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SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Vitamin B12 alleviates stroke effects
Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.
Highly relevant study findings
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Read More
8
Vitamin B12 and stroke outcomes
Serum Vitamin B12 Levels as a Risk Factor and Prognostic Marker in Patients With Acute Ischemic Stroke at a Tertiary Care Center in Northern India: A Case-Control Study.
Direct connection to stroke risk
We conducted a study to understand how vitamin B12 levels might influence acute ischemic stroke. By comparing 75 stroke patients with 75 age- and sex-matched controls, we were able to assess the levels of vitamin B12 and homocysteine—an amino acid linked to stroke risk.
Our findings revealed that stroke patients had significantly lower levels of vitamin B12 and higher levels of homocysteine. More importantly, those who experienced worse outcomes, including mortality, also had lower vitamin B12 levels.
We observed strong correlations: as vitamin B12 levels decreased, stroke severity increased, and functional outcomes worsened. This suggests that vitamin B12 could play a significant role in both the occurrence and severity of ischemic strokes, emphasizing the potential importance of monitoring and potentially supplementing this vitamin for better patient management.
However, our study highlights the need for further research to explore how vitamin B12 supplementation may help reduce stroke risk and improve outcomes for patients. The insights we gathered pave the way for future investigations into the therapeutic use of vitamin B12 in stroke care.
Our findings revealed that stroke patients had significantly lower levels of vitamin B12 and higher levels of homocysteine. More importantly, those who experienced worse outcomes, including mortality, also had lower vitamin B12 levels.
We observed strong correlations: as vitamin B12 levels decreased, stroke severity increased, and functional outcomes worsened. This suggests that vitamin B12 could play a significant role in both the occurrence and severity of ischemic strokes, emphasizing the potential importance of monitoring and potentially supplementing this vitamin for better patient management.
However, our study highlights the need for further research to explore how vitamin B12 supplementation may help reduce stroke risk and improve outcomes for patients. The insights we gathered pave the way for future investigations into the therapeutic use of vitamin B12 in stroke care.
Read More
7
Vitamin B12 impacts stroke recovery
Association between vitamin B12 status and heart rate variability in patients with ischemic stroke.
Direct correlation with HRV
We explored the connection between vitamin B12 levels and heart rate variability (HRV) in patients who have experienced ischemic stroke. The study involved a look back at the medical records of 87 patients from January 2015 to December 2022. Each patient had their serum vitamin B12 levels measured and underwent 24-hour heart rhythm monitoring.
Our findings revealed a significant relationship between vitamin B12 status and HRV, particularly in the frequency domain, which is a crucial area for understanding autonomic function. The statistical analysis indicated that vitamin B12 levels are a substantial predictor of HRV parameters, suggesting that lower levels of this vitamin may coincide with poorer heart rate regulation in stroke patients.
This research highlights the potential impact of vitamin B12 on maintaining heart health in those who have suffered strokes. By demonstrating that vitamin B12 status could be linked to autonomic dysfunction, we provide valuable insights into how maintaining proper vitamin levels might aid recovery and improve overall cardiovascular health in these patients.
Our findings revealed a significant relationship between vitamin B12 status and HRV, particularly in the frequency domain, which is a crucial area for understanding autonomic function. The statistical analysis indicated that vitamin B12 levels are a substantial predictor of HRV parameters, suggesting that lower levels of this vitamin may coincide with poorer heart rate regulation in stroke patients.
This research highlights the potential impact of vitamin B12 on maintaining heart health in those who have suffered strokes. By demonstrating that vitamin B12 status could be linked to autonomic dysfunction, we provide valuable insights into how maintaining proper vitamin levels might aid recovery and improve overall cardiovascular health in these patients.
Read More
Most Useful Reviews
8.8
Reduces stroke risk
This complex is truly wonderful, containing essential B vitamins (B12, B6, B9) in their active forms. They assist with chronic viral loads and lower homocysteine levels, consequently reducing the risk of cardiovascular diseases, particularly stroke. This complex is vital for the elderly who are at risk.
Read More
8.8
Supports stroke prevention
This product wonderfully supports the nervous system, heart, and blood pressure, preventing thrombus formation, atherosclerosis, heart attacks, and strokes. It is an excellent addition for cardiovascular health.
