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SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
USERS' SCORE
Good
Based on 10 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin reduces depression severity
Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.
High relevance to research topic
We conducted a study to explore the effects of curcumin, a natural supplement found in turmeric, on depression among obese patients with type 2 diabetes. Using a randomized, double-blind, placebo-controlled approach, we engaged 227 participants to assess how curcumin might help alleviate symptoms of depression.
Over the course of 12 months, we monitored changes in depression severity using a standard questionnaire, the Patient Health Questionnaire-9. Additionally, we evaluated various biomarkers such as serotonin levels, inflammatory markers, and antioxidant activity to better understand curcumin's potential benefits.
Our findings were quite promising. By the end of the study, those taking curcumin reported significantly lower depression severity. We also observed that curcumin increased serotonin levels while reducing markers associated with inflammation. Improvements in antioxidant activity were noted in the curcumin group too.
Overall, these results suggest that curcumin could be a beneficial addition to the treatment plan for individuals dealing with depression, particularly for those who are also managing obesity and type 2 diabetes. This research not only highlights the antidepressant effects of curcumin but also emphasizes the importance of holistic approaches in healthcare.
Over the course of 12 months, we monitored changes in depression severity using a standard questionnaire, the Patient Health Questionnaire-9. Additionally, we evaluated various biomarkers such as serotonin levels, inflammatory markers, and antioxidant activity to better understand curcumin's potential benefits.
Our findings were quite promising. By the end of the study, those taking curcumin reported significantly lower depression severity. We also observed that curcumin increased serotonin levels while reducing markers associated with inflammation. Improvements in antioxidant activity were noted in the curcumin group too.
Overall, these results suggest that curcumin could be a beneficial addition to the treatment plan for individuals dealing with depression, particularly for those who are also managing obesity and type 2 diabetes. This research not only highlights the antidepressant effects of curcumin but also emphasizes the importance of holistic approaches in healthcare.
Read More
9.5
Turmeric extract shows antidepressant promise
Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect.
Highly relevant to depression treatment
We investigated the potential of turmeric extract, rich in curcumin and its derivatives, for alleviating depression. This study aimed to develop a nano-delivery system, called TUR-NE, to enhance the absorption and effectiveness of turmeric's active ingredients.
We explored the antidepressant properties of turmeric using various models, including tests for oxidative stress and cell injury. After creating and optimizing the TUR-NE, we tested its bioavailability in rats and its antidepressant effects in mice exposed to mild stress.
The results were promising; TUR was shown to have significant antioxidant properties, even outperforming standard treatments. The TUR-NE had a small particle size, high stability, and excellent encapsulation rates. Importantly, our pharmacokinetic analysis revealed that TUR-NE was absorbed much better than traditional curcumin alone.
We found that TUR-NE significantly improved depressive behaviors and elevated serotonin levels in the mice, suggesting that it could be an effective new treatment for depression. Overall, this study highlights the exciting potential of turmeric-based treatments in tackling depression, paving the way for innovative oral therapies.
We explored the antidepressant properties of turmeric using various models, including tests for oxidative stress and cell injury. After creating and optimizing the TUR-NE, we tested its bioavailability in rats and its antidepressant effects in mice exposed to mild stress.
The results were promising; TUR was shown to have significant antioxidant properties, even outperforming standard treatments. The TUR-NE had a small particle size, high stability, and excellent encapsulation rates. Importantly, our pharmacokinetic analysis revealed that TUR-NE was absorbed much better than traditional curcumin alone.
We found that TUR-NE significantly improved depressive behaviors and elevated serotonin levels in the mice, suggesting that it could be an effective new treatment for depression. Overall, this study highlights the exciting potential of turmeric-based treatments in tackling depression, paving the way for innovative oral therapies.
Read More
9
Turmeric oil alleviates depression
Inhalation of Curcumae Rhizoma volatile oil attenuates depression-like behaviours via activating the Nrf2 pathway to alleviate oxidative stress and improve mitochondrial dysfunction.
Research focused on turmeric's effects
We explored the potential benefits of Curcumae Rhizoma volatile oil (CRVO), a traditional treatment derived from turmeric, in tackling depression. Using a model of chronic unpredictable mild stress (CUMS), we observed that inhaling CRVO significantly improved depressive-like behaviors in mice.
Beyond improving mood, our findings indicated that CRVO also helps combat oxidative stress and reduces damage to neurons and mitochondria, vital components of overall brain health.
