5/22/2025
Last update
5/22/2025
Reviewed By
Infographics 
Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
Read More
8
We explored how vitamin B12 might protect against nerve damage caused by diabetes. In a research study, diabetic rats received B12 supplements for four months. By examining their brains, we found that B12 reduced nerve cell death and supported healthy brain functions, even under diabetic conditions. The treatment improved important markers related to nerve support and minimized harmful inflammatory responses. This suggests that vitamin B12 could be a valuable addition for helping diabetic patients maintain better brain health.
Read More
9
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
Read More
Most Useful Reviews
9
Cured neuropathy pain
508 people found this helpful
My friend, a type II diabetic, suffered severe neuropathy due to a B-12 deficiency caused by statin and metformin use. After ceasing these medications and starting B-12 shots, his neuropathy improved, but it wasn't until he switched to Methyl B-12 and added Serrapeptase that he achieved permanent relief. He is now focusing on overcoming type II diabetes, which was induced by metabolic syndrome, with promising progress.
Read More
7.5
Good B-12 source
12 people found this helpful
These Jarrow Formulas Methyl B-12 have excellent flavour and are beneficial for those on Metformin for type 2 diabetes, as it can lead to B-12 deficiency. This form of B-12 absorbs well into the bloodstream rather than being wasted. The taste is enjoyable, and they are easy to manage, making them a great choice for maintaining vitamin levels while managing diabetes.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
- All Researches
9
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
Read More
8
B12 in multi-nutrient diabetes study
We explored how a combination of nutrients, including B12, impacts people with diabetic neuropathy. In a study with 73 individuals suffering from type 2 diabetes, participants were split into two groups: one received the combination of nutrients while the other received a placebo for six months.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Read More
8
We investigated how gastrectomy impacts the risk of type 2 diabetes in gastric cancer survivors. Analyzing data from over 150,000 patients, we observed that those who underwent total gastrectomy had a higher chance of developing diabetes, especially if they didn't take vitamin B12 supplements. Surprisingly, patients who had subtotal gastrectomy enjoyed a lower risk of diabetes. Furthermore, B12 supplementation appeared to shield those who underwent total gastrectomy from heightened diabetes risk. This highlights the importance of monitoring and managing vitamin levels post-surgery.
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8
We examined the relationship between B vitamin intake and the risk of developing type 2 diabetes (T2D) through a large study in Shanghai. Using data from nearly 45,000 adults, we found that higher consumption of B vitamins, particularly B1, B2, B6, B9, and B12, was linked to a lower risk of T2D.
Our analysis also suggested that inflammation played a mediating role in this effect. While we did not find a significant link with B3, vitamin B6 was notably influential in reducing T2D risk. Overall, incorporating these B vitamins in our diet may help mitigate T2D, at least in part, through controlling inflammation.
Our analysis also suggested that inflammation played a mediating role in this effect. While we did not find a significant link with B3, vitamin B6 was notably influential in reducing T2D risk. Overall, incorporating these B vitamins in our diet may help mitigate T2D, at least in part, through controlling inflammation.
Read More
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cured neuropathy pain
508 people found this helpful
My friend, a type II diabetic, suffered severe neuropathy due to a B-12 deficiency caused by statin and metformin use. After ceasing these medications and starting B-12 shots, his neuropathy improved, but it wasn't until he switched to Methyl B-12 and added Serrapeptase that he achieved permanent relief. He is now focusing on overcoming type II diabetes, which was induced by metabolic syndrome, with promising progress.
Read More
7.5
Good B-12 source
12 people found this helpful
These Jarrow Formulas Methyl B-12 have excellent flavour and are beneficial for those on Metformin for type 2 diabetes, as it can lead to B-12 deficiency. This form of B-12 absorbs well into the bloodstream rather than being wasted. The taste is enjoyable, and they are easy to manage, making them a great choice for maintaining vitamin levels while managing diabetes.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. 10.3390/nu16183045
- Kim G, Han KD, Cho SH, Oh R, Lee YB, et al. Association between gastrectomy and the risk of type 2 diabetes in gastric cancer survivors: A nationwide cohort study. Diabetes Metab. 2024;50:101569. 10.1016/j.diabet.2024.101569
- Zhu Y, Ying T, Xu M, Chen Q, Wu M, et al. Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort. Nutrients. 2024;16. 10.3390/nu16121901
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. 10.59556/japi.72.0493
- Zhou J, Ma H, Guan M, Feng J, Dong X, et al. Anti-inflammatory Fucoidan-ConA oral insulin nanosystems for smart blood glucose regulation. Int J Pharm. 2024;659:124250. 10.1016/j.ijpharm.2024.124250
- Hakola L, Mramba LK, Uusitalo U, Andrén Aronsson C, Hummel S, et al. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024;63:1329. 10.1007/s00394-024-03346-6
- Suryavanshi U, Angadi KK, Reddy VS, Reddy GB. Neuroprotective role of vitamin B12 in streptozotocin-induced type 1 diabetic rats. Chem Biol Interact. 2024;387:110823. 10.1016/j.cbi.2023.110823
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. 10.7759/cureus.75656
- Abu-Zahab ZA, Qureshi H, Adham GM, Elzefzafy WM, Zalam SS, et al. Frequency of comorbid diseases with high serum Vitamin B12 levels in patients attending King Salman Medical City (KSAMC), at Madinah. Int J Health Sci (Qassim). 2025;19:15.
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. 10.1111/1753-0407.70045
- Asghar S, Tanvir H, Riaz A, Ejaz MH, Akram M, et al. Prevalence of Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus on Metformin Therapy: A Cross-Sectional Study. Cureus. 2024;16:e72184. 10.7759/cureus.72184
