Last update
3/27/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Saccharomyces boulardii(an S. cerevisiae Strain)
250 mg(5 Billion CFU)
†
MOS Yeast Fraction(Min. 35% Manno-oligosaccharides [MOS]) (S. cerevisiae)
200 mg
†
Top Medical Research Studies
9.5
We examined how Saccharomyces boulardii offers protection against Salmonella Enteritidis, a common foodborne pathogen that can cause severe liver damage. Using a mouse model, we found that pretreatment with S. boulardii significantly reduced the translocation of Salmonella to the liver by an impressive 96%, while also alleviating associated liver tissue damage after infection.
These results suggest that S. boulardii is quite effective in combating the harmful effects of Salmonella Enteritidis, making it a promising option for prevention of liver injury in such infections.
These results suggest that S. boulardii is quite effective in combating the harmful effects of Salmonella Enteritidis, making it a promising option for prevention of liver injury in such infections.
Read More
9
Yeast mitigates Salmonella infection effects
We explored the effects of the yeast Saccharomyces cerevisiae CNCM I-3856 on mice infected with Salmonella Typhimurium. Our study showed that this yeast could significantly reduce mortality and weight loss compared to mice treated only with saline.
We observed that S. cerevisiae effectively colonized the intestines, helping to lower harmful inflammation and improve overall outcomes. It also seemed to influence immune responses by decreasing inflammatory markers at infection sites.
Overall, our findings suggest that this yeast holds promise for managing Salmonella-induced inflammation and could be a helpful tool in treating related infections.
We observed that S. cerevisiae effectively colonized the intestines, helping to lower harmful inflammation and improve overall outcomes. It also seemed to influence immune responses by decreasing inflammatory markers at infection sites.
Overall, our findings suggest that this yeast holds promise for managing Salmonella-induced inflammation and could be a helpful tool in treating related infections.
Read More
9
Probiotic beer shows infection benefits
We evaluated the potential of a craft wheat beer fermented with Saccharomyces cerevisiae UFMG A-905 to fight against Salmonella Typhimurium in mice. In our study, mice received unfiltered or filtered beer, along with a control. Those treated with unfiltered beer showed high levels of yeast and experienced reduced mortality and weight loss from the infection. Additionally, various inflammatory responses linked to the infection were significantly lowered with this treatment. Overall, our findings suggest that this specific probiotic beer retains its beneficial properties when consumed in the face of Salmonella infection.
Read More
Most Useful Reviews
8
Effective for Salmonella
54 people found this helpful
Our companion on all trips, Bulardi's saccharomycetes are identical to the pharmacy antidiarrheal drug Enterol. I cannot travel without it! For adults, we use it during trips or at the onset of gastrointestinal issues; it has always worked well. For children experiencing vomiting, I administer it alongside sorbents (not concurrently) and probiotics. If vomiting occurs shortly after taking the capsule and I notice that the stomach isn't functioning well, I give the medication again. Generally, normalisation happens within a day. The drug effectively counters Clostridium difficile, Salmonella, and other pathogens, enhancing intestinal enzyme function and having a notable antitoxic effect. Moreover, Bulardi's saccharomycetes are resistant to gastric juices and antibiotics, allowing simultaneous treatment. They must be taken consistently to achieve therapeutic benefits.
Read More
9
Stops Salmonella diarrhoea
8 people found this helpful
It aids digestion after a fatty meal. Some individuals make the mistake of using it just once; it's essential to take it for at least seven days to see the results. If any negative reactions, such as allergies, occur, you should stop immediately. It's vital to remain patient, as Bulardi is renowned for combating fungi, particularly candida, and for terminating diarrhoea caused by Salmonella and E. coli.
Read More
4
Prevention of poisoning
1 people found this helpful
This is essential for travel, suitable for adults and children alike. One capsule can aid in preventing poisoning and effectively combats salmonella. I strongly recommend keeping some on hand for summer trips.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
- All Researches
9.5
We examined how Saccharomyces boulardii offers protection against Salmonella Enteritidis, a common foodborne pathogen that can cause severe liver damage. Using a mouse model, we found that pretreatment with S. boulardii significantly reduced the translocation of Salmonella to the liver by an impressive 96%, while also alleviating associated liver tissue damage after infection.
