Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 42 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Probiotic Blend
134 mg (1 Billion CFU§)
†
Lactobacillus rhamnosus (GR-1®)
Lactobacillus reuteri (RC-14®)
Top Medical Research Studies
9
We evaluated the effectiveness of Lactobacillus reuteri DSM 17938 as an addition to oral rehydration therapy for children suffering from acute gastroenteritis. This randomized, controlled trial took place in a pediatric emergency setting and included children aged 1 month to 5 years.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
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9
We investigated how the probiotic LRa05 affects acute watery diarrhea in young children. In a randomized controlled trial with 57 children receiving LRa05 and 54 on a placebo, we observed that those in the LRa05 group experienced a significantly shorter duration of diarrhea and improved fecal consistency.
These children also showed better gut microbiome changes. Specifically, more of them reported improvement compared to the placebo group. Overall, LRa05 proved to be a promising treatment option for easing diarrhea in children.
These children also showed better gut microbiome changes. Specifically, more of them reported improvement compared to the placebo group. Overall, LRa05 proved to be a promising treatment option for easing diarrhea in children.
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8
We explored the effects of equine-derived Lactobacillus reuteri on diarrhea caused by E. coli. Our study highlighted that this probiotic could ease symptoms by improving gut microbiota balance and reinforcing the intestinal barrier.
We found that Lactobacillus reuteri supplementation not only curbed E. coli-induced diarrhea but also helped restore key tight junction proteins and adjusted levels of inflammatory markers. Additionally, it was effective in rebuilding beneficial gut bacteria that E. coli had diminished.
Overall, these findings point to the potential of Lactobacillus reuteri as a viable treatment option for diarrhea, with promising applications in probiotic product development.
We found that Lactobacillus reuteri supplementation not only curbed E. coli-induced diarrhea but also helped restore key tight junction proteins and adjusted levels of inflammatory markers. Additionally, it was effective in rebuilding beneficial gut bacteria that E. coli had diminished.
Overall, these findings point to the potential of Lactobacillus reuteri as a viable treatment option for diarrhea, with promising applications in probiotic product development.
Read More
Most Useful Reviews
9
No more diarrhea
I consume this on an empty stomach, and while other probiotics led to diarrhea, this one has not caused such issues. I find it effective when taken daily without any adverse effects, making it a suitable choice for me.
Read More
9
Good for lactose intolerance
After taking this for two weeks, I find it to be effective, particularly for those with lactose intolerance. Unlike other brands, which sometimes induced diarrhea or flatulence, this product has not caused any adverse effects.
Read More
7.5
Healthy bowel movement
These pills are quite small and effective with no side effects. My bowel movements are healthy, without a diarrheal texture. I plan to continue taking it regularly for ongoing benefits.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 42 Researches
7.8
- All Researches
9.5
Lactobacillus improves H. pylori treatment
We examined the impact of Lactobacillus spp. on diarrhea related to Helicobacter pylori infections through a comprehensive analysis of 26 studies. Our findings suggest that using Lactobacillus significantly improves H. pylori eradication rates and reduces gastrointestinal side effects, including diarrhea.
Supplementation was particularly effective when paired with standard triple therapy, showing promising results, especially in children. This positions Lactobacillus as a valuable adjunct treatment option for managing these infections while reducing discomfort.
Supplementation was particularly effective when paired with standard triple therapy, showing promising results, especially in children. This positions Lactobacillus as a valuable adjunct treatment option for managing these infections while reducing discomfort.
Read More
9
Probiotics reinforce intestinal barriers
We explored the potential of a multi-strain probiotic blend (Serobioma) in improving gut health for individuals with Irritable Bowel Syndrome (IBS).
Using samples from 28 IBS patients and 7 healthy controls, we examined how this probiotic affects the intestinal barrier.
The results were promising: Serobioma significantly strengthened the intestinal lining and countered permeability changes caused by IBS-related substances. This was especially true for IBS patients who primarily experienced diarrhea, suggesting that probiotics could be a useful addition to their treatment plans.
