Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
Read More
8
We investigated whether vitamin B12 (methylcobalamin) could assist adolescents struggling with persistent sleep-wake schedule disorders. Remarkably, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—saw impressive improvements after taking high doses of B12 daily.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
Read More
8
Vitamin B12 aids sleep-wake disorders
We explored the effects of Vitamin B12 on patients with long-standing sleep-wake rhythm disorders. In one case, a 15-year-old blind girl with a 25-hour sleep cycle improved dramatically after starting a regimen of 1.5 mg of B12 three times a day. Her sleep pattern aligned with the 24-hour cycle, but, after stopping the supplement, her issues returned within two months.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Read More
Most Useful Reviews
9
Improved sleep quality
4 people found this helpful
I confirm the results on myself! After giving birth, I experienced constant fatigue and insomnia. Initially, I didn't see any effects from the tablets, but I persevered. Gradually, I realised these vitamins are highly effective for me: I now fall asleep quicker, return to sleep effortlessly after waking during the night, and feel more refreshed in the morning. I strongly recommend this for anyone struggling with insomnia, especially fellow mothers!
Read More
9
Normalised sleep cycle
3 people found this helpful
I feel sleepy, and the next morning I wake up refreshed. Taking Vitamin B12 under the tongue before bed has regulated my sleep pattern and alleviated my insomnia. I noticed that when my B12 levels were low, I felt irritable, but this supplement has provided better mental stability.
Read More
9
Helplessness lifted
2 people found this helpful
I struggled daily with insomnia until I found this product. Now, I feel sleepy, and my eyes appear brighter and less tired each morning.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
- All Researches
8
We investigated whether vitamin B12 (methylcobalamin) could assist adolescents struggling with persistent sleep-wake schedule disorders. Remarkably, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—saw impressive improvements after taking high doses of B12 daily.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
Read More
8
Vitamin B12 aids sleep-wake disorders
We explored the effects of Vitamin B12 on patients with long-standing sleep-wake rhythm disorders. In one case, a 15-year-old blind girl with a 25-hour sleep cycle improved dramatically after starting a regimen of 1.5 mg of B12 three times a day. Her sleep pattern aligned with the 24-hour cycle, but, after stopping the supplement, her issues returned within two months.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Read More
8
We explored the relationship between vitamin B12 levels and insomnia in a case involving a woman experiencing excessive daytime sleepiness alternating with insomnia. This case fit the criteria for a non-24-hour sleep-wake disorder, where traditional treatments failed to provide relief.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
Read More
8
In our exploration of insomnia treatment, we worked with 60 patients diagnosed with the condition. They were split into two groups: one received the Magnesium-melatonin-vitamin B complex, while the other acted as a control. The specific goal was to determine if this combination, which included Vitamin B12, could effectively improve sleep quality over a three-month period.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
Read More
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved sleep quality
4 people found this helpful
I confirm the results on myself! After giving birth, I experienced constant fatigue and insomnia. Initially, I didn't see any effects from the tablets, but I persevered. Gradually, I realised these vitamins are highly effective for me: I now fall asleep quicker, return to sleep effortlessly after waking during the night, and feel more refreshed in the morning. I strongly recommend this for anyone struggling with insomnia, especially fellow mothers!
Read More
9
Normalised sleep cycle
3 people found this helpful
I feel sleepy, and the next morning I wake up refreshed. Taking Vitamin B12 under the tongue before bed has regulated my sleep pattern and alleviated my insomnia. I noticed that when my B12 levels were low, I felt irritable, but this supplement has provided better mental stability.
Read More
9
Helplessness lifted
2 people found this helpful
I struggled daily with insomnia until I found this product. Now, I feel sleepy, and my eyes appear brighter and less tired each morning.
Read More
9
Great for sleep
2 people found this helpful
This really helps me sleep! I take vitamin B12 daily for insomnia, and it’s an excellent product. It tastes good and dissolves quickly. After struggling with insomnia, I now sleep 6-7 hours each night without issues. If you have this problem, I recommend giving B12 a try; you may find it beneficial.
Read More
9
Relieved insomnia
Vitamin B12 is known for enhancing alertness, cognition, energy, mood, and also for relieving insomnia.
Read More
Frequently Asked Questions
9
Miracle for insomnia
I struggled with insomnia and discovered through a blood test that my vitamin B12 was severely depleted. It was alarming, especially since my haemoglobin levels were low. After taking this vitamin, I experienced a remarkable improvement; I feel like a new person. Highly recommended!
7.5
Effective sleep aid
3 people found this helpful
I always turn to this product for insomnia and foot numbness. While I'm uncertain about the numbness effects, it has proven effective for my insomnia. I take it before bed, and it dissolves under my tongue, making me sleepy within 15 minutes. The pleasant taste encourages regular use, despite some grittiness compared to previous brands. Overall, it's cost-effective if it helps me sleep.
2
No effect on focus
3 people found this helpful
I did not observe any changes in my concentration, but my circadian rhythm has improved—I now sleep on time and wake up early. Initially, I aimed to address my insomnia, but after 25 days, I did not notice increased focus. I won’t repurchase and prefer to eat liver and meat for better results.
9
Improved sleep quality
4 people found this helpful
I confirm the results on myself! After giving birth, I experienced constant fatigue and insomnia. Initially, I didn't see any effects from the tablets, but I persevered. Gradually, I realised these vitamins are highly effective for me: I now fall asleep quicker, return to sleep effortlessly after waking during the night, and feel more refreshed in the morning. I strongly recommend this for anyone struggling with insomnia, especially fellow mothers!
