We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
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9
Scallop oil significantly reduces cholesterol
Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice.
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
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9
Omega-3s improve cholesterol parameters
Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats.
We examined how swapping a saturated fat diet for omega-3 polyunsaturated fatty acids (n-3PUFAs) affects cholesterol and bone health in hypercholesterolemic rats.
In our study, rats that shifted to an n-3PUFA diet saw a notable decrease in serum lipids. While the diet appeared to positively impact their bone loss linked to periodontitis, rats on the n-3PUFA diet showed results similar to those on a commercial diet, indicating no major advantage of fish oil over a balanced diet.
Overall, our findings suggest that while omega-3s can help with cholesterol, they don't offer significant improvements over typical diets in these conditions.
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Most Useful Reviews
7.5
Reduced inflammation
368 people found this helpful
Omega-3 is essential for our daily needs, particularly DHA and EPA, which aid in fat burning, mood stabilisation, and reducing cardiovascular disease risk. The capsules contain 600 mg of omega-3, a great concentration. The fish oil is sourced from the fish's subcutaneous fat, ensuring lower contamination. These omega-3 capsules are highly concentrated and purified, offering excellent value for money. I've been purchasing them for three years, and notice improvements in my overall health, particularly in managing high cholesterol.
Read More
9
Supports cognitive function
160 people found this helpful
I chose this fish oil for its ideal EPA to DHA ratio (2:1). It alleviates depression symptoms, enhances vision, and improves brain function, while also lowering high cholesterol levels and reducing cancer risk.
Read More
9
Brain health benefit
114 people found this helpful
I highly recommend this excellent DHA and EPA composition for brain health. I'm very pleased with the 240 capsules. The price and quality are superb. If you don’t live near the sea, I suggest you and your children take it for at least 9-10 months a year to maintain health.
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
Read More
9
CA-rich fish oils lower cholesterol
Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis.
We investigated whether cetoleic acid (CA), a healthy fat found in certain fish, can help lower cholesterol levels in rodents. Our systematic review included 12 studies, assessing how CA-rich fish oils influenced total cholesterol compared to regular diets.
The results showed a significant reduction in cholesterol levels in rodents that consumed CA-rich oils. However, it’s important to note that the risk of bias in the studies varied, making our conclusions tentative. Overall, these findings suggest CA-rich fish oils could play a beneficial role in heart health, but further research in humans is needed.
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9
Scallop oil significantly reduces cholesterol
Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice.
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Read More
9
Omega-3 effective for heart risk
The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention.
We examined the role of eicosapentaenoic acid (EPA), specifically icosapent ethyl, in reducing cardiovascular disease risks. Approved by the FDA, this omega-3 treatment showed a notable 25% reduction in major heart events for high-risk patients. These patients already had controlled cholesterol but elevated triglyceride levels.
Importantly, while EPA proved effective, mixed omega-3 products lacking substantial evidence for heart health did not provide the same benefits. We believe adding EPA-only formulations to cardiovascular prevention guidelines is essential for at-risk individuals.
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9
8-HEPE benefits cholesterol management
8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice.
We explored how 8-hydroxyeicosapentaenoic acid (8-HEPE), derived from Pacific krill, could improve cholesterol levels in mice commonly used for dyslipidemia studies.
Over eighteen weeks, mice on a high-cholesterol diet receiving 8-HEPE showed significantly higher levels of good HDL cholesterol, alongside lower levels of bad LDL cholesterol and liver triglycerides.
This suggests that 8-HEPE may enhance lipid profiles and liver health by influencing certain genes in macrophages. While promising, further research is needed to confirm these benefits in humans.
Omega-3 is essential for our daily needs, particularly DHA and EPA, which aid in fat burning, mood stabilisation, and reducing cardiovascular disease risk. The capsules contain 600 mg of omega-3, a great concentration. The fish oil is sourced from the fish's subcutaneous fat, ensuring lower contamination. These omega-3 capsules are highly concentrated and purified, offering excellent value for money. I've been purchasing them for three years, and notice improvements in my overall health, particularly in managing high cholesterol.
Read More
9
Supports cognitive function
160 people found this helpful
I chose this fish oil for its ideal EPA to DHA ratio (2:1). It alleviates depression symptoms, enhances vision, and improves brain function, while also lowering high cholesterol levels and reducing cancer risk.
Read More
9
Brain health benefit
114 people found this helpful
I highly recommend this excellent DHA and EPA composition for brain health. I'm very pleased with the 240 capsules. The price and quality are superb. If you don’t live near the sea, I suggest you and your children take it for at least 9-10 months a year to maintain health.