Using samples from 28 IBS patients and 7 healthy controls, we examined how this probiotic affects the intestinal barrier.
The results were promising: Serobioma significantly strengthened the intestinal lining and countered permeability changes caused by IBS-related substances. This was especially true for IBS patients who primarily experienced diarrhea, suggesting that probiotics could be a useful addition to their treatment plans.
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9
Turcz. mitigates antibiotic-induced diarrhea
We explored how Turcz. (TCT) can alleviate antibiotic-associated diarrhea (AAD) in a mouse model. Through various research methods, we observed that TCT significantly improved gut health by enhancing microbiota diversity and regulating specific signaling pathways.
Treatment with TCT led to less inflammation, indicated by lower levels of IL-6 and TNF-α, and improved colon tissue structure. Notably, TCT increased beneficial bacteria like Lactobacillus. This study highlights a promising approach to managing AAD through natural compounds.
Treatment with TCT led to less inflammation, indicated by lower levels of IL-6 and TNF-α, and improved colon tissue structure. Notably, TCT increased beneficial bacteria like Lactobacillus. This study highlights a promising approach to managing AAD through natural compounds.
Read More
9
We evaluated the effectiveness of Lactobacillus reuteri DSM 17938 as an addition to oral rehydration therapy for children suffering from acute gastroenteritis. This randomized, controlled trial took place in a pediatric emergency setting and included children aged 1 month to 5 years.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
Read More
9
We explored the impact of Lactobacillus plantarum (LP) probiotics on reducing diarrhea caused by Salmonella in broiler chickens. Our study used different growth media for LP, revealing that the MRS medium yielded a probiotic formulation that significantly boosted body weight and reduced diarrhea by up to 86.45%.
This impressive outcome suggests that LP not only strengthens gut health but also helps combat harmful bacteria. Our findings indicate that LP could be a safe and eco-friendly option for improving poultry health and productivity.
This impressive outcome suggests that LP not only strengthens gut health but also helps combat harmful bacteria. Our findings indicate that LP could be a safe and eco-friendly option for improving poultry health and productivity.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
No more diarrhea
I consume this on an empty stomach, and while other probiotics led to diarrhea, this one has not caused such issues. I find it effective when taken daily without any adverse effects, making it a suitable choice for me.
Read More
9
Good for lactose intolerance
After taking this for two weeks, I find it to be effective, particularly for those with lactose intolerance. Unlike other brands, which sometimes induced diarrhea or flatulence, this product has not caused any adverse effects.
Read More
7.5
Healthy bowel movement
These pills are quite small and effective with no side effects. My bowel movements are healthy, without a diarrheal texture. I plan to continue taking it regularly for ongoing benefits.
Read More
Frequently Asked Questions
9
Good for lactose intolerance
After taking this for two weeks, I find it to be effective, particularly for those with lactose intolerance. Unlike other brands, which sometimes induced diarrhea or flatulence, this product has not caused any adverse effects.
9
No more diarrhea
I consume this on an empty stomach, and while other probiotics led to diarrhea, this one has not caused such issues. I find it effective when taken daily without any adverse effects, making it a suitable choice for me.
7.5
Healthy bowel movement
These pills are quite small and effective with no side effects. My bowel movements are healthy, without a diarrheal texture. I plan to continue taking it regularly for ongoing benefits.
9
We evaluated the effectiveness of Lactobacillus reuteri DSM 17938 as an addition to oral rehydration therapy for children suffering from acute gastroenteritis. This randomized, controlled trial took place in a pediatric emergency setting and included children aged 1 month to 5 years.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
8
To explore how Limosilactobacillus reuteri may help with diarrhea caused by enterotoxigenic E. coli (ETEC), we looked at different types of yogurt made with this bacteria. Our findings show that L. reuteri yogurt can strengthen the intestinal barrier, reduce inflammation, and lower ETEC levels in infected mice.
Additionally, it helps keep the gut's microbiota in balance, moving them closer to a healthy state. This suggests that incorporating L. reuteri yogurt into the diet could be beneficial for preventing or managing traveler’s diarrhea.
Additionally, it helps keep the gut's microbiota in balance, moving them closer to a healthy state. This suggests that incorporating L. reuteri yogurt into the diet could be beneficial for preventing or managing traveler’s diarrhea.
9
We conducted a multi-hospital study to tackle the common issue of antibiotic-associated diarrhea (AAD). By comparing probiotics, specifically Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, with a placebo among 340 adult patients, we aimed to find out if these friendly bacteria could help.
Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.
Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.
8
We explored how probiotics, particularly Lactobacillus rhamnosus, might help prevent and treat antibiotic-associated diarrhea (AAD) in children. Our analysis included 20 systematic reviews and utilized various assessment tools to evaluate their quality.
While high doses of probiotics showed significant effects, we noticed concerns about the quality of reporting and evidence in many reviews. This means that, while the potential is there, cautious interpretation of results is necessary as further improvements in study methodology are needed.
While high doses of probiotics showed significant effects, we noticed concerns about the quality of reporting and evidence in many reviews. This means that, while the potential is there, cautious interpretation of results is necessary as further improvements in study methodology are needed.
8
We explored how adding Lactobacillus reuteri to treatment plans helps children suffering from diarrhea. After analyzing data from nine randomized controlled trials involving 963 participants, we found significant reductions in the number of diarrhea cases within the first few days of treatment.
While the probiotic improved symptoms and reduced the duration of diarrhea, it did not show effectiveness in preventing diarrheal diseases, such as those caused by rotavirus or following antibiotic use. The focus remains on enhancing probiotics for better outcomes.
While the probiotic improved symptoms and reduced the duration of diarrhea, it did not show effectiveness in preventing diarrheal diseases, such as those caused by rotavirus or following antibiotic use. The focus remains on enhancing probiotics for better outcomes.
References
- Mei LN, Wang ZJ, Duan Y, Shen JS, Ye HB, et al. 4-Hydroxyboesenbergin B of Alpinia japonica protected gastrointestinal tract by inhibiting vancomycin-resistant enterococcus and balancing intestinal microbiota. J Ethnopharmacol. 2025;347:119737. doi:10.1016/j.jep.2025.119737
- Barbaro MR, Bianco F, Cremon C, Marasco G, Stanghellini V, et al. A Probiotic Mixture of LR 32, BL 04, and BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1. Int J Mol Sci. 2025;26. doi:10.3390/ijms26062656
- Fan D, Jiao S, Fu Y, Zhang J, Zhuang Y, et al. improves intestinal microbiota and barrier function to alleviate diarrhea of neonatal goats. Anim Nutr. 2025;20:366. doi:10.1016/j.aninu.2024.10.008
- Xu H, Zhang F, Huang Y, Yao Q, Guan Y, et al. [ Turcz. alleviates antibiotic-associated diarrhea in mice by modulating gut microbiota structure and regulating the EGFR/PI3K/Akt signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2025;45:285. doi:10.12122/j.issn.1673-4254.2025.02.09
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- Wang Z, Zhao Y, Fan D, Zhang J, Diao Q, et al. Sheep-Derived M5 Enhances Immunity and Antioxidant Capacity, Alleviates Diarrhea, and Improves Intestinal Health in Early-Weaned Lambs. Microorganisms. 2025;13. doi:10.3390/microorganisms13020404
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- Hai PV, Phuong HTA, Hung PHS, Na TT, Lai NH, et al. Selection of Lactobacillus strains from native chicken feces for the fermentation of purple onion ( L.) as an antibiotic alternative against spp. in chickens. Open Vet J. 2024;14:3525. doi:10.5455/OVJ.2024.v14.i12.35
