Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
The product is found useful for the following medical conditions
Dizziness details
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.7
USERS' SCORE
Excellent
Based on 5 Reviews
9
We explored the effectiveness of L-methylfolate, a form of folate, on alleviating dizziness, particularly in individuals with a specific genetic mutation. In one case, a patient experienced prolonged symptoms like headache, fatigue, and dizziness after taking terbinafine, known as Lamisil.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
10
Dizziness eliminated
Most Useful Review
2 people found this helpful
Favourite complex of good vitamins! I have been taking these for myself and my family for five months now, as everyone has folate cycle mutations. My low erythrocytes improved significantly, and during this period, the severe dizziness that plagued me for more than eight years has vanished. I've noticed many positive changes in my well-being. The convenient form delivers three vitamins at once in an active form.
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 14 Reviews
8.6
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
9
Increased energy
Most Useful Review
17 people found this helpful
Helped very cold feet and numb toes! This supplement worked wonders in just two days, reducing numbness in my toes, and alleviating the coldness in my feet. I've also noticed a boost in my energy levels and look forward to more improvements as time goes on. I highly recommend it to anyone experiencing similar issues.
Gout details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Folate's impact on gout therapy
Botson JK, Tesser JRP, Bennett R, Kenney HM, Peloso PM, et al. A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study. Arthritis Res Ther. 2022;24:208. doi:10.1186/s13075-022-02865-z
We explored the efficacy of methotrexate in conjunction with folate as a treatment approach for patients suffering from uncontrolled gout, specifically those using the medication pegloticase. The study aimed to understand how this combination therapy could enhance response rates and overall treatment success compared to pegloticase alone.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
9
Gout improvement
Most Useful Review
228 people found this helpful
I was sceptical about vitamin effectiveness, but the studies show that vitamins, especially folate and B vitamins, can be beneficial. I sent some to my father, who has gout, and since his first dose, he has had no more gout attacks. He has it on auto order now.
Tinnitus details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
10
Relieved neuropathy pain
Most Useful Review
10 people found this helpful
My doctor prescribed an expensive medication for neuropathy in my feet, which I couldn’t afford. Instead, I found similar products on Amazon and achieved instant relief from my numb feet and tinnitus. Soon after, I discovered this product pre-made with the original formula's amounts. It works and is cost-effective.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 12 Reviews
8.5
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
10
Metabolism improved
Most Useful Review
Excellent quality product with well-chosen ingredients. I experienced no allergies or negative reactions. The packaging is ample, and the capsules are medium in size with a neutral taste. After one week, I noticed improved bowel function and a calmer nervous system. I have no doubt regarding its effectiveness – just ensure you check the dosage based on your age.
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.5
We sought to understand how intramuscular vitamin B12 could help alleviate low back pain in patients with mechanical lumbago. In a rigorous study involving 60 participants, we compared the effects of vitamin B12 to a placebo.
Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.
Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.
Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.
Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.
9
Improved iron levels
Most Useful Review
22 people found this helpful
After struggling with anaemia in 2018 and spending about 8000r on injections and tests, my iron level increased by just 3 units, which was disappointing. I discovered the Aicher website and ordered vitamin B12 along with iron, as B12 aids absorption. After three weeks, my results improved significantly. Additionally, the B vitamins help to decrease homocysteine levels, which is crucial for vascular health.
Bone Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 8 Reviews
8.5
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
9
Reduced joint pain
Most Useful Review
15 people found this helpful
The endocrinologist prescribed this drug for me due to elevated homocysteine and a disturbed folate cycle. I received delicious vitamins to take under the tongue. Surprisingly, I noticed significant relief from my joint pain, especially in my back, which is affected by a lumbar spine hernia. After reading about B vitamins' ability to alleviate joint pain, I realised their benefits. I began to feel ill less frequently and even bought the product for my grandson, as it truly works. This is my second purchase!
Celiac details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Highly recommended product
Most Useful Review
Perfect! An excellent quality and reliable product. It is vegan and gluten-free, ideal for those with coeliac disease, and dissolves easily in the mouth, eliminating the necessity to swallow. The taste is also pleasant. It comprises the active forms of vitamins B12, B9, and B6. I wholeheartedly recommend it.
