Last update
5/21/2026
Reviewed By
Infographics
Overview
SCIENTIFIC SCORE
Very Likely Ineffective
Based on 1 Research
2
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
N-Acetyl-L-Cystein
500 mg
†
Top Medical Research Studies
2
We analyzed eight randomized controlled trials involving 910 women with polycystic ovary syndrome (PCOS) to assess how N-acetylcysteine (NAC) affects various health outcomes. NAC showed promise for improving pregnancy rates and ovulation compared to placebo, suggesting potential fertility benefits for women with PCOS.
However, when it came to acne—one of PCOS's most visible symptoms—NAC made no significant difference compared to placebo. The same held true for hirsutism, menstrual regulation, and hormonal markers like testosterone and insulin levels. While NAC outperformed placebo in some areas, it fell short of metformin's effectiveness for pregnancy and ovulation. The research quality varied, with some studies showing methodological concerns, underscoring the need for larger, well-designed future trials.
However, when it came to acne—one of PCOS's most visible symptoms—NAC made no significant difference compared to placebo. The same held true for hirsutism, menstrual regulation, and hormonal markers like testosterone and insulin levels. While NAC outperformed placebo in some areas, it fell short of metformin's effectiveness for pregnancy and ovulation. The research quality varied, with some studies showing methodological concerns, underscoring the need for larger, well-designed future trials.
Read More
Most Useful Reviews
7.5
Balances hormones
26 people found this helpful
Vital supplement. I selected this product based on a research article that recommended it for endometriosis. While combined with other supplements, I've noticed a significant improvement in balancing my hormones and enhancing digestive health, which also alleviates hormonal acne. I have taken it consistently for almost four months and now consider it an indispensable part of my supplement routine.
Read More
9
Improved skin clarity
17 people found this helpful
I love this product! My dermatologist recommended it due to my damaged skin from excessive sun exposure, and I've always struggled with acne into my 40s. My skin appears much clearer and healthier now. Another added benefit is that as a former heavy drinker, this has eased the effects of hangovers.
Read More
Medical Researches
SCIENTIFIC SCORE
Very Likely Ineffective
Based on 1 Research
2
- All Researches
2
We analyzed eight randomized controlled trials involving 910 women with polycystic ovary syndrome (PCOS) to assess how N-acetylcysteine (NAC) affects various health outcomes. NAC showed promise for improving pregnancy rates and ovulation compared to placebo, suggesting potential fertility benefits for women with PCOS.
However, when it came to acne—one of PCOS's most visible symptoms—NAC made no significant difference compared to placebo. The same held true for hirsutism, menstrual regulation, and hormonal markers like testosterone and insulin levels. While NAC outperformed placebo in some areas, it fell short of metformin's effectiveness for pregnancy and ovulation. The research quality varied, with some studies showing methodological concerns, underscoring the need for larger, well-designed future trials.
However, when it came to acne—one of PCOS's most visible symptoms—NAC made no significant difference compared to placebo. The same held true for hirsutism, menstrual regulation, and hormonal markers like testosterone and insulin levels. While NAC outperformed placebo in some areas, it fell short of metformin's effectiveness for pregnancy and ovulation. The research quality varied, with some studies showing methodological concerns, underscoring the need for larger, well-designed future trials.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Balances hormones
26 people found this helpful
Vital supplement. I selected this product based on a research article that recommended it for endometriosis. While combined with other supplements, I've noticed a significant improvement in balancing my hormones and enhancing digestive health, which also alleviates hormonal acne. I have taken it consistently for almost four months and now consider it an indispensable part of my supplement routine.
Read More
9
Improved skin clarity
17 people found this helpful
I love this product! My dermatologist recommended it due to my damaged skin from excessive sun exposure, and I've always struggled with acne into my 40s. My skin appears much clearer and healthier now. Another added benefit is that as a former heavy drinker, this has eased the effects of hangovers.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Thakker D, Raval A, Patel I, Walia R. N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials. Obstet Gynecol Int. 2015;2015:817849. 10.1155/2015/817849
