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SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
USERS' SCORE
Good
Based on 17 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
8
Curcumin shows promise for acne
In vitro anti-propionibacterium activity by curcumin containing vesicle system.
Highly relevant for acne treatment
We investigated the potential of curcumin, a natural compound from turmeric, as an effective treatment for acne caused by Propionibacterium acnes. This bacterium can contribute to the development of inflammatory acne, especially when it grows excessively in hair follicles. Our goal was to create lipid-based vehicles to effectively deliver curcumin and see if it could inhibit the growth of this troublesome bacteria.
Using innovative testing methods, including bioluminescence assays, we evaluated how well our curcumin-infused vehicles performed against P. acnes. Additionally, we studied how much curcumin could accumulate in the skin using specialized diffusion cells and high-tech microscopy. The results were promising: we found that our lipid vehicles could accumulate an impressive amount of curcumin in the skin while significantly reducing the bacteria's growth.
Notably, curcumin showed discernible inhibitory effects at a concentration of just 0.43 µg/mL. Moreover, we confirmed through microscopy that the curcumin effectively formed a reservoir in the skin, enabling longer-lasting effects against acne. Overall, these findings suggest that curcumin-based vehicles, particularly when mixed with lauric acid, could serve as a promising new option for treating acne vulgaris.
Using innovative testing methods, including bioluminescence assays, we evaluated how well our curcumin-infused vehicles performed against P. acnes. Additionally, we studied how much curcumin could accumulate in the skin using specialized diffusion cells and high-tech microscopy. The results were promising: we found that our lipid vehicles could accumulate an impressive amount of curcumin in the skin while significantly reducing the bacteria's growth.
Notably, curcumin showed discernible inhibitory effects at a concentration of just 0.43 µg/mL. Moreover, we confirmed through microscopy that the curcumin effectively formed a reservoir in the skin, enabling longer-lasting effects against acne. Overall, these findings suggest that curcumin-based vehicles, particularly when mixed with lauric acid, could serve as a promising new option for treating acne vulgaris.
Read More
8
Curcumin effectively treats acne
Curcumin-mediated photodynamic therapy for mild to moderate Acne: A self-controlled split-face randomized study.
Investigation of curcumin in acne
We conducted a study to evaluate how effective Curcumin-mediated Photodynamic Therapy (Curcumin-PDT) is for treating mild to moderate acne. In our research design, we used a randomized split-face approach involving 11 patients. This meant that each patient received treatment on one side of their face with Curcumin-PDT while the other side was treated with just LED light.
The Curcumin treatment began with the application of a mask containing 1% curcumin, which was left on for 20 minutes. Following this, the skin was exposed to LED light for a specified duration. Treatments were conducted twice a week for two weeks. After evaluating both sides of the face, we found significant differences in effectiveness.
Remarkably, two weeks after the final treatment, we observed a total lesion clearance rate of 54.7% for the Curcumin-PDT side compared to only 28.1% for the control side. The improvement was especially noticeable for inflammatory lesions, which showed a clearance rate of almost 59.3% with Curcumin-PDT.
While both treatments resulted in some mild erythema, this cleared up quickly. Additionally, there were only minimal adverse effects like mild localized pigmentation in a couple of patients that resolved within a month. Overall, we can conclude that Curcumin-PDT appears to be a promising, safe, and effective method for managing acne.
The Curcumin treatment began with the application of a mask containing 1% curcumin, which was left on for 20 minutes. Following this, the skin was exposed to LED light for a specified duration. Treatments were conducted twice a week for two weeks. After evaluating both sides of the face, we found significant differences in effectiveness.
Remarkably, two weeks after the final treatment, we observed a total lesion clearance rate of 54.7% for the Curcumin-PDT side compared to only 28.1% for the control side. The improvement was especially noticeable for inflammatory lesions, which showed a clearance rate of almost 59.3% with Curcumin-PDT.
While both treatments resulted in some mild erythema, this cleared up quickly. Additionally, there were only minimal adverse effects like mild localized pigmentation in a couple of patients that resolved within a month. Overall, we can conclude that Curcumin-PDT appears to be a promising, safe, and effective method for managing acne.