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- Mishra V, Dash D, Panda AK, Pathak SK. Efficacy of Lactobacillus spp. Supplementation in Helicobacter pylori Eradication: A Systematic Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. Helicobacter. 2024;29:e70006. doi:10.1111/hel.70006
- Li S, Lu T, Lin Z, Zhang Y, Zhou X, et al. Supplementation with probiotics co-cultivation improves the reproductive performance in a sow-piglet model by mother-infant microbiota transmission and placental mTOR signaling. World J Microbiol Biotechnol. 2024;41:13. doi:10.1007/s11274-024-04222-5
- Mirsalami SM, Mirsalami M. Leveraging Lactobacillus plantarum probiotics to mitigate diarrhea and Salmonella infections in broiler chickens. AMB Express. 2024;14:137. doi:10.1186/s13568-024-01792-3
- Shah SA, Naz S, Jabeen F, Rashid MA, Rahman A, et al. COMPARISON OF BACTERIAL PROBIOTICS (BIFIDOBACTERIUM AND LACTOBACILLUS) VERSUS FUNGAL PROBIOTICS (SACCHAROMYCES) IN THE TREATMENT OF ACUTE DIARRHOEA IN CHILDREN AGED 6 MONTHS TO 5 YEARS. J Ayub Med Coll Abbottabad. 2024;36:537. doi:10.55519/JAMC-03-13464
- Chen K, Zeng K, Jin S, Ma Y, Cai L, et al. LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial. Front Nutr. 2024;11:1479186. doi:10.3389/fnut.2024.1479186
- Shin I, Kang Y, Ahn J, Kim Y, Nam J, et al. The potential probiotic role of Lacticaseibacillus rhamnosus on growth performance, gut health, and immune responses of weaned pigs. J Anim Sci. 2025. doi:10.1093/jas/skaf089
- Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. doi:10.1111/jgh.16809
- Shah J, Adnan SH, Yousaf MS, Din SJU, Haq MU, et al. A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea in Adult Patients. Cureus. 2024;16:e70881. doi:10.7759/cureus.70881
- Shawky LM, Abo El Wafa SM, Behery M, Bahr MH, Abu Alnasr MT, et al. Lactobacillus rhamnosus GG and Tannic Acid Synergistically Promote the Gut Barrier Integrity in a Rat Model of Experimental Diarrhea via Selective Immunomodulatory Cytokine Targeting. Mol Nutr Food Res. 2024;68:e2400295. doi:10.1002/mnfr.202400295
- Anvarifard P, Anbari M, Ghalichi F, Ghoreishi Z, Zarezadeh M. The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis. Food Funct. 2024;15:5737. doi:10.1039/d3fo04653b
- Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. doi:10.1016/j.tmaid.2024.102703
- Abdulah DM, Sulaiman SJ, Ahmed ZW. Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial. Clin Exp Pediatr. 2024;67:203. doi:10.3345/cep.2023.01340
- Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. doi:10.1007/s12325-024-02783-3
- Saviano A, Petruzziello C, Cancro C, Macerola N, Petti A, et al. The Efficacy of a Mix of Probiotics ( LMG P-27481 and GG ATCC 53103) in Preventing Antibiotic-Associated Diarrhea and Infection in Hospitalized Patients: Single-Center, Open-Label, Randomized Trial. Microorganisms. 2024;12. doi:10.3390/microorganisms12010198
- Poeta M, Cioffi V, Tarallo A, Damiano C, Lo Vecchio A, et al. Postbiotic Preparation of against Diarrhea and Oxidative Stress Induced by Spike Protein of SARS-CoV-2 in Human Enterocytes. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12101878
- Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
- Mego M, Danis R, Chovanec J, Jurisova S, Bystricky B, et al. Randomized double-blind, placebo-controlled multicenter phase III study of prevention of irinotecan-induced diarrhea by a probiotic mixture containing Bifidobacterium BB-12 LGG in colorectal cancer patients. Front Oncol. 2023;13:1168654. doi:10.3389/fonc.2023.1168654
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- Roshanzamiri S, Alemzadeh M, Ahmadizadeh SN, Behzad A, Hashemi SM, et al. Probiotic prophylaxis to prevent ventilator-associated pneumonia in children on mechanical ventilation: A randomized double-blind clinical trial. Front Pediatr. 2022;10:1045941. doi:10.3389/fped.2022.1045941
