Symptoms of Low Histamine -Pear shaped body (body fat accumulation near abdominal, hips and chest) -^^ GYNECOMASTIA ^^ as well. -Balding in men, unusual body* hair growth / heavy body* hair growth in both men and women -Acne *(due to related estrogen imbalance, high copper and ZINC deficiency noted in histapenics) -Veins hiding, or very hard to find veins when doing bloodwork. -Lack of diuresis and STRONG thirst. -CAVITIES, and DRY MOUTH.... -Lack of energy, General fatigue, Daytime Sleepiness, Narcolepsy. -Lack of Normal Nerve Function, Erectile Dysfunction, Sexual Dysfunction. -Low Pain Respondency / Feeling -Lack of seasonal allergies, pet allergies. -No symptoms and / or never seems to gets sick. Cold fails to produce a rhinitis/congestion. -Frequent headaches and / or Migraine...or a complete absense of headaches. -Tan very easily (Copper stimulates Mealnin and A-MSH) I fit pretty much all those. -Poor Spatial Memory, Problems remembering basic tasks. -Hyperactivity in Children, and Mood Swings / BiPolar episodes in Adults. -Depression, Suicidal Ideations but lack of energy to carry it out. -Generalized Anxiety, Obsessions but not Compulsions..or Altered Compulsions (mainly mental, in head obsessions as opposed to things like hand washing). -Cravings for Alcohol and / or Stimulants. -Low Appetite, Low Sex Drive and General Lack of Motivation / Zest for Life. -Trouble forming relationships / friendships with people, lack of communication skills or no desire for communication and / or interaction with society. -Intense Paranoia, even of close relatives. -Panic Disorders; Claustrophobia, Agoraphobia. -Other Phobias. -Loss of creativity, or an extra zest for Art that wasn't there before..but no motivation to do anything with it or lacks focus to APPLY it to real-life scenarios. -Grandiose sense of self, delusions of Grandeur, Fantasizing about Unlimited Power and Success. -Aggressive, Unpredictable and Acts on Fear. Emotinally unstable, but at times apathetic. (lack of emotions). As well as These. Wow. JUST WOW....I thought maybe the dose might be a little too big but this is my second dose and I can FEEL THIS STUFF. Oh my GOD. IT feels like a switch has been flipped. I was taking Sam-e for depression and it worked for about a week then started to make things worse. I read up on methylation and I decided that I might be undermethylated. Wrong. After identifying with nearly ALL of the symptoms of overmethylation, I decided to go the b12 route. Best decision ever....Yesterday, I became such a happy person. Natural. Exciting driven. IT's so weird how quickly this worked but it did. As far as the dose, I must've been REALLY deficient despite eating a nutrient rich diet. I feel really good. Really happy. Music sounds better. Life feels more enjoyable. this absolutely vanquished my depression. As far as that goes, I believe if you are a low histamine person like I am, this is the way to go to kickstart your life into positive direction.. Things I noticed - Slight mild sense of euphoria/focus - Colors are much brighter and more intense than before. - Incredibly outgoing mood despite being "introvert" - Automatically assuming best intention of people - Confidence GALORE ( I fearlessly told a few girls I liked them with favorable responses whereas before I'd freeze and overanalyze everything) - Focus. I completed all my college assignments - ENERGY. Wow. I only got about 6-7 hours of sleep but I felt RESTED. I am going to continue to take this with folate, and b6 and zinc and I think I will be back to feeling like myself again :D I think long term it may be safer to take the 1000mcg but I feel rather fantastic on this stuff. WARNING : If you are a high histamine person, this could potentially trigger a panic attack as this stuff brings on an intense feeling of goodness and joy for those who lack that. Vitamin b12 is amazing