Heart Attack details
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
USERS' SCORE
Good
Based on 8 Reviews
8.5
We explored whether vitamin B6 can aid heart recovery after a heart attack. Our study showed that vitamin B6 promotes angiogenesis, the formation of new blood vessels, which plays a key role in heart function recovery.
We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.
We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.
9
Homocysteine reduction
Most Useful Review
59 people found this helpful
Does it really work? I took this to lower my homocysteine, which can damage blood vessels and increase the risk of heart attack. My levels dropped from 9.3 to 5.5, which is excellent. It's essential for women planning to conceive, though not all doctors mention it.
Mild Cognitive Impairment details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Supports energy levels
Most Useful Review
Vitamin B12 spray is a convenient supplement that allows quick absorption through the mouth's mucous membrane. It is particularly beneficial for individuals struggling with gastrointestinal absorption, such as those with stomach-related issues or vegans, who often lack B12, primarily found in animal products. The benefits of this spray include fast absorption, ease of use, and suitability for those with digestive problems. Moreover, vitamin B12 supports the nervous system, boosts energy levels by aiding red blood cell production, enhances memory and concentration, and fosters mental health by preventing disorders linked to its deficiency. Usage typically involves one to two sprays daily, and side effects are rare due to its water-solubility.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
9
Calms insomnia and anxiety
Most Useful Review
51 people found this helpful
I have the MTHFR gene mutation, which causes anxiety symptoms. I was searching for a soluble methyl-folate and found this product incredible. It works fast, calming my nerves and reducing insomnia. I now take two a day, and it's made a significant difference in alleviating my anxiety and ensuring a calm sleep. I won't leave home without it; I highly recommend it.
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.4
We evaluated the impact of vitamin B6 on chest pain and its potential role in preventing related cardiac issues. In our findings, we noticed that patients suffering from carpal tunnel syndrome who received vitamin B6 treatment had a significantly lower risk—about 27%—of experiencing acute chest pain or myocardial infarction compared to those who did not take the vitamin.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
9
Numbness relief
Most Useful Review
7 people found this helpful
I developed severe shoulder blade pain and carpal tunnel syndrome from poor posture, which caused numbness for two months. I feared it might be permanent and considered surgery but opted for vitamin B12 instead. After a week, the symptoms began to lessen, and after a month, I feel markedly better. The numbness has disappeared, which feels unbelievable. I highly recommend this supplement if you're experiencing similar issues.
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.4
We explored the effects of vitamin B6, specifically pyridoxine, on hypothyroidism through a study involving adult male Sprague-Dawley rats. These rats were placed on a pyridoxine-deficient diet for 8 weeks, during which they developed significant hypertension compared to those that received adequate pyridoxine.
Upon analyzing the results, we discovered that the hypothalamic levels of important substances like pyridoxal phosphate, serotonin, and gamma-aminobutyric acid were notably lower in the pyridoxine-deficient rats. This deficiency was linked to increased sympathetic activity, contributing to the observed hypertension.
The exciting part came when we treated the pyridoxine-deficient rats with a single dose of pyridoxine. Within 24 hours, we saw a remarkable improvement—their blood pressure returned to normal, and their hypothalamic levels of serotonin and gamma-aminobutyric acid rebounded as well. Additionally, levels of norepinephrine and epinephrine returned to normal, indicating a restoration of balance within their systems.
Ultimately, our findings suggest a strong association between vitamin B6 deficiency and hypothalamic dysfunction, highlighting vitamin B6's potential role in alleviating related conditions like hypertension and hypothyroidism.
Upon analyzing the results, we discovered that the hypothalamic levels of important substances like pyridoxal phosphate, serotonin, and gamma-aminobutyric acid were notably lower in the pyridoxine-deficient rats. This deficiency was linked to increased sympathetic activity, contributing to the observed hypertension.
