5/12/2025
Last update
5/12/2025
Reviewed By
Research Authors
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
†
Top Medical Research Studies
9
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
8
We investigated whether coenzyme Q10 (CoQ10) could help reduce migraines. By examining five studies with 346 participants, we learned that CoQ10 may not significantly cut down on the number of attacks or their severity.
However, it appears to decrease the number of migraine days and duration each month. This suggests that while CoQ10 may not be a cure-all, it could help those suffering from migraines find some relief. Further research will be necessary to confirm these findings.
However, it appears to decrease the number of migraine days and duration each month. This suggests that while CoQ10 may not be a cure-all, it could help those suffering from migraines find some relief. Further research will be necessary to confirm these findings.
8
Co-Q10 potentially benefits migraine patients
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
Most Useful Reviews
10
No pain experienced
I took this medication on the recommendation for complex migraines. I've been using it for over a month and have ordered more; I have no pain.
9
Effective for migraines
This product genuinely helps with migraines. I purchased it for my dad, and his migraines have significantly improved!
9
Stops migraines quickly
I bought this for my daughter with migraines, and this product stops her migraines immediately.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
- All Researches
9
Nano-curcumin and CoQ10 reduce migraines
We explored how the combination of nano-curcumin and coenzyme Q10 (CoQ10) affects migraine symptoms and patients' quality of life. In a double-blind, placebo-controlled study involving 100 participants, we assessed the impacts on headache frequency, severity, and duration over eight weeks.
Our findings were promising: the group taking both nano-curcumin and CoQ10 showed significant improvements compared to those receiving the placebo or single supplements alone. Remarkably, this combination enhanced migraine-specific scores without any reported side effects. Overall, it highlights the potential benefits of these supplements in managing migraine.
Our findings were promising: the group taking both nano-curcumin and CoQ10 showed significant improvements compared to those receiving the placebo or single supplements alone. Remarkably, this combination enhanced migraine-specific scores without any reported side effects. Overall, it highlights the potential benefits of these supplements in managing migraine.
9
CoQ10 and L-carnitine aid migraines
We explored the impact of Coenzyme Q10 in combination with L-carnitine on migraine symptoms in a well-structured trial involving 56 participants aged 20-40. Over eight weeks, subjects received these supplements or a placebo.
Our findings show a substantial improvement in migraine-related aspects, including a decrease in headache severity, duration, and frequency, alongside lower serum lactate levels. This suggests that these supplements could be beneficial for those suffering from migraines.
Our findings show a substantial improvement in migraine-related aspects, including a decrease in headache severity, duration, and frequency, alongside lower serum lactate levels. This suggests that these supplements could be beneficial for those suffering from migraines.
9
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
9
We explored the effects of a daily supplement containing coenzyme Q10, feverfew, and magnesium on migraine prevention. In our observational study, which included adult migraine sufferers, participants took the supplement for three months after a one-month baseline phase.
Results revealed a significant reduction in migraine days, dropping from an average of 4.9 days to 1.3 days by the third month. Additionally, 75% of participants experienced at least a 50% reduction in migraine frequency.
The treatment was well tolerated and also appeared to improve anxiety and depressive symptoms, enhancing overall quality of life.
Results revealed a significant reduction in migraine days, dropping from an average of 4.9 days to 1.3 days by the third month. Additionally, 75% of participants experienced at least a 50% reduction in migraine frequency.
The treatment was well tolerated and also appeared to improve anxiety and depressive symptoms, enhancing overall quality of life.
9
We aimed to explore how a nutraceutical combination of Ginkgolide B, Coenzyme Q10, Riboflavin, and Magnesium could help children with neurofibromatosis type 1 manage migraine without aura. Over six months, 18 school-aged children took this supplement twice a day and kept journals tracking their migraine symptoms.
Remarkably, we observed significant reductions in frequency, intensity, duration, and overall migraine-related disability. Our findings reveal that this nutraceutical blend may effectively alleviate migraine symptoms for these children, marking a promising step forward in managing headaches associated with NF1.
Remarkably, we observed significant reductions in frequency, intensity, duration, and overall migraine-related disability. Our findings reveal that this nutraceutical blend may effectively alleviate migraine symptoms for these children, marking a promising step forward in managing headaches associated with NF1.
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
No pain experienced
I took this medication on the recommendation for complex migraines. I've been using it for over a month and have ordered more; I have no pain.
9
Effective for migraines
This product genuinely helps with migraines. I purchased it for my dad, and his migraines have significantly improved!
9
Stops migraines quickly
I bought this for my daughter with migraines, and this product stops her migraines immediately.
7.5
Significant improvement
Good stuff! I take this as a migraine supplement, 400mg daily. It makes a noticeable difference.