The study delved into the mechanisms at play, highlighting the activation of the Nrf2/HO-1/NQO1 signaling pathway, which plays a crucial role in our body's antioxidant defenses. When we introduced an Nrf2 inhibitor, we noted a reduction in the benefits offered by CRVO, confirming its importance in this process.
Overall, the results suggest that using CRVO could serve as a promising approach to alleviate depression-related symptoms by addressing underlying oxidative stress and mitochondrial dysfunction.
Beyond improving mood, our findings indicated that CRVO also helps combat oxidative stress and reduces damage to neurons and mitochondria, vital components of overall brain health.
The study delved into the mechanisms at play, highlighting the activation of the Nrf2/HO-1/NQO1 signaling pathway, which plays a crucial role in our body's antioxidant defenses. When we introduced an Nrf2 inhibitor, we noted a reduction in the benefits offered by CRVO, confirming its importance in this process.
Overall, the results suggest that using CRVO could serve as a promising approach to alleviate depression-related symptoms by addressing underlying oxidative stress and mitochondrial dysfunction.
Read More
Most Useful Reviews
9.5
Fights depression effectively
Curcumin demonstrates powerful antioxidant properties that enhance heart health and may aid in preventing cancer. It also helps combat depression by blocking inflammatory signals. It has proven effective compared to some anti-inflammatory drugs in certain studies.
Read More
8.8
Improves mood
Curcumin is an excellent supplement, especially for those who prefer not to take multiple additives. I discovered its potential anti-cancer properties from David Servan-Schreiber's book “Anti-Cancer”. Studies suggest it alleviates osteoarthritis and rheumatoid arthritis symptoms. Furthermore, curcumin improves intelligence, attention, and memory. It also helps reduce stress, anxiety, and fatigue, and I've noticed a slight increase in testosterone levels. For best results, take it with phospholipids and black pepper to enhance absorption.
Read More
8.8
Supports mental health
At 77, I'm passionate about health and consider Curcumin 95 one of my top supplements. It purportedly combats inflammation, depression, and various brain disorders such as multiple sclerosis. I also take turmeric for its other benefits. It’s remarkable how these supplements can enhance health, and I continue to work as a Police Officer while feeling good.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
9.5
Turmeric extract shows antidepressant promise
Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect.
Highly relevant to depression treatment
We investigated the potential of turmeric extract, rich in curcumin and its derivatives, for alleviating depression. This study aimed to develop a nano-delivery system, called TUR-NE, to enhance the absorption and effectiveness of turmeric's active ingredients.
We explored the antidepressant properties of turmeric using various models, including tests for oxidative stress and cell injury. After creating and optimizing the TUR-NE, we tested its bioavailability in rats and its antidepressant effects in mice exposed to mild stress.
The results were promising; TUR was shown to have significant antioxidant properties, even outperforming standard treatments. The TUR-NE had a small particle size, high stability, and excellent encapsulation rates. Importantly, our pharmacokinetic analysis revealed that TUR-NE was absorbed much better than traditional curcumin alone.
We found that TUR-NE significantly improved depressive behaviors and elevated serotonin levels in the mice, suggesting that it could be an effective new treatment for depression. Overall, this study highlights the exciting potential of turmeric-based treatments in tackling depression, paving the way for innovative oral therapies.
We explored the antidepressant properties of turmeric using various models, including tests for oxidative stress and cell injury. After creating and optimizing the TUR-NE, we tested its bioavailability in rats and its antidepressant effects in mice exposed to mild stress.
The results were promising; TUR was shown to have significant antioxidant properties, even outperforming standard treatments. The TUR-NE had a small particle size, high stability, and excellent encapsulation rates. Importantly, our pharmacokinetic analysis revealed that TUR-NE was absorbed much better than traditional curcumin alone.
We found that TUR-NE significantly improved depressive behaviors and elevated serotonin levels in the mice, suggesting that it could be an effective new treatment for depression. Overall, this study highlights the exciting potential of turmeric-based treatments in tackling depression, paving the way for innovative oral therapies.
Read More
9
Curcumin and exercise aid depression
Curcumin and exercise prevent depression alleviating hippocampus injury and improve depressive-like behaviors in chronically stressed depression rats.
Direct relevance to treatment effectiveness
We explored how curcumin, a natural compound found in turmeric, along with exercise, can help combat depression, particularly by addressing the damage to the hippocampus—an area of the brain associated with mood and memory. In our study, we focused on male rats that had been exposed to chronic stress, a common model for studying depressive-like behaviors.
The rats were treated with curcumin and engaged in regular treadmill exercise for two weeks. We assessed their behaviors and brain health through a series of tests. Notably, we measured their immobility in water, general movement, and preference for sweet solutions—signs that can indicate depression. Our findings revealed that combining curcumin with exercise significantly improved their movement and reduced signs of depression, while also supporting cell health in the hippocampus.
These positive results suggest that curcumin, when used alongside physical activity, may offer a promising alternative to traditional depression treatments, which often come with delayed effects and unwanted side effects. This study adds to the growing interest in natural therapies for mental health and opens up new avenues for research into effective treatments for depression.
The rats were treated with curcumin and engaged in regular treadmill exercise for two weeks. We assessed their behaviors and brain health through a series of tests. Notably, we measured their immobility in water, general movement, and preference for sweet solutions—signs that can indicate depression. Our findings revealed that combining curcumin with exercise significantly improved their movement and reduced signs of depression, while also supporting cell health in the hippocampus.
These positive results suggest that curcumin, when used alongside physical activity, may offer a promising alternative to traditional depression treatments, which often come with delayed effects and unwanted side effects. This study adds to the growing interest in natural therapies for mental health and opens up new avenues for research into effective treatments for depression.
Read More
9
Curcumin reduces depression severity
Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.
High relevance to research topic
We conducted a study to explore the effects of curcumin, a natural supplement found in turmeric, on depression among obese patients with type 2 diabetes. Using a randomized, double-blind, placebo-controlled approach, we engaged 227 participants to assess how curcumin might help alleviate symptoms of depression.
Over the course of 12 months, we monitored changes in depression severity using a standard questionnaire, the Patient Health Questionnaire-9. Additionally, we evaluated various biomarkers such as serotonin levels, inflammatory markers, and antioxidant activity to better understand curcumin's potential benefits.
Our findings were quite promising. By the end of the study, those taking curcumin reported significantly lower depression severity. We also observed that curcumin increased serotonin levels while reducing markers associated with inflammation. Improvements in antioxidant activity were noted in the curcumin group too.
Overall, these results suggest that curcumin could be a beneficial addition to the treatment plan for individuals dealing with depression, particularly for those who are also managing obesity and type 2 diabetes. This research not only highlights the antidepressant effects of curcumin but also emphasizes the importance of holistic approaches in healthcare.
Over the course of 12 months, we monitored changes in depression severity using a standard questionnaire, the Patient Health Questionnaire-9. Additionally, we evaluated various biomarkers such as serotonin levels, inflammatory markers, and antioxidant activity to better understand curcumin's potential benefits.
Our findings were quite promising. By the end of the study, those taking curcumin reported significantly lower depression severity. We also observed that curcumin increased serotonin levels while reducing markers associated with inflammation. Improvements in antioxidant activity were noted in the curcumin group too.
Overall, these results suggest that curcumin could be a beneficial addition to the treatment plan for individuals dealing with depression, particularly for those who are also managing obesity and type 2 diabetes. This research not only highlights the antidepressant effects of curcumin but also emphasizes the importance of holistic approaches in healthcare.
Read More
9
Turmeric oil alleviates depression
Inhalation of Curcumae Rhizoma volatile oil attenuates depression-like behaviours via activating the Nrf2 pathway to alleviate oxidative stress and improve mitochondrial dysfunction.
Research focused on turmeric's effects
We explored the potential benefits of Curcumae Rhizoma volatile oil (CRVO), a traditional treatment derived from turmeric, in tackling depression. Using a model of chronic unpredictable mild stress (CUMS), we observed that inhaling CRVO significantly improved depressive-like behaviors in mice.
Beyond improving mood, our findings indicated that CRVO also helps combat oxidative stress and reduces damage to neurons and mitochondria, vital components of overall brain health.
The study delved into the mechanisms at play, highlighting the activation of the Nrf2/HO-1/NQO1 signaling pathway, which plays a crucial role in our body's antioxidant defenses. When we introduced an Nrf2 inhibitor, we noted a reduction in the benefits offered by CRVO, confirming its importance in this process.
