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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Nano-curcumin reduces IL-17 levels
The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial.
Directly addresses turmeric's impact.
We conducted a study to explore how nano-curcumin, a special formulation of turmeric, influences the balance of immune proteins associated with migraines. By randomly assigning forty participants with episodic migraines to receive either an 80 mg dose of nano-curcumin or a placebo for two months, we ensured that our findings would be robust and reliable.
Our primary focus was on two key proteins: interferon gamma (IFN-γ) and interleukin-17 (IL-17). These proteins play significant roles in immune responses and are implicated in migraine pathophysiology. Using advanced techniques like real-time PCR and ELISA, we measured the levels of these proteins in our participants' blood.
The results were promising; we noted a significant decrease in the levels and gene expression of IL-17 in the group taking nano-curcumin compared to the placebo group. However, it’s important to mention that we found no significant differences in the levels of IFN-γ between the groups.
Overall, our findings suggest that nano-curcumin supplementation may provide beneficial effects for migraine patients by specifically targeting IL-17, which could lead to new approaches for managing migraine symptoms going forward.
Our primary focus was on two key proteins: interferon gamma (IFN-γ) and interleukin-17 (IL-17). These proteins play significant roles in immune responses and are implicated in migraine pathophysiology. Using advanced techniques like real-time PCR and ELISA, we measured the levels of these proteins in our participants' blood.
The results were promising; we noted a significant decrease in the levels and gene expression of IL-17 in the group taking nano-curcumin compared to the placebo group. However, it’s important to mention that we found no significant differences in the levels of IFN-γ between the groups.
Overall, our findings suggest that nano-curcumin supplementation may provide beneficial effects for migraine patients by specifically targeting IL-17, which could lead to new approaches for managing migraine symptoms going forward.
Read More
8
Nano-curcumin reduces migraine severity
The effects of nano-curcumin supplementation on adipokines levels in obese and overweight patients with migraine: a double blind clinical trial study.
Highly relevant migraine treatment study
We explored how nano-curcumin, a more bioavailable form of turmeric, could affect migraine symptoms and adipokine levels in individuals who are overweight or obese. Our study involved 44 patients experiencing episodic migraines, divided into a nano-curcumin group receiving 80 mg daily and a control group over a two-month period.
We measured serum levels of certain biomarkers associated with inflammation, such as MCP-1, Resistin, and Visfatin, before and after the treatment. Notably, we found that the nano-curcumin group experienced a significant reduction in the MCP-1 serum levels. For Resistin and Visfatin, however, no significant changes were observed.
Additionally, participants taking nano-curcumin reported fewer headache attacks, less severe pain, and shorter durations of migraines compared to those in the control group. While the results are promising, particularly regarding the reduction of headache symptoms, we recognize the need for further research to solidify these findings before making definitive claims.
We measured serum levels of certain biomarkers associated with inflammation, such as MCP-1, Resistin, and Visfatin, before and after the treatment. Notably, we found that the nano-curcumin group experienced a significant reduction in the MCP-1 serum levels. For Resistin and Visfatin, however, no significant changes were observed.
Additionally, participants taking nano-curcumin reported fewer headache attacks, less severe pain, and shorter durations of migraines compared to those in the control group. While the results are promising, particularly regarding the reduction of headache symptoms, we recognize the need for further research to solidify these findings before making definitive claims.
Read More
8
Curcumin alleviates migraine symptoms
Effects of Curcumin Supplementation on Clinical Features and Inflammation, in Migraine Patients: A Double-Blind Controlled, Placebo Randomized Clinical Trial.
High relevance to migraine treatment.
We conducted a study to explore the effects of curcumin, a well-known herb with anti-inflammatory properties, on migraine symptoms. Through a randomized double-blind placebo-controlled trial involving 44 women suffering from migraines, we provided participants with either 500 mg of curcumin twice a day or a placebo for 8 weeks.
At the end of the study, we observed significant improvements among those taking curcumin. There was a notable reduction in levels of calcitonin gene-related peptide (CGRP) and interleukin-6 (IL-6), which are markers related to inflammatory processes. Participants also reported decreased headache severity and duration, along with a slight decrease in headache frequency.
These findings suggest that curcumin might be beneficial for those experiencing migraines, potentially due to its anti-inflammatory properties. Importantly, there were no significant changes in body mass index, weight, or body composition between the groups, indicating that the effects were likely specific to migraine symptoms rather than overall health changes.
At the end of the study, we observed significant improvements among those taking curcumin. There was a notable reduction in levels of calcitonin gene-related peptide (CGRP) and interleukin-6 (IL-6), which are markers related to inflammatory processes. Participants also reported decreased headache severity and duration, along with a slight decrease in headache frequency.