These results suggest that S. boulardii is quite effective in combating the harmful effects of Salmonella Enteritidis, making it a promising option for prevention of liver injury in such infections.
These results suggest that S. boulardii is quite effective in combating the harmful effects of Salmonella Enteritidis, making it a promising option for prevention of liver injury in such infections.
Read More
9.5
We investigated how Saccharomyces boulardii can help reduce Salmonella and Campylobacter in broiler chickens experiencing transport stress. In our study, half of the chickens were fed dried yeast before being transported.
We found that, without yeast, transport stress greatly increased Salmonella colonization. However, the yeast treatment remarkably reduced these levels, even lower than pre-stress rates.
Although yeast didn't affect the frequency of Campylobacter isolation, it did significantly lower its populations in chickens exposed to mixed strains.
We found that, without yeast, transport stress greatly increased Salmonella colonization. However, the yeast treatment remarkably reduced these levels, even lower than pre-stress rates.
Although yeast didn't affect the frequency of Campylobacter isolation, it did significantly lower its populations in chickens exposed to mixed strains.
Read More
9
Saccharomyces boulardii shows protective effects
We investigated how Saccharomyces boulardii (SB) affects Salmonella infections in mice. Our study involved two groups: one was a control group challenged with Salmonella Typhimurium, while the other received SB treatment before the challenge.
We observed that the SB-treated mice showed improved survival rates and less bacterial translocation. Additionally, SB helped reduce liver damage and inflammation by decreasing inflammatory cytokines and regulating key signaling pathways involved in inflammation.
This suggests that SB can effectively combat Salmonella infections by protecting intestinal health.
We observed that the SB-treated mice showed improved survival rates and less bacterial translocation. Additionally, SB helped reduce liver damage and inflammation by decreasing inflammatory cytokines and regulating key signaling pathways involved in inflammation.
This suggests that SB can effectively combat Salmonella infections by protecting intestinal health.
Read More
9
Probiotic yeast protects against Salmonella
In our exploration of how Saccharomyces boulardii interacts with Salmonella, we discovered some compelling results. When mice were treated with S. boulardii, it helped protect them from deadly infections caused by Salmonella enterica.
We also found that this probiotic yeast prevents Salmonella from entering human cells in laboratory settings, reducing inflammation and preserving cellular barrier functions. These findings suggest that S. boulardii could be a valuable tool in managing Salmonella infections and lessening their impact on health.
We also found that this probiotic yeast prevents Salmonella from entering human cells in laboratory settings, reducing inflammation and preserving cellular barrier functions. These findings suggest that S. boulardii could be a valuable tool in managing Salmonella infections and lessening their impact on health.
Read More
9
Yeast probiotic shows protective effects
We explored the protective effects of various yeast probiotic formulations against Salmonella in mice. Using a group of five products, including Saccharomyces boulardii, we measured their viability and survival rates in the digestive tracts of treated mice.
Our findings showed that the Saccharomyces boulardii formulation (Product A) had the highest number of viable cells, leading to better protection and survival of intestinal and liver tissues compared to the other products.
Unfortunately, another formulation did not show any significant beneficial effects.
Our findings showed that the Saccharomyces boulardii formulation (Product A) had the highest number of viable cells, leading to better protection and survival of intestinal and liver tissues compared to the other products.
Unfortunately, another formulation did not show any significant beneficial effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
8
Effective for Salmonella
54 people found this helpful
Our companion on all trips, Bulardi's saccharomycetes are identical to the pharmacy antidiarrheal drug Enterol. I cannot travel without it! For adults, we use it during trips or at the onset of gastrointestinal issues; it has always worked well. For children experiencing vomiting, I administer it alongside sorbents (not concurrently) and probiotics. If vomiting occurs shortly after taking the capsule and I notice that the stomach isn't functioning well, I give the medication again. Generally, normalisation happens within a day. The drug effectively counters Clostridium difficile, Salmonella, and other pathogens, enhancing intestinal enzyme function and having a notable antitoxic effect. Moreover, Bulardi's saccharomycetes are resistant to gastric juices and antibiotics, allowing simultaneous treatment. They must be taken consistently to achieve therapeutic benefits.
