Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 3 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
4
We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
Read More
8
We explored the possible connection between serum vitamin B12 levels and autism spectrum disorder (ASD) using a genetic study design known as Mendelian randomization. This approach allowed us to sift through various genetic markers linked to these factors to see if there was a tangible link between vitamin B12 and the risk of developing ASD.
Our analysis included a significant number of genetic variants and aimed to determine if higher vitamin B12 levels could be causally connected to an increased risk of autism. We found evidence suggesting that elevated serum vitamin B12 levels might be associated with a greater risk of ASD, with our primary analysis indicating an odds ratio of 1.68, suggesting a nearly 70% increase in risk.
However, it's important to note that while our main findings pointed towards a potential link, other analytical methods didn't consistently support this association. For instance, when using different approaches, like the weighted median method, the results were not significant. Additionally, we didn’t find any direct causal relationships between ASD and levels of vitamin B6, folate, or homocysteine.
Given these mixed results, we feel that while there is an intriguing association between high vitamin B12 levels and ASD risk, further research is necessary to validate these findings and understand the underlying mechanisms before establishing treatment implications.
Our analysis included a significant number of genetic variants and aimed to determine if higher vitamin B12 levels could be causally connected to an increased risk of autism. We found evidence suggesting that elevated serum vitamin B12 levels might be associated with a greater risk of ASD, with our primary analysis indicating an odds ratio of 1.68, suggesting a nearly 70% increase in risk.
However, it's important to note that while our main findings pointed towards a potential link, other analytical methods didn't consistently support this association. For instance, when using different approaches, like the weighted median method, the results were not significant. Additionally, we didn’t find any direct causal relationships between ASD and levels of vitamin B6, folate, or homocysteine.
Given these mixed results, we feel that while there is an intriguing association between high vitamin B12 levels and ASD risk, further research is necessary to validate these findings and understand the underlying mechanisms before establishing treatment implications.
Read More
8
We examined the potential of a syrup form of methylcobalamin, a type of vitamin B12, in improving the lives of individuals with autism. Over a period of 200 days, 25 children and young adults received a daily dose of 500 µg of this treatment. Throughout this time, both parents and psychologists regularly evaluated the clinical and psychological progress of the participants.
The findings were promising. Participants showed noticeable improvements, particularly in social skills, cognitive function, as well as behavioral and communication aspects. We found a strong correlation between these enhancements and changes in levels of reduced glutathione, a substance that helps protect cells from damage and supports overall health.
It's intriguing to see how a relatively simple vitamin supplement can have such a positive impact on the lives of autistic individuals. The treatment appeared to not only raise the oxidative status of the participants but also support their emotional and psychological well-being.
The findings were promising. Participants showed noticeable improvements, particularly in social skills, cognitive function, as well as behavioral and communication aspects. We found a strong correlation between these enhancements and changes in levels of reduced glutathione, a substance that helps protect cells from damage and supports overall health.
It's intriguing to see how a relatively simple vitamin supplement can have such a positive impact on the lives of autistic individuals. The treatment appeared to not only raise the oxidative status of the participants but also support their emotional and psychological well-being.
Read More
Most Useful Reviews
7.5
Increased focus
13 people found this helpful
For my child with autism, trying methyl-B12 injections and nasal sprays is advised by some online. However, this Jarrow lozenge seemed much easier and at 16.67% of the recommended daily dose for methyl-B12, I found it difficult to ascertain what benefits other methods could provide. I began giving my 10-year-old son about 1-2 lozenges per week, and he appears slightly more focused. I have also introduced some additional B vitamins, including Metafolin and B6, but I don't endorse mega doses; he takes them alternately at most. He also receives vitamin D and omega-3 supplements.
Read More
6
Good response
I gave my child with autism half a tablet and it seems to have a good effect.
Read More
6
Improved symptoms
93 people found this helpful
It needs 50% of the population. It helped me immensely, with a striking effect noticeable by the third day of treatment. Recent DNA studies indicate that about 50% of the population experience failures in B12 and folic acid absorption. The manifestations of autism and ADHD can resemble "normal" ailments and neuralgia. While many symptoms may be compensated in childhood, they tend to worsen with age. Furthermore, blood levels can be normal, albeit generally low. The crucial aspect is that most DNA defects can be addressed with specific forms of vitamin B12 and folic acid—methylcobalamin 1000mcg and methylfolate 400-800mcg. It's essential to understand this topic fully, especially for those suffering from chronic iron deficiency, gut diseases, neuralgia, depression, chronic fatigue, hair loss, and reduced immunity.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
- All Researches
8
We explored the possible connection between serum vitamin B12 levels and autism spectrum disorder (ASD) using a genetic study design known as Mendelian randomization. This approach allowed us to sift through various genetic markers linked to these factors to see if there was a tangible link between vitamin B12 and the risk of developing ASD.
