Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
We explored the impact of folic acid supplementation on stroke risk by analyzing data from 21 randomized clinical trials involving over 115,000 participants.
This study revealed that folic acid reduces stroke risk by about 10%. Interestingly, it appeared more effective in areas without grain fortification and among individuals without a prior history of stroke or heart attack.
These findings suggest that folic acid could play a vital role in preventing strokes, particularly in specific populations.
This study revealed that folic acid reduces stroke risk by about 10%. Interestingly, it appeared more effective in areas without grain fortification and among individuals without a prior history of stroke or heart attack.
These findings suggest that folic acid could play a vital role in preventing strokes, particularly in specific populations.
Read More
8
We examined how tetrahydrofolate (THF), a form of folic acid, helps cognitive recovery after intracerebral hemorrhage (ICH), a common type of hemorrhagic stroke.
THF was shown to boost the growth of neural stem cells, supporting new brain cell formation. This, in turn, appears to enhance cognitive abilities following ICH. We discovered that THF works by lowering elevated PTEN levels and promoting important pathways for brain health.
While these findings offer hope, more research is needed to fully understand THF's benefits on cognition post-stroke.
THF was shown to boost the growth of neural stem cells, supporting new brain cell formation. This, in turn, appears to enhance cognitive abilities following ICH. We discovered that THF works by lowering elevated PTEN levels and promoting important pathways for brain health.
While these findings offer hope, more research is needed to fully understand THF's benefits on cognition post-stroke.
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8
We examined how folic acid (FA) can help in cases of cerebral ischemia-reperfusion injury, a condition linked to low levels of FA. Our findings showed that after such injury, FA levels drop while GCPII levels rise. By administering FA, we observed a reduction in cognitive decline and neuronal damage caused by this condition. The protective effects of FA appear to stem from its ability to block certain proteins that contribute to cell damage. Overall, this suggests that FA could be a valuable treatment for reducing stroke-related injury.
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Most Useful Reviews
9
Effective for stroke
1 people found this helpful
This methyl folate is from a reputable firm, with adequate dosage. Though capsules are larger than tablets, they’re manageable to swallow. This form is better absorbed, benefiting those with absorption issues. Methyl folate can help lower the risk of strokes.
Read More
9
Maintaining stroke levels
1 people found this helpful
Methylfolate is crucial to regulate homocysteine levels, as high levels can lead to stroke risks. I've opted for this form due to personal genetic factors, as there are few alternatives in Russia.
Read More
9
Promotes stroke recovery
1 people found this helpful
On my endocrinologist's advice, I started taking methyl folate while planning my pregnancy due to thyroid issues. It aided my quick conception and my uncle's swift recovery after his stroke, normalising his pressure and blood circulation.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
- All Researches
9
We explored the effects of folic acid and homocysteine levels on the outcomes of ischemic stroke in over 3,500 patients. Our findings revealed that higher folate levels were linked to a 29% lower risk of severe complications, such as death or major disability, within three months after a stroke.
In contrast, elevated homocysteine levels significantly increased the risk, suggesting that homocysteine may mediate some benefits of folate. Overall, maintaining high folate levels may play a protective role following ischemic stroke.
In contrast, elevated homocysteine levels significantly increased the risk, suggesting that homocysteine may mediate some benefits of folate. Overall, maintaining high folate levels may play a protective role following ischemic stroke.
Read More
9
We explored how platelet activation measures and specific genetic factors might shape the effectiveness of folic acid in preventing strokes. Our analysis, based on data from the China Stroke Primary Prevention Trial with over 11,000 hypertensive adults, revealed that individuals with low plateletcrit and certain MTHFR genotypes experienced significant benefits from folic acid treatment. Specifically, this group saw a striking 66% reduction in stroke risk. Thus, identifying low plateletcrit could help target folic acid treatment to those at highest risk.
