Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9.5
We explored the effects of vitamin B6, specifically pyridoxine, on hypothyroidism through a study involving adult male Sprague-Dawley rats. These rats were placed on a pyridoxine-deficient diet for 8 weeks, during which they developed significant hypertension compared to those that received adequate pyridoxine.
Upon analyzing the results, we discovered that the hypothalamic levels of important substances like pyridoxal phosphate, serotonin, and gamma-aminobutyric acid were notably lower in the pyridoxine-deficient rats. This deficiency was linked to increased sympathetic activity, contributing to the observed hypertension.
The exciting part came when we treated the pyridoxine-deficient rats with a single dose of pyridoxine. Within 24 hours, we saw a remarkable improvement—their blood pressure returned to normal, and their hypothalamic levels of serotonin and gamma-aminobutyric acid rebounded as well. Additionally, levels of norepinephrine and epinephrine returned to normal, indicating a restoration of balance within their systems.
Ultimately, our findings suggest a strong association between vitamin B6 deficiency and hypothalamic dysfunction, highlighting vitamin B6's potential role in alleviating related conditions like hypertension and hypothyroidism.
Upon analyzing the results, we discovered that the hypothalamic levels of important substances like pyridoxal phosphate, serotonin, and gamma-aminobutyric acid were notably lower in the pyridoxine-deficient rats. This deficiency was linked to increased sympathetic activity, contributing to the observed hypertension.
The exciting part came when we treated the pyridoxine-deficient rats with a single dose of pyridoxine. Within 24 hours, we saw a remarkable improvement—their blood pressure returned to normal, and their hypothalamic levels of serotonin and gamma-aminobutyric acid rebounded as well. Additionally, levels of norepinephrine and epinephrine returned to normal, indicating a restoration of balance within their systems.
Ultimately, our findings suggest a strong association between vitamin B6 deficiency and hypothalamic dysfunction, highlighting vitamin B6's potential role in alleviating related conditions like hypertension and hypothyroidism.
Read More
9
Thiamine enhances memory in hypothyroidism
We explored the impact of thiamine (Vitamin B1) on memory and learning in rats with hypothyroidism. In a study involving 50 young rats, we treated them with a hypothyroid-inducing agent and varying doses of thiamine over seven weeks.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
Read More
9
Folic acid aids hypothyroid cognition
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
Read More
Most Useful Reviews
7.5
Improved performance.
144 people found this helpful
Very good help with hypothyroidism; it also helps correct anaemia. After just one course, my performance improves, and we are satisfied.
Read More
9
Feeling great!
113 people found this helpful
Chewable tablets but not just sweets! I have hypothyroidism and high homocysteine. I take this B12 with other supplements and after a month, I feel great! The dosage is optimal, and my deficiency is replenished while homocysteine has reduced. I usually don’t forget to take it as they are delicious. More importantly, B12 is better absorbed sublingually, through the oral mucosa! A good addition, I highly recommend!
Read More
9
Boosted strength!
5 people found this helpful
Assimilated well! Gives strength and vigour! I am very pleased with this complex! Almost immediately, I experienced increased strength and energy. The tablets must be resorbed, as this complex is absorbed through the oral mucosa, which is beneficial for those with low stomach acidity and hypothyroidism. B12 enters directly into the bloodstream this way. The tablets have a pleasant berry taste and can replace sweets. It takes around 10 minutes to dissolve them completely, although they are small.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
- All Researches
9.5
We explored the effects of vitamin B6, specifically pyridoxine, on hypothyroidism through a study involving adult male Sprague-Dawley rats. These rats were placed on a pyridoxine-deficient diet for 8 weeks, during which they developed significant hypertension compared to those that received adequate pyridoxine.
Upon analyzing the results, we discovered that the hypothalamic levels of important substances like pyridoxal phosphate, serotonin, and gamma-aminobutyric acid were notably lower in the pyridoxine-deficient rats. This deficiency was linked to increased sympathetic activity, contributing to the observed hypertension.