The exciting part came when we treated the pyridoxine-deficient rats with a single dose of pyridoxine. Within 24 hours, we saw a remarkable improvement—their blood pressure returned to normal, and their hypothalamic levels of serotonin and gamma-aminobutyric acid rebounded as well. Additionally, levels of norepinephrine and epinephrine returned to normal, indicating a restoration of balance within their systems.
Ultimately, our findings suggest a strong association between vitamin B6 deficiency and hypothalamic dysfunction, highlighting vitamin B6's potential role in alleviating related conditions like hypertension and hypothyroidism.
7.5
Improved performance.
Most Useful Review
144 people found this helpful
Very good help with hypothyroidism; it also helps correct anaemia. After just one course, my performance improves, and we are satisfied.
Leg Cramps details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.4
We conducted a randomized, double-blind study to see if vitamin B complex could help older adults with nighttime leg cramps. Over three months, participants reported their cramp frequency and intensity.
The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.
The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.
7.5
Improved sleep quality
Most Useful Review
1 people found this helpful
My mind is clearer now. Approximately 15 years ago, when I experienced foggy thinking, I began taking vitamin B12. After finishing one bottle, my clarity improved. At that time, I was in my mid-40s. I believe it was the vitamin B12 that helped, particularly as I also struggled with neuralgia, leading to shaking and tension in my legs at night, disrupting my sleep due to restless leg syndrome. This B12 has proven effective. I tried various products but chose Jarrow due to its high purity, excellent quality, and palatable taste. This product has been beneficial in numerous respects.
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
USERS' SCORE
Good
Based on 9 Reviews
8.4
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
10
Lowered homocysteine
Most Useful Review
17 people found this helpful
Many gynecologists recommend folic acid for pregnancy, but in Russia, most options are inactive. This supplement contains the best active forms of B vitamins and quickly lowers homocysteine, which is crucial for avoiding complications like liver disease.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.3
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
8
Essential for pregnancy
Most Useful Review
Excellent! Methylfolate ((6S)-5-methyltetrahydrofolate) is a highly effective active form of folic acid. Quatrefolic® is a fourth-generation production technology. ✅ Folic acid deficiency can cause brain dysfunction, colon cancer, and heart disease! Vitamin C during pregnancy is vital for both mother and child. Sufficient folate in a pregnant woman's diet can reduce the risk of developmental defects in the brain and spinal cord. Additionally, Vitamin C is crucial for all cell growth processes, including supporting immunity and heart function.
Ear Infection details
SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
USERS' SCORE
Good
Based on 2 Reviews
8.3
We explored the effectiveness of folate treatment in children with ear infections by evaluating hematologic abnormalities during antibiotic therapy. In a study involving 120 children with otitis media, we divided the participants into three groups: one received cotrimoxazole (the combination of trimethoprim and sulfamethoxazole), the second group received cotrimoxazole with folinic acid (a form of folate), and the third group was given amoxicillin.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
9
Improved immunity
Most Useful Review
2 people found this helpful
My neurologist prescribed this vitamin B12 supplement to support my nervous system and help with my ear infection-related tinnitus. The small, slightly sweet pills seem to be well absorbed and effective. This autumn, I didn't catch a single cold, and my immunity improved noticeably. It has also enhanced my memory, sleep, and emotional stability, contributing to a better overall state.
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.3
We investigated how niacin intake impacts pain and function in individuals with knee osteoarthritis (OA).
Using data from the Osteoarthritis Initiative, we analyzed niacin consumption alongside pain and functional scores.
Our findings reveal a significant association between higher niacin intake and reduced knee pain, suggesting that boosting niacin levels might improve the quality of life for OA patients.
Notably, specific groups, including middle-aged individuals and women, experienced even greater benefits.
Using data from the Osteoarthritis Initiative, we analyzed niacin consumption alongside pain and functional scores.
Our findings reveal a significant association between higher niacin intake and reduced knee pain, suggesting that boosting niacin levels might improve the quality of life for OA patients.
Notably, specific groups, including middle-aged individuals and women, experienced even greater benefits.