Overall, the results suggest that using CRVO could serve as a promising approach to alleviate depression-related symptoms by addressing underlying oxidative stress and mitochondrial dysfunction.
Beyond improving mood, our findings indicated that CRVO also helps combat oxidative stress and reduces damage to neurons and mitochondria, vital components of overall brain health.
The study delved into the mechanisms at play, highlighting the activation of the Nrf2/HO-1/NQO1 signaling pathway, which plays a crucial role in our body's antioxidant defenses. When we introduced an Nrf2 inhibitor, we noted a reduction in the benefits offered by CRVO, confirming its importance in this process.
Overall, the results suggest that using CRVO could serve as a promising approach to alleviate depression-related symptoms by addressing underlying oxidative stress and mitochondrial dysfunction.
Read More
9
Tetrahydrocurcumin's antidepressant mechanism
The role and mechanism of TGF-β1 in the antidepressant-like effects of tetrahydrocurcumin.
Relevant study with significant findings
We explored the effects of tetrahydrocurcumin (THC), the active compound in turmeric, on depression-like behaviors. By studying mice that underwent chronic restraint stress, we aimed to understand how THC can affect inflammation, neurotrophins, and a protein called TGF-β1 in the brain, particularly in the prefrontal cortex.
Our findings were quite enlightening. THC appeared to reduce anxiety and depressive behaviors in the stressed mice. It also positively impacted the expression levels of several important proteins, including TGF-β1 and neurotrophins that help in brain cell health and function. Specifically, THC increased the levels of TGF-β1, which plays a vital role in brain and immune function while reducing inflammatory markers associated with stress.
Interestingly, when we inhibited the TGF-β1 receptors with a specific blocker, we found that THC lost its beneficial effects on the brain. This suggests that TGF-β1 is crucial for THC’s antidepressant effects. Overall, our research highlights that THC may combat depression through mechanisms involving inflammation reduction while enhancing brain health and signaling.
Our findings were quite enlightening. THC appeared to reduce anxiety and depressive behaviors in the stressed mice. It also positively impacted the expression levels of several important proteins, including TGF-β1 and neurotrophins that help in brain cell health and function. Specifically, THC increased the levels of TGF-β1, which plays a vital role in brain and immune function while reducing inflammatory markers associated with stress.
Interestingly, when we inhibited the TGF-β1 receptors with a specific blocker, we found that THC lost its beneficial effects on the brain. This suggests that TGF-β1 is crucial for THC’s antidepressant effects. Overall, our research highlights that THC may combat depression through mechanisms involving inflammation reduction while enhancing brain health and signaling.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.7
9.5
Fights depression effectively
Curcumin demonstrates powerful antioxidant properties that enhance heart health and may aid in preventing cancer. It also helps combat depression by blocking inflammatory signals. It has proven effective compared to some anti-inflammatory drugs in certain studies.
8.8
Improves mood
Curcumin is an excellent supplement, especially for those who prefer not to take multiple additives. I discovered its potential anti-cancer properties from David Servan-Schreiber's book “Anti-Cancer”. Studies suggest it alleviates osteoarthritis and rheumatoid arthritis symptoms. Furthermore, curcumin improves intelligence, attention, and memory. It also helps reduce stress, anxiety, and fatigue, and I've noticed a slight increase in testosterone levels. For best results, take it with phospholipids and black pepper to enhance absorption.
Read More
8.8
Supports mental health
At 77, I'm passionate about health and consider Curcumin 95 one of my top supplements. It purportedly combats inflammation, depression, and various brain disorders such as multiple sclerosis. I also take turmeric for its other benefits. It’s remarkable how these supplements can enhance health, and I continue to work as a Police Officer while feeling good.
Read More
8.8
Helps with depression
If you suffer from inflammation or pain, this supplement is essential. Curcumin has been shown to be as effective as ibuprofen. Just remember to take it with a meal that includes fat and black pepper to boost absorption. It significantly alleviates my joint pain and headaches. I also find it beneficial for depression linked to inflammation.
Read More
8.8
Helps alleviate depression
Elixir of Women's Health! It possesses anti-inflammatory and antibacterial properties, combats skin irritation, and rejuvenates the face, tightening it and smoothing wrinkles. It aids in weight stabilisation, alleviates PMS symptoms, and assists with menstrual irregularities. Moreover, it has neuroprotective benefits, stimulates the brain, enhances memory, and helps combat depression.
Read More