Read More
8.5
Prevents stroke occurrences
Vitamin B12 is crucial for the nervous system and blood cell formation. Its deficiency can have severe consequences. It is known to alleviate pain and prevent pernicious anaemia, heart attacks, and strokes. This product is of high quality, with natural ingredients and an excellent composition.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
9
Vitamin B12 alleviates stroke effects
Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.
Highly relevant study findings
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Read More
8
Vitamin B12 and stroke outcomes
Serum Vitamin B12 Levels as a Risk Factor and Prognostic Marker in Patients With Acute Ischemic Stroke at a Tertiary Care Center in Northern India: A Case-Control Study.
Direct connection to stroke risk
We conducted a study to understand how vitamin B12 levels might influence acute ischemic stroke. By comparing 75 stroke patients with 75 age- and sex-matched controls, we were able to assess the levels of vitamin B12 and homocysteine—an amino acid linked to stroke risk.
Our findings revealed that stroke patients had significantly lower levels of vitamin B12 and higher levels of homocysteine. More importantly, those who experienced worse outcomes, including mortality, also had lower vitamin B12 levels.
We observed strong correlations: as vitamin B12 levels decreased, stroke severity increased, and functional outcomes worsened. This suggests that vitamin B12 could play a significant role in both the occurrence and severity of ischemic strokes, emphasizing the potential importance of monitoring and potentially supplementing this vitamin for better patient management.
However, our study highlights the need for further research to explore how vitamin B12 supplementation may help reduce stroke risk and improve outcomes for patients. The insights we gathered pave the way for future investigations into the therapeutic use of vitamin B12 in stroke care.
Our findings revealed that stroke patients had significantly lower levels of vitamin B12 and higher levels of homocysteine. More importantly, those who experienced worse outcomes, including mortality, also had lower vitamin B12 levels.
We observed strong correlations: as vitamin B12 levels decreased, stroke severity increased, and functional outcomes worsened. This suggests that vitamin B12 could play a significant role in both the occurrence and severity of ischemic strokes, emphasizing the potential importance of monitoring and potentially supplementing this vitamin for better patient management.
However, our study highlights the need for further research to explore how vitamin B12 supplementation may help reduce stroke risk and improve outcomes for patients. The insights we gathered pave the way for future investigations into the therapeutic use of vitamin B12 in stroke care.
Read More
8
Vitamin B12 linked to stroke risk
Serum levels of vitamin B12 combined with folate and plasma total homocysteine predict ischemic stroke disease: a retrospective case-control study.
Moderate relevance to stroke research
We explored how levels of vitamin B12, along with folate and plasma total homocysteine (tHcy), could predict the risk of acute ischemic stroke. In our study, we analyzed data from 259 patients who had their first ischemic stroke and compared them to a similar group of 259 healthy individuals.
Patients were divided based on the cause of their stroke, such as large-artery atherosclerosis and small vessel disease. Through sophisticated statistical methods, we assessed how these vitamin levels correlated with stroke risk.
Our findings revealed that vitamin B12 stood out as an independent risk factor for acute ischemic stroke. Notably, a combined risk model using vitamin B12, folate, and tHcy exhibited the best diagnostic accuracy, particularly for small vessel disease strokes. This indicates that monitoring these vitamin levels could be valuable for evaluating stroke risk, enriching our understanding of how nutrition might play a role in brain health.
Patients were divided based on the cause of their stroke, such as large-artery atherosclerosis and small vessel disease. Through sophisticated statistical methods, we assessed how these vitamin levels correlated with stroke risk.
Our findings revealed that vitamin B12 stood out as an independent risk factor for acute ischemic stroke. Notably, a combined risk model using vitamin B12, folate, and tHcy exhibited the best diagnostic accuracy, particularly for small vessel disease strokes. This indicates that monitoring these vitamin levels could be valuable for evaluating stroke risk, enriching our understanding of how nutrition might play a role in brain health.
Read More
8
B-Vitamins' Role in Stroke Prevention
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review.