9
Resolved knee pain
Most Useful Review
7 people found this helpful
I developed a straight neck from poor posture, leading to shoulder blade pain, a cervical hernia, and carpal tunnel syndrome. After taking B12 for a month, the numbness and pain improved significantly. It felt almost unbelievable that my symptoms disappeared, especially the knee pain, giving me hope against potential surgery.
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.2
7.5
Greatly alleviates discomfort
Most Useful Review
I bought it for myself and take it regularly. Previously, I used picolinate, but I decided to try these lozenges this time and I haven’t regretted it at all (even though zinc is in a different form here)! They have a very pleasant taste and help to soothe my throat when dissolved. Occasionally, other zinc supplements have made me feel nauseous, but I haven’t experienced that with these lozenges. If you find yourself feeling that way, try taking it with food. I can see the effects; I take it as soon as my throat begins to hurt, following the instructions every two hours, and it significantly eases my discomfort. I recommend it!
Atrial Septal Defect details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.2
7.5
Significant developmental leap
Most Useful Review
2 people found this helpful
I worked with a doctor who prescribed an additive for my child with an atrial septal defect, who is 5 years old. The B vitamins needed to be injected gradually, but we gave him half a pill initially, resulting in a strong overexcitation reaction. We then reduced the dosage to 1/8 of the tablet. Once the supplement was introduced, there was a noticeable leap in development; my child began to speak much more and engaged in echolalia. After two months, echolalia occurred only during emotional moments.
Autism details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 5 Reviews
8.2
We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
9
Great concentration
Most Useful Review
Good for kids who have autism! My boy's concentration and vitality have significantly improved. He takes it every other day; it’s an active vitamin B complex optimised for children who struggle with swallowing pills.
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
USERS' SCORE
Good
Based on 11 Reviews
8.2
We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
9
Reduced blood clot
Most Useful Review
59 people found this helpful
I switched to this more affordable complex to lower my homocysteine, which is harmful to blood vessels and can cause blood clots. After taking it, my levels went down from 9.3 to 5.5. I'll continue using it, particularly since it’s essential for girls planning pregnancy.
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 12 Reviews
8.2
9
Flu recovery
Most Useful Review
It's a good brand with the right dosage and taste. When I caught the flu and had a low fever, I followed the instructions and took one pill daily. After two days, the fever and cough were surprisingly relieved, indicating its effectiveness.
Heart Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8
USERS' SCORE
Good
Based on 16 Reviews
8.2
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
9
Heart health improvements
Most Useful Review
105 people found this helpful
Finding this supplement was a revelation; it combines active folic acid and B12 in a sublingual form, helping absorption and potentially lowering heart disease risks. I noticed a lift in mood and energy shortly after taking it. The slight chemical sweet taste is the only downside for me.
Pelvic Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.2
We assessed how effective oral vitamin B1 could be in treating primary dysmenorrhea, which causes significant pelvic pain in young women. In a robust study involving 556 participants aged 12-21 years, we administered 100 mg of vitamin B1 daily for 90 days.
The results were promising, with 87% of participants reportedly completely cured, while 8% experienced some relief. Notably, these positive outcomes persisted for two months after treatment ended, showcasing vitamin B1 as a safe and cost-effective approach to address the root cause of pelvic pain.
The results were promising, with 87% of participants reportedly completely cured, while 8% experienced some relief. Notably, these positive outcomes persisted for two months after treatment ended, showcasing vitamin B1 as a safe and cost-effective approach to address the root cause of pelvic pain.
9
Numbness alleviated
Most Useful Review
7 people found this helpful
I developed a straight neck from poor posture, leading to shoulder blade pain, cervical hernia, and carpal tunnel syndrome, with persistent numbness for two months. I considered surgery but opted for vitamin B12 after extensive research. It doesn’t work instantly, but after a week, the numbness began to subside, and soon disappeared. I feel much better now. If you experience similar symptoms, I strongly recommend this supplement.
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 7 Reviews
8.2
We conducted a thorough investigation into how dietary components, particularly folate, relate to the severity of obstructive sleep apnea (OSA) in a group of adults living in Cyprus. Our study included a diverse sample of 303 participants aged over 18, who completed detailed food frequency and physical activity questionnaires, along with undergoing sleep studies to assess OSA severity.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
9
Better sleep achieved
Most Useful Review
1 people found this helpful
I initially took B12 to address my deficiency, but to my delight, it also improved my sleep. I now fall asleep quickly, which was a problem before, even with other medications.
