Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.2
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
7
We set out to understand how vitamin B12 levels relate to migraine frequency and pain severity. In our study, we included 127 migraine patients and 45 healthy controls from Okmeydanı Training and Research Hospital. Notably, we measured the frequency and duration of migraine attacks and assessed pain severity using a visual analogue scale (VAS).
Our findings revealed that migraine patients had significantly lower vitamin B12 levels compared to the healthy controls. Specifically, the average vitamin B12 level in migraine sufferers was 227.30 ng/L, while the controls had an average of 278.44 ng/L.
Furthermore, we observed that chronic migraine patients had even lower vitamin B12 levels than those experiencing less frequent migraines. While our study suggests a correlation between low vitamin B12 and increased migraine severity, we did not explicitly evaluate the treatment effects of vitamin B12 supplements on migraines.
Thus, while low vitamin B12 may be associated with more severe migraines, it remains unclear if supplementation would provide a significant therapeutic benefit. Regular monitoring of vitamin B12 levels in patients with migraines could still be a valuable practice.
Our findings revealed that migraine patients had significantly lower vitamin B12 levels compared to the healthy controls. Specifically, the average vitamin B12 level in migraine sufferers was 227.30 ng/L, while the controls had an average of 278.44 ng/L.
Furthermore, we observed that chronic migraine patients had even lower vitamin B12 levels than those experiencing less frequent migraines. While our study suggests a correlation between low vitamin B12 and increased migraine severity, we did not explicitly evaluate the treatment effects of vitamin B12 supplements on migraines.
Thus, while low vitamin B12 may be associated with more severe migraines, it remains unclear if supplementation would provide a significant therapeutic benefit. Regular monitoring of vitamin B12 levels in patients with migraines could still be a valuable practice.
Read More
7
We explored the potential benefits of hydroxocobalamin, a form of vitamin B12, in helping reduce migraine frequency and severity. In a pilot study involving 20 participants with a history of migraines, we administered 1 mg of intranasal hydroxocobalamin daily for three months. Each participant kept a diary detailing their migraine attacks throughout the study.
Our results were promising. About 53% of the patients experienced a significant decrease in their migraine frequency, with a reduction of 50% or more in their attacks. Overall, the average number of migraine attacks per month dropped from 4.7 to 2.7, which is quite a noteworthy change. Additionally, we observed reductions in the total duration of migraine attacks and the number of medication doses used for acute treatment.
While this was the first prospective study indicating the potential of hydroxycobalamin for migraine prophylaxis, we recommend conducting a double-blind study for further validation, especially since a responder rate of over 35-40% may exceed what’s typically expected from a placebo effect. Our findings suggest that vitamin B12 could be a valuable option for individuals struggling with migraines.
Our results were promising. About 53% of the patients experienced a significant decrease in their migraine frequency, with a reduction of 50% or more in their attacks. Overall, the average number of migraine attacks per month dropped from 4.7 to 2.7, which is quite a noteworthy change. Additionally, we observed reductions in the total duration of migraine attacks and the number of medication doses used for acute treatment.
While this was the first prospective study indicating the potential of hydroxycobalamin for migraine prophylaxis, we recommend conducting a double-blind study for further validation, especially since a responder rate of over 35-40% may exceed what’s typically expected from a placebo effect. Our findings suggest that vitamin B12 could be a valuable option for individuals struggling with migraines.
Read More
Most Useful Reviews
7.5
Effective for migraines
5 people found this helpful
It works well! I find this vitamin B12 beneficial for my migraines, especially considering its easy-to-take ramune form. Traditional tablet types are difficult for me to swallow. This supplement helps refresh my mind and eases neck stiffness, which contributes to my tinnitus. I particularly recommend it for anyone suffering from light sensitivity associated with migraines.
Read More
9
Pain relief
After knee surgery, I was prescribed various painkillers, yet I still experienced a bad headache and ocular migraine. Upon discovering that some pain medications could elevate homocysteine levels, I took this supplement along with a B12 spray. Within 30 minutes, my headache dissipated.
Read More
7.5
Migraine improvement
2 people found this helpful
I enjoy the lemon flavour. Taking 1 to 3 tablets daily feels like eating ramune candy, making it convenient. I've noticed a positive impact on my migraines and vision.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.2
- All Researches
8
We looked into how vitamin B supplementation affects migraines among women and the role of specific gene variants. In a 6-month study involving 206 female migraineurs, we found that daily vitamins B6, B9, and B12 significantly decreased homocysteine levels, headache severity, and migraine-related disabilities. Interestingly, women with specific genetic markers showed an even greater improvement. The benefits of supplements were significant, suggesting they can effectively reduce migraine symptoms by addressing underlying conditions tied to genetics.
Read More
8
We examined how vitamin supplementation could affect migraine symptoms in patients. In a randomized, double-blind trial with 52 participants, daily vitamins, including B12, led to a significant 39% reduction in homocysteine levels.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
Read More
7
Vitamin B12 & magnesium aid migraines
This study examined the impact of vitamin B12 and magnesium, combined with high-intensity interval training (HIIT), on women's migraine attacks.