Read More
8
Curcumin delivery enhances acne treatment
Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition.
Moderate relevance to turmeric effects
We explored how curcumin, a compound derived from turmeric, can be delivered more effectively to treat acne and psoriasis. The study focused on creating a specific formulation, known as nanostructured lipid carriers (NLC), which helps in better absorption and retention of curcumin on the skin.
By using a method that combines hot emulsification with probe sonication, we successfully prepared curcumin-loaded NLCs. These formulations showed a small particle size, high entrapment efficiency, and a negative zeta potential, indicating stability.
When we tested the drug release, the curcumin NLCs demonstrated a prolonged release over 48 hours, significantly outperforming free curcumin, which was released completely within just 4 hours. Notably, the NLC gel improved skin permeation and retention by over three times compared to traditional gels containing free curcumin.
The safety of our formulation was also important, and cell viability tests indicated no toxicity towards skin cells. Additionally, we found that keratinocyte cells absorbed curcumin more effectively when delivered via NLCs compared to free curcumin. These findings suggest that curcumin, when delivered using this innovative approach, holds promise in enhancing treatment for acne.
By using a method that combines hot emulsification with probe sonication, we successfully prepared curcumin-loaded NLCs. These formulations showed a small particle size, high entrapment efficiency, and a negative zeta potential, indicating stability.
When we tested the drug release, the curcumin NLCs demonstrated a prolonged release over 48 hours, significantly outperforming free curcumin, which was released completely within just 4 hours. Notably, the NLC gel improved skin permeation and retention by over three times compared to traditional gels containing free curcumin.
The safety of our formulation was also important, and cell viability tests indicated no toxicity towards skin cells. Additionally, we found that keratinocyte cells absorbed curcumin more effectively when delivered via NLCs compared to free curcumin. These findings suggest that curcumin, when delivered using this innovative approach, holds promise in enhancing treatment for acne.
Read More
Most Useful Reviews
9.5
Hormonal acne solution
I finally found relief for my hormonal acne after trying everything. Reading about milk thistle's effectiveness pushed me to give it a chance, and I'm thrilled with the investment; it truly made a difference!
Read More
8.8
Left-side acne success
I used to suffer from acne on the left side of my face but after taking one of these daily, I've noticed a significant decrease. It's the only change I made in my lifestyle.
Read More
10
Acne-free at last
After 35 years of acne, I took my friend's recommended milk thistle and have seen fantastic results! I take it daily and it's been excellent for detoxifying my body while clearing my skin.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
9
Curcumin affects acne treatment efficacy
Utilizing the photodynamic properties of curcumin to disrupt biofilms in Cutibacterium acnes: A promising approach for treating acne.
Relevance score indicates moderate importance
We examined the effectiveness of curcumin, a compound found in turmeric, in tackling acne by disrupting the biofilms formed by Cutibacterium acnes (C.acnes), a key player in acne development. The study primarily focused on how curcumin combined with light therapy could provide a promising alternative treatment, especially in light of rising antibiotic resistance.
Following established guidelines, we tested 25 clinical strains of C.acnes against various antibiotics and curcumin. Our findings revealed that while C.acnes exhibited substantial resistance to most antibiotics, curcumin showed robust potential. It was found to effectively reduce the survival rates of planktonic C.acnes, and significantly disrupt the three-dimensional structure of biofilms when used in conjunction with blue light therapy.
This suggests that curcumin photodynamic therapy could be a viable option for treating acne, particularly for individuals facing challenges with antibiotic-resistant bacteria. Overall, we observed encouraging results that highlight curcumin's potential in acne treatments and its role in combating stubborn biofilm formations.
Following established guidelines, we tested 25 clinical strains of C.acnes against various antibiotics and curcumin. Our findings revealed that while C.acnes exhibited substantial resistance to most antibiotics, curcumin showed robust potential. It was found to effectively reduce the survival rates of planktonic C.acnes, and significantly disrupt the three-dimensional structure of biofilms when used in conjunction with blue light therapy.
This suggests that curcumin photodynamic therapy could be a viable option for treating acne, particularly for individuals facing challenges with antibiotic-resistant bacteria. Overall, we observed encouraging results that highlight curcumin's potential in acne treatments and its role in combating stubborn biofilm formations.