Our analysis included a significant number of genetic variants and aimed to determine if higher vitamin B12 levels could be causally connected to an increased risk of autism. We found evidence suggesting that elevated serum vitamin B12 levels might be associated with a greater risk of ASD, with our primary analysis indicating an odds ratio of 1.68, suggesting a nearly 70% increase in risk.
However, it's important to note that while our main findings pointed towards a potential link, other analytical methods didn't consistently support this association. For instance, when using different approaches, like the weighted median method, the results were not significant. Additionally, we didn’t find any direct causal relationships between ASD and levels of vitamin B6, folate, or homocysteine.
Given these mixed results, we feel that while there is an intriguing association between high vitamin B12 levels and ASD risk, further research is necessary to validate these findings and understand the underlying mechanisms before establishing treatment implications.
Our analysis included a significant number of genetic variants and aimed to determine if higher vitamin B12 levels could be causally connected to an increased risk of autism. We found evidence suggesting that elevated serum vitamin B12 levels might be associated with a greater risk of ASD, with our primary analysis indicating an odds ratio of 1.68, suggesting a nearly 70% increase in risk.
However, it's important to note that while our main findings pointed towards a potential link, other analytical methods didn't consistently support this association. For instance, when using different approaches, like the weighted median method, the results were not significant. Additionally, we didn’t find any direct causal relationships between ASD and levels of vitamin B6, folate, or homocysteine.
Given these mixed results, we feel that while there is an intriguing association between high vitamin B12 levels and ASD risk, further research is necessary to validate these findings and understand the underlying mechanisms before establishing treatment implications.
Read More
8
We delved into the relationship between vitamin B12 levels and autism in children and adolescents by analyzing a comprehensive review of studies on this topic. The review encapsulated 56 studies, including nearly 38,000 participants, and found that those diagnosed with autism spectrum disorders (ASD) had significantly lower vitamin B12 levels compared to the control group. Specifically, the findings revealed a striking difference, with the standardized mean difference indicating a notable deficiency in individuals with ASD.
Moreover, our exploration also pointed to lower vitamin B12 intake in children with autism as compared to those without similar diagnoses. While this suggests a potential link, we noted that no significant differences in vitamin B12 intake were found when comparing children with depression to the control group. However, the study did highlight an encouraging finding: higher vitamin B12 intake appeared to correlate with a reduced risk of depression and behavioral problems.
Overall, the gathered evidence suggests that there may be beneficial effects of ensuring sufficient vitamin B12 levels in children and adolescents, particularly regarding autism and general mental health. This could mean that vitamin B12 deficiency might be a reversible factor involved in some mental health conditions among young individuals.
Moreover, our exploration also pointed to lower vitamin B12 intake in children with autism as compared to those without similar diagnoses. While this suggests a potential link, we noted that no significant differences in vitamin B12 intake were found when comparing children with depression to the control group. However, the study did highlight an encouraging finding: higher vitamin B12 intake appeared to correlate with a reduced risk of depression and behavioral problems.
Overall, the gathered evidence suggests that there may be beneficial effects of ensuring sufficient vitamin B12 levels in children and adolescents, particularly regarding autism and general mental health. This could mean that vitamin B12 deficiency might be a reversible factor involved in some mental health conditions among young individuals.
Read More
8
We examined the potential of a syrup form of methylcobalamin, a type of vitamin B12, in improving the lives of individuals with autism. Over a period of 200 days, 25 children and young adults received a daily dose of 500 µg of this treatment. Throughout this time, both parents and psychologists regularly evaluated the clinical and psychological progress of the participants.
The findings were promising. Participants showed noticeable improvements, particularly in social skills, cognitive function, as well as behavioral and communication aspects. We found a strong correlation between these enhancements and changes in levels of reduced glutathione, a substance that helps protect cells from damage and supports overall health.
It's intriguing to see how a relatively simple vitamin supplement can have such a positive impact on the lives of autistic individuals. The treatment appeared to not only raise the oxidative status of the participants but also support their emotional and psychological well-being.
The findings were promising. Participants showed noticeable improvements, particularly in social skills, cognitive function, as well as behavioral and communication aspects. We found a strong correlation between these enhancements and changes in levels of reduced glutathione, a substance that helps protect cells from damage and supports overall health.