These findings suggest that curcumin might be beneficial for those experiencing migraines, potentially due to its anti-inflammatory properties. Importantly, there were no significant changes in body mass index, weight, or body composition between the groups, indicating that the effects were likely specific to migraine symptoms rather than overall health changes.
Read More
Most Useful Reviews
9.5
Migraine benefits
Curcumin acts as a tonic, analgesic, and hemostatic. Its regular use increases antimicrobial proteins, bolstering immune support against fungi and viruses. I benefit from it for migraines, gallstones, and more. It also lowers cholesterol, preventing thrombosis and atherosclerosis. I take one capsule daily with food.
Read More
8.8
Migraine relief
Curcumin is the active compound in turmeric, known for its strong anti-inflammatory and antioxidant properties. I have found it helpful in alleviating migraine headaches and easing osteoarthritis. The capsules come well-packaged.
Read More
7
Mild pain relief
I took it for my migraine and found it offers slight pain relief.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
9.5
Combined turmeric and omega-3 benefits
The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients.
Turmeric's isolated effectiveness unclear
To investigate the impact of turmeric on migraines, we evaluated the effects of nano-curcumin, a potent form of turmeric, combined with omega-3 fatty acids over a two-month clinical trial. The study involved 74 individuals who experienced episodic migraines, divided into four groups. Each group received either the omega-3 fatty acids, nano-curcumin, a combination of the two, or a placebo.
Our results revealed that the combination of omega-3 fatty acids and nano-curcumin significantly reduced the expression of a specific inflammatory marker called TNF-α, which has been linked to migraine triggers. Interestingly, while supplements of omega-3 fatty acids and nano-curcumin alone did not demonstrate a noteworthy reduction in either TNF-α gene expression or its serum levels, the combined treatment did show promising results.
Additionally, we found that the reduction in migraine attack frequency was more pronounced in those taking the combination therapy. These findings suggested that while turmeric on its own may not substantially alleviate migraine symptoms, its combination with omega-3s offers a new approach worth considering for migraine management.
Our results revealed that the combination of omega-3 fatty acids and nano-curcumin significantly reduced the expression of a specific inflammatory marker called TNF-α, which has been linked to migraine triggers. Interestingly, while supplements of omega-3 fatty acids and nano-curcumin alone did not demonstrate a noteworthy reduction in either TNF-α gene expression or its serum levels, the combined treatment did show promising results.
Additionally, we found that the reduction in migraine attack frequency was more pronounced in those taking the combination therapy. These findings suggested that while turmeric on its own may not substantially alleviate migraine symptoms, its combination with omega-3s offers a new approach worth considering for migraine management.
Read More
9
Nano-curcumin reduces IL-17 levels
The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial.
Directly addresses turmeric's impact.
We conducted a study to explore how nano-curcumin, a special formulation of turmeric, influences the balance of immune proteins associated with migraines. By randomly assigning forty participants with episodic migraines to receive either an 80 mg dose of nano-curcumin or a placebo for two months, we ensured that our findings would be robust and reliable.
Our primary focus was on two key proteins: interferon gamma (IFN-γ) and interleukin-17 (IL-17). These proteins play significant roles in immune responses and are implicated in migraine pathophysiology. Using advanced techniques like real-time PCR and ELISA, we measured the levels of these proteins in our participants' blood.
The results were promising; we noted a significant decrease in the levels and gene expression of IL-17 in the group taking nano-curcumin compared to the placebo group. However, it’s important to mention that we found no significant differences in the levels of IFN-γ between the groups.
Overall, our findings suggest that nano-curcumin supplementation may provide beneficial effects for migraine patients by specifically targeting IL-17, which could lead to new approaches for managing migraine symptoms going forward.
Our primary focus was on two key proteins: interferon gamma (IFN-γ) and interleukin-17 (IL-17). These proteins play significant roles in immune responses and are implicated in migraine pathophysiology. Using advanced techniques like real-time PCR and ELISA, we measured the levels of these proteins in our participants' blood.
The results were promising; we noted a significant decrease in the levels and gene expression of IL-17 in the group taking nano-curcumin compared to the placebo group. However, it’s important to mention that we found no significant differences in the levels of IFN-γ between the groups.
Overall, our findings suggest that nano-curcumin supplementation may provide beneficial effects for migraine patients by specifically targeting IL-17, which could lead to new approaches for managing migraine symptoms going forward.
Read More
9
Curcumin and Naproxen for Migraine
Liposomal Curcumin Enhances the Effect of Naproxen in a Rat Model of Migraine.
Focus on combination treatments
Our study examined the effects of curcumin, a natural compound known for its antioxidant properties, in combination with naproxen, a common pain reliever, on migraine-like symptoms in a rat model. We set up a controlled experiment with 63 male Wistar rats, dividing them into groups to compare various treatments: some received naproxen alone, while others received it alongside either a standard curcumin solution or a more advanced liposomal curcumin.