Read More
7.5
Effective cholesterol reduction
102 people found this helpful
Omega must be consumed as these acids are primarily obtained through food. I have been taking this brand's omega for a long time and am very satisfied with its quality. It lowers pressure and cholesterol levels, as confirmed by my tests.
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9
Cholesterol plaque prevention
101 people found this helpful
Omega-3 acids help clear blood vessels of "bad" cholesterol, preventing cholesterol plaques. They improve blood viscosity and normalise blood pressure while boosting "good" cholesterol levels. I strongly recommend it.
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has been widely discussed for its potential benefits in managing cardiovascular health, including high cholesterol. Research indicates that omega-3 fatty acids, particularly EPA and DHA found in fish oil, can help lower triglyceride levels—a type of fat in the blood that contributes to high cholesterol. In some cases, these fatty acids may also raise levels of HDL (high-density lipoprotein), often referred to as "good" cholesterol. However, while omega-3s can be a beneficial part of a heart-healthy diet, they are not a stand-alone solution for cholesterol management.
It's essential to understand that fish oil supplementation should not replace standard cholesterol-lowering medications or lifestyle changes like diet and exercise. Consult with a healthcare professional before adding omega-3 supplements to your regimen, especially if you have existing health conditions or are taking other medications. Keeping a balanced diet rich in omega-3s from sources like fatty fish, flaxseeds, and walnuts can also support overall health and align with cholesterol management goals.
Based on user reviews, many individuals reported that they noticed improvements in their cholesterol levels within a few months of taking Omega-3 supplements. For instance, one user mentioned significant improvements in their cholesterol levels after taking the supplement for three months, stating their levels returned to normal during this timeframe Read Review. Another user noted a family-wide improvement in cholesterol levels, indicating that they experienced "tangible benefits" from their consistent use of the supplement Read Review.
Overall, while experiences vary, the general consensus among users suggests that consistent use over a period of one to three months is common before seeing noticeable results in managing high cholesterol levels. Supplements like Omega-3 are typically viewed as part of an ongoing health regimen rather than a quick fix Read Review. It's important to consult with a healthcare provider for personalized advice and to monitor cholesterol levels during this process.
Several studies support the effectiveness of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in managing high cholesterol levels. For instance, research involving omega-3 supplementation demonstrated significant reductions in triglycerides and LDL cholesterol among participants, indicating their potential role in improving lipid profiles. One study found that patients taking EPA daily experienced a drop in triglycerides from an average of 2.97 to 1.75 mmol/L, showcasing the benefits of incorporating this omega-3 into dietary regimens for those at risk of cardiovascular events [27].
Moreover, Antarctic krill oil, a source rich in EPA and DHA, was shown to mitigate cholesterol metabolism issues and reduce fat accumulation in obese mice, suggesting a promising avenue for addressing obesity-related high cholesterol. The presence of DHA in krill oil specifically has been linked to improved cholesterol metabolism pathways [1]. Overall, the scientific evidence supports the potential of these omega-3 fatty acids as safe and effective supplements for managing high cholesterol, particularly for individuals facing cardiovascular issues.
Based on user reviews, many individuals report notable improvements in various health symptoms after taking Omega-3 supplements. A significant number have focused on their cholesterol levels, with one user stating that consistent usage over three months helped normalize their cholesterol, allowing them to maintain a balanced level since then Read Review. Other users have echoed similar experiences, such as a family reporting nearly normal cholesterol levels after initially facing hyperlipidemia Read Review.
In addition to cholesterol management, many users have emphasized benefits concerning mental health and general well-being. They have reported improvements in mood stabilization and cognitive function, with one user noting reductions in depression symptoms and better vision Read Review. Overall, while results can vary, the mounting anecdotal evidence suggests that incorporating Omega-3 into one's health regimen can lead to tangible health benefits when used regularly.
Based on user reviews, many individuals report positive experiences when combining Omega-3 supplements with other dietary interventions or medications for managing high cholesterol. One user shared that their blood pressure and cholesterol levels improved significantly while using Omega-3 alongside conventional medications to assist recovery after a stroke Read Review. Another reviewer indicated a family-wide improvement in cholesterol levels attributed to consistent use of Omega-3, highlighting the supplement's effectiveness as part of a broader health regimen Read Review.