It's intriguing to see how a relatively simple vitamin supplement can have such a positive impact on the lives of autistic individuals. The treatment appeared to not only raise the oxidative status of the participants but also support their emotional and psychological well-being.
Read More
8
We examined how vitamin B12, a common nutritional supplement, may impact symptoms of autism spectrum disorder (ASD). Our analysis is based on a national survey that included responses from 1,286 participants across the United States. Participants shared their experiences regarding the perceived benefits and side effects of various nutraceuticals, with vitamin B12 emerging as one of the top-rated treatments.
Interestingly, the survey revealed that nutraceuticals, including vitamin B12, were viewed as more beneficial and had fewer adverse effects compared to traditional psychiatric and seizure medications. Specifically, the overall benefit rating for nutraceuticals was 1.59, compared to 1.39 for medications, while adverse effects for nutraceuticals were rated at 0.1 versus 0.9 for medications.
These findings suggest that vitamin B12, among other nutraceuticals, may offer clinical benefits for those with ASD, particularly in addressing core symptoms and associated comorbidities. However, it's essential to approach these results with an open mind and consider the diverse experiences shared by participants in the survey.
Interestingly, the survey revealed that nutraceuticals, including vitamin B12, were viewed as more beneficial and had fewer adverse effects compared to traditional psychiatric and seizure medications. Specifically, the overall benefit rating for nutraceuticals was 1.59, compared to 1.39 for medications, while adverse effects for nutraceuticals were rated at 0.1 versus 0.9 for medications.
These findings suggest that vitamin B12, among other nutraceuticals, may offer clinical benefits for those with ASD, particularly in addressing core symptoms and associated comorbidities. However, it's essential to approach these results with an open mind and consider the diverse experiences shared by participants in the survey.
Read More
5
We investigated the connection between maternal serum vitamin B12 levels during early pregnancy and the occurrence of autism spectrum disorders (ASD) in children. In this study, we looked at data from a Finnish national birth cohort, which included 1,558 children diagnosed with ASD between 1987 and 2007. Each of these cases was carefully matched with a control child based on their date of birth, sex, and place of birth.
Our findings revealed that higher levels of maternal vitamin B12, specifically those at or above the 81st percentile, were linked to an increased risk of childhood autism. The adjusted odds ratio was 1.59, indicating a significant association. However, it’s critical to note that there were no significant findings regarding the relationships between maternal vitamin B12 levels and other ASD subtypes, like Asperger's or pervasive developmental disorder (NOS).
This study underscores a potential risk factor associated with higher maternal vitamin B12 levels, yet it does not suggest that vitamin B12 treatment can effectively address autism. In fact, the findings highlight the complexity of autism development and emphasize the need for further research to understand these relationships better.
Our findings revealed that higher levels of maternal vitamin B12, specifically those at or above the 81st percentile, were linked to an increased risk of childhood autism. The adjusted odds ratio was 1.59, indicating a significant association. However, it’s critical to note that there were no significant findings regarding the relationships between maternal vitamin B12 levels and other ASD subtypes, like Asperger's or pervasive developmental disorder (NOS).
This study underscores a potential risk factor associated with higher maternal vitamin B12 levels, yet it does not suggest that vitamin B12 treatment can effectively address autism. In fact, the findings highlight the complexity of autism development and emphasize the need for further research to understand these relationships better.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Increased focus
13 people found this helpful
For my child with autism, trying methyl-B12 injections and nasal sprays is advised by some online. However, this Jarrow lozenge seemed much easier and at 16.67% of the recommended daily dose for methyl-B12, I found it difficult to ascertain what benefits other methods could provide. I began giving my 10-year-old son about 1-2 lozenges per week, and he appears slightly more focused. I have also introduced some additional B vitamins, including Metafolin and B6, but I don't endorse mega doses; he takes them alternately at most. He also receives vitamin D and omega-3 supplements.
Read More
6
Good response
I gave my child with autism half a tablet and it seems to have a good effect.
Read More
6
Improved symptoms
93 people found this helpful
It needs 50% of the population. It helped me immensely, with a striking effect noticeable by the third day of treatment. Recent DNA studies indicate that about 50% of the population experience failures in B12 and folic acid absorption. The manifestations of autism and ADHD can resemble "normal" ailments and neuralgia. While many symptoms may be compensated in childhood, they tend to worsen with age. Furthermore, blood levels can be normal, albeit generally low. The crucial aspect is that most DNA defects can be addressed with specific forms of vitamin B12 and folic acid—methylcobalamin 1000mcg and methylfolate 400-800mcg. It's essential to understand this topic fully, especially for those suffering from chronic iron deficiency, gut diseases, neuralgia, depression, chronic fatigue, hair loss, and reduced immunity.
