Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
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9
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Read More
9
We explored how vitamin B12, specifically methylcobalamin, could help treat persistent sleep-wake disorders in adolescents. In this study, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—struggled with sleep issues that significantly impacted their daily lives and school attendance.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Read More
Most Useful Reviews
9.5
Calms insomnia and anxiety
I have the MTHFR gene mutation, which causes anxiety symptoms. I was searching for a soluble methyl-folate and found this product incredible. It works fast, calming my nerves and reducing insomnia. I now take two a day, and it's made a significant difference in alleviating my anxiety and ensuring a calm sleep. I won't leave home without it; I highly recommend it.
Read More
8.8
Enhanced sleep experience
I started taking this after being diagnosed with Hashimoto's Thyroiditis, suspecting a MTHFR mutation. I began at a low dosage and found my sleep has greatly improved. I realised my insomnia returned after forgetting to take it for three days, and it improved again when I resumed. I take it after lunch, and I've had no negative effects. The taste is quite mild, and I plan to continue purchasing it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.9
- All Researches
9
We examined a unique case of a 58-year-old woman with recurrent endometrial cancer who showed signs of severe depression and attempted suicide. Initially, her symptoms were believed to be linked to major depressive disorder.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
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9
We set out to investigate how vitamin B6 contributes to improving sleep quality in individuals experiencing mild to moderate insomnia. Our study involved 40 participants who were given a combination treatment containing melatonin, vitamin B6, and extracts from various medicinal plants.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Read More
9
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Read More
9
We explored how vitamin B12, specifically methylcobalamin, could help treat persistent sleep-wake disorders in adolescents. In this study, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—struggled with sleep issues that significantly impacted their daily lives and school attendance.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Read More
8
In a 4-week open-label study involving 40 individuals with mild-to-moderate insomnia, we explored the effects of a combination formula containing melatonin and vitamin B6.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Calms insomnia and anxiety
I have the MTHFR gene mutation, which causes anxiety symptoms. I was searching for a soluble methyl-folate and found this product incredible. It works fast, calming my nerves and reducing insomnia. I now take two a day, and it's made a significant difference in alleviating my anxiety and ensuring a calm sleep. I won't leave home without it; I highly recommend it.
Read More
8.8
Enhanced sleep experience
I started taking this after being diagnosed with Hashimoto's Thyroiditis, suspecting a MTHFR mutation. I began at a low dosage and found my sleep has greatly improved. I realised my insomnia returned after forgetting to take it for three days, and it improved again when I resumed. I take it after lunch, and I've had no negative effects. The taste is quite mild, and I plan to continue purchasing it.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- De Simone M, De Feo R, Choucha A, Ciaglia E, Fezeu F. Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin. Med Sci (Basel). 2023;12. doi:10.3390/medsci12010002
- Ishida M, Sato S, Sato I, Yoshioka A, Uchida N, et al. What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder. Palliat Support Care. 2024;22:205. doi:10.1017/S1478951523001128
- Lemoine P, Bablon JC, Da Silva C. A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Complement Ther Med. 2019;45:104. doi:10.1016/j.ctim.2019.05.024
- Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.
- Okawa M, Mishima K, Nanami T, Shimizu T, Iijima S, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13:15.
- Djokic G, Vojvodić P, Korcok D, Agic A, Rankovic A, et al. The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia. Open Access Maced J Med Sci. 2019;7:3101. doi:10.3889/oamjms.2019.771
- Lemoine P, Bablon JC, Da Silva C. A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Complement Ther Med. 2019;45:104. doi:10.1016/j.ctim.2019.05.024
- Mydlík M, Derzsiová K. Kidney damage in acute intermittent porphyria. Przegl Lek. 2011;68:610.
- An H, Xue Q, Zhang J. The association between serum total folic acid concentration and severe difficulty falling asleep in US adults: NHANES 2005-2008. Front Neurol. 2023;14:1225403. doi:10.3389/fneur.2023.1225403
- Zhang X, Wang Y, Zhao R, Hu X, Zhang B, et al. Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP). Oxid Med Cell Longev. 2019;2019:4569614. doi:10.1155/2019/4569614
- Beydoun MA, Gamaldo AA, Canas JA, Beydoun HA, Shah MT, et al. Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys. PLoS One. 2014;9:e103490. doi:10.1371/journal.pone.0103490
- Bouloukaki I, Lampou M, Raouzaiou KM, Lambraki E, Schiza S, et al. Association of Vitamin B12 Levels with Sleep Quality, Insomnia, and Sleepiness in Adult Primary Healthcare Users in Greece. Healthcare (Basel). 2023;11. doi:10.3390/healthcare11233026
- Radlberger RF, Kunz AB. Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Front Neurol. 2023;14:1141835. doi:10.3389/fneur.2023.1141835
- Xiong S, Liu Z, Yao N, Zhang X, Ge Q. The independent association between vitamin B12 and insomnia in Chinese patients with type 2 diabetes mellitus: a cross-sectional study. Nutr Diabetes. 2022;12:3. doi:10.1038/s41387-022-00181-8
- Djokic G, Vojvodić P, Korcok D, Agic A, Rankovic A, et al. The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia. Open Access Maced J Med Sci. 2019;7:3101. doi:10.3889/oamjms.2019.771
- Chang HY, Sei H, Morita Y. Effects of intravenously administered vitamin B12 on sleep in the rat. Physiol Behav. 1995;57:1019.
- Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.
- Okawa M, Mishima K, Nanami T, Shimizu T, Iijima S, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13:15.