The exciting part came when we treated the pyridoxine-deficient rats with a single dose of pyridoxine. Within 24 hours, we saw a remarkable improvement—their blood pressure returned to normal, and their hypothalamic levels of serotonin and gamma-aminobutyric acid rebounded as well. Additionally, levels of norepinephrine and epinephrine returned to normal, indicating a restoration of balance within their systems.
Ultimately, our findings suggest a strong association between vitamin B6 deficiency and hypothalamic dysfunction, highlighting vitamin B6's potential role in alleviating related conditions like hypertension and hypothyroidism.
Upon analyzing the results, we discovered that the hypothalamic levels of important substances like pyridoxal phosphate, serotonin, and gamma-aminobutyric acid were notably lower in the pyridoxine-deficient rats. This deficiency was linked to increased sympathetic activity, contributing to the observed hypertension.
The exciting part came when we treated the pyridoxine-deficient rats with a single dose of pyridoxine. Within 24 hours, we saw a remarkable improvement—their blood pressure returned to normal, and their hypothalamic levels of serotonin and gamma-aminobutyric acid rebounded as well. Additionally, levels of norepinephrine and epinephrine returned to normal, indicating a restoration of balance within their systems.
Ultimately, our findings suggest a strong association between vitamin B6 deficiency and hypothalamic dysfunction, highlighting vitamin B6's potential role in alleviating related conditions like hypertension and hypothyroidism.
Read More
9
Thiamine enhances memory in hypothyroidism
We explored the impact of thiamine (Vitamin B1) on memory and learning in rats with hypothyroidism. In a study involving 50 young rats, we treated them with a hypothyroid-inducing agent and varying doses of thiamine over seven weeks.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
Read More
9
Folic acid aids hypothyroid cognition
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
Read More
8
We aimed to explore how B vitamins, including pyridoxine, betaine, folic acid, and cyanocobalamin, can correct homocysteine metabolism disrupted by hypothyroidism. By studying experimental rats treated for prolonged periods, we found that hypothyroidism severely reduced the activity of key enzymes involved in methylation, which in turn raised homocysteine levels—linked to heart disease risk.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
Read More
8
We explored the effects of pyridoxine, also known as vitamin B6, on individuals with primary hypothyroidism. The study involved administering a single intravenous dose of 300 mg of pyridoxine to six patients.
Our findings revealed that this treatment led to a significant reduction in serum thyrotropin (TSH) levels. Surprisingly, the concentrations of thyroid hormones, thyroxine and triiodothyronine, showed no consistent change throughout the experiment.
Additionally, we observed that prolactin (PRL) levels were also suppressed after pyridoxine administration. These results suggest that pyridoxine may inhibit the secretion of both TSH and PRL, potentially acting directly on the hypothalamus or pituitary gland.
However, while pyridoxine showed promise in reducing specific hormone levels, it did not provide overall benefits in regulating thyroid hormone concentrations during the study.
This insight is important as it opens up potential avenues for further research into vitamin B6's role in thyroid function and its implications for managing hypothyroidism.
Our findings revealed that this treatment led to a significant reduction in serum thyrotropin (TSH) levels. Surprisingly, the concentrations of thyroid hormones, thyroxine and triiodothyronine, showed no consistent change throughout the experiment.
Additionally, we observed that prolactin (PRL) levels were also suppressed after pyridoxine administration. These results suggest that pyridoxine may inhibit the secretion of both TSH and PRL, potentially acting directly on the hypothalamus or pituitary gland.
However, while pyridoxine showed promise in reducing specific hormone levels, it did not provide overall benefits in regulating thyroid hormone concentrations during the study.
This insight is important as it opens up potential avenues for further research into vitamin B6's role in thyroid function and its implications for managing hypothyroidism.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved performance.
144 people found this helpful
Very good help with hypothyroidism; it also helps correct anaemia. After just one course, my performance improves, and we are satisfied.
Read More
9
Feeling great!