Conversely, some users voiced concerns about negative interactions. For instance, one particular individual reported that their lipid profile worsened after taking an Omega-3 supplement, resulting in a decline in good cholesterol (HDL), even though triglyceride levels improved Read Review. This suggests that while combining Omega-3 with other supplements or medications can yield beneficial effects, individual responses may vary significantly, emphasizing the importance of monitoring health changes and consulting healthcare professionals when integrating supplements into one's routine.
When it comes to treating high cholesterol with Omega-3 fish oil, research points to eicosapentaenoic acid (EPA) as a key player. A standout study revealed that a daily dose of 4 grams of EPA led to significant improvements in lipid profiles for individuals with high triglycerides and other cardiovascular risk factors, highlighting a drop in triglyceride levels and low-density lipoprotein (LDL) cholesterol [27]. Furthermore, another investigation found that even as part of a combination therapy with docosahexaenoic acid (DHA), EPA supplementation resulted in lower occurrences of cardiovascular events, illustrating its potential in enhancing heart health [18].
For those considering Omega-3 fish oil specifically for cholesterol management, the evidence suggests that a higher dose of EPA, approximately 4 grams daily, may be optimal for achieving meaningful results. This dosage not only helps reduce triglycerides significantly but also contributes to overall cardiovascular health depending on each individual’s lipid profile. While both EPA and DHA play beneficial roles, it's clear that EPA is the front-runner when targeting high cholesterol in a practical and effective manner [22]. As always, consult with a healthcare professional before starting any new supplement regime, especially when managing cholesterol levels.
9
Regulated cholesterol
8 people found this helpful
Taking two tablets daily significantly improved my cholesterol levels within three months, bringing them back to normal. I continue to use this product as it's helped maintain my levels effectively.
9
Family health improvement
7 people found this helpful
Our family's cholesterol has improved significantly since using this Omega-3. Initially diagnosed with hyperlipidemia, we noticed nearly normal cholesterol levels now, showing tangible benefits for everyone's health.
9
Highly beneficial
4 people found this helpful
Omega-3 is crucial for cardiovascular health, brain function, and lowering inflammation. Most people don’t get enough Omega-3 from food. Each capsule contains a beneficial dose, and I appreciate the sweet strawberry taste. My husband takes it daily, and it's part of our ongoing health regimen.
9
Supports cognitive function
160 people found this helpful
I chose this fish oil for its ideal EPA to DHA ratio (2:1). It alleviates depression symptoms, enhances vision, and improves brain function, while also lowering high cholesterol levels and reducing cancer risk.
7.5
Cholesterol reduction
6 people found this helpful
Very profitable Omega! I regularly give it to my parents to lower their cholesterol levels alongside other medications, helping them recover following a stroke.
0
Worsened results
36 people found this helpful
The Omega worsened my lipidogram results. Despite evaluating many brands for EPA/DHA ratios and raw material quality, this one caused declines in good cholesterol (HDL). After using it, triglycerides improved, but overall results were disappointing.
9
High-purity EPA benefits cholesterol
Pleiotropic beneficial cardiometabolic actions of a high-purity eicosapentaenoic acid product in high cardiovascular risk individuals.
We examined the impact of a highly purified eicosapentaenoic acid (EPA) formulation on cholesterol levels and overall heart health in individuals considered at high risk for cardiovascular issues. The study involved 226 patients who had high triglycerides and one or more cardiovascular risk factors, such as hypertension or diabetes.
Participants received 4 grams of EPA daily for three months alongside regular nutritional counseling. By tracking key health markers, we noted significant improvements in cholesterol levels, particularly in triglycerides and low-density lipoprotein (LDL). For instance, triglyceride levels dropped from an average of 2.97 mmol/L to 1.75 mmol/L in just three months.
Additionally, we found improvements in other important metrics, including total cholesterol and glucose levels, indicating that EPA supplementation may have broad benefits for cardiometabolic health. Although apolipoprotein A levels did not change significantly, the overall trend suggests that incorporating EPA could play a role in achieving better heart health outcomes.
9
Antarctic krill oil aids cholesterol
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
8
Icosapent ethyl reduces cardiovascular events
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
We examined the effects of icosapent ethyl, a form of eicosapentaenoic acid, on patients with high cholesterol, specifically those who also have elevated triglyceride levels. In this analysis of the REDUCE-IT trial, we focused on statin-treated individuals who had a high risk of cardiovascular problems and found that the treatment could lower the occurrence of serious cardiovascular events.
