Last update
3/22/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.9
USERS' SCORE
Good
Based on 36 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9.5
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
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9.5
We observed that Vitamin B6 (VB6) plays a crucial role in preventing certain types of anemia, particularly in individuals undergoing treatment for Parkinson's disease. In this case, a 75-year-old man who was receiving levodopa/carbidopa intestinal gel therapy developed severe VB6 deficiency anemia. This condition is characterized by microcytic, hypochromic, and sideroblastic blood profiles, which can resemble myelodysplastic syndrome.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
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9
We explored the intriguing link between vitamin B12 deficiency and anemia, particularly through a rare condition known as pseudo-thrombotic microangiopathy. This condition mimics other thrombotic microangiopathies and could lead to unnecessary treatments such as plasmapheresis.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
Read More
Most Useful Reviews
9
Improves absorption rates
277 people found this helpful
This is a good quality product. The combination of Methylfolate and B12 in active forms tastes great and is effective. I find that taking it sublingually helps with the absorption of B12, supporting my recovery from anaemia. I recommend it.
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7.5
Improves B12 absorption
75 people found this helpful
All ingredients are in active, digestible forms! I have B12 deficiency anemia and require daily supplementation. This preparation contains methylcobalamin, which is easily absorbed. It also includes vitamin B6 and B9, improving B12 absorption and preventing homocysteine from rising. My blood tests show normal B12 levels, and I’m pleased with the results.
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9
Boosts energy levels
65 people found this helpful
This excellent quality product raises my B12 levels efficiently. It aids in detoxification and helps tackle anaemia while improving my mood. I highly recommend it.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.9
- All Researches
9.5
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
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9.5
Thiamine resolves rare anemia effectively
In our examination, we focused on thiamine-responsive megaloblastic anemia (TRMA), a rare genetic disorder affecting young individuals. We learned about a young man with diabetes who faced pancytopenia, initially linked to a COVID-19 infection.
Genetic testing revealed pathogenic variants indicating TRMA, and following treatment with oral thiamine supplementation, we observed a complete resolution of his symptoms. This case underscores the importance of considering genetic factors in anemia, emphasizing that early diagnosis and treatment can significantly improve health outcomes.
Genetic testing revealed pathogenic variants indicating TRMA, and following treatment with oral thiamine supplementation, we observed a complete resolution of his symptoms. This case underscores the importance of considering genetic factors in anemia, emphasizing that early diagnosis and treatment can significantly improve health outcomes.
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9.5
We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Read More
9.5
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Read More
9.5
We observed that Vitamin B6 (VB6) plays a crucial role in preventing certain types of anemia, particularly in individuals undergoing treatment for Parkinson's disease. In this case, a 75-year-old man who was receiving levodopa/carbidopa intestinal gel therapy developed severe VB6 deficiency anemia. This condition is characterized by microcytic, hypochromic, and sideroblastic blood profiles, which can resemble myelodysplastic syndrome.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 36 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves absorption rates
277 people found this helpful
This is a good quality product. The combination of Methylfolate and B12 in active forms tastes great and is effective. I find that taking it sublingually helps with the absorption of B12, supporting my recovery from anaemia. I recommend it.
Read More
7.5
Improves B12 absorption
75 people found this helpful
All ingredients are in active, digestible forms! I have B12 deficiency anemia and require daily supplementation. This preparation contains methylcobalamin, which is easily absorbed. It also includes vitamin B6 and B9, improving B12 absorption and preventing homocysteine from rising. My blood tests show normal B12 levels, and I’m pleased with the results.
Read More
9
Boosts energy levels
65 people found this helpful
This excellent quality product raises my B12 levels efficiently. It aids in detoxification and helps tackle anaemia while improving my mood. I highly recommend it.
Read More
7.5
Essential for habits
39 people found this helpful
This complex is excellent! As a nutritionist, I recommend it to many clients since it addresses common B vitamin deficiencies. It is crucial for lowering homocysteine levels and is necessary for those with anemia, as B vitamins improve iron absorption. Testing for genetic mutations may be wise for those unable to absorb B vitamins from food.