Combination effects are unclear
We analyzed the effects of vitamin B12, among other B-vitamins, on stroke prevention through a thorough review of randomized controlled trials. Our investigation included examining 14 studies with over 76,000 participants, focusing on how supplements containing vitamins B6, B12, and folic acid influenced stroke risk.
In areas where folic acid is not fortified, we observed that combining these B-vitamins was linked to a significant 34% reduction in stroke risk. Specifically regarding vitamin B12, the most effective dosage appeared to be 0.4 mg per day when taken alongside folic acid. However, in regions where people already receive fortified folic acid, no distinct advantage from the combined supplementation was found.
Therefore, our findings suggest that while vitamin B12 can play a beneficial role in stroke prevention when taken with other B-vitamins, this benefit surfaces mainly in populations not receiving sufficient folic acid from fortification. Overall, it emphasizes the importance of targeted B-vitamin supplementation strategies based on local dietary practices and fortification policies.
In areas where folic acid is not fortified, we observed that combining these B-vitamins was linked to a significant 34% reduction in stroke risk. Specifically regarding vitamin B12, the most effective dosage appeared to be 0.4 mg per day when taken alongside folic acid. However, in regions where people already receive fortified folic acid, no distinct advantage from the combined supplementation was found.
Therefore, our findings suggest that while vitamin B12 can play a beneficial role in stroke prevention when taken with other B-vitamins, this benefit surfaces mainly in populations not receiving sufficient folic acid from fortification. Overall, it emphasizes the importance of targeted B-vitamin supplementation strategies based on local dietary practices and fortification policies.
Read More
8
Vitamin B12 may aid stroke recovery
Can supplementing vitamin B12 improve mental health outcomes?: a literature review.
Relates to stroke and depression
We took a close look at how vitamin B12 affects stroke recovery and mental health, particularly focusing on its role in preventing post-stroke depression. Conducting a systematic review, we analyzed several studies examining the relationship between B12 and various aspects of mental well-being in stroke patients. Over 280 articles were initially reviewed, and through careful selection, we zeroed in on five randomised controlled trials.
These studies assessed vitamin B12, combined with other vitamins like folic acid and B6, and its effects on different conditions, including post-stroke depression and symptoms of depression in older adults. While the results of these trials were inconclusive overall, they provided strong evidence that in specific high-risk groups—particularly after a stroke—B12 supplementation could help prevent depression.
Ultimately, our findings highlighted that while vitamin B12 shows promise, more research is needed to clarify its effectiveness, especially among particular patient groups. There's a case for considering B12 supplements as part of recovery plans for those at high risk of depression after a stroke.
These studies assessed vitamin B12, combined with other vitamins like folic acid and B6, and its effects on different conditions, including post-stroke depression and symptoms of depression in older adults. While the results of these trials were inconclusive overall, they provided strong evidence that in specific high-risk groups—particularly after a stroke—B12 supplementation could help prevent depression.
Ultimately, our findings highlighted that while vitamin B12 shows promise, more research is needed to clarify its effectiveness, especially among particular patient groups. There's a case for considering B12 supplements as part of recovery plans for those at high risk of depression after a stroke.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
8.8
Reduces stroke risk
This complex is truly wonderful, containing essential B vitamins (B12, B6, B9) in their active forms. They assist with chronic viral loads and lower homocysteine levels, consequently reducing the risk of cardiovascular diseases, particularly stroke. This complex is vital for the elderly who are at risk.
Read More
8.8
Supports stroke prevention
This product wonderfully supports the nervous system, heart, and blood pressure, preventing thrombus formation, atherosclerosis, heart attacks, and strokes. It is an excellent addition for cardiovascular health.
8.8
Offers stroke benefits
Vitamin B12 is crucial as it alleviates pain and prevents pernicious anaemia, heart attacks, and strokes. The natural ingredients are excellent, and I really appreciate the packaging and price. The benefits to health are remarkable.
8.5
Prevents stroke occurrences
Vitamin B12 is crucial for the nervous system and blood cell formation. Its deficiency can have severe consequences. It is known to alleviate pain and prevent pernicious anaemia, heart attacks, and strokes. This product is of high quality, with natural ingredients and an excellent composition.
Read More