Read More
9
Curcumin microemulsions show promise
Antimicrobial activity of curcumin-loaded myristic acid microemulsions against Staphylococcus epidermidis.
Moderate relevance to curcumin's impact
We dove into the antibacterial properties of curcumin, a compound found in turmeric, to see how it could help fight acne. Our focus was on curcumin-loaded myristic acid microemulsions and their ability to inhibit Staphylococcus epidermidis, a bacteria known to cause skin infections and acne.
The study involved assessing the spread and penetration of curcumin through the skin using advanced microscopy techniques. We found that these microemulsions could effectively deliver curcumin into the skin, with significant amounts absorbed. In fact, when tested, curcumin in the microemulsion was twelve times more effective at inhibiting bacterial growth than when it was simply dissolved in a common solvent.
This combination of myristic acid and curcumin worked well together, showcasing a potential new method for treating acne and skin infections linked to this bacteria. While the spotlight was on turmeric’s promising antibacterial effects, we recognize that it was the synergy with myristic acid that enhanced the overall efficacy, hinting at an alternative approach for tackling S. epidermidis-related skin issues.
The study involved assessing the spread and penetration of curcumin through the skin using advanced microscopy techniques. We found that these microemulsions could effectively deliver curcumin into the skin, with significant amounts absorbed. In fact, when tested, curcumin in the microemulsion was twelve times more effective at inhibiting bacterial growth than when it was simply dissolved in a common solvent.
This combination of myristic acid and curcumin worked well together, showcasing a potential new method for treating acne and skin infections linked to this bacteria. While the spotlight was on turmeric’s promising antibacterial effects, we recognize that it was the synergy with myristic acid that enhanced the overall efficacy, hinting at an alternative approach for tackling S. epidermidis-related skin issues.
Read More
8
Curcumin effectively treats acne
Curcumin-mediated photodynamic therapy for mild to moderate Acne: A self-controlled split-face randomized study.
Investigation of curcumin in acne
We conducted a study to evaluate how effective Curcumin-mediated Photodynamic Therapy (Curcumin-PDT) is for treating mild to moderate acne. In our research design, we used a randomized split-face approach involving 11 patients. This meant that each patient received treatment on one side of their face with Curcumin-PDT while the other side was treated with just LED light.
The Curcumin treatment began with the application of a mask containing 1% curcumin, which was left on for 20 minutes. Following this, the skin was exposed to LED light for a specified duration. Treatments were conducted twice a week for two weeks. After evaluating both sides of the face, we found significant differences in effectiveness.
Remarkably, two weeks after the final treatment, we observed a total lesion clearance rate of 54.7% for the Curcumin-PDT side compared to only 28.1% for the control side. The improvement was especially noticeable for inflammatory lesions, which showed a clearance rate of almost 59.3% with Curcumin-PDT.
While both treatments resulted in some mild erythema, this cleared up quickly. Additionally, there were only minimal adverse effects like mild localized pigmentation in a couple of patients that resolved within a month. Overall, we can conclude that Curcumin-PDT appears to be a promising, safe, and effective method for managing acne.
The Curcumin treatment began with the application of a mask containing 1% curcumin, which was left on for 20 minutes. Following this, the skin was exposed to LED light for a specified duration. Treatments were conducted twice a week for two weeks. After evaluating both sides of the face, we found significant differences in effectiveness.
Remarkably, two weeks after the final treatment, we observed a total lesion clearance rate of 54.7% for the Curcumin-PDT side compared to only 28.1% for the control side. The improvement was especially noticeable for inflammatory lesions, which showed a clearance rate of almost 59.3% with Curcumin-PDT.
While both treatments resulted in some mild erythema, this cleared up quickly. Additionally, there were only minimal adverse effects like mild localized pigmentation in a couple of patients that resolved within a month. Overall, we can conclude that Curcumin-PDT appears to be a promising, safe, and effective method for managing acne.
Read More
8
Curcumin enhances acne treatment methods
Curcumin/Fusidic Acid Bitherapy Loaded Mixed Micellar Nanogel for Acne Vulgaris Treatment: In Vitro and In Vivo Studies.