113 people found this helpful
Chewable tablets but not just sweets! I have hypothyroidism and high homocysteine. I take this B12 with other supplements and after a month, I feel great! The dosage is optimal, and my deficiency is replenished while homocysteine has reduced. I usually don’t forget to take it as they are delicious. More importantly, B12 is better absorbed sublingually, through the oral mucosa! A good addition, I highly recommend!
Read More
9
Boosted strength!
5 people found this helpful
Assimilated well! Gives strength and vigour! I am very pleased with this complex! Almost immediately, I experienced increased strength and energy. The tablets must be resorbed, as this complex is absorbed through the oral mucosa, which is beneficial for those with low stomach acidity and hypothyroidism. B12 enters directly into the bloodstream this way. The tablets have a pleasant berry taste and can replace sweets. It takes around 10 minutes to dissolve them completely, although they are small.
Read More
9
Convenient and effective.
1 people found this helpful
Essential supplement for hypothyroidism. Those with hypothyroidism often struggle to absorb B12, leading to fatigue and poor adrenal health. A vegan diet increases this risk, as does excessive vitamin C intake. I use courses for hypothyroidism to meet my body's needs. I recommend this convenient and effective form!
Read More
9
Highly recommend!
Good chewable tablets but not just sweets! I have hypothyroidism and high homocysteine. I take this B12 with other supplements, and after a month, I feel great! The dosage is optimal, replenishing the deficiency while reducing homocysteine. I usually don’t forget to take it as they are delicious. More importantly, B12 is better absorbed sublingually, through the oral mucosa! A good addition, I highly recommend! If my review was helpful, please click Yes. Thank you!
Read More
Frequently Asked Questions
7.5
Improved performance.
144 people found this helpful
Very good help with hypothyroidism; it also helps correct anaemia. After just one course, my performance improves, and we are satisfied.
9
Feeling great!
113 people found this helpful
Chewable tablets but not just sweets! I have hypothyroidism and high homocysteine. I take this B12 with other supplements and after a month, I feel great! The dosage is optimal, and my deficiency is replenished while homocysteine has reduced. I usually don’t forget to take it as they are delicious. More importantly, B12 is better absorbed sublingually, through the oral mucosa! A good addition, I highly recommend!
9
Boosted strength!
5 people found this helpful
Assimilated well! Gives strength and vigour! I am very pleased with this complex! Almost immediately, I experienced increased strength and energy. The tablets must be resorbed, as this complex is absorbed through the oral mucosa, which is beneficial for those with low stomach acidity and hypothyroidism. B12 enters directly into the bloodstream this way. The tablets have a pleasant berry taste and can replace sweets. It takes around 10 minutes to dissolve them completely, although they are small.
9
Highly recommend!
Good chewable tablets but not just sweets! I have hypothyroidism and high homocysteine. I take this B12 with other supplements, and after a month, I feel great! The dosage is optimal, replenishing the deficiency while reducing homocysteine. I usually don’t forget to take it as they are delicious. More importantly, B12 is better absorbed sublingually, through the oral mucosa! A good addition, I highly recommend! If my review was helpful, please click Yes. Thank you!
7
Vitamin B12 deficiency linked to hypothyroidism
We explored the connection between vitamin B12 levels and hypothyroidism in a study involving 100 patients. A significant 68% of these patients were found to be vitamin B12 deficient, with a notable correlation to the presence of anti TPO and anti Thyroglobulin antibodies.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
8
We explored the effects of pyridoxine, also known as vitamin B6, on individuals with primary hypothyroidism. The study involved administering a single intravenous dose of 300 mg of pyridoxine to six patients.
Our findings revealed that this treatment led to a significant reduction in serum thyrotropin (TSH) levels. Surprisingly, the concentrations of thyroid hormones, thyroxine and triiodothyronine, showed no consistent change throughout the experiment.
Additionally, we observed that prolactin (PRL) levels were also suppressed after pyridoxine administration. These results suggest that pyridoxine may inhibit the secretion of both TSH and PRL, potentially acting directly on the hypothalamus or pituitary gland.
However, while pyridoxine showed promise in reducing specific hormone levels, it did not provide overall benefits in regulating thyroid hormone concentrations during the study.
This insight is important as it opens up potential avenues for further research into vitamin B6's role in thyroid function and its implications for managing hypothyroidism.
Our findings revealed that this treatment led to a significant reduction in serum thyrotropin (TSH) levels. Surprisingly, the concentrations of thyroid hormones, thyroxine and triiodothyronine, showed no consistent change throughout the experiment.
Additionally, we observed that prolactin (PRL) levels were also suppressed after pyridoxine administration. These results suggest that pyridoxine may inhibit the secretion of both TSH and PRL, potentially acting directly on the hypothalamus or pituitary gland.
However, while pyridoxine showed promise in reducing specific hormone levels, it did not provide overall benefits in regulating thyroid hormone concentrations during the study.
This insight is important as it opens up potential avenues for further research into vitamin B6's role in thyroid function and its implications for managing hypothyroidism.
9
Folic acid aids hypothyroid cognition
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
7
We examined the effects of Myo-inositol on autoimmune thyroiditis and hypothyroidism. Clinical studies indicated that combining Myo-inositol with seleniomethionine significantly reduced TSH levels in patients with subclinical hypothyroidism.
This treatment not only lowered TSH but also reduced antithyroid autoantibodies, suggesting a positive immune-modulatory effect. However, further research with larger populations is needed to better understand how this treatment impacts overall quality of life and to investigate the underlying mechanisms involved.
This treatment not only lowered TSH but also reduced antithyroid autoantibodies, suggesting a positive immune-modulatory effect. However, further research with larger populations is needed to better understand how this treatment impacts overall quality of life and to investigate the underlying mechanisms involved.
References
- Saberi R, Mirazi N, Amirahmadi S, Darbandi ZK, Vafaee F, et al. Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase. Metab Brain Dis. 2023;38:2603. doi:10.1007/s11011-023-01317-0
- Chatterjee T, Gupta R, Choudhary S. A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital. J Assoc Physicians India. 2023;71:1.
- Nechyporuk V, Korda M, Pentiuk L, Dmytrenko I, Bulko I. The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats. Pol Merkur Lekarski. 2020;48:55.
- Fallahi P, Ferrari SM, Elia G, Ragusa F, Paparo SR, et al. Myo-inositol in autoimmune thyroiditis, and hypothyroidism. Rev Endocr Metab Disord. 2018;19:349. doi:10.1007/s11154-018-9477-9
- Paulose CS, Dakshinamurti K, Packer S, Stephens NL. Sympathetic stimulation and hypertension in the pyridoxine-deficient adult rat. Hypertension. 1988;11:387.
- Delitala G, Rovasio P, Lotti G. Suppression of thyrotropin (TSH) and prolactin (PRL) release by pyridoxine in chronic primary hypothyroidism. J Clin Endocrinol Metab. 1977;45:1019.
- Kakhki S, Goodarzi M, Abbaszade-Cheragheali A, Rajabi M, Masoumipour AH, et al. Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring. Int J Dev Neurosci. 2023;83:615. doi:10.1002/jdn.10289
- Amirahmadi S, Hosseini M, Ahmadabady S, Akbarian M, Abrari K, et al. Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats. Metab Brain Dis. 2021;36:2393. doi:10.1007/s11011-021-00815-3
- Adam LN, Abbas AM. Thyroid function and its association with vitamin deficiencies: a case-control study in Duhok. Expert Rev Endocrinol Metab. 2025. doi:10.1080/17446651.2025.2469686
- Gupta R, Choudhary S, Chatterjee T. A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital. Cureus. 2023;15:e44197. doi:10.7759/cureus.44197
- Benites-Zapata VA, Ignacio-Cconchoy FL, Ulloque-Badaracco JR, Hernandez-Bustamante EA, Alarcón-Braga EA, et al. Vitamin B12 levels in thyroid disorders: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023;14:1070592. doi:10.3389/fendo.2023.1070592