Stroke details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
USERS' SCORE
Good
Based on 13 Reviews
8.2
We investigated the impact of combined B-vitamin supplementation—specifically folic acid, vitamin B12, and vitamin B6—on stroke prevention. Through a thorough analysis of 14 randomized controlled trials, we found that these vitamins significantly reduced stroke risk, especially in areas lacking folic acid fortification.
Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.
Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.
9
Reduced homocysteine levels
Most Useful Review
59 people found this helpful
Does it really work? I previously ordered a more expensive product, but I decided to try this one to lower my homocysteine levels. For those unaware, homocysteine can damage our vessels, leading to high blood pressure, strokes, and other serious issues. After taking this medication, my homocysteine dropped from 9.3 to 5.5, which is perfect. I’m delighted with the results and have recommended it to my husband and mother. It’s crucial to manage homocysteine levels, especially for women planning to conceive, although many doctors overlook this.
Neuropathy details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.2
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
9
Instant relief
Most Useful Review
10 people found this helpful
My doctor prescribed an expensive medication for neuropathy in my feet, which I couldn't afford. I discovered similar ingredients available on Amazon and found instant relief, not just from foot numbness but my Tinnitus vanished too. Later, we found a pre-made product with the same quantities as the original formulation. It is effective and affordable, and I love it!
Anemia details
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.9
USERS' SCORE
Good
Based on 53 Reviews
8.1
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
7.5
Supports energy production
Most Useful Review
571 people found this helpful
Excellent composition! I take these vitamins daily, finding them delicious and effective against anaemia. They support energy and biochemical processes. I highly recommend them, especially since they're hard to find elsewhere.
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.9
USERS' SCORE
Good
Based on 9 Reviews
8.1
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
9
Supports heart health
Most Useful Review
B12 and folate Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) merges the biologically active forms of vitamins B12, B9, and B6 to bolster cellular energy metabolism and neurotransmitter synthesis. This blend aids in converting homocysteine to methionine, promoting cardiovascular health.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.5
USERS' SCORE
Good
Based on 15 Reviews
8.1
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
9
Cognitive function enhanced
Most Useful Review
2 people found this helpful
This product combines active forms of vitamins to support DNA synthesis, neurotransmitter function, and amino acid metabolism. It is beneficial for brain activity, red blood cell formation, and cognitive functions. Additionally, it helps to alleviate depression and normalise hormones.
High Cholesterol details
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
USERS' SCORE
Good
Based on 18 Reviews
8.1
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
9
Effective for health
Most Useful Review
238 people found this helpful
A very good, effective product. It combines Methylfolate and B12 in active forms, and the taste is pleasant. It enhances absorption and assists with high cholesterol and anaemia. I have noticed improvements in my overall wellbeing and mood.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.7
USERS' SCORE
Good
Based on 19 Reviews
8
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
9
Lowered homocysteine
Most Useful Review
59 people found this helpful
I'd previously ordered a costlier product aimed at reducing homocysteine, which can harm blood vessels and lead to complications like miscarriages. After taking two tablets of this supplement for some time, my homocysteine levels significantly dropped from 9.3 to 5.5—an excellent result! Especially important for women planning to conceive.
Hair Loss details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.4
USERS' SCORE
Good
Based on 14 Reviews
8
We examined a new strain derived from the human microbiome, Cicaria, to see how it helps with hair loss. Through testing on individuals with hair loss and comparing them to a control group with normal scalps, we found that Cicaria produced key compounds like adenosine and biotin. Notably, hair follicles treated with these elements displayed longer lengths and maintained healthier root diameters. Furthermore, these treatments appeared to support the phases of hair growth, slowing the transition to hair loss. Thus, Cicaria shows potential as a treatment for hair loss.