Frequently Asked Questions
10
No pain experienced
I took this medication on the recommendation for complex migraines. I've been using it for over a month and have ordered more; I have no pain.
9
Stops migraines quickly
I bought this for my daughter with migraines, and this product stops her migraines immediately.
9
Effective for migraines
This product genuinely helps with migraines. I purchased it for my dad, and his migraines have significantly improved!
7.5
Significant improvement
Good stuff! I take this as a migraine supplement, 400mg daily. It makes a noticeable difference.
7
We explored the effects of coenzyme Q10 on migraine headaches through a comprehensive review of existing studies. Our goal was to determine if this supplement can effectively reduce the frequency of migraine attacks, as well as their severity and duration.
Upon reviewing various studies that included adult participants between the ages of 18 and 65, we found promising results regarding the frequency of migraines. Coenzyme Q10 appeared to help decrease how often these painful episodes occurred.
However, when it came to the severity and duration of the migraines, the results were mixed. Some studies showed slight improvements, while others did not demonstrate significant benefits. Importantly, we noted that participants reported no concerning side effects from taking coenzyme Q10, which is great news for those looking for natural alternatives to traditional medications.
Overall, we believe that coenzyme Q10 could be a valuable option for individuals who experience adverse reactions to conventional migraine treatments and prefer a more holistic approach.
Upon reviewing various studies that included adult participants between the ages of 18 and 65, we found promising results regarding the frequency of migraines. Coenzyme Q10 appeared to help decrease how often these painful episodes occurred.
However, when it came to the severity and duration of the migraines, the results were mixed. Some studies showed slight improvements, while others did not demonstrate significant benefits. Importantly, we noted that participants reported no concerning side effects from taking coenzyme Q10, which is great news for those looking for natural alternatives to traditional medications.
Overall, we believe that coenzyme Q10 could be a valuable option for individuals who experience adverse reactions to conventional migraine treatments and prefer a more holistic approach.
8
We aimed to understand how coenzyme Q10 affects migraine symptoms. This review highlighted that low levels of essential nutrients, including coenzyme Q10, may influence the severity and frequency of migraine attacks.
Our investigation revealed that oxidative stress and inflammation contribute to migraines. Coenzyme Q10 is noted for its role in mitochondrial function, which is vital for energy production in our cells. By supporting these processes, coenzyme Q10 could potentially alleviate migraine episodes.
Evidence from various studies indicated that coenzyme Q10 supplementation could lead to a reduction in migraine frequency and intensity. While we saw promising results, it’s clear that further prospective studies are necessary to establish a more definitive understanding of its effects.
Our investigation revealed that oxidative stress and inflammation contribute to migraines. Coenzyme Q10 is noted for its role in mitochondrial function, which is vital for energy production in our cells. By supporting these processes, coenzyme Q10 could potentially alleviate migraine episodes.
Evidence from various studies indicated that coenzyme Q10 supplementation could lead to a reduction in migraine frequency and intensity. While we saw promising results, it’s clear that further prospective studies are necessary to establish a more definitive understanding of its effects.
8
Combination supplement shows promise
Our investigation aimed to understand the impact of a supplement containing magnesium, vitamin B2, feverfew, andrographis paniculata, and coenzyme Q10 on preventing episodic migraines. We conducted a pilot study with 113 participants who regularly experience migraines. After a month of tracking migraine frequency, participants began taking the supplement for three months.
We found that the combination appeared to reduce the number of migraine days significantly, suggesting that it could be an effective preventive strategy. Importantly, coenzyme Q10 was one of the components in this blend, and while we couldn't isolate its individual effects, we did observe overall positive results in reducing migraine frequency and severity.
Participants also reported improvements in their quality of life and less reliance on acute migraine medications during the study. Although the results are promising, further research, particularly randomized controlled trials, is necessary to confirm these findings and better understand the role of coenzyme Q10 and the other ingredients in this supplementation regimen.
We found that the combination appeared to reduce the number of migraine days significantly, suggesting that it could be an effective preventive strategy. Importantly, coenzyme Q10 was one of the components in this blend, and while we couldn't isolate its individual effects, we did observe overall positive results in reducing migraine frequency and severity.
Participants also reported improvements in their quality of life and less reliance on acute migraine medications during the study. Although the results are promising, further research, particularly randomized controlled trials, is necessary to confirm these findings and better understand the role of coenzyme Q10 and the other ingredients in this supplementation regimen.
8
Coenzyme Q10 shows promise in migraine
We explored the use of coenzyme Q10 as a preventive treatment for migraine headaches in children aged 5 to 15. Conducted as a randomized controlled trial with 72 participants, we aimed to compare how effectively coenzyme Q10 works against a commonly used medication, amitriptyline. Both treatments were assessed for their impact on the frequency, duration, and severity of migraines, as well as improvements in children's quality of life.