In our findings, we noted that the group treated with liposomal curcumin and naproxen showed significant improvements in reducing oxidative stress markers and pain levels compared to those receiving just naproxen or curcumin solution alone. Interestingly, higher doses of the curcumin solution combined with naproxen enhanced its effectiveness during early pain phases.
Overall, our research suggests that pairing liposomal curcumin with naproxen may provide better relief from migraine symptoms than using either treatment alone. This combination not only improved pain management but could also potentially offer better antioxidant benefits, making it a promising area for further exploration in migraine therapy.
In our findings, we noted that the group treated with liposomal curcumin and naproxen showed significant improvements in reducing oxidative stress markers and pain levels compared to those receiving just naproxen or curcumin solution alone. Interestingly, higher doses of the curcumin solution combined with naproxen enhanced its effectiveness during early pain phases.
Overall, our research suggests that pairing liposomal curcumin with naproxen may provide better relief from migraine symptoms than using either treatment alone. This combination not only improved pain management but could also potentially offer better antioxidant benefits, making it a promising area for further exploration in migraine therapy.
Read More
9
Curcumin shows promise in migraines
The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats.
Moderate importance for migraine therapy
In our investigation, we looked at how liposomal curcumin could impact migraine treatment, particularly when combined with sumatriptan, a common medication used for migraines. We set up a systematic study with seven groups of rats, some receiving nitroglycerin to induce migraines, while others were treated with sumatriptan and varying doses of curcumin or liposomal curcumin. By comparing different combinations, we aimed to see if curcumin could enhance the effectiveness of sumatriptan.
Our results showed that liposomal curcumin, especially at a dose of 2 mg per 100 grams of body weight, appeared to be the most promising in alleviating migraine symptoms. This suggests that liposomal curcumin might serve as a beneficial addition to traditional migraine treatment strategies.
It's insightful to consider the potential of curcumin, known for its antioxidative properties, in migraine management. We believe this research lays the groundwork for further studies into how curcumin can be effectively used alongside existing migraine therapies. It opens up exciting new avenues for migraine sufferers looking for alternative or adjunct treatments.
Our results showed that liposomal curcumin, especially at a dose of 2 mg per 100 grams of body weight, appeared to be the most promising in alleviating migraine symptoms. This suggests that liposomal curcumin might serve as a beneficial addition to traditional migraine treatment strategies.
It's insightful to consider the potential of curcumin, known for its antioxidative properties, in migraine management. We believe this research lays the groundwork for further studies into how curcumin can be effectively used alongside existing migraine therapies. It opens up exciting new avenues for migraine sufferers looking for alternative or adjunct treatments.
Read More
8
Nano-curcumin reduces migraine severity
The effects of nano-curcumin supplementation on adipokines levels in obese and overweight patients with migraine: a double blind clinical trial study.
Highly relevant migraine treatment study
We explored how nano-curcumin, a more bioavailable form of turmeric, could affect migraine symptoms and adipokine levels in individuals who are overweight or obese. Our study involved 44 patients experiencing episodic migraines, divided into a nano-curcumin group receiving 80 mg daily and a control group over a two-month period.
We measured serum levels of certain biomarkers associated with inflammation, such as MCP-1, Resistin, and Visfatin, before and after the treatment. Notably, we found that the nano-curcumin group experienced a significant reduction in the MCP-1 serum levels. For Resistin and Visfatin, however, no significant changes were observed.
Additionally, participants taking nano-curcumin reported fewer headache attacks, less severe pain, and shorter durations of migraines compared to those in the control group. While the results are promising, particularly regarding the reduction of headache symptoms, we recognize the need for further research to solidify these findings before making definitive claims.
We measured serum levels of certain biomarkers associated with inflammation, such as MCP-1, Resistin, and Visfatin, before and after the treatment. Notably, we found that the nano-curcumin group experienced a significant reduction in the MCP-1 serum levels. For Resistin and Visfatin, however, no significant changes were observed.
Additionally, participants taking nano-curcumin reported fewer headache attacks, less severe pain, and shorter durations of migraines compared to those in the control group. While the results are promising, particularly regarding the reduction of headache symptoms, we recognize the need for further research to solidify these findings before making definitive claims.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Migraine benefits
Curcumin acts as a tonic, analgesic, and hemostatic. Its regular use increases antimicrobial proteins, bolstering immune support against fungi and viruses. I benefit from it for migraines, gallstones, and more. It also lowers cholesterol, preventing thrombosis and atherosclerosis. I take one capsule daily with food.
Read More
8.8
Migraine relief
Curcumin is the active compound in turmeric, known for its strong anti-inflammatory and antioxidant properties. I have found it helpful in alleviating migraine headaches and easing osteoarthritis. The capsules come well-packaged.
7
Mild pain relief
I took it for my migraine and found it offers slight pain relief.