Read More
Frequently Asked Questions
7.5
Increased focus
13 people found this helpful
For my child with autism, trying methyl-B12 injections and nasal sprays is advised by some online. However, this Jarrow lozenge seemed much easier and at 16.67% of the recommended daily dose for methyl-B12, I found it difficult to ascertain what benefits other methods could provide. I began giving my 10-year-old son about 1-2 lozenges per week, and he appears slightly more focused. I have also introduced some additional B vitamins, including Metafolin and B6, but I don't endorse mega doses; he takes them alternately at most. He also receives vitamin D and omega-3 supplements.
6
Improved symptoms
93 people found this helpful
It needs 50% of the population. It helped me immensely, with a striking effect noticeable by the third day of treatment. Recent DNA studies indicate that about 50% of the population experience failures in B12 and folic acid absorption. The manifestations of autism and ADHD can resemble "normal" ailments and neuralgia. While many symptoms may be compensated in childhood, they tend to worsen with age. Furthermore, blood levels can be normal, albeit generally low. The crucial aspect is that most DNA defects can be addressed with specific forms of vitamin B12 and folic acid—methylcobalamin 1000mcg and methylfolate 400-800mcg. It's essential to understand this topic fully, especially for those suffering from chronic iron deficiency, gut diseases, neuralgia, depression, chronic fatigue, hair loss, and reduced immunity.
6
Good response
I gave my child with autism half a tablet and it seems to have a good effect.
4
We explored the connection between vitamin B12 levels and Autism Spectrum Disorder (ASD) symptoms in children. In our research, we compared two groups: 50 children with ASD and 50 healthy children.
We found that children with ASD had lower serum levels of vitamin B12 and higher levels of homocysteine (Hcy) compared to those in the control group. Interestingly, there was a pattern observed; those with more severe autism symptoms had even lower vitamin B12 and folate levels but higher Hcy and IL-17 A levels.
This suggests that low vitamin B12 and high Hcy might be associated with the severity of ASD symptoms. While this study highlights potential links, it does not firmly conclude that vitamin B12 treatment will be effective for managing autism symptoms, as the interaction of various factors still needs consideration.
We found that children with ASD had lower serum levels of vitamin B12 and higher levels of homocysteine (Hcy) compared to those in the control group. Interestingly, there was a pattern observed; those with more severe autism symptoms had even lower vitamin B12 and folate levels but higher Hcy and IL-17 A levels.
This suggests that low vitamin B12 and high Hcy might be associated with the severity of ASD symptoms. While this study highlights potential links, it does not firmly conclude that vitamin B12 treatment will be effective for managing autism symptoms, as the interaction of various factors still needs consideration.
5
We investigated the connection between maternal serum vitamin B12 levels during early pregnancy and the occurrence of autism spectrum disorders (ASD) in children. In this study, we looked at data from a Finnish national birth cohort, which included 1,558 children diagnosed with ASD between 1987 and 2007. Each of these cases was carefully matched with a control child based on their date of birth, sex, and place of birth.
Our findings revealed that higher levels of maternal vitamin B12, specifically those at or above the 81st percentile, were linked to an increased risk of childhood autism. The adjusted odds ratio was 1.59, indicating a significant association. However, it’s critical to note that there were no significant findings regarding the relationships between maternal vitamin B12 levels and other ASD subtypes, like Asperger's or pervasive developmental disorder (NOS).
This study underscores a potential risk factor associated with higher maternal vitamin B12 levels, yet it does not suggest that vitamin B12 treatment can effectively address autism. In fact, the findings highlight the complexity of autism development and emphasize the need for further research to understand these relationships better.
Our findings revealed that higher levels of maternal vitamin B12, specifically those at or above the 81st percentile, were linked to an increased risk of childhood autism. The adjusted odds ratio was 1.59, indicating a significant association. However, it’s critical to note that there were no significant findings regarding the relationships between maternal vitamin B12 levels and other ASD subtypes, like Asperger's or pervasive developmental disorder (NOS).
This study underscores a potential risk factor associated with higher maternal vitamin B12 levels, yet it does not suggest that vitamin B12 treatment can effectively address autism. In fact, the findings highlight the complexity of autism development and emphasize the need for further research to understand these relationships better.