Read More
9
Stops Salmonella diarrhoea
8 people found this helpful
It aids digestion after a fatty meal. Some individuals make the mistake of using it just once; it's essential to take it for at least seven days to see the results. If any negative reactions, such as allergies, occur, you should stop immediately. It's vital to remain patient, as Bulardi is renowned for combating fungi, particularly candida, and for terminating diarrhoea caused by Salmonella and E. coli.
Read More
4
Prevention of poisoning
1 people found this helpful
This is essential for travel, suitable for adults and children alike. One capsule can aid in preventing poisoning and effectively combats salmonella. I strongly recommend keeping some on hand for summer trips.
Read More
7
Restores gut health
Excellent! It promotes the restoration of normal intestinal microflora. The anti-toxic action of Saccharomyces Boulardii is noteworthy; it resists gastric juices and antibiotics, allowing simultaneous use. Since it does not disintegrate in the stomach, it effectively cleanses the intestines of unnecessary substances and prevents the growth of harmful bacteria, including salmonella and candida. It also aids in treating rotavirus. I recommend a course of at least 14 days, ideally 21 days. I use it twice annually, in spring and autumn, and I am very pleased with the results.
Read More
Frequently Asked Questions
4
Prevention of poisoning
1 people found this helpful
This is essential for travel, suitable for adults and children alike. One capsule can aid in preventing poisoning and effectively combats salmonella. I strongly recommend keeping some on hand for summer trips.
9.5
We examined how Saccharomyces boulardii offers protection against Salmonella Enteritidis, a common foodborne pathogen that can cause severe liver damage. Using a mouse model, we found that pretreatment with S. boulardii significantly reduced the translocation of Salmonella to the liver by an impressive 96%, while also alleviating associated liver tissue damage after infection.
These results suggest that S. boulardii is quite effective in combating the harmful effects of Salmonella Enteritidis, making it a promising option for prevention of liver injury in such infections.
These results suggest that S. boulardii is quite effective in combating the harmful effects of Salmonella Enteritidis, making it a promising option for prevention of liver injury in such infections.
8
We explored how the probiotic yeast Saccharomyces boulardii influences Salmonella Typhimurium in the gastrointestinal tract. Using advanced imaging techniques, we watched how S.b-B seems to speed up the removal of the bacteria from the body and alters immune responses during the early stages of infection.
Our findings revealed that S.b-B not only aids in faster elimination of Salmonella but also modifies the immune response in the intestines. This suggests potential protective benefits of S.b-B against Salmonella infections.
Our findings revealed that S.b-B not only aids in faster elimination of Salmonella but also modifies the immune response in the intestines. This suggests potential protective benefits of S.b-B against Salmonella infections.
7
We examined how various feed additives, including Saccharomyces boulardii, impacted broiler chicks facing Salmonella challenges. The study involved 600 day-old chicks split into 10 treatment groups to assess their growth and intestinal health amidst infection.
The findings revealed that while the control group showed the best performance in terms of feed intake and weight gain, Saccharomyces boulardii did improve feed conversion ratios compared to the Salmonella-infected group. However, the overall effectiveness varied with other additives showing mixed results.
This suggests that incorporating Saccharomyces boulardii could offer some benefits in managing Salmonella in poultry, but it should be part of a broader strategy that includes various options.
The findings revealed that while the control group showed the best performance in terms of feed intake and weight gain, Saccharomyces boulardii did improve feed conversion ratios compared to the Salmonella-infected group. However, the overall effectiveness varied with other additives showing mixed results.
This suggests that incorporating Saccharomyces boulardii could offer some benefits in managing Salmonella in poultry, but it should be part of a broader strategy that includes various options.
8
We explored the effectiveness of probiotics, specifically Saccharomyces boulardii, against harmful Salmonella Heidelberg in broilers.