7.5
Reduced hair loss
Most Useful Review
10 people found this helpful
I used it for a month and experienced lethargy, fatigue, and hair loss. Prior to using this, I suffered from spinning and dizziness, but that has now disappeared. Additionally, I have noticed less hair loss. If my comment helps you, please give me a like 🤩.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.5
USERS' SCORE
Good
Based on 10 Reviews
8
Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
10
Headaches disappeared
Most Useful Review
After a month of taking, my nearly daily headaches vanished, and my health significantly improved. I am exceedingly pleased with the effects.
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.7
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
7.5
Improved blood counts
Most Useful Review
26 people found this helpful
My husband has type 2 diabetes. He takes Glucofazhlong 1000 regularly, which has decreased his vitamin B12 and folic acid levels. He uses this product once daily under the tongue for three months with two-month intervals. His blood counts have improved, and his homocysteine levels have decreased. Additionally, he takes Q10, necessary for those with metabolic syndrome due to diabetes. I highly recommend it!
Rash details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
9
Vitamin B deficiency leads to rash
Adie MA, Martes Gomez M, Yom J, Durand M, Wertheimer F, et al. Twin Premature Infants With Riboflavin and Biotin Deficiency Presenting With Refractory Lactic Acidosis, Rash, and Multiorgan Failure During Prolonged Parenteral Nutrition. J Investig Med High Impact Case Rep. 2023;11:23247096231168111. doi:10.1177/23247096231168111
We explored the effects of riboflavin and biotin deficiencies in premature twins, who initially presented with skin rashes among other severe symptoms. After being diagnosed, one twin began supplementation with these vitamins.
Remarkably, this led to a quick improvement in clinical condition and laboratory findings within days. Though one twin experienced tragic complications resulting in death, the surviving twin went home in stable condition, highlighting the importance of addressing vitamin deficiencies early.
Remarkably, this led to a quick improvement in clinical condition and laboratory findings within days. Though one twin experienced tragic complications resulting in death, the surviving twin went home in stable condition, highlighting the importance of addressing vitamin deficiencies early.
9
No allergies experienced
Most Useful Review
All other vitamin B12 brands caused an allergic rash on my face, but these suited me perfectly.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.3
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.8
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
9
Anxiety and insomnia relief
Most Useful Review
51 people found this helpful
Having the MTHFR gene mutation causes me anxiety symptoms, so I was on the lookout for a soluble methyl-folate, as I find them more effective than regular pills. I discovered this product by Jarrow, which I find incredible. I feel its effects almost immediately, calming my anxiety within minutes. Additionally, it helps with my insomnia on anxious nights, helping me to achieve restful sleep. I recommend never leaving home without it!
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.8
We examined how Cariban, a combination of doxylamine and pyridoxine, helps alleviate nausea and vomiting during pregnancy. Using a controlled study involving 12 healthy women, we looked at how the modified-release capsules perform in the body compared to other forms.
Our findings showed that Cariban is absorbed quickly and maintains its effectiveness over an extended period. This makes it a reliable option for managing nausea in pregnant women, underscoring its value in clinical practice.
Our findings showed that Cariban is absorbed quickly and maintains its effectiveness over an extended period. This makes it a reliable option for managing nausea in pregnant women, underscoring its value in clinical practice.
8
Reduced nausea significantly
Most Useful Review
1 people found this helpful
Great buy. Recommended by my naturopathic doctor, this product helped me metabolise folate better when expecting. It supported my baby's health, reduced my nausea (I had none after seven weeks), and increased my energy.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.2
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.7
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9
Numbness alleviated
Most Useful Review
7 people found this helpful
After developing chronic fatigue syndrome with numbness due to poor posture, I sought a supplement. After a week of taking vitamin B12, my symptoms lessened significantly. Within a month, the numbness vanished, and I felt much better. If you face similar issues, I strongly recommend trying this supplement.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.2
USERS' SCORE
Medium or Average
Based on 9 Reviews
6.7
We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
9
Effective treatment
Most Useful Review
I was prescribed this by an endocrinologist for my skin problems, and I noticed that my acne disappeared after a month of use. The results are outstanding, and I also enjoy the flavour.
