Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Phosphatidylserine (PS) from Lecithin (Sunflower) (Helianthus annuus) Seed Oil
100 mg
†
Top Medical Research Studies
8
We investigated whether phosphatidylserine (BC-PS) could effectively treat depression and enhance cognitive function. In our study, rats took BC-PS in various doses and were compared to a control group. We observed that BC-PS significantly reduced how long the rats remained immobile in a stress test, suggesting an antidepressive effect.
However, when it came to improving memory in different maze tasks, BC-PS showed no significant benefits compared to the control group. This indicates that while BC-PS may help with depression, it doesn't appear to boost cognitive abilities.
However, when it came to improving memory in different maze tasks, BC-PS showed no significant benefits compared to the control group. This indicates that while BC-PS may help with depression, it doesn't appear to boost cognitive abilities.
Read More
7
Phosphatidylserine improves depressive symptoms
We measured the blood levels of certain cytokines in 10 elderly women with major depressive disorder (MDD) and compared them to two groups of healthy controls. After 30 days of treatment with phosphatidylserine, a supplement given at 600 mg daily, we found that while depressive symptoms improved significantly, the cytokine levels remained unchanged. This suggests that phosphatidylserine may help alleviate depression symptoms without affecting these specific inflammatory markers in the blood.
Read More
9
PSL shows promise for depression relief
We explored how phosphatidylserine liposomes (PSL) can affect depression following a stroke. The study involved inducing brain ischemia in mice and using behavioral tests to assess the antidepressant-like effects of PSL.
After treatment, we found that mice showed less immobility in tests, which suggests an improvement in depressive behavior. Additionally, PSL treatment led to more surviving neurons and a reduction in inflammatory markers in the brain.
Overall, our findings suggest that oral PSL may help alleviate post-stroke depression by reducing inflammation.
After treatment, we found that mice showed less immobility in tests, which suggests an improvement in depressive behavior. Additionally, PSL treatment led to more surviving neurons and a reduction in inflammatory markers in the brain.
Overall, our findings suggest that oral PSL may help alleviate post-stroke depression by reducing inflammation.
Read More
Most Useful Reviews
7.5
Alleviates seasonal depression
61 people found this helpful
No soy from Jerow! The phosphatidylserine is sourced from sunflower, which is a significant advantage. It's beneficial for the nervous system, aids in seasonal depression, lowers cortisol levels and enhances cognitive functions like thinking and memory. Overall, all the supplements from Jerow that I ordered here are effective!
Read More
7.5
Improves cognitive functions
36 people found this helpful
I took it to restore cognitive functions post-depression. It enhances brain cell metabolism and restores nervous tissue structure. I’ve noticed results after several orders. Phosphatidylserine is essential for me, being sourced from sunflower as soy contains phytoestrogens. The white jar is from sunflower, and the black one is from soy. Please be cautious. I hope this helps, thank you!
Read More
9
Improves mood swings
10 people found this helpful
I take one capsule thrice a day as directed. Within a week, I felt calmer and no longer stressed over trivial matters, leading to an uplifted mood. I became more sociable and began enjoying life again. This supplement helps with mood swings and improves overall health. Additionally, it aids thinking clarity and improves sleep quality. I recommend it for its varied beneficial effects.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
- All Researches
9
PSL shows promise for depression relief
We explored how phosphatidylserine liposomes (PSL) can affect depression following a stroke. The study involved inducing brain ischemia in mice and using behavioral tests to assess the antidepressant-like effects of PSL.
After treatment, we found that mice showed less immobility in tests, which suggests an improvement in depressive behavior. Additionally, PSL treatment led to more surviving neurons and a reduction in inflammatory markers in the brain.
Overall, our findings suggest that oral PSL may help alleviate post-stroke depression by reducing inflammation.
After treatment, we found that mice showed less immobility in tests, which suggests an improvement in depressive behavior. Additionally, PSL treatment led to more surviving neurons and a reduction in inflammatory markers in the brain.
Overall, our findings suggest that oral PSL may help alleviate post-stroke depression by reducing inflammation.