Read More
9
We examined a case involving a young man in his late 20s who suffered a sudden ischemic stroke. This incident was surprisingly linked to elevated homocysteine levels, a risk factor often associated with stroke. Through our observations, it became clear that hyperhomocysteinemia is an important factor to consider, even among younger adults who might otherwise seem healthy.
Following the stroke, the patient received targeted treatment along with a regimen that included folic acid, vitamin B6, vitamin B12, and methylcobalamin. As a result, we saw significant improvement in his condition, culminating in his discharge with normalized homocysteine levels.
Highlighting this case is particularly important in regions like Pakistan, where hyperhomocysteinemia is notably prevalent. Our experience emphasizes the need for healthcare providers to thoroughly evaluate potential stroke causes, including the role of homocysteine, especially in younger populations.
Following the stroke, the patient received targeted treatment along with a regimen that included folic acid, vitamin B6, vitamin B12, and methylcobalamin. As a result, we saw significant improvement in his condition, culminating in his discharge with normalized homocysteine levels.
Highlighting this case is particularly important in regions like Pakistan, where hyperhomocysteinemia is notably prevalent. Our experience emphasizes the need for healthcare providers to thoroughly evaluate potential stroke causes, including the role of homocysteine, especially in younger populations.
Read More
8
We investigated the link between serum folate levels and stroke risk over ten years in a community-based study of nearly 5,000 participants.
Our findings revealed that those in the highest folate group had a lower risk for strokes compared to those with minimal folate. Specifically, elevated folate resulted in a significant reduction in hazard ratio for strokes and ischemic strokes.
Interestingly, homocysteine levels appeared to play a substantial role in this relationship, while certain genetic factors influenced the association as well. Overall, inadequate folate concentrations were tied to increased stroke risk.
Our findings revealed that those in the highest folate group had a lower risk for strokes compared to those with minimal folate. Specifically, elevated folate resulted in a significant reduction in hazard ratio for strokes and ischemic strokes.
Interestingly, homocysteine levels appeared to play a substantial role in this relationship, while certain genetic factors influenced the association as well. Overall, inadequate folate concentrations were tied to increased stroke risk.
Read More
8
MTHFR variant increases stroke risk
We examined the MTHFR rs1801133 variant's association with various health issues in a large sample, comparing 2431 cases to 1265 healthy controls. Our findings revealed that this genetic variant increases the risk of ischemic stroke, developmental challenges, and several neurological disorders, especially in regions lacking folate fortification.
Specifically, the study indicated that individuals with the TT genotype of MTHFR face significantly higher risks for adverse health outcomes, emphasizing the importance of understanding this association in populations with low dietary folate.
Specifically, the study indicated that individuals with the TT genotype of MTHFR face significantly higher risks for adverse health outcomes, emphasizing the importance of understanding this association in populations with low dietary folate.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for stroke
1 people found this helpful
This methyl folate is from a reputable firm, with adequate dosage. Though capsules are larger than tablets, they’re manageable to swallow. This form is better absorbed, benefiting those with absorption issues. Methyl folate can help lower the risk of strokes.
Read More
9
Maintaining stroke levels
1 people found this helpful
Methylfolate is crucial to regulate homocysteine levels, as high levels can lead to stroke risks. I've opted for this form due to personal genetic factors, as there are few alternatives in Russia.
Read More
9
Promotes stroke recovery
1 people found this helpful
On my endocrinologist's advice, I started taking methyl folate while planning my pregnancy due to thyroid issues. It aided my quick conception and my uncle's swift recovery after his stroke, normalising his pressure and blood circulation.
Read More
9
Effective against stroke
1 people found this helpful
Methylfolate is crucial for effectively managing folate levels, especially for preventing birth defects and reducing high homocysteine linked to stroke risks. Regular analysis of homocysteine levels is necessary for maintaining cardiovascular health. This is one of the most cost-effective options available.