Our findings revealed that coenzyme Q10 offered encouraging long-term benefits for managing migraines, showing notable efficacy particularly over extended periods. While amitriptyline responded more quickly, the side effects were more pronounced in children taking this medication. Interestingly, after three months of treatment, both groups exhibited similar clinical outcomes and enhancements in quality of life.
Overall, we determined that coenzyme Q10 could serve as a viable alternative for migraine prophylaxis, given its favorable side effect profile and comparable effectiveness to traditional treatments like amitriptyline.
Our findings revealed that coenzyme Q10 offered encouraging long-term benefits for managing migraines, showing notable efficacy particularly over extended periods. While amitriptyline responded more quickly, the side effects were more pronounced in children taking this medication. Interestingly, after three months of treatment, both groups exhibited similar clinical outcomes and enhancements in quality of life.
Overall, we determined that coenzyme Q10 could serve as a viable alternative for migraine prophylaxis, given its favorable side effect profile and comparable effectiveness to traditional treatments like amitriptyline.
8
Co-Q10 potentially benefits migraine patients
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
4
We explored the potential role of coenzyme Q10 as a treatment option for migraines, particularly against the backdrop of mitochondrial dysfunction. This condition suggests that individuals with migraines may experience an imbalance between energy supply and demand in their brains. Through our examination of existing trials, we noted that some studies have found promising results for coenzyme Q10, especially among those who had lower levels of this nutrient before treatment.
However, it's important to be candid about the study’s limitations. Many of these trials lacked proper control groups or sufficient sample sizes to draw more conclusive results. Although the initial findings are intriguing, more rigorous research is needed to verify whether coenzyme Q10 can genuinely make a difference for migraine sufferers.
Overall, we recognize the potential that coenzyme Q10 holds as an adjunctive therapy for migraines, particularly as part of a personalized approach that considers individual nutrient deficiencies. By focusing on tailored treatments, we may pave the way for more effective management of migraines in the future.
However, it's important to be candid about the study’s limitations. Many of these trials lacked proper control groups or sufficient sample sizes to draw more conclusive results. Although the initial findings are intriguing, more rigorous research is needed to verify whether coenzyme Q10 can genuinely make a difference for migraine sufferers.
Overall, we recognize the potential that coenzyme Q10 holds as an adjunctive therapy for migraines, particularly as part of a personalized approach that considers individual nutrient deficiencies. By focusing on tailored treatments, we may pave the way for more effective management of migraines in the future.
References
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- Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. 10.1136/bmjopen-2020-039358
- Lisicki M, Schoenen J. Metabolic treatments of migraine. Expert Rev Neurother. 2020;20:295. 10.1080/14737175.2020.1729130
- Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, et al. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci. 2021;24:317. 10.1080/1028415X.2019.1627770
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- Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. 10.1177/0333102418821661
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- Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci. 2019;22:607. 10.1080/1028415X.2017.1421039
- Guilbot A, Bangratz M, Ait Abdellah S, Lucas C. A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. BMC Complement Altern Med. 2017;17:433. 10.1186/s12906-017-1933-7
- Shoeibi A, Olfati N, Soltani Sabi M, Salehi M, Mali S, et al. Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Acta Neurol Belg. 2017;117:103. 10.1007/s13760-016-0697-z
- Gaul C, Diener HC, Danesch U. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. J Headache Pain. 2015;16:516. 10.1186/s10194-015-0516-6
- Carotenuto M, Esposito M. Nutraceuticals safety and efficacy in migraine without aura in a population of children affected by neurofibromatosis type I. Neurol Sci. 2013;34:1905. 10.1007/s10072-013-1403-z
- Pringsheim T, Davenport W, Mackie G, Worthington I, Aubé M, et al. Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci. 2012;39:S1.
- Slater SK, Nelson TD, Kabbouche MA, LeCates SL, Horn P, et al. A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine. Cephalalgia. 2011;31:897. 10.1177/0333102411406755
- Schiapparelli P, Allais G, Castagnoli Gabellari I, Rolando S, Terzi MG, et al. Non-pharmacological approach to migraine prophylaxis: part II. Neurol Sci. 2010;31 Suppl 1:S137. 10.1007/s10072-010-0307-4
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- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
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- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. 10.7762/cnr.2023.12.4.257
- Ebrahimi A, Kamyab A, Hosseini S, Ebrahimi S, Ashkani-Esfahani S. Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases. Biochem Res Int. 2023;2023:5510874. 10.1155/2023/5510874
- Stearns SA, Xun H, Haddad A, Rinkinen J, Bustos VP, et al. Therapeutic Options for Migraines in the Microsurgical Patient: A Scoping Review. Plast Reconstr Surg. 2024;153:988e. 10.1097/PRS.0000000000010861
- Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. 10.4103/abr.abr_235_20
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
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- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246