Read More
9
Phosphatidylserine improves mood, not immunity
We explored how phosphatidylserine (BC-PS), taken at 200 mg per day for 30 days, impacts depression in elderly women with nonmelancholic Major Depressive Disorders (MDD). The study included 30 participants, where T-lymphocyte responses were examined before and after treatment.
While phosphatidylserine significantly improved depressive symptoms, it did not change the immune response of T-lymphocytes to stimulation. This finding suggests that while BC-PS may enhance mood, it doesn't alter the underlying immune function related to depression.
While phosphatidylserine significantly improved depressive symptoms, it did not change the immune response of T-lymphocytes to stimulation. This finding suggests that while BC-PS may enhance mood, it doesn't alter the underlying immune function related to depression.
Read More
8
We investigated how luteolin (LUT), a natural flavonoid, may help alleviate late-onset depression (LOD) in older adults. Using advanced metabolomics techniques, we identified significant changes in glycerophospholipid metabolism in the brains of LOD rats treated with LUT. Notably, LUT improved anxiety and depression-like behaviors while enhancing cognitive functions.
The study found that key lipids like phosphatidylserine were significantly affected by LUT, indicating its role in managing depression. Overall, LUT appears to positively influence brain metabolism, offering a potential avenue for treating depression in the elderly.
The study found that key lipids like phosphatidylserine were significantly affected by LUT, indicating its role in managing depression. Overall, LUT appears to positively influence brain metabolism, offering a potential avenue for treating depression in the elderly.
Read More
8
We investigated whether phosphatidylserine (BC-PS) could effectively treat depression and enhance cognitive function. In our study, rats took BC-PS in various doses and were compared to a control group. We observed that BC-PS significantly reduced how long the rats remained immobile in a stress test, suggesting an antidepressive effect.
However, when it came to improving memory in different maze tasks, BC-PS showed no significant benefits compared to the control group. This indicates that while BC-PS may help with depression, it doesn't appear to boost cognitive abilities.
However, when it came to improving memory in different maze tasks, BC-PS showed no significant benefits compared to the control group. This indicates that while BC-PS may help with depression, it doesn't appear to boost cognitive abilities.
Read More
8
Phosphatidylserine improves depression symptoms
We explored how phosphatidylserine, specifically BC-PS, affects depression and cognitive functions in 10 elderly women diagnosed with depressive disorders. After a 15-day placebo phase, participants took 300 mg of BC-PS daily for 30 days.
The results showed consistent improvements in depressive symptoms, memory, and overall behavior. However, we found no significant changes in some biochemical markers or hormonal responses, which suggests that the mood and cognitive enhancements occur independently of certain chemical alterations in the body.
The results showed consistent improvements in depressive symptoms, memory, and overall behavior. However, we found no significant changes in some biochemical markers or hormonal responses, which suggests that the mood and cognitive enhancements occur independently of certain chemical alterations in the body.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Alleviates seasonal depression
61 people found this helpful
No soy from Jerow! The phosphatidylserine is sourced from sunflower, which is a significant advantage. It's beneficial for the nervous system, aids in seasonal depression, lowers cortisol levels and enhances cognitive functions like thinking and memory. Overall, all the supplements from Jerow that I ordered here are effective!
Read More
7.5
Improves cognitive functions
36 people found this helpful
I took it to restore cognitive functions post-depression. It enhances brain cell metabolism and restores nervous tissue structure. I’ve noticed results after several orders. Phosphatidylserine is essential for me, being sourced from sunflower as soy contains phytoestrogens. The white jar is from sunflower, and the black one is from soy. Please be cautious. I hope this helps, thank you!
Read More
9
Improves mood swings
10 people found this helpful
I take one capsule thrice a day as directed. Within a week, I felt calmer and no longer stressed over trivial matters, leading to an uplifted mood. I became more sociable and began enjoying life again. This supplement helps with mood swings and improves overall health. Additionally, it aids thinking clarity and improves sleep quality. I recommend it for its varied beneficial effects.
Read More
9
Reduces cortisol levels
7 people found this helpful
This is not my first time using it; it normalises nervous system function, enhances memory and mental abilities, promotes weight loss, and alleviates depression while reducing cortisol levels. It provides calming effects and improves mood, effectively slowing the ageing process. I cycle my intake twice yearly, and it's best used with fish oil, DMAE, or ginkgo biloba.