8
We examined how vitamin B12, a common nutritional supplement, may impact symptoms of autism spectrum disorder (ASD). Our analysis is based on a national survey that included responses from 1,286 participants across the United States. Participants shared their experiences regarding the perceived benefits and side effects of various nutraceuticals, with vitamin B12 emerging as one of the top-rated treatments.
Interestingly, the survey revealed that nutraceuticals, including vitamin B12, were viewed as more beneficial and had fewer adverse effects compared to traditional psychiatric and seizure medications. Specifically, the overall benefit rating for nutraceuticals was 1.59, compared to 1.39 for medications, while adverse effects for nutraceuticals were rated at 0.1 versus 0.9 for medications.
These findings suggest that vitamin B12, among other nutraceuticals, may offer clinical benefits for those with ASD, particularly in addressing core symptoms and associated comorbidities. However, it's essential to approach these results with an open mind and consider the diverse experiences shared by participants in the survey.
Interestingly, the survey revealed that nutraceuticals, including vitamin B12, were viewed as more beneficial and had fewer adverse effects compared to traditional psychiatric and seizure medications. Specifically, the overall benefit rating for nutraceuticals was 1.59, compared to 1.39 for medications, while adverse effects for nutraceuticals were rated at 0.1 versus 0.9 for medications.
These findings suggest that vitamin B12, among other nutraceuticals, may offer clinical benefits for those with ASD, particularly in addressing core symptoms and associated comorbidities. However, it's essential to approach these results with an open mind and consider the diverse experiences shared by participants in the survey.
8
We examined the potential of a syrup form of methylcobalamin, a type of vitamin B12, in improving the lives of individuals with autism. Over a period of 200 days, 25 children and young adults received a daily dose of 500 µg of this treatment. Throughout this time, both parents and psychologists regularly evaluated the clinical and psychological progress of the participants.
The findings were promising. Participants showed noticeable improvements, particularly in social skills, cognitive function, as well as behavioral and communication aspects. We found a strong correlation between these enhancements and changes in levels of reduced glutathione, a substance that helps protect cells from damage and supports overall health.
It's intriguing to see how a relatively simple vitamin supplement can have such a positive impact on the lives of autistic individuals. The treatment appeared to not only raise the oxidative status of the participants but also support their emotional and psychological well-being.
The findings were promising. Participants showed noticeable improvements, particularly in social skills, cognitive function, as well as behavioral and communication aspects. We found a strong correlation between these enhancements and changes in levels of reduced glutathione, a substance that helps protect cells from damage and supports overall health.
It's intriguing to see how a relatively simple vitamin supplement can have such a positive impact on the lives of autistic individuals. The treatment appeared to not only raise the oxidative status of the participants but also support their emotional and psychological well-being.
References
- Li H, Dang Y, Yan Y. Serum interleukin-17 A and homocysteine levels in children with autism. BMC Neurosci. 2024;25:17. doi:10.1186/s12868-024-00860-5
- Jin T, Huang W, Pang Q, He Z, Yuan L, et al. Inferring the genetic effects of serum homocysteine and vitamin B levels on autism spectral disorder through Mendelian randomization. Eur J Nutr. 2024;63:977. doi:10.1007/s00394-024-03329-7
- Tan Y, Zhou L, Gu K, Xie C, Wang Y, et al. Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis. Clin Psychopharmacol Neurosci. 2023;21:617. doi:10.9758/cpn.22.1040
- Sourander A, Silwal S, Surcel HM, Hinkka-Yli-Salomäki S, Upadhyaya S, et al. Maternal Serum Vitamin B12 during Pregnancy and Offspring Autism Spectrum Disorder. Nutrients. 2023;15. doi:10.3390/nu15082009
- Čorejová A, Fazekaš T, Jánošíková D, Repiský J, Pospíšilová V, et al. Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration. Nutrients. 2022;14. doi:10.3390/nu14102035
- Adams JB, Bhargava A, Coleman DM, Frye RE, Rossignol DA. Ratings of the Effectiveness of Nutraceuticals for Autism Spectrum Disorders: Results of a National Survey. J Pers Med. 2021;11. doi:10.3390/jpm11090878
- Erden S, Akbaş İleri B, Sadıç Çelikkol Ç, Nalbant K, Kılınç İ, et al. Serum B12, homocysteine, and anti-parietal cell antibody levels in children with autism. Int J Psychiatry Clin Pract. 2022;26:8. doi:10.1080/13651501.2021.1906906