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9
Raises hemoglobin
37 people found this helpful
A good quality product. A combination of Methylfolate and B12 that doesn’t require washing down and tastes pleasant. Vitamin B12 is often poorly absorbed; this sublingual form works well, boosting detoxification and combating anemia. An excellent remedy for raising haemoglobin, highly recommended!
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Frequently Asked Questions
7.5
Excellent energy boost
571 people found this helpful
Excellent composition; I rate these vitamins 100%. They are delightful, taken once a day between meals with vitamin B-1, and work excellently against anemia, boosting energy and other bodily processes. Many overlook B vitamins, yet production in our bodies is often low. I highly recommend them.
9
Tasty folate tablets
1 people found this helpful
Folate helped me recover from severe anaemia after five years of struggling, including multiple blood transfusions. My body cannot store iron effectively, despite numerous medications. A friend's doctor recommended Folate, and I wish I'd discovered it sooner. Jarrow's chewable tablet tastes good, making it enjoyable to take.
7.5
Aids iron absorption
2 people found this helpful
I bought these vitamins to take with chelated iron due to azemia. They improve iron absorption when combined with B vitamins and folic acid, which are in forms that the body can easily absorb.
9
Supports pregnancy health
4 people found this helpful
During pregnancy, with low iron and increased homocysteine, I found this chelated folic acid and its cofactors essential. The added vitamins significantly enhance absorption, especially for those with folate cycle mutations. It is advisable to begin taking this before pregnancy for the best results in preventing anemia and promoting healthy iron levels.
9
Love this product
19 people found this helpful
This supplement is a must-have for my history with deficiency anaemia. My haemoglobin levels have remained stable at 140 since I began taking it regularly.
7.5
Anemia treatment
1 people found this helpful
I take it on my doctor’s advice to help restore thyroid function and address anemia. This complex is very convenient for my needs.
8
We explored a compelling case of pernicious anemia in a 51-year-old Ugandan man presenting with lower limb weakness. Initially treated for vitamin B12 deficiency years earlier, he experienced similar symptoms once again.
Through careful testing, he was diagnosed with pernicious anemia, confirming that a lack of vitamin B12 affects many aspects of health. The patient showed improvement after receiving parenteral methylcobalamin therapy, indicating that vitamin B complex can be beneficial in treating anemia caused by deficiencies.
This case underlines the need for awareness and early diagnosis of vitamin B12 deficiency, especially in resource-limited settings.
Through careful testing, he was diagnosed with pernicious anemia, confirming that a lack of vitamin B12 affects many aspects of health. The patient showed improvement after receiving parenteral methylcobalamin therapy, indicating that vitamin B complex can be beneficial in treating anemia caused by deficiencies.
This case underlines the need for awareness and early diagnosis of vitamin B12 deficiency, especially in resource-limited settings.
9.5
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
8
WIFAS improving folate and hemoglobin
We explored how a school-based weekly iron and folic acid supplementation program (WIFAS) impacts serum folate levels among adolescent girls in the Sidama Region of Ethiopia.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
References
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
- Anato A, Reshid M. Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study. Sci Rep. 2025;15:3556. 10.1038/s41598-025-87957-x
- Aziz Ali S, Genkinger J, Kahe K, Valeri L, Khowaja N, et al. Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials. Syst Rev. 2025;14:11. 10.1186/s13643-024-02726-7
- Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. 10.1177/03795721241304475
- Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. 10.4103/ijph.ijph_844_23
- Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. 10.1021/acsami.4c15206
- Pascoe MA, Hall AM, Gray A. Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia. BMJ Case Rep. 2024;17. 10.1136/bcr-2024-261435
- Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. 10.1186/s13052-024-01757-z
- Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. 10.1186/s13052-024-01759-x
- Finkelstein JL, Cuthbert A, Weeks J, Venkatramanan S, Larvie DY, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2024;8:CD004736. 10.1002/14651858.CD004736.pub6
- Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. 10.1007/s00277-024-05878-7
- Cai J, Liu T, Huang Y, Chen H, Yu M, et al. A novel and apparent missense variant associated with congenital sideroblastic anemia. Front Pediatr. 2024;12:1411676. 10.3389/fped.2024.1411676
- Ducamp S, Sendamarai AK, Campagna DR, Chin DWL, Fujiwara Y, et al. Murine models of erythroid 5ALA synthesis disorders and their conditional synthetic lethal dependency on pyridoxine. Blood. 2024;144:1418. 10.1182/blood.2023023078
- Shao Y, He L, Ding S, Fu R. Luspatercept for the treatment of congenital sideroblastic anemia: Two case reports. Curr Res Transl Med. 2024;72:103438. 10.1016/j.retram.2024.103438
- Mohamed S, Ibrahim F, Alasafar MN, Alshurafa A, Akiki S, et al. Recurrent sideroblastic anemia during pregnancy. Clin Case Rep. 2023;11:e6814. 10.1002/ccr3.6814
- Yasuda H, Hatano T, Honda T, Tsutsui M, Hattori N, et al. Vitamin B6 Deficiency Anemia Attributed to Levodopa/Carbidopa Intestinal Gel Therapy for Parkinson's Disease: A Diagnostic Pitfall for Myelodysplastic Syndrome with Ring Sideroblasts. Intern Med. 2022;61:3719. 10.2169/internalmedicine.9577-22
- Abu-Zeinah G, DeSancho MT. Understanding Sideroblastic Anemia: An Overview of Genetics, Epidemiology, Pathophysiology and Current Therapeutic Options. J Blood Med. 2020;11:305. 10.2147/JBM.S232644
- Merga RT, Birhane M, Dhinsa M, Muleta B, Jemal J, et al. Determinants of compliance with iron-folic acid supplementation among pregnant mothers in Bule Hora district, Southern Ethiopia: unmatched case-control study. BMC Public Health. 2025;25:832. 10.1186/s12889-025-22005-x
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. 10.1016/S2214-109X(24)00559-X
- Weeks CJ, Mian M, Stokes M, Gold M, Shah A, et al. The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma. Hematol Rep. 2025;17. 10.3390/hematolrep17010005
- Taye M, Mohammed T, Taye W, Glagn M, Yihune M. Compliance with iron-folate supplementation among pregnant women in Southern Ethiopia: a multi-center cross-sectional study. Reprod Health. 2025;22:22. 10.1186/s12978-025-01944-z
- Kant SB, Bashir R, Khan B, Shabbir NA, Nizami AA, et al. A Cross-Sectional Study of the Maternal Health Factors: The Interplay Between Breastfeeding Patterns, Gut Microbiota, Anemia, and Cardiovascular Risk in Lactating Mothers. Cureus. 2024;16:e76316. 10.7759/cureus.76316
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. 10.1016/j.tracli.2025.01.006
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. 10.7759/cureus.75676
- Kataria S, Kataria S, Chougule D, Bharti B, Rastogi A. Evaluating the Impact of an Iron Supplementation Program for Combating Anemia in School-Age and Adolescent Females by a Grassroots Organization in India. Cureus. 2024;16:e75608. 10.7759/cureus.75608
- Chillo SL, Woldesemayat EM, Dangisso MH. Intermittent versus daily oral iron folic acid supplementation and pregnancy outcome in low- and middle-income countries: a systematic review and meta-analysis of experimental studies. Reprod Health. 2025;22:2. 10.1186/s12978-024-01917-8
- Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. 10.7759/cureus.75257
- Contreras R, Méndez GP, Mujica J, Padilla C, Selamé ME, et al. [Paroxysmal Nocturnal Hemoglobinuria: A Rare but Treatable Cause of Acute Kidney Injury. Case Report]. Rev Med Chil. 2024;152:627. 10.4067/s0034-98872024000500627
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. 10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. 10.1007/s13668-025-00622-7
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. 10.5692/clinicalneurol.cn-002023
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. 10.7759/cureus.75800
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. 10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. 10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. 10.1155/2024/3258227
- Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, et al. Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial. Front Nutr. 2024;11:1493593. 10.3389/fnut.2024.1493593
Data last updated:
