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SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
7
Vitamin B12 deficiency and migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Highly relevant to migraine research
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
7
Vitamin B12 and migraine correlation
A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine.
Your relevance score indicates significance
We set out to understand how vitamin B12 levels relate to migraine frequency and pain severity. In our study, we included 127 migraine patients and 45 healthy controls from Okmeydanı Training and Research Hospital. Notably, we measured the frequency and duration of migraine attacks and assessed pain severity using a visual analogue scale (VAS).
Our findings revealed that migraine patients had significantly lower vitamin B12 levels compared to the healthy controls. Specifically, the average vitamin B12 level in migraine sufferers was 227.30 ng/L, while the controls had an average of 278.44 ng/L.
Furthermore, we observed that chronic migraine patients had even lower vitamin B12 levels than those experiencing less frequent migraines. While our study suggests a correlation between low vitamin B12 and increased migraine severity, we did not explicitly evaluate the treatment effects of vitamin B12 supplements on migraines.
Thus, while low vitamin B12 may be associated with more severe migraines, it remains unclear if supplementation would provide a significant therapeutic benefit. Regular monitoring of vitamin B12 levels in patients with migraines could still be a valuable practice.
Our findings revealed that migraine patients had significantly lower vitamin B12 levels compared to the healthy controls. Specifically, the average vitamin B12 level in migraine sufferers was 227.30 ng/L, while the controls had an average of 278.44 ng/L.
Furthermore, we observed that chronic migraine patients had even lower vitamin B12 levels than those experiencing less frequent migraines. While our study suggests a correlation between low vitamin B12 and increased migraine severity, we did not explicitly evaluate the treatment effects of vitamin B12 supplements on migraines.
Thus, while low vitamin B12 may be associated with more severe migraines, it remains unclear if supplementation would provide a significant therapeutic benefit. Regular monitoring of vitamin B12 levels in patients with migraines could still be a valuable practice.
Read More
7
Vitamin B12's impact on migraines
Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study.
High relevance to migraine research
We set out to investigate the connection between vitamin B12 levels and migraines by comparing serum vitamin B12 and methylmalonic acid (MMA) levels in migraine patients and healthy individuals. Our study involved 70 migraine sufferers and 70 controls, aiming to understand whether vitamin B12 deficiencies might be linked to migraine frequency and intensity.
The results indicated that migraine patients had significantly lower vitamin B12 levels compared to the healthy group, alongside higher MMA levels. Importantly, those with the lowest vitamin B12 levels had an 80% higher chance of experiencing migraines. Conversely, participants with elevated MMA levels faced more than a fivefold increase in migraine risk.
While the findings provide insightful associations between vitamin B12 status and migraines, it's crucial to note that the study doesn't include direct treatment interventions. This means while we observed intriguing links, we cannot confirm that vitamin B12 supplementation would definitively alleviate migraine symptoms based solely on this study.
The results indicated that migraine patients had significantly lower vitamin B12 levels compared to the healthy group, alongside higher MMA levels. Importantly, those with the lowest vitamin B12 levels had an 80% higher chance of experiencing migraines. Conversely, participants with elevated MMA levels faced more than a fivefold increase in migraine risk.
While the findings provide insightful associations between vitamin B12 status and migraines, it's crucial to note that the study doesn't include direct treatment interventions. This means while we observed intriguing links, we cannot confirm that vitamin B12 supplementation would definitively alleviate migraine symptoms based solely on this study.
Read More
Most Useful Reviews
8.8
Effective for migraines
It works well! I find this vitamin B12 beneficial for my migraines, especially considering its easy-to-take ramune form. Traditional tablet types are difficult for me to swallow. This supplement helps refresh my mind and eases neck stiffness, which contributes to my tinnitus. I particularly recommend it for anyone suffering from light sensitivity associated with migraines.
Read More
9.5
Pain relief
After knee surgery, I was prescribed various painkillers, yet I still experienced a bad headache and ocular migraine. Upon discovering that some pain medications could elevate homocysteine levels, I took this supplement along with a B12 spray. Within 30 minutes, my headache dissipated.
Read More
8.8
Migraine improvement
I enjoy the lemon flavour. Taking 1 to 3 tablets daily feels like eating ramune candy, making it convenient. I've noticed a positive impact on my migraines and vision.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
9
Vitamin B12 supplementation aids migraines
Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation.
Study notes B12's role
We conducted a comprehensive study to explore the effectiveness of vitamin B supplementation, including B12, in reducing migraine occurrences, particularly in women diagnosed with migraines accompanied by aura. Over a period of six months, we administered daily vitamin B supplements to a group of 206 participants, comparing their results to those taking a placebo.
Our findings were quite promising. Vitamin supplementation notably lowered homocysteine levels, which is linked to migraine severity. We observed significant reductions in headache severity and the degree of migraine-related disability among those taking the vitamins compared to those on the placebo.
Furthermore, when we examined the genetic backgrounds of participants, we found that specific variants in the MTHFR and MTRR genes influenced the response to vitamin B supplementation. Carriers of certain gene variants experienced even greater improvements. Importantly, the positive effects from vitamin treatments seemed independent of the MTHFR variant, suggesting a broader impact of B vitamins on migraines.
Overall, our research indicates that vitamin B supplementation, including B12, holds potential as an effective intervention for reducing migraine symptoms, enhancing the quality of life for those affected.
Our findings were quite promising. Vitamin supplementation notably lowered homocysteine levels, which is linked to migraine severity. We observed significant reductions in headache severity and the degree of migraine-related disability among those taking the vitamins compared to those on the placebo.
Furthermore, when we examined the genetic backgrounds of participants, we found that specific variants in the MTHFR and MTRR genes influenced the response to vitamin B supplementation. Carriers of certain gene variants experienced even greater improvements. Importantly, the positive effects from vitamin treatments seemed independent of the MTHFR variant, suggesting a broader impact of B vitamins on migraines.
Overall, our research indicates that vitamin B supplementation, including B12, holds potential as an effective intervention for reducing migraine symptoms, enhancing the quality of life for those affected.
Read More
9
Migraine relief through vitamin B12
The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability.
Vitamin B12's effect on migraines
We conducted a thorough investigation into the effects of vitamin B12 supplementation on individuals suffering from migraines, specifically those with aura. Our study focused on how daily doses of a vitamin combination, including B12, influenced migraine symptoms and disability levels over six months. We employed a randomized, double-blind, placebo-controlled trial to ensure the reliability of our findings.
Our results were promising. Participants who received vitamin supplementation showed a significant drop in homocysteine levels by 39%, which was markedly more than those in the placebo group. This reduction was linked to a substantial decrease in migraine disability; moving from 60% prevalence at the start to just 30% after six months of treatment.
Furthermore, we noted that headache frequency and pain severity also improved with vitamin supplementation. Notably, those carrying the C allele of the MTHFR (C677T) genotype responded even better to this treatment compared to the TT genotype individuals. This suggests that genotype can play a role in how effective vitamin B12 and its related vitamins can be for migraine sufferers.
While these findings highlight the potential benefits of vitamin B12, more extensive research is necessary to determine if this combination therapy is a safe and effective long-term option for preventing migraines. Our work shines a light on a possible new pathway to relief for many individuals who struggle with this debilitating condition.
Our results were promising. Participants who received vitamin supplementation showed a significant drop in homocysteine levels by 39%, which was markedly more than those in the placebo group. This reduction was linked to a substantial decrease in migraine disability; moving from 60% prevalence at the start to just 30% after six months of treatment.
Furthermore, we noted that headache frequency and pain severity also improved with vitamin supplementation. Notably, those carrying the C allele of the MTHFR (C677T) genotype responded even better to this treatment compared to the TT genotype individuals. This suggests that genotype can play a role in how effective vitamin B12 and its related vitamins can be for migraine sufferers.
While these findings highlight the potential benefits of vitamin B12, more extensive research is necessary to determine if this combination therapy is a safe and effective long-term option for preventing migraines. Our work shines a light on a possible new pathway to relief for many individuals who struggle with this debilitating condition.
Read More
8
Vitamin B12 shows promise for migraines
Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial.
Moderate relevance for migraine therapy
We conducted a study to explore the effects of vitamin B12, when combined with magnesium and high-intensity interval training (HIIT), on alleviating migraine symptoms. Our research involved 60 participants who were divided into four groups: one group practiced HIIT, another consumed vitamin B12 and magnesium supplements, a third group did both HIIT and supplements, and a control group received no intervention.
Over two months, we measured changes in migraine frequency, intensity, and duration, along with serum levels of a specific marker known as calcitonin gene-related peptide (CGRP). We noted that the combination of vitamin B12 and magnesium, coupled with regular exercise, appeared to positively influence inflammation pathways related to migraines, suggesting a potential way to reduce migraine pain.
However, it is important to recognize that the study had limitations in isolating the specific effects of vitamin B12 from the other treatment components. Nonetheless, our findings indicate that incorporating vitamin B12 and magnesium with physical activity could be a promising approach to help those suffering from migraines.
Over two months, we measured changes in migraine frequency, intensity, and duration, along with serum levels of a specific marker known as calcitonin gene-related peptide (CGRP). We noted that the combination of vitamin B12 and magnesium, coupled with regular exercise, appeared to positively influence inflammation pathways related to migraines, suggesting a potential way to reduce migraine pain.
However, it is important to recognize that the study had limitations in isolating the specific effects of vitamin B12 from the other treatment components. Nonetheless, our findings indicate that incorporating vitamin B12 and magnesium with physical activity could be a promising approach to help those suffering from migraines.
Read More
7
Vitamin B12 deficiency and migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Highly relevant to migraine research
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
7
Investigating Vitamin B12 for Migraine
Modifiable factors for migraine prophylaxis: A mendelian randomization analysis.
Potential link to migraine treatment
We explored the potential impact of vitamin B12 on migraine pathogenesis by analyzing data from several sources including the UK Biobank and others. Our study involved participants suffering from migraines without aura (MwoA) and migraines with aura (MwA), and we looked at 51 different risk factors that could influence these conditions.
Our findings suggested that higher vitamin B12 intake was associated with lower odds of developing migraines without aura. Specifically, the odds ratio for vitamin B12 was 0.49, indicating a potentially significant protective effect. This suggests that increasing vitamin B12 intake might be a beneficial strategy for reducing the risk of MwoA, adding to a growing body of evidence about the nutrient's importance.
However, we also recognized the need for further exploration of how vitamin B12 should be administered and its isolated effects on different types of migraines. It's important to note that while these results are promising, they are just part of a larger picture of migraine management, which includes various lifestyle factors we also examined, such as stress and physical activity.
Overall, identifying vitamin B12 as a protective factor opens doors for potential interventions in migraine prophylaxis focused on dietary modifications and increased awareness of nutrient consumption.
Our findings suggested that higher vitamin B12 intake was associated with lower odds of developing migraines without aura. Specifically, the odds ratio for vitamin B12 was 0.49, indicating a potentially significant protective effect. This suggests that increasing vitamin B12 intake might be a beneficial strategy for reducing the risk of MwoA, adding to a growing body of evidence about the nutrient's importance.
However, we also recognized the need for further exploration of how vitamin B12 should be administered and its isolated effects on different types of migraines. It's important to note that while these results are promising, they are just part of a larger picture of migraine management, which includes various lifestyle factors we also examined, such as stress and physical activity.
Overall, identifying vitamin B12 as a protective factor opens doors for potential interventions in migraine prophylaxis focused on dietary modifications and increased awareness of nutrient consumption.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Pain relief
After knee surgery, I was prescribed various painkillers, yet I still experienced a bad headache and ocular migraine. Upon discovering that some pain medications could elevate homocysteine levels, I took this supplement along with a B12 spray. Within 30 minutes, my headache dissipated.
Read More
8.8
Effective for migraines
It works well! I find this vitamin B12 beneficial for my migraines, especially considering its easy-to-take ramune form. Traditional tablet types are difficult for me to swallow. This supplement helps refresh my mind and eases neck stiffness, which contributes to my tinnitus. I particularly recommend it for anyone suffering from light sensitivity associated with migraines.
Read More
8.8
Migraine improvement
I enjoy the lemon flavour. Taking 1 to 3 tablets daily feels like eating ramune candy, making it convenient. I've noticed a positive impact on my migraines and vision.
8.8
Migraine boost
This B12 supplement is my favourite; it provides a midday boost and helps alleviate chronic migraines.
8.8
High-quality ingredients
This product is of high quality and effectively aids my migraines when used alongside CoQ10 and magnesium.