Read More
6
Potential dementia support
53 people found this helpful
The methyl form of folate is believed to be the most easily absorbed type. I purchased this supplement for my 96-year-old mother, who has dementia and aphasia. My research indicates it may help slow or halt the progression of dementia. In addition to brain support, folate can help with various conditions, including lowering the risk of strokes associated with elevated homocysteine levels. Adequate folate levels are essential for brain function and may mitigate the effects of ageing.
Read More
Frequently Asked Questions
7.5
Reduced stroke risk
301 people found this helpful
Fully active folate lowers homocysteine levels! It's vital for women and the elderly to monitor homocysteine. For those planning pregnancy, it should ideally be under 7. I’ve seen my levels drop from 10 to 7 in 1.5 months, and my mother’s levels decreased from 15—an alarming figure linked to stroke risk. Now we're both taking folate. Please take care of your loved ones!
9
Stroke risk reduction
18 people found this helpful
If you plan to conceive, ensure you check homocysteine. Methylfolate is an easily digestible form of vitamin B9. I took two capsules daily for two months, lowering my levels from 11.8 to 6.9. High homocysteine increases stroke risk, so I highly recommend this supplement!
9
Promotes stroke recovery
1 people found this helpful
On my endocrinologist's advice, I started taking methyl folate while planning my pregnancy due to thyroid issues. It aided my quick conception and my uncle's swift recovery after his stroke, normalising his pressure and blood circulation.
7.5
Stroke risk management
I took this methyl folate while pregnant, in addition to my B complex, to increase my folate levels due to a stroke risk. After childbirth, I had to reduce my intake because of bruising. I would repurchase it.
7.5
Important for stroke
210 people found this helpful
Monitoring homocysteine is crucial for women, especially those planning a pregnancy. I reduced my homocysteine from 10 to 7 in 1.5 months, while my mother’s levels were at 15, posing a stroke risk. We're now both taking folate. Look after your parents!
8
We investigated how a combination of folic acid, vitamin B12, and vitamin B6 can help prevent strokes.
By analyzing data from 14 trials involving over 76,000 participants, we learned that this vitamin trio significantly lowered stroke risk—by 34% in areas without folic acid fortification.
However, in regions with complete fortification, we found no benefit at all.
Limiting doses to 0.8 mg/day of folic acid and 0.4 mg/day of vitamin B12 appears most effective for stroke prevention.
By analyzing data from 14 trials involving over 76,000 participants, we learned that this vitamin trio significantly lowered stroke risk—by 34% in areas without folic acid fortification.
However, in regions with complete fortification, we found no benefit at all.
Limiting doses to 0.8 mg/day of folic acid and 0.4 mg/day of vitamin B12 appears most effective for stroke prevention.
9
We explored how platelet activation measures and specific genetic factors might shape the effectiveness of folic acid in preventing strokes. Our analysis, based on data from the China Stroke Primary Prevention Trial with over 11,000 hypertensive adults, revealed that individuals with low plateletcrit and certain MTHFR genotypes experienced significant benefits from folic acid treatment. Specifically, this group saw a striking 66% reduction in stroke risk. Thus, identifying low plateletcrit could help target folic acid treatment to those at highest risk.