The study included a significant number of patients who were divided based on their low-density lipoprotein cholesterol (LDL-C) levels. An interesting finding was that icosapent ethyl appeared to benefit both groups—those with LDL-C levels below 55 mg/dL and those with levels at or above 55 mg/dL. For patients with very well-controlled cholesterol, the treatment resulted in a lower rate of cardiovascular issues compared to a placebo, indicating its effectiveness even among those managing their cholesterol well.
While we did find that icosapent ethyl could help manage cardiovascular risks in patients with heightened cholesterol, it's essential to clarify that the study primarily focused on the rate of cardiovascular events rather than a direct impact purely on cholesterol levels. Overall, our findings suggest that even patients with optimal cholesterol control can still gain benefits from this treatment regarding cardiovascular health.
8
EPA's effects on cholesterol explored
The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials.
We examined the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on high cholesterol levels. In a systematic review of randomized controlled trials, we looked at studies involving at least 2 grams of EPA or its counterpart, docosahexaenoic acid (DHA).
Both EPA and DHA were found to lower triglyceride levels, with DHA appearing slightly more effective. Interestingly, we also saw that DHA increases high-density lipoprotein (HDL) cholesterol, which is known to promote heart health, while EPA does so as well, but to a lesser extent.
On the flip side, DHA has been observed to increase low-density lipoprotein (LDL) cholesterol, but it also enhances the size of LDL particles, making them less likely to contribute to artery blockages. Moreover, we noted that DHA might be more effective than EPA in reducing heart rate and blood pressure, which are essential factors in heart health.
Although both EPA and DHA show potential in promoting heart health by reducing inflammation and oxidative stress, the variations in their effects can make things complicated. We found that the evidence comparing EPA and DHA directly is limited, and more high-quality research is necessary to better understand their individual impacts on cholesterol and other cardiovascular risk factors.
Overall, while EPA has beneficial effects on cholesterol, further studies are needed to isolate these effects clearly from those of DHA.
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Mjaatveit M, Oldernes H, Gudbrandsen OA. Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis. Br J Nutr. 2024;131:606. 10.1017/S0007114523002118
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Blom WAM, Koppenol WP, Hiemstra H, Stojakovic T, Scharnagl H, et al. A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia. Eur J Nutr. 2019;58:1615. 10.1007/s00394-018-1706-1
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Uthaiah NM, Venkataramareddy SR, Mudhol S, Sheikh AY. EPA-rich Nannochloropsis oceanica biomass regulates gut microbiota, alleviates inflammation and ameliorates liver fibrosis in rats. Food Res Int. 2025;202:115733. 10.1016/j.foodres.2025.115733
Yoshikiyo K, Shimizu H, Nagato EG, Ishizuka S, Yamamoto T. Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels. Molecules. 2025;30. 10.3390/molecules30020281
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Kobayashi Y, Fujikawa T, Haruna A, Kawano R, Ozawa M, et al. Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study. Medicina (Kaunas). 2023;60. 10.3390/medicina60010075
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Chang Y, Xuan Y, Zhang R, Ding X, Zeng Q, et al. Effects of Dietary Schizochytrium Algae as ω-3 PUFA Source on the Egg-Laying Quail Performance, Serum Indexes, and Egg Yolk Fatty Acids Contents. Animals (Basel). 2024;15. 10.3390/ani15010021
Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. 10.1039/d4fo04961f
Coelho-Júnior HJ, Álvarez-Bustos A, Picca A, Calvani R, Rodriguez-Mañas L, et al. Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults. Nutrients. 2024;16. 10.3390/nu16234087
Cabrita ARJ, Barroso C, Fontes-Sousa AP, Correia A, Teixeira L, et al. Assessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota. Front Vet Sci. 2024;11:1449141. 10.3389/fvets.2024.1449141
Zhang D, Wang Z, Guo S, Sun Y, Zhou D, et al. F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol. Exp Gerontol. 2024;196:112577. 10.1016/j.exger.2024.112577
Zhao W, Wang Y, Li J, Chen T, Yin D, et al. Efficacy and safety of omega-3-acid ethyl acetate 90 capsules in severe hypertriglyceridemia: A randomized, controlled, multicenter study. Lipids. 2024;59:145. 10.1002/lipd.12406
Li P, Khan S, Huang Y, Lu S, Zhou P, et al. Effect of Perilla seeds inclusion on the performance, egg quality characteristics, biochemical parameters and egg yolk fatty acid composition of laying hens. Trop Anim Health Prod. 2024;56:147. 10.1007/s11250-024-03983-3