016-0652-7
- Menon S, Lea RA, Ingle S, Sutherland M, Wee S, et al. Effects of dietary folate intake on migraine disability and frequency. Headache. 2015;55:301. 10.1111/head.12490
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. 10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. 10.1097/FPC.0b013e32832af5a3
- Di Rosa G, Attinà S, Spanò M, Ingegneri G, Sgrò DL, et al. Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms. Headache. 2007;47:1342. PubMed
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. 10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. 10.3389/fnut.2024.1456502