In a thorough study involving both lab and real-life testing, we saw that some probiotics like Lactiplantibacillus plantarum showed strong inhibition of Salmonella. However, Saccharomyces boulardii did not significantly reduce Salmonella colonization.
The good news was that chickens receiving other probiotics had lower Salmonella levels in their guts. Overall, this suggests that while some probiotics can help broilers stay healthier and reduce Salmonella risk, Saccharomyces boulardii didn't specifically show strong benefits in this case.
In a thorough study involving both lab and real-life testing, we saw that some probiotics like Lactiplantibacillus plantarum showed strong inhibition of Salmonella. However, Saccharomyces boulardii did not significantly reduce Salmonella colonization.
The good news was that chickens receiving other probiotics had lower Salmonella levels in their guts. Overall, this suggests that while some probiotics can help broilers stay healthier and reduce Salmonella risk, Saccharomyces boulardii didn't specifically show strong benefits in this case.
8
We investigated how various yeasts, especially Saccharomyces boulardii, can prevent harmful bacteria like Salmonella from sticking to intestinal cells. Our research involved examining the co-aggregation of yeasts with pathogenic bacteria and assessing their effectiveness through microscopy. We found that different strains of yeasts reduced the adhesion of Salmonella Enteritidis and other pathogens to intestinal cells by up to 50%. These yeasts compete for resources rather than producing antimicrobial compounds, proving effective without resorting to chemical defenses.
References
- Yang Z, Lin Z, You Y, Zhang M, Gao N, et al. Gut Microbiota-Derived Hyocholic Acid Enhances Type 3 Immunity and Protects Against Salmonella enterica Serovar Typhimurium in Neonatal Rats. Adv Sci (Weinh). 2025;12:e2412071. 10.1002/advs.202412071
- Hoepers PG, Nunes PLF, Almeida-Souza HO, Martins MM, Carvalho RDO, et al. Harnessing probiotics capability to combat Salmonella Heidelberg and improve intestinal health in broilers. Poult Sci. 2024;103:103739. 10.1016/j.psj.2024.103739
- Menezes AGT, Melo DS, Ramos CL, Moreira SI, Alves E, et al. Yeasts isolated from Brazilian fermented foods in the protection against infection by pathogenic food bacteria. Microb Pathog. 2020;140:103969. 10.1016/j.micpath.2020.103969
- Abudabos AM, Hussein EOS, Ali MH, Al-Ghadi MQ. The effect of some natural alternative to antibiotics on growth and changes in intestinal histology in broiler exposed to Salmonella challenge. Poult Sci. 2019;98:1441. 10.3382/ps/pey449
- Mountzouris KC, Dalaka E, Palamidi I, Paraskeuas V, Demey V, et al. Evaluation of yeast dietary supplementation in broilers challenged or not with Salmonella on growth performance, cecal microbiota composition and Salmonella in ceca, cloacae and carcass skin. Poult Sci. 2015;94:2445. 10.3382/ps/pev243
- Wu D, Teng D, Wang X, Dai C, Wang J. Saccharomyces boulardii prevention of the hepatic injury induced by Salmonella Enteritidis infection. Can J Microbiol. 2014;60:681. 10.1139/cjm-2014-0259
- Pontier-Bres R, Munro P, Boyer L, Anty R, Imbert V, et al. Saccharomyces boulardii modifies Salmonella typhimurium traffic and host immune responses along the intestinal tract. PLoS One. 2014;9:e103069. 10.1371/journal.pone.0103069
- Martins FS, Vieira AT, Elian SD, Arantes RM, Tiago FC, et al. Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect. 2013;15:270. 10.1016/j.micinf.2012.12.007