References
- Hu X, Jiang Y. The impact of SLCO1B1 polymorphisms on homocysteine concentrations: evidence for a stronger association in men. Front Nephrol. 2024;4:1465380. 10.3389/fneph.2024.1465380
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. 10.3390/nu17010159
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. 10.1186/s12889-024-21005-7
- Kadali S, Radhika A, Kanaka Durga Devi YR, Sreemanthula JB, Palakonda G, et al. High penetrance and phenotypic landscape of methylenetetrahydrofolate reductase c.665 C>T polymorphism in the absence of folate fortification. Clin Nutr ESPEN. 2025;65:126. 10.1016/j.clnesp.2024.11.027
- Shi M, Zheng J, Liu Y, Mao X, Wu X, et al. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke. J Am Heart Assoc. 2024;13:e036527. 10.1161/JAHA.124.036527
- Yaldiko A, Coonrod S, Marella P, Hurley L, Jadavji NM. Maternal dietary deficiencies in folic acid or choline reduce primary neuron viability after exposure to hypoxia through increased levels of apoptosis. Nutr Neurosci. 2024. 10.1080/1028415X.2024.2398365
- Yang J, Wang J, Li B, Zhang Y. Folic acid for the primary prevention of stroke: a systematic review and meta-analysis. Front Nutr. 2024;11:1288417. 10.3389/fnut.2024.1288417
- Zhang N, Zhou Z, Chi X, Fan F, Li S, et al. Folic acid supplementation for stroke prevention: A systematic review and meta-analysis of 21 randomized clinical trials worldwide. Clin Nutr. 2024;43:1706. 10.1016/j.clnu.2024.05.034
- Zhang X, Zhang Q, Zhang Q, Wang H, Yin Y, et al. Tetrahydrofolate Attenuates Cognitive Impairment after Hemorrhagic Stroke by Promoting Hippocampal Neurogenesis via PTEN Signaling. eNeuro. 2024;11. 10.1523/ENEURO.0021-24.2024
- Shi Y, Zhang Z, Wang B, Wang Y, Kong X, et al. Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention. Signal Transduct Target Ther. 2024;9:110. 10.1038/s41392-024-01817-0
- Zhang N, Wu Z, Bai X, Song Y, Li P, et al. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119:821. 10.1016/j.ajcnut.2023.12.021
- Chi X, Zhang N, Fan F, Jia J, Zheng J, et al. Systemic immune-inflammation index predicts first stroke and affects the efficacy of folic acid in stroke prevention. Heliyon. 2024;10:e24837. 10.1016/j.heliyon.2024.e24837
- Nri-Ezedi CA, Ulasi T, Efobi CC, Aneke JC, Ugwu N, et al. Bloodless management of significantly elevated transcranial Doppler velocity value in a Jehovah's witness child with sickle cell disease: A tertiary centre experience-A case report. J Natl Med Assoc. 2024;116:247. 10.1016/j.jnma.2024.01.016
- Li ZC, Huang M, Yao QY, Lin CH, Hong BC, et al. Association between Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia. J Integr Neurosci. 2024;23:3. 10.31083/j.jin2301003
- Wang P, Huang Y, Sun B, Chen H, Ma Y, et al. Folic acid blocks ferroptosis induced by cerebral ischemia and reperfusion through regulating folate hydrolase transcriptional adaptive program. J Nutr Biochem. 2024;124:109528. 10.1016/j.jnutbio.2023.109528
- Bennett DA, Parish S, Millwood IY, Guo Y, Chen Y, et al. MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults. Int J Epidemiol. 2023;52:1862. 10.1093/ije/dyad147
- Gonçalves-Pereira J, Mergulhão P, Froes F. Medications to Modify Aspiration Risk: Those That Add to Risk and Those That May Reduce Risk. Semin Respir Crit Care Med. 2024;45:694. 10.1055/s-0044-1791827
- Zhou L, Wang J, Wu H, Yu P, He Z, et al. Serum levels of vitamin B12 combined with folate and plasma total homocysteine predict ischemic stroke disease: a retrospective case-control study. Nutr J. 2024;23:76. 10.1186/s12937-024-00977-7
- Moti Wala S, AlEdani EM, Samuel EA, Ahmad K, Manongi NJ, et al. Exploring the Nexus: A Systematic Review on the Interplay of the Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T Genotype, Hyperhomocysteinemia, and Spontaneous Cervical/Vertebral Artery Dissection in Young Adults. Cureus. 2024;16:e60878. 10.7759/cureus.60878
- Rafay A, Abdul Fatir C, Hiba HT, Jamil M, Talha Awan M. Hyperhomocysteinemia Presenting as Stroke in a Young Individual: A Case Report. Cureus. 2024;16:e52381. 10.7759/cureus.52381