Read More
7.5
Reduces anxiety levels
4 people found this helpful
Phosphatidylserine supports neuron vitality and benefits anyone with nervous system issues. It enhances mental activity, performance, and alleviates asthenic symptoms like fatigue and mood swings. It reduces anxiety, aids with mild to moderate depression by stimulating serotonin production and improving mood. Its benefits also include increasing vitality.
Read More
Frequently Asked Questions
9
Improves mood swings
10 people found this helpful
I take one capsule thrice a day as directed. Within a week, I felt calmer and no longer stressed over trivial matters, leading to an uplifted mood. I became more sociable and began enjoying life again. This supplement helps with mood swings and improves overall health. Additionally, it aids thinking clarity and improves sleep quality. I recommend it for its varied beneficial effects.
7.5
Clears depression symptoms
8 people found this helpful
I believe this is beneficial for depression. Even after months of use, I've noticed a clarity in my mind, and my depression symptoms have markedly improved.
6
Boosts motivation
33 people found this helpful
As someone self-employed with ADHD and depression, I struggled with daily stress and motivation. I bought this supplement hoping for relief and found that it calmed my frustrations, and I began to take positive actions in my work. It may stem from my feelings, but I cannot imagine being without it! The soft gel form has proven more effective than the capsules for me.
7.5
Enhances focus
25 people found this helpful
This supplement eliminates past flashbacks, allowing me to concentrate on the present. Additionally, I've noticed I can process information more quickly. Honestly, it's remarkably effective, which is slightly daunting given my ADHD background. Sometimes, during weekends, I fell into a depression and became inactive at home. This supplement has significantly improved my quality of life.
7.5
Stabilizes mood
3 people found this helpful
Research indicates that up to 400 mg of phosphatidylserine daily enhances memory and cognitive functions. It helps regulate stress-related neurotransmitters, stabilising mood and reducing symptoms of stress, depression, and anxiety. By improving cognitive skills and alleviating stress, phosphatidylserine optimises focus effectively.
9
Reduces cortisol levels
7 people found this helpful
This is not my first time using it; it normalises nervous system function, enhances memory and mental abilities, promotes weight loss, and alleviates depression while reducing cortisol levels. It provides calming effects and improves mood, effectively slowing the ageing process. I cycle my intake twice yearly, and it's best used with fish oil, DMAE, or ginkgo biloba.
6
Reduced brain fog
3 people found this helpful
I've been taking this alongside SAM-e, which helped reduce my brain fog and improved memory. However, SAM-e worsened my depression, prompting me to stop. After discontinuing it, I noticed lingering benefits. I’ve recently started 5HTP, which is proving helpful.
7.5
Improves cognitive functions
36 people found this helpful
I took it to restore cognitive functions post-depression. It enhances brain cell metabolism and restores nervous tissue structure. I’ve noticed results after several orders. Phosphatidylserine is essential for me, being sourced from sunflower as soy contains phytoestrogens. The white jar is from sunflower, and the black one is from soy. Please be cautious. I hope this helps, thank you!
7
Phosphatidylserine improves depressive symptoms
We measured the blood levels of certain cytokines in 10 elderly women with major depressive disorder (MDD) and compared them to two groups of healthy controls. After 30 days of treatment with phosphatidylserine, a supplement given at 600 mg daily, we found that while depressive symptoms improved significantly, the cytokine levels remained unchanged. This suggests that phosphatidylserine may help alleviate depression symptoms without affecting these specific inflammatory markers in the blood.
7
We investigated how phosphatidylserine therapy affects elderly women suffering from major depression. Over 30 days, these patients took 200 mg of phosphatidylserine daily.
Although we observed significant improvements in their depressive symptoms, beta-endorphin levels did not change from baseline, even after the therapy. This suggests that phosphatidylserine may help alleviate depression without altering beta-endorphin concentrations in the blood.
So, while phosphatidylserine shows promise in improving mood, it does not appear to impact beta-endorphin levels.