We organized participants into four groups over two months, comparing those on supplements, those doing HIIT, and those using both approaches. We measured serum levels of a specific signaling molecule and assessed migraine severity throughout.
The results highlighted that the combination of B12, magnesium, and exercise appears to reduce migraine pain by targeting inflammation pathways.
We organized participants into four groups over two months, comparing those on supplements, those doing HIIT, and those using both approaches. We measured serum levels of a specific signaling molecule and assessed migraine severity throughout.
The results highlighted that the combination of B12, magnesium, and exercise appears to reduce migraine pain by targeting inflammation pathways.
Read More
7
We conducted a systematic review to examine the effects of vitamin B6, folate, and B12 on migraine.
Our findings revealed that while these vitamins did not show significant benefits for treating acute migraines, they may help prevent migraines with aura in adults.
Out of five studies, most showed promising results when these vitamins were used together, but folate alone didn’t outperform a placebo.
However, more research is needed, particularly for other types of migraines in both adults and children.
Our findings revealed that while these vitamins did not show significant benefits for treating acute migraines, they may help prevent migraines with aura in adults.
Out of five studies, most showed promising results when these vitamins were used together, but folate alone didn’t outperform a placebo.
However, more research is needed, particularly for other types of migraines in both adults and children.
Read More
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective for migraines
5 people found this helpful
It works well! I find this vitamin B12 beneficial for my migraines, especially considering its easy-to-take ramune form. Traditional tablet types are difficult for me to swallow. This supplement helps refresh my mind and eases neck stiffness, which contributes to my tinnitus. I particularly recommend it for anyone suffering from light sensitivity associated with migraines.
Read More
9
Pain relief
After knee surgery, I was prescribed various painkillers, yet I still experienced a bad headache and ocular migraine. Upon discovering that some pain medications could elevate homocysteine levels, I took this supplement along with a B12 spray. Within 30 minutes, my headache dissipated.
Read More
7.5
Migraine improvement
2 people found this helpful
I enjoy the lemon flavour. Taking 1 to 3 tablets daily feels like eating ramune candy, making it convenient. I've noticed a positive impact on my migraines and vision.
Read More
7.5
Migraine boost
This B12 supplement is my favourite; it provides a midday boost and helps alleviate chronic migraines.
Read More
7.5
High-quality ingredients
This product is of high quality and effectively aids my migraines when used alongside CoQ10 and magnesium.
Read More
Frequently Asked Questions
9
Pain relief
After knee surgery, I was prescribed various painkillers, yet I still experienced a bad headache and ocular migraine. Upon discovering that some pain medications could elevate homocysteine levels, I took this supplement along with a B12 spray. Within 30 minutes, my headache dissipated.
7.5
Migraine improvement
2 people found this helpful
I enjoy the lemon flavour. Taking 1 to 3 tablets daily feels like eating ramune candy, making it convenient. I've noticed a positive impact on my migraines and vision.
7.5
Migraine boost
This B12 supplement is my favourite; it provides a midday boost and helps alleviate chronic migraines.
7.5
Effective for migraines
5 people found this helpful
It works well! I find this vitamin B12 beneficial for my migraines, especially considering its easy-to-take ramune form. Traditional tablet types are difficult for me to swallow. This supplement helps refresh my mind and eases neck stiffness, which contributes to my tinnitus. I particularly recommend it for anyone suffering from light sensitivity associated with migraines.
7.5
High-quality ingredients
This product is of high quality and effectively aids my migraines when used alongside CoQ10 and magnesium.
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
8
We examined how vitamin supplementation could affect migraine symptoms in patients. In a randomized, double-blind trial with 52 participants, daily vitamins, including B12, led to a significant 39% reduction in homocysteine levels.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
7
We conducted a systematic review to examine the effects of vitamin B6, folate, and B12 on migraine.
Our findings revealed that while these vitamins did not show significant benefits for treating acute migraines, they may help prevent migraines with aura in adults.
Out of five studies, most showed promising results when these vitamins were used together, but folate alone didn’t outperform a placebo.
However, more research is needed, particularly for other types of migraines in both adults and children.
Our findings revealed that while these vitamins did not show significant benefits for treating acute migraines, they may help prevent migraines with aura in adults.
Out of five studies, most showed promising results when these vitamins were used together, but folate alone didn’t outperform a placebo.
However, more research is needed, particularly for other types of migraines in both adults and children.
7
We explored the potential impact of vitamin B12 on migraine pathogenesis by analyzing data from several sources including the UK Biobank and others. Our study involved participants suffering from migraines without aura (MwoA) and migraines with aura (MwA), and we looked at 51 different risk factors that could influence these conditions.
Our findings suggested that higher vitamin B12 intake was associated with lower odds of developing migraines without aura. Specifically, the odds ratio for vitamin B12 was 0.49, indicating a potentially significant protective effect. This suggests that increasing vitamin B12 intake might be a beneficial strategy for reducing the risk of MwoA, adding to a growing body of evidence about the nutrient's importance.
However, we also recognized the need for further exploration of how vitamin B12 should be administered and its isolated effects on different types of migraines. It's important to note that while these results are promising, they are just part of a larger picture of migraine management, which includes various lifestyle factors we also examined, such as stress and physical activity.
Overall, identifying vitamin B12 as a protective factor opens doors for potential interventions in migraine prophylaxis focused on dietary modifications and increased awareness of nutrient consumption.
Our findings suggested that higher vitamin B12 intake was associated with lower odds of developing migraines without aura. Specifically, the odds ratio for vitamin B12 was 0.49, indicating a potentially significant protective effect. This suggests that increasing vitamin B12 intake might be a beneficial strategy for reducing the risk of MwoA, adding to a growing body of evidence about the nutrient's importance.
However, we also recognized the need for further exploration of how vitamin B12 should be administered and its isolated effects on different types of migraines. It's important to note that while these results are promising, they are just part of a larger picture of migraine management, which includes various lifestyle factors we also examined, such as stress and physical activity.
Overall, identifying vitamin B12 as a protective factor opens doors for potential interventions in migraine prophylaxis focused on dietary modifications and increased awareness of nutrient consumption.
4
This study examined the relationship between serum vitamin B12 levels, methylmalonic acid (MMA), and migraines. We found that migraine patients had significantly lower B12 levels and higher MMA compared to healthy individuals.
Essentially, those with higher B12 levels seemed to have a reduced risk of experiencing migraines, while higher MMA levels correlated with increased migraine risk. Despite these findings, there was no connection between vitamin B12 and MMA levels and the characteristics of the migraines themselves.
Overall, our results suggest a notable link between B12 deficiency and the likelihood of migraines.
Essentially, those with higher B12 levels seemed to have a reduced risk of experiencing migraines, while higher MMA levels correlated with increased migraine risk. Despite these findings, there was no connection between vitamin B12 and MMA levels and the characteristics of the migraines themselves.
Overall, our results suggest a notable link between B12 deficiency and the likelihood of migraines.
8
We looked into how vitamin B supplementation affects migraines among women and the role of specific gene variants. In a 6-month study involving 206 female migraineurs, we found that daily vitamins B6, B9, and B12 significantly decreased homocysteine levels, headache severity, and migraine-related disabilities. Interestingly, women with specific genetic markers showed an even greater improvement. The benefits of supplements were significant, suggesting they can effectively reduce migraine symptoms by addressing underlying conditions tied to genetics.
7
We explored the potential benefits of hydroxocobalamin, a form of vitamin B12, in helping reduce migraine frequency and severity. In a pilot study involving 20 participants with a history of migraines, we administered 1 mg of intranasal hydroxocobalamin daily for three months. Each participant kept a diary detailing their migraine attacks throughout the study.
Our results were promising. About 53% of the patients experienced a significant decrease in their migraine frequency, with a reduction of 50% or more in their attacks. Overall, the average number of migraine attacks per month dropped from 4.7 to 2.7, which is quite a noteworthy change. Additionally, we observed reductions in the total duration of migraine attacks and the number of medication doses used for acute treatment.
While this was the first prospective study indicating the potential of hydroxycobalamin for migraine prophylaxis, we recommend conducting a double-blind study for further validation, especially since a responder rate of over 35-40% may exceed what’s typically expected from a placebo effect. Our findings suggest that vitamin B12 could be a valuable option for individuals struggling with migraines.
Our results were promising. About 53% of the patients experienced a significant decrease in their migraine frequency, with a reduction of 50% or more in their attacks. Overall, the average number of migraine attacks per month dropped from 4.7 to 2.7, which is quite a noteworthy change. Additionally, we observed reductions in the total duration of migraine attacks and the number of medication doses used for acute treatment.
While this was the first prospective study indicating the potential of hydroxycobalamin for migraine prophylaxis, we recommend conducting a double-blind study for further validation, especially since a responder rate of over 35-40% may exceed what’s typically expected from a placebo effect. Our findings suggest that vitamin B12 could be a valuable option for individuals struggling with migraines.
References
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. doi:10.1007/s10072-021-05843-6
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. doi:10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. doi:10.1097/FPC.0b013e32832af5a3
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. doi:10.1080/01616412.2025.2462735
- Zheng H, Shi YZ, Liang JT, Lu LL, Chen M. Modifiable factors for migraine prophylaxis: A mendelian randomization analysis. Front Pharmacol. 2023;14:1010996. doi:10.3389/fphar.2023.1010996
- Üstün Özek S. A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine. Arq Neuropsiquiatr. 2022;80:586. doi:10.1590/0004-282X-ANP-2021-0192
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. doi:10.1007/s13760-020-01491-3
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. doi:10.1186/s10194-016-0652-7
- van der Kuy PH, Merkus FW, Lohman JJ, ter Berg JW, Hooymans PM. Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study. Cephalalgia. 2002;22:513.