9
Normalised sleep cycle
3 people found this helpful
I feel sleepy, and the next morning I wake up refreshed. Taking Vitamin B12 under the tongue before bed has regulated my sleep pattern and alleviated my insomnia. I noticed that when my B12 levels were low, I felt irritable, but this supplement has provided better mental stability.
7.5
Enhanced overall mood
After undergoing tests, my doctor advised me to take these capsules. Although I haven’t finished the full course, I already feel the benefits: improved mood, increased energy in the mornings, and better quality sleep with less insomnia. These results are significant for me.
7.5
Helpful with melatonin
3 people found this helpful
The low price of methylcobalamin, which aids the nervous system and enhances melatonin effectiveness, suits me perfectly as I suffer from spinal stenosis and insomnia while taking 15-20 mg of melatonin.
2
Not effective
2 people found this helpful
I avoid eating much meat or eggs, making B12 supplementation crucial. I previously tried another brand that effectively alleviated my insomnia, but this one has huge tablets that take a long time to dissolve, and my insomnia has worsened since switching. It didn’t work for me.
8
We investigated whether vitamin B12 (methylcobalamin) could assist adolescents struggling with persistent sleep-wake schedule disorders. Remarkably, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—saw impressive improvements after taking high doses of B12 daily.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
The girl's sleep improved significantly, reducing her sleep time from 10 hours to 7 hours and enabling her to fall asleep earlier. The boy's sleep-wake cycle also showed a positive shift. Overall, these initial findings suggest that B12 might play a helpful role in addressing certain sleep disorders in young individuals.
8
Vitamin B12 aids sleep-wake disorders
We explored the effects of Vitamin B12 on patients with long-standing sleep-wake rhythm disorders. In one case, a 15-year-old blind girl with a 25-hour sleep cycle improved dramatically after starting a regimen of 1.5 mg of B12 three times a day. Her sleep pattern aligned with the 24-hour cycle, but, after stopping the supplement, her issues returned within two months.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
Similarly, a 55-year-old man with delayed sleep phase syndrome also benefitted from B12, experiencing sustained improvement for over six months. These findings suggest Vitamin B12 may be a valuable treatment for certain sleep-wake rhythm disorders.
7
We assessed the relationship between vitamin B12 levels and insomnia symptoms in a diverse group of adults visiting primary healthcare clinics in Greece. Our research involved 512 participants, from which we gathered a variety of information including age, weight, and health history. Using standardized scales, we measured excessive daytime sleepiness, insomnia symptoms, and overall sleep quality.
Our findings highlighted that lower vitamin B12 levels, particularly below 342 pg/mL, were linked to increased insomnia symptoms. This association was particularly pronounced in certain groups, such as elderly, non-obese, and female participants. Interestingly, we found that excessive daytime sleepiness connected with low B12 levels only affected obese participants.
However, we did not find a significant connection between vitamin B12 levels and poor overall sleep quality. This indicates that while vitamin B12 may play a role in insomnia for specific individuals, its impact on sleep quality itself remains unclear. Therefore, while our study sheds light on these associations, further research is needed to explore the underlying dynamics between sleep and vitamin B12 more fully.
Our findings highlighted that lower vitamin B12 levels, particularly below 342 pg/mL, were linked to increased insomnia symptoms. This association was particularly pronounced in certain groups, such as elderly, non-obese, and female participants. Interestingly, we found that excessive daytime sleepiness connected with low B12 levels only affected obese participants.
However, we did not find a significant connection between vitamin B12 levels and poor overall sleep quality. This indicates that while vitamin B12 may play a role in insomnia for specific individuals, its impact on sleep quality itself remains unclear. Therefore, while our study sheds light on these associations, further research is needed to explore the underlying dynamics between sleep and vitamin B12 more fully.
8
In our exploration of insomnia treatment, we worked with 60 patients diagnosed with the condition. They were split into two groups: one received the Magnesium-melatonin-vitamin B complex, while the other acted as a control. The specific goal was to determine if this combination, which included Vitamin B12, could effectively improve sleep quality over a three-month period.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
8
We explored the relationship between vitamin B12 levels and insomnia in a case involving a woman experiencing excessive daytime sleepiness alternating with insomnia. This case fit the criteria for a non-24-hour sleep-wake disorder, where traditional treatments failed to provide relief.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
References
- Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.
- Okawa M, Mishima K, Nanami T, Shimizu T, Iijima S, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13:15.
- Bouloukaki I, Lampou M, Raouzaiou KM, Lambraki E, Schiza S, et al. Association of Vitamin B12 Levels with Sleep Quality, Insomnia, and Sleepiness in Adult Primary Healthcare Users in Greece. Healthcare (Basel). 2023;11. doi:10.3390/healthcare11233026
- Radlberger RF, Kunz AB. Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Front Neurol. 2023;14:1141835. doi:10.3389/fneur.2023.1141835
- Xiong S, Liu Z, Yao N, Zhang X, Ge Q. The independent association between vitamin B12 and insomnia in Chinese patients with type 2 diabetes mellitus: a cross-sectional study. Nutr Diabetes. 2022;12:3. doi:10.1038/s41387-022-00181-8
- Djokic G, Vojvodić P, Korcok D, Agic A, Rankovic A, et al. The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia. Open Access Maced J Med Sci. 2019;7:3101. doi:10.3889/oamjms.2019.771
- Chang HY, Sei H, Morita Y. Effects of intravenously administered vitamin B12 on sleep in the rat. Physiol Behav. 1995;57:1019.