Although we observed significant improvements in their depressive symptoms, beta-endorphin levels did not change from baseline, even after the therapy. This suggests that phosphatidylserine may help alleviate depression without altering beta-endorphin concentrations in the blood.
So, while phosphatidylserine shows promise in improving mood, it does not appear to impact beta-endorphin levels.
9
PSL shows promise for depression relief
We explored how phosphatidylserine liposomes (PSL) can affect depression following a stroke. The study involved inducing brain ischemia in mice and using behavioral tests to assess the antidepressant-like effects of PSL.
After treatment, we found that mice showed less immobility in tests, which suggests an improvement in depressive behavior. Additionally, PSL treatment led to more surviving neurons and a reduction in inflammatory markers in the brain.
Overall, our findings suggest that oral PSL may help alleviate post-stroke depression by reducing inflammation.
After treatment, we found that mice showed less immobility in tests, which suggests an improvement in depressive behavior. Additionally, PSL treatment led to more surviving neurons and a reduction in inflammatory markers in the brain.
Overall, our findings suggest that oral PSL may help alleviate post-stroke depression by reducing inflammation.
8
We investigated how luteolin (LUT), a natural flavonoid, may help alleviate late-onset depression (LOD) in older adults. Using advanced metabolomics techniques, we identified significant changes in glycerophospholipid metabolism in the brains of LOD rats treated with LUT. Notably, LUT improved anxiety and depression-like behaviors while enhancing cognitive functions.
The study found that key lipids like phosphatidylserine were significantly affected by LUT, indicating its role in managing depression. Overall, LUT appears to positively influence brain metabolism, offering a potential avenue for treating depression in the elderly.
The study found that key lipids like phosphatidylserine were significantly affected by LUT, indicating its role in managing depression. Overall, LUT appears to positively influence brain metabolism, offering a potential avenue for treating depression in the elderly.
9
Phosphatidylserine improves mood, not immunity
We explored how phosphatidylserine (BC-PS), taken at 200 mg per day for 30 days, impacts depression in elderly women with nonmelancholic Major Depressive Disorders (MDD). The study included 30 participants, where T-lymphocyte responses were examined before and after treatment.
While phosphatidylserine significantly improved depressive symptoms, it did not change the immune response of T-lymphocytes to stimulation. This finding suggests that while BC-PS may enhance mood, it doesn't alter the underlying immune function related to depression.
While phosphatidylserine significantly improved depressive symptoms, it did not change the immune response of T-lymphocytes to stimulation. This finding suggests that while BC-PS may enhance mood, it doesn't alter the underlying immune function related to depression.
References
- Wu X, Xu H, Zeng N, Li H, Yao G, et al. Luteolin alleviates depression-like behavior by modulating glycerophospholipid metabolism in the hippocampus and prefrontal cortex of LOD rats. CNS Neurosci Ther. 2024;30:e14455. doi:10.1111/cns.14455
- Partoazar A, Seyyedian Z, Zamanian G, Saffari PM, Muhammadnejad A, et al. Neuroprotective phosphatidylserine liposomes alleviate depressive-like behavior related to stroke through neuroinflammation attenuation in the mouse hippocampus. Psychopharmacology (Berl). 2021;238:1531. doi:10.1007/s00213-021-05783-1
- Castilho JC, Perry JC, Andreatini R, Vital MA. Phosphatidylserine: an antidepressive or a cognitive enhancer?. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:731.
- Brambilla F, Maggioni M. Blood levels of cytokines in elderly patients with major depressive disorder. Acta Psychiatr Scand. 1998;97:309.
- Brambilla F, Maggioni M, Panerai AE, Sacerdote P, Cenacchi T. Beta-endorphin concentration in peripheral blood mononuclear cells of elderly depressed patients--effects of phosphatidylserine therapy. Neuropsychobiology. 1996;34:18.
- Brambilla F, Maggioni M, Cenacchi T, Sacerdote P, Panerai AR. T-lymphocyte proliferative response to mitogen stimulation in elderly depressed patients. J Affect Disord. 1995;36:51.
- Maggioni M, Picotti GB, Bondiolotti GP, Panerai A, Cenacchi T, et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand. 1990;81:265.