Combined treatment poses challenges
We evaluated how curcumin, a natural compound found in turmeric, can affect acne when combined with fusidic acid, a topical antibiotic. This research also focused on a hybrid delivery method using mixed micelles incorporated into a nanogel to enhance the effectiveness of this combination.
Through various tests, we found that the curcumin-fusidic acid-loaded mixed micelles showed a good structure, ensuring both drugs were well-encapsulated and released effectively over time. In our animal studies, we observed significant improvements in skin inflammation and other symptoms related to acne in those treated with the curcumin-fusidic acid nanogel.
Ultimately, this approach appears promising for not only treating acne but also potentially reducing the issues of antibiotic resistance. By enhancing the solubility and absorption of curcumin, we could harness its antioxidant and antibacterial properties more effectively.
However, since we focused on the combination treatment, separating the individual effects of curcumin specifically on acne remains challenging.
Through various tests, we found that the curcumin-fusidic acid-loaded mixed micelles showed a good structure, ensuring both drugs were well-encapsulated and released effectively over time. In our animal studies, we observed significant improvements in skin inflammation and other symptoms related to acne in those treated with the curcumin-fusidic acid nanogel.
Ultimately, this approach appears promising for not only treating acne but also potentially reducing the issues of antibiotic resistance. By enhancing the solubility and absorption of curcumin, we could harness its antioxidant and antibacterial properties more effectively.
However, since we focused on the combination treatment, separating the individual effects of curcumin specifically on acne remains challenging.
Read More
8
Curcumin delivery enhances acne treatment
Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition.
Moderate relevance to turmeric effects
We explored how curcumin, a compound derived from turmeric, can be delivered more effectively to treat acne and psoriasis. The study focused on creating a specific formulation, known as nanostructured lipid carriers (NLC), which helps in better absorption and retention of curcumin on the skin.
By using a method that combines hot emulsification with probe sonication, we successfully prepared curcumin-loaded NLCs. These formulations showed a small particle size, high entrapment efficiency, and a negative zeta potential, indicating stability.
When we tested the drug release, the curcumin NLCs demonstrated a prolonged release over 48 hours, significantly outperforming free curcumin, which was released completely within just 4 hours. Notably, the NLC gel improved skin permeation and retention by over three times compared to traditional gels containing free curcumin.
The safety of our formulation was also important, and cell viability tests indicated no toxicity towards skin cells. Additionally, we found that keratinocyte cells absorbed curcumin more effectively when delivered via NLCs compared to free curcumin. These findings suggest that curcumin, when delivered using this innovative approach, holds promise in enhancing treatment for acne.
By using a method that combines hot emulsification with probe sonication, we successfully prepared curcumin-loaded NLCs. These formulations showed a small particle size, high entrapment efficiency, and a negative zeta potential, indicating stability.
When we tested the drug release, the curcumin NLCs demonstrated a prolonged release over 48 hours, significantly outperforming free curcumin, which was released completely within just 4 hours. Notably, the NLC gel improved skin permeation and retention by over three times compared to traditional gels containing free curcumin.
The safety of our formulation was also important, and cell viability tests indicated no toxicity towards skin cells. Additionally, we found that keratinocyte cells absorbed curcumin more effectively when delivered via NLCs compared to free curcumin. These findings suggest that curcumin, when delivered using this innovative approach, holds promise in enhancing treatment for acne.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.6
10
Acne-free at last
After 35 years of acne, I took my friend's recommended milk thistle and have seen fantastic results! I take it daily and it's been excellent for detoxifying my body while clearing my skin.
9.5
Effective acne treatment
My doctor prescribed this for my nephew, who struggled with severe acne. After the treatment, the bacteria causing his acne was no longer present during follow-up tests.
9.5
Cleared acne
I purchased this for my niece, and it effectively cleared her acne.
9.5
Hormonal acne solution
I finally found relief for my hormonal acne after trying everything. Reading about milk thistle's effectiveness pushed me to give it a chance, and I'm thrilled with the investment; it truly made a difference!
9.5
Effective for blemishes
Using milk thistle has greatly enhanced my skin, helping clear up blemishes while also providing anti-aging benefits. I've tried various brands, but this one stands out as a winner!