- Tiago FCP, Martins FS, Souza ELS, Pimenta PFP, Araujo HRC, et al. Adhesion to the yeast cell surface as a mechanism for trapping pathogenic bacteria by Saccharomyces probiotics. J Med Microbiol. 2012;61:1194. 10.1099/jmm.0.042283-0
- Pontier-Bres R, Prodon F, Munro P, Rampal P, Lemichez E, et al. Modification of Salmonella Typhimurium motility by the probiotic yeast strain Saccharomyces boulardii. PLoS One. 2012;7:e33796. 10.1371/journal.pone.0033796
- Martins FS, Dalmasso G, Arantes RM, Doye A, Lemichez E, et al. Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection. PLoS One. 2010;5:e8925. 10.1371/journal.pone.0008925
- Martins FS, Veloso LC, Arantes RM, Nicoli JR. Effects of yeast probiotic formulation on viability, revival and protection against infection with Salmonella enterica ssp. enterica serovar Typhimurium in mice. Lett Appl Microbiol. 2009;49:738. 10.1111/j.1472-765X.2009.02732.x
- Gil de los Santos JR, Storch OB, Gil-Turnes C. Bacillus cereus var. toyoii and Saccharomyces boulardii increased feed efficiency in broilers infected with Salmonella enteritidis. Br Poult Sci. 2005;46:494. PubMed
- Line JE, Bailey JS, Cox NA, Stern NJ, Tompkins T. Effect of yeast-supplemented feed on Salmonella and Campylobacter populations in broilers. Poult Sci. 1998;77:405. PubMed
- Line JE, Bailey JS, Cox NA, Stern NJ. Yeast treatment to reduce Salmonella and Campylobacter populations associated with broiler chickens subjected to transport stress. Poult Sci. 1997;76:1227. PubMed
- Rodrigues AC, Nardi RM, Bambirra EA, Vieira EC, Nicoli JR. Effect of Saccharomyces boulardii against experimental oral infection with Salmonella typhimurium and Shigella flexneri in conventional and gnotobiotic mice. J Appl Bacteriol. 1996;81:251. PubMed
- Campos LL, Oliveira SRM, Amaral MNS, Gallotti B, Oliveira AF, et al. Oral Treatment with Saccharomyces cerevisiae CNCM I-3856 Mitigates the Inflammatory Response Experimentally Induced by Salmonella enterica subsp. enterica Serovar Typhimurium in Mice. Probiotics Antimicrob Proteins. 2024. 10.1007/s12602-024-10359-4
- Hofacre CL, Baxter J, Berghaus R, Bonato MA, de Souza FA. Yeast cell wall supplementation affects the Salmonella enteretidis load in the ceca and ovaries of layer pullets. Poult Sci. 2024;103:104187. 10.1016/j.psj.2024.104187
- Costello M, Rubinelli P, Brown J, Olson E, Dittoe D, et al. Comparison of yeast-derived commercial feed additives on Salmonella Enteritidis survival and microbiota populations in rooster cecal in vitro incubations. PLoS One. 2023;18:e0295657. 10.1371/journal.pone.0295657
- Hashem NM, Hosny NS, El-Desoky N, Soltan YA, Elolimy AA, et al. Alginate Nanoencapsulated Synbiotic Composite of Pomegranate Peel Phytogenics and Multi-Probiotic Species as a Potential Feed Additive: Physicochemical, Antioxidant, and Antimicrobial Activities. Animals (Basel). 2023;13. 10.3390/ani13152432
- Chaney WE, McBride H, Girgis G. Effect of a Postbiotic Feed Additive on Enteritidis Colonization of Cecal and Ovarian Tissues in Directly Challenged and Horizontally Exposed Layer Pullets. Animals (Basel). 2023;13. 10.3390/ani13071186
- Bzducha Wróbel A, Farkaš P, Chraniuk P, Popielarz D, Synowiec A, et al. Antimicrobial and prebiotic activity of mannoproteins isolated from conventional and nonconventional yeast species-the study on selected microorganisms. World J Microbiol Biotechnol. 2022;38:256. 10.1007/s11274-022-03448-5
- Oliveira SRM, Campos LL, Amaral MNS, Galotti B, Ricci MF, et al. Evaluation of a Functional Craft Wheat Beer Fermented with Saccharomyces cerevisiae UFMG A-905 to treat Salmonella Typhimurium infection in mice. Probiotics Antimicrob Proteins. 2023;15:1180. 10.1007/s12602-022-09973-x
Data last updated:
