5/22/2025
Last update
5/22/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.2
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
7
We set out to understand how vitamin B12 levels relate to migraine frequency and pain severity. In our study, we included 127 migraine patients and 45 healthy controls from Okmeydanı Training and Research Hospital. Notably, we measured the frequency and duration of migraine attacks and assessed pain severity using a visual analogue scale (VAS).
Our findings revealed that migraine patients had significantly lower vitamin B12 levels compared to the healthy controls. Specifically, the average vitamin B12 level in migraine sufferers was 227.30 ng/L, while the controls had an average of 278.44 ng/L.
Furthermore, we observed that chronic migraine patients had even lower vitamin B12 levels than those experiencing less frequent migraines. While our study suggests a correlation between low vitamin B12 and increased migraine severity, we did not explicitly evaluate the treatment effects of vitamin B12 supplements on migraines.
Thus, while low vitamin B12 may be associated with more severe migraines, it remains unclear if supplementation would provide a significant therapeutic benefit. Regular monitoring of vitamin B12 levels in patients with migraines could still be a valuable practice.
Our findings revealed that migraine patients had significantly lower vitamin B12 levels compared to the healthy controls. Specifically, the average vitamin B12 level in migraine sufferers was 227.30 ng/L, while the controls had an average of 278.44 ng/L.
Furthermore, we observed that chronic migraine patients had even lower vitamin B12 levels than those experiencing less frequent migraines. While our study suggests a correlation between low vitamin B12 and increased migraine severity, we did not explicitly evaluate the treatment effects of vitamin B12 supplements on migraines.
Thus, while low vitamin B12 may be associated with more severe migraines, it remains unclear if supplementation would provide a significant therapeutic benefit. Regular monitoring of vitamin B12 levels in patients with migraines could still be a valuable practice.
Read More
7
We explored the potential benefits of hydroxocobalamin, a form of vitamin B12, in helping reduce migraine frequency and severity. In a pilot study involving 20 participants with a history of migraines, we administered 1 mg of intranasal hydroxocobalamin daily for three months. Each participant kept a diary detailing their migraine attacks throughout the study.
Our results were promising. About 53% of the patients experienced a significant decrease in their migraine frequency, with a reduction of 50% or more in their attacks. Overall, the average number of migraine attacks per month dropped from 4.7 to 2.7, which is quite a noteworthy change. Additionally, we observed reductions in the total duration of migraine attacks and the number of medication doses used for acute treatment.
While this was the first prospective study indicating the potential of hydroxycobalamin for migraine prophylaxis, we recommend conducting a double-blind study for further validation, especially since a responder rate of over 35-40% may exceed what’s typically expected from a placebo effect. Our findings suggest that vitamin B12 could be a valuable option for individuals struggling with migraines.
Our results were promising. About 53% of the patients experienced a significant decrease in their migraine frequency, with a reduction of 50% or more in their attacks. Overall, the average number of migraine attacks per month dropped from 4.7 to 2.7, which is quite a noteworthy change. Additionally, we observed reductions in the total duration of migraine attacks and the number of medication doses used for acute treatment.
While this was the first prospective study indicating the potential of hydroxycobalamin for migraine prophylaxis, we recommend conducting a double-blind study for further validation, especially since a responder rate of over 35-40% may exceed what’s typically expected from a placebo effect. Our findings suggest that vitamin B12 could be a valuable option for individuals struggling with migraines.
Read More
Most Useful Reviews
7.5
Migraine management aided
9 people found this helpful
I take one of these daily after discovering my B12 deficiency caused dizziness and body sway. Alongside taking Migrelief for vestibular migraines, I have experienced significant improvements after years of balance issues. I stopped taking the B12 supplement to see if it made a difference, and my symptoms returned. Now, I take this regularly. While I'm not sure about increased energy, I noticed an improvement in memory and focus. Thankfully, I haven’t had any allergic reactions, even though I have many allergies.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.2
- All Researches
8
We looked into how vitamin B supplementation affects migraines among women and the role of specific gene variants. In a 6-month study involving 206 female migraineurs, we found that daily vitamins B6, B9, and B12 significantly decreased homocysteine levels, headache severity, and migraine-related disabilities. Interestingly, women with specific genetic markers showed an even greater improvement. The benefits of supplements were significant, suggesting they can effectively reduce migraine symptoms by addressing underlying conditions tied to genetics.
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8
We examined how vitamin supplementation could affect migraine symptoms in patients. In a randomized, double-blind trial with 52 participants, daily vitamins, including B12, led to a significant 39% reduction in homocysteine levels.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
Read More
7
Vitamin B12 & magnesium aid migraines
This study examined the impact of vitamin B12 and magnesium, combined with high-intensity interval training (HIIT), on women's migraine attacks.
We organized participants into four groups over two months, comparing those on supplements, those doing HIIT, and those using both approaches. We measured serum levels of a specific signaling molecule and assessed migraine severity throughout.
The results highlighted that the combination of B12, magnesium, and exercise appears to reduce migraine pain by targeting inflammation pathways.
We organized participants into four groups over two months, comparing those on supplements, those doing HIIT, and those using both approaches. We measured serum levels of a specific signaling molecule and assessed migraine severity throughout.
The results highlighted that the combination of B12, magnesium, and exercise appears to reduce migraine pain by targeting inflammation pathways.
Read More
7
We conducted a systematic review to examine the effects of vitamin B6, folate, and B12 on migraine.
Our findings revealed that while these vitamins did not show significant benefits for treating acute migraines, they may help prevent migraines with aura in adults.
Out of five studies, most showed promising results when these vitamins were used together, but folate alone didn’t outperform a placebo.
However, more research is needed, particularly for other types of migraines in both adults and children.
Our findings revealed that while these vitamins did not show significant benefits for treating acute migraines, they may help prevent migraines with aura in adults.
Out of five studies, most showed promising results when these vitamins were used together, but folate alone didn’t outperform a placebo.
However, more research is needed, particularly for other types of migraines in both adults and children.
Read More
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Migraine management aided
9 people found this helpful
I take one of these daily after discovering my B12 deficiency caused dizziness and body sway. Alongside taking Migrelief for vestibular migraines, I have experienced significant improvements after years of balance issues. I stopped taking the B12 supplement to see if it made a difference, and my symptoms returned. Now, I take this regularly. While I'm not sure about increased energy, I noticed an improvement in memory and focus. Thankfully, I haven’t had any allergic reactions, even though I have many allergies.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. 10.1007/s10072-021-05843-6
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. 10.1111/head.13618
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. 10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. 10.1097/FPC.0b013e32832af5a3
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. 10.1080/01616412.2025.2462735
- Zheng H, Shi YZ, Liang JT, Lu LL, Chen M. Modifiable factors for migraine prophylaxis: A mendelian randomization analysis. Front Pharmacol. 2023;14:1010996. 10.3389/fphar.2023.1010996
- Üstün Özek S. A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine. Arq Neuropsiquiatr. 2022;80:586. 10.1590/0004-282X-ANP-2021-0192
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. 10.1007/s13760-020-01491-3
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. 10.1186/s10194-016-0652-7
- van der Kuy PH, Merkus FW, Lohman JJ, ter Berg JW, Hooymans PM. Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study. Cephalalgia. 2002;22:513.